{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T13:23:11Z","timestamp":1785417791192,"version":"3.56.0"},"reference-count":7,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,4,6]],"date-time":"2021-04-06T00:00:00Z","timestamp":1617667200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,4,6]],"date-time":"2021-04-06T00:00:00Z","timestamp":1617667200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Neurol"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Neurodegenerative disorders are characterized by insidious progression with poorly-delineated long latent period. Antecedent clinical insult could rarely unmask latent neurodegenerative disorders. Here, we report an autopsy-proven case of corticobasal degeneration which was preceded by a lacunar infarction.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>A 58-year-old man presented with acute ataxia associated with a lacunar infarction in the right paramedian pons. His ataxia persisted with additional progressive gait difficulty and left arm clumsiness. Six months later, a follow-up neurological examination showed asymmetrical bradykinesia, apraxia, dystonic posturing, postural instability, and mild ataxia of the left limbs. Cognitive examination revealed frontal executive dysfunction and visuospatial difficulties. Dopamine transporter imaging scan demonstrated bilateral reduced uptakes in mid-to-posterior putamen, more prominent on the right side. Levodopa-unresponsive parkinsonism, asymmetric limb dystonia, and ideomotor apraxia became more conspicuous, while limb ataxia gradually vanished. The patient became unable to walk without assistance after 1\u2009year, and died 4\u2009years after the symptom onset. Autopsy findings showed frontoparietal cortical atrophy, ballooned neurons, and phosphorylated tau-positive astrocytic plaques and neuropil threads with gliosis and neuronal loss, confirming the corticobasal degeneration.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>The case illustrates that precedent clinical events such as stroke might tip a patient with subclinical CBS into overt clinical manifestations.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12883-021-02178-9","type":"journal-article","created":{"date-parts":[[2021,4,6]],"date-time":"2021-04-06T07:02:32Z","timestamp":1617692552000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["An autopsy-proven case of Corticobasal degeneration heralded by Pontine infarction"],"prefix":"10.1186","volume":"21","author":[{"given":"Dallah","family":"Yoo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung-Hye","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sungwook","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7315-6298","authenticated-orcid":false,"given":"Tae-Beom","family":"Ahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,4,6]]},"reference":[{"issue":"11","key":"2178_CR1","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1093\/jnen\/61.11.935","volume":"61","author":"DW Dickson","year":"2002","unstructured":"Dickson DW, Bergeron C, Chin SS, Duyckaerts C, Horoupian D, Ikeda K, et al. Office of Rare Diseases Neuropathologic Criteria for Corticobasal degeneration. J Neuropathol Exp Neurol. 2002;61(11):935\u201346. https:\/\/doi.org\/10.1093\/jnen\/61.11.935.","journal-title":"J Neuropathol Exp Neurol"},{"issue":"5","key":"2178_CR2","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1212\/WNL.0b013e31827f0fd1","volume":"80","author":"MJ Armstrong","year":"2013","unstructured":"Armstrong MJ, Litvan I, Lang AE, Bak TH, Bhatia KP, Borroni B, et al. Criteria for the diagnosis of corticobasal degeneration. Neurology. 2013;80(5):496\u2013503. https:\/\/doi.org\/10.1212\/WNL.0b013e31827f0fd1.","journal-title":"Neurology."},{"issue":"1","key":"2178_CR3","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1212\/wnl.48.1.119","volume":"48","author":"I Litvan","year":"1997","unstructured":"Litvan I, Agid Y, Goetz C, Jankovic J, Wenning GK, Brandel JP, et al. Accuracy of the clinical diagnosis of Corticobasal degeneration. A Clinicopathologic Study. 1997;48(1):119\u201325. https:\/\/doi.org\/10.1212\/wnl.48.1.119.","journal-title":"A Clinicopathologic Study"},{"issue":"5","key":"2178_CR4","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1007\/s00401-013-1087-8","volume":"125","author":"N Kouri","year":"2013","unstructured":"Kouri N, Oshima K, Takahashi M, Murray ME, Ahmed Z, Parisi JE, et al. Corticobasal degeneration with olivopontocerebellar atrophy and TDP-43 pathology: an unusual clinicopathologic variant of CBD. Acta Neuropathol. 2013;125(5):741\u201352. https:\/\/doi.org\/10.1007\/s00401-013-1087-8.","journal-title":"Acta Neuropathol"},{"issue":"2","key":"2178_CR5","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1093\/brain\/awz310","volume":"143","author":"A Quartarone","year":"2019","unstructured":"Quartarone A, Cacciola A, Milardi D, Ghilardi MF, Calamuneri A, Chillemi G, et al. New insights into cortico-basal-cerebellar connectome: clinical and physiological considerations. Brain. 2019;143(2):396\u2013406. https:\/\/doi.org\/10.1093\/brain\/awz310.","journal-title":"Brain."},{"issue":"3\u20134","key":"2178_CR6","doi-asserted-by":"publisher","first-page":"199","DOI":"10.3233\/jad-2000-23-402","volume":"2","author":"C Hesse","year":"2000","unstructured":"Hesse C, Rosengren L, Vanmechelen E, Vanderstichele H, Jensen C, Davidsson P, et al. Cerebrospinal fluid markers for Alzheimer's disease evaluated after acute ischemic stroke. J Alzheimers Dis. 2000;2(3\u20134):199\u2013206. https:\/\/doi.org\/10.3233\/jad-2000-23-402.","journal-title":"J Alzheimers Dis"},{"issue":"3","key":"2178_CR7","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1007\/s00259-009-1289-4","volume":"37","author":"FJ Diaz-Corrales","year":"2010","unstructured":"Diaz-Corrales FJ, Sanz-Viedma S, Garcia-Solis D, Escobar-Delgado T, Mir P. Clinical features and 123I-FP-CIT SPECT imaging in drug-induced parkinsonism and Parkinson's disease. Eur J Nucl Med Mol Imaging. 2010;37(3):556\u201364. https:\/\/doi.org\/10.1007\/s00259-009-1289-4.","journal-title":"Eur J Nucl Med Mol Imaging"}],"container-title":["BMC Neurology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12883-021-02178-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12883-021-02178-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12883-021-02178-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,6]],"date-time":"2021-04-06T07:02:34Z","timestamp":1617692554000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcneurol.biomedcentral.com\/articles\/10.1186\/s12883-021-02178-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,6]]},"references-count":7,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["2178"],"URL":"https:\/\/doi.org\/10.1186\/s12883-021-02178-9","relation":{},"ISSN":["1471-2377"],"issn-type":[{"value":"1471-2377","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,6]]},"assertion":[{"value":"13 December 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 March 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 April 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The autopsy was permitted by his family members and conducted under the approved protocol by local ethics committee (Seoul National University Hospital).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The study has been conducted in accordance with The Code of Ethics of the World Medical Association (Declaration of Helsinki), the informed consent from the patient to participate in the study was waived by local ethics committee (Kyung Hee University Hospital), and the written consent for publication was obtained from the kin of the patient.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"148"}}