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Total 124 typical AD patients were consecutively recruited from April 2014 to April 2017. In 124\u2009AD patients, 47 cases (37.9%) were male and 77 cases were female; patients\u2019 age were 43\u201393\u2009years with an average of 68\u2009years. Patients were divided into AD with apathy (AD-A) and AD with no apathy (AD-NA) groups according to the score of Modified Apathy Evaluation Scale, then were evaluated cognitive functions, neuropsychiatric symptoms and activity of daily living, and tested olfactory functions. Above variables were compared between AD-A and AD-NA groups. Further correlation analyses and linear regression analysis were performed between apathy and above variables.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Compared with AD-NA group, global cognitive level, verbal memory, verbal fluency and activity of daily living were significantly compromised in AD-A group (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.002); depression and agitation were severely displayed in AD-A group (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.002). Apathy was negatively correlated with global cognitive function, verbal memory, verbal fluency and activity of daily living (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). There was no significant difference of olfactory functions between the two groups (<jats:italic>P<\/jats:italic>\u2009&gt;\u20090.002), and correlations between apathy and olfactory threshold, olfactory identification and global olfactory function were significant (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) but quite weak (|r|\u2009&lt;\u20090.3). Further linear regression analysis showed that only verbal fluency and instrumental activities of daily living were independently associated with apathy.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Independent correlations among apathy, verbal fluency and instrumental activities of daily living in AD patients might be related to the common brain area involved in their pathogeneses.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12883-020-01978-9","type":"journal-article","created":{"date-parts":[[2020,11,14]],"date-time":"2020-11-14T05:08:19Z","timestamp":1605330499000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Correlations of apathy with clinical symptoms of Alzheimer\u2019s disease and olfactory dysfunctions: a cross-sectional study"],"prefix":"10.1186","volume":"20","author":[{"given":"Shu-yang","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teng-hong","family":"Lian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-xia","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Du-yu","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan-ning","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-jun","family":"Zuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-hua","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiu-jin","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui-dan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong-yan","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-min","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,11,14]]},"reference":[{"issue":"5","key":"1978_CR1","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1097\/01.JGP.0000235689.42910.0d","volume":"15","author":"CU Onyike","year":"2007","unstructured":"Onyike CU, Sheppard JM, Tschanz JT, Norton MC, Green RC, Steinberg M, et al. 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The study was conducted in accordance with the Declaration of Helsinki, and the protocol was approved by the Beijing Tiantan Hospital review board (KY2013\u2013003-02).","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"All authors have seen and agreed with the contents of the manuscript.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"416"}}