{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T22:48:24Z","timestamp":1793832504228,"version":"4.6.1"},"reference-count":12,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,8,12]],"date-time":"2020-08-12T00:00:00Z","timestamp":1597190400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,8,12]],"date-time":"2020-08-12T00:00:00Z","timestamp":1597190400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Neurol"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cerebral cryptococcomas is a rare form of central nervous system cryptococcosis. Most previous cases were mistaken for neoplasm before surgery. We present a case of cerebral cryptococcomas whose radiological profiles resembled demyelinating disease, especially tumefactive demyelinating lesion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>\n                      A 40-year-old male was admitted for 1-week-long unconsciousness. Brain MRI revealed a rim-enhanced mass within the corpus callosum body. Central nervous system demyelinating disease was suspected. Empirical corticosteroid treatment led to some improvement, but his condition deteriorated 2 months later. Brain MRI revealed punctate new foci.\n                      <jats:italic>Cryptococcus neoformans<\/jats:italic>\n                      was detected in cerebrospinal fluid. Cryptococcus antigen test was positive in his current and previous cerebrospinal fluid samples. The patient died despite standard antifungal treatment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Diagnosis of cerebral cryptococcomas is challenging. It may mimic demyelinating diseases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12883-020-01880-4","type":"journal-article","created":{"date-parts":[[2020,8,12]],"date-time":"2020-08-12T03:03:02Z","timestamp":1597201382000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Central nervous system Cryptococcoma mimicking demyelinating disease: a case report"],"prefix":"10.1186","volume":"20","author":[{"given":"Jie","family":"Wei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang-Yu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1572-7910","authenticated-orcid":false,"given":"Yue","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,8,12]]},"reference":[{"issue":"1","key":"1880_CR1","first-page":"107","volume":"18","author":"KS Caldemeyer","year":"1997","unstructured":"Caldemeyer KS, Mathews VP, Edwards-Brown MK, Smith RR. Central nervous system cryptococcosis: parenchymal calcification and large gelatinous pseudocysts. AJNR Am J Neuroradiol. 1997;18(1):107\u20139.","journal-title":"AJNR Am J Neuroradiol"},{"key":"1880_CR2","doi-asserted-by":"publisher","first-page":"bcr2016218824","DOI":"10.1136\/bcr-2016-218824","volume":"2017","author":"KB Ulett","year":"2017","unstructured":"Ulett KB, Cockburn JW, Jeffree R, Woods ML. Cerebral cryptococcoma mimicking glioblastoma. BMJ Case Rep. 2017;2017:bcr2016218824.","journal-title":"BMJ Case Rep"},{"key":"1880_CR3","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.mmcr.2014.08.003","volume":"6","author":"SS Velamakanni","year":"2014","unstructured":"Velamakanni SS, Bahr NC, Musubire AK, Boulware DR, Rhein J, Nabeta HW. Central nervous system cryptococcoma in a Ugandan patient with human immunodeficiency virus. 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