{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T01:15:45Z","timestamp":1772673345277,"version":"3.50.1"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,1,17]],"date-time":"2020-01-17T00:00:00Z","timestamp":1579219200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,1,17]],"date-time":"2020-01-17T00:00:00Z","timestamp":1579219200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Neurol"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Necrotizing myopathy (NM) is defined by the dominant pathological feature of necrosis of muscle fibers without substantial lymphocytic inflammatory infiltration. Anti-signal recognition particle (SRP)-antibody-positive myopathy is related to NM. Anti-SRP-antibody-positive myopathy can comorbid with other disorders in some patients, however, comorbidity with malignant tumor and myopericarditis has still not been reported.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>An 87-year-old woman with dyspnea on exertion and leg edema was referred to our hospital because of suspected heart failure and elevated serum creatine kinase level. Upon hospitalization, she developed muscle weakness predominantly in the proximal muscles. Muscle biopsy and immunological blood test led to the diagnosis of anti-SRP-antibody-positive myopathy. A colon carcinoma was also found and surgically removed. The muscle weakness remained despite the tumor resection and treatment with methylprednisolone. Cardiac screening revealed arrhythmia and diastolic dysfunction with pericardial effusion, which recovered with intravenous immunoglobulin (IVIg) treatment.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>We reported the first case of anti-SRP-positive myopathy comorbid with colon carcinoma and myopericarditis. This case is rare in the point that heart failure symptoms were the first clinical presentation. The underlying mechanism is still not clear, however, physicians should be carefully aware of the neoplasm and cardiac involvement in anti-SRP-antibody positive-myopathy patients and should consider farther evaluation and management.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12883-020-1599-5","type":"journal-article","created":{"date-parts":[[2020,1,17]],"date-time":"2020-01-17T13:02:23Z","timestamp":1579266143000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Secondary cardiac involvement in anti-SRP-antibody-positive myopathy: an 87-year-old woman with heart failure symptoms as the first clinical presentation"],"prefix":"10.1186","volume":"20","author":[{"given":"Arika","family":"Hara","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryota","family":"Amano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroaki","family":"Yokote","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahide","family":"Ijima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Zeniya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiki","family":"Uchihara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sawako","family":"Yada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayumi","family":"Masumura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidenobu","family":"Takei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ichizo","family":"Nishino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuta","family":"Toru","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,1,17]]},"reference":[{"issue":"4","key":"1599_CR1","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1007\/s11926-018-0732-6","volume":"20","author":"I Pinal-Fernandez","year":"2018","unstructured":"Pinal-Fernandez I, Casal-Dominguez M, Mammen AL. Immune-mediated necrotizing myopathy. Curr Rheumatol Rep. 2018;20(4):21.","journal-title":"Curr Rheumatol Rep"},{"issue":"12","key":"1599_CR2","doi-asserted-by":"publisher","first-page":"7112","DOI":"10.1073\/pnas.77.12.7112","volume":"77","author":"P Walter","year":"1980","unstructured":"Walter P, Blobel G. Purification of a membrane-associated protein complex required for protein translocation across the endoplasmic reticulum. Proc Natl Acad Sci U S A. 1980;77(12):7112\u20136.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"24","key":"1599_CR3","doi-asserted-by":"publisher","first-page":"9507","DOI":"10.1073\/pnas.83.24.9507","volume":"83","author":"WH Reeves","year":"1986","unstructured":"Reeves WH, Nigam SK, Blobel G. Human autoantibodies reactive with the signal-recognition particle. Proc Natl Acad Sci U S A. 1986;83(24):9507\u201311.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"9","key":"1599_CR4","doi-asserted-by":"publisher","first-page":"1361","DOI":"10.1002\/art.1780330908","volume":"33","author":"IN Targoff","year":"1990","unstructured":"Targoff IN, Johnson AE, Miller FW. Antibody to signal recognition particle in polymyositis. Arthritis Rheum. 1990;33(9):1361\u201370.","journal-title":"Arthritis Rheum"},{"issue":"4","key":"1599_CR5","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1136\/jnnp.73.4.420","volume":"73","author":"T Miller","year":"2002","unstructured":"Miller T, Al-Lozi MT, Lopate G, Pestronk A. Myopathy with antibodies to the signal recognition particle: clinical and pathological features. J Neurol Neurosurg Psychiatry. 2002;73(4):420\u20138.","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"1","key":"1599_CR6","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1002\/art.11484","volume":"50","author":"AH Kao","year":"2004","unstructured":"Kao AH, Lacomis D, Lucas M, Fertig N, Oddis CV. Anti-signal recognition particle autoantibody in patients with and patients without idiopathic inflammatory myopathy. Arthritis Rheum. 2004;50(1):209\u201315.","journal-title":"Arthritis Rheum"},{"issue":"1\u20132","key":"1599_CR7","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1016\/j.jneuroim.2014.07.006","volume":"274","author":"S Suzuki","year":"2014","unstructured":"Suzuki S, Yonekawa T, Kuwana M, Hayashi YK, Okazaki Y, Kawaguchi Y, Suzuki N, Nishino I. Clinical and histological findings associated with autoantibodies detected by RNA immunoprecipitation in inflammatory myopathies. J Neuroimmunol. 2014;274(1\u20132):202\u20138.","journal-title":"J Neuroimmunol"},{"issue":"5","key":"1599_CR8","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/j.nmd.2004.02.006","volume":"14","author":"JE Hoogendijk","year":"2004","unstructured":"Hoogendijk JE, Amato AA, Lecky BR, Choy EH, Lundberg IE, Rose MR, Vencovsky J, de Visser M, Hughes RA. 119th ENMC international workshop: trial design in adult idiopathic inflammatory myopathies, with the exception of inclusion body myositis, 10-12 October 2003, Naarden, The Netherlands. Neuromuscul Disord. 2004;14(5):337\u201345.","journal-title":"Neuromuscul Disord"},{"issue":"12","key":"1599_CR9","first-page":"46","volume":"55","author":"M Takeguchi","year":"2006","unstructured":"Takeguchi M, Nanri K, Okita M, Morihara Y, Taguchi T, Ishiko T, Saitoh H. A case of belated diagnosis of anti-SRP antibody positive Polymyositis Ocuuring from myocarditis. J New Rem and Clin. 2006;55(12):46\u201353.","journal-title":"J New Rem and Clin"},{"issue":"12","key":"1599_CR10","doi-asserted-by":"publisher","first-page":"862","DOI":"10.5692\/clinicalneurol.cn-000916","volume":"56","author":"M Tanaka","year":"2016","unstructured":"Tanaka M, Gamou N, Shizukawa H, Tsuda E, Shimohama S. Myopericarditis in a case of anti-signal recognition particle (anti-SRP) antibody-positive myopathy. Rinsho Shinkeigaku. 2016;56(12):862\u20135.","journal-title":"Rinsho Shinkeigaku"},{"issue":"2","key":"1599_CR11","first-page":"75","volume":"43","author":"Y Fukai","year":"2017","unstructured":"Fukai Y, Ohsawa Y, Kutoku Y, Hemmi S, Sunada Y. Complete atrioventricular block in anti-signal recognition particle (anti-SRP) antibody-positive myopathy. Kawasaki Med J. 2017;43(2):75\u201380.","journal-title":"Kawasaki Med J"},{"issue":"12","key":"1599_CR12","doi-asserted-by":"publisher","first-page":"1635","DOI":"10.1136\/ard.2006.052191","volume":"65","author":"GJ Hengstman","year":"2006","unstructured":"Hengstman GJ, ter Laak HJ, Vree Egberts WT, Lundberg IE, Moutsopoulos HM, Vencovsky J, Doria A, Mosca M, van Venrooij WJ, van Engelen BG. Anti-signal recognition particle autoantibodies: marker of a necrotising myopathy. Ann Rheum Dis. 2006;65(12):1635\u20138.","journal-title":"Ann Rheum Dis"},{"key":"1599_CR13","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1186\/s13023-015-0277-y","volume":"10","author":"S Suzuki","year":"2015","unstructured":"Suzuki S, Nishikawa A, Kuwana M, Nishimura H, Watanabe Y, Nakahara J, Hayashi YK, Suzuki N, Nishino I. Inflammatory myopathy with anti-signal recognition particle antibodies: case series of 100 patients. Orphanet J Rare Dis. 2015;10:61.","journal-title":"Orphanet J Rare Dis"},{"issue":"9","key":"1599_CR14","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1001\/jamaneurol.2015.1207","volume":"72","author":"CD Kassardjian","year":"2015","unstructured":"Kassardjian CD, Lennon VA, Alfugham NB, Mahler M, Milone M. Clinical features and treatment outcomes of necrotizing autoimmune myopathy. JAMA Neurol. 2015;72(9):996\u20131003.","journal-title":"JAMA Neurol"},{"issue":"6","key":"1599_CR15","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1097\/00005792-199111000-00002","volume":"70","author":"LA Love","year":"1991","unstructured":"Love LA, Leff RL, Fraser DD, Targoff IN, Dalakas M, Plotz PH, Miller FW. A new approach to the classification of idiopathic inflammatory myopathy: myositis-specific autoantibodies define useful homogeneous patient groups. Medicine. 1991;70(6):360\u201374.","journal-title":"Medicine"},{"issue":"Pt 8","key":"1599_CR16","doi-asserted-by":"publisher","first-page":"2131","DOI":"10.1093\/brain\/aww054","volume":"139","author":"Y Allenbach","year":"2016","unstructured":"Allenbach Y, Keraen J, Bouvier AM, Jooste V, Champtiaux N, Hervier B, Schoindre Y, Rigolet A, Gilardin L, Musset L, et al. High risk of cancer in autoimmune necrotizing myopathies: usefulness of myositis specific antibody. Brain. 2016;139(Pt 8):2131\u20135.","journal-title":"Brain"},{"issue":"7","key":"1599_CR17","doi-asserted-by":"publisher","first-page":"1104","DOI":"10.1016\/j.clineuro.2011.12.055","volume":"114","author":"F Hanisch","year":"2012","unstructured":"Hanisch F, Muller T, Stoltenburg G, Zierz S. Unusual manifestations in two cases of necrotizing myopathy associated with SRP-antibodies. Clin Neurol Neurosurg. 2012;114(7):1104\u20136.","journal-title":"Clin Neurol Neurosurg"},{"issue":"21","key":"1599_CR18","doi-asserted-by":"publisher","first-page":"3189","DOI":"10.2169\/internalmedicine.2564-18","volume":"58","author":"S Takeguchi-Kikuchi","year":"2019","unstructured":"Takeguchi-Kikuchi S, Hayasaka T, Katayama T, Kano K, Takahashi K, Saito T, Sawada J, Minoshima A, Sakamoto N, Akasaka K, et al. Anti-signal recognition particle antibody-positive necrotizing myopathy with secondary cardiomyopathy: the first myocardial biopsy- and multimodal imaging-proven case. Intern Med. 2019;58(21):3189\u201394.","journal-title":"Intern Med"},{"issue":"11","key":"1599_CR19","doi-asserted-by":"publisher","first-page":"1767","DOI":"10.1111\/1756-185X.13158","volume":"20","author":"JA Vargas-Hitos","year":"2017","unstructured":"Vargas-Hitos JA, Saez-Uran LM, Rosales-Castillo A, Jimenez-Alonso J. Constitutional syndrome and chest pain as clinical onset feature of necrotizing myopathy with myocardial involvement. Int J Rheum Dis. 2017;20(11):1767\u20139.","journal-title":"Int J Rheum Dis"},{"issue":"5","key":"1599_CR20","doi-asserted-by":"publisher","first-page":"e434","DOI":"10.1161\/CIRCULATIONAHA.112.118877","volume":"127","author":"M Thiebaut","year":"2013","unstructured":"Thiebaut M, Terrier B, Menacer S, Berezne A, Bussone G, Goulvestre C, Bellance R, Guillevin L, Vignaux O, Mouthon L. Antisignal recognition particle antibodies-related cardiomyopathy. Circulation. 2013;127(5):e434\u20136.","journal-title":"Circulation"}],"container-title":["BMC Neurology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12883-020-1599-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12883-020-1599-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12883-020-1599-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,16]],"date-time":"2021-01-16T00:09:44Z","timestamp":1610755784000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcneurol.biomedcentral.com\/articles\/10.1186\/s12883-020-1599-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,17]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["1599"],"URL":"https:\/\/doi.org\/10.1186\/s12883-020-1599-5","relation":{},"ISSN":["1471-2377"],"issn-type":[{"value":"1471-2377","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,17]]},"assertion":[{"value":"9 October 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 January 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 January 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This case report was approved by Nitobe Memorial Nakano General Hospital.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"We obtained written consent from the patient to publish this report and the accompanying images. A copy of the written consent is available for review by the Editor of this journal.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"29"}}