{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T23:22:43Z","timestamp":1745968963785,"version":"3.37.3"},"reference-count":6,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,1,10]],"date-time":"2022-01-10T00:00:00Z","timestamp":1641772800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,1,10]],"date-time":"2022-01-10T00:00:00Z","timestamp":1641772800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Neurol"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>We report the case of a patient with recurrent episodes of disturbed memory suggestive of transient epileptic amnesia, and a focal hippocampal lesion typically associated with transient global amnesia. We argue how careful consideration of clinical, electrophysiological and imaging findings can resolve this apparent contradiction and lead to a diagnosis of early symptomatic post-stroke seizures that links brain structure to function in a new, clinically relevant way.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>A 70-year-old patient was identified in clinical practice in our tertiary care centre and was evaluated clinically as well as by repeated electroencephalography and magnetic resonance imaging. The presenting complaint were recurrent episodes of short-term memory disturbance which manifested as isolated anterograde amnesia on neurocognitive evaluation. EEG and MRI revealed predominantly right frontotemporal spikes and a punctate diffusion-restricted lesion in the left hippocampus, respectively. Both symptoms and EEG changes subsided under anticonvulsant treatment with levetiracetam.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Our report contributes to the current discussion of clinical challenges in the differential diagnosis of transient memory disturbance. It suggests that focal diffusion-restricted hippocampal lesions, as seen in TGA, might be ischemic and thus highlights the importance of considering post-stroke seizures as a possible cause of transient memory disturbance.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12883-021-02543-8","type":"journal-article","created":{"date-parts":[[2022,1,10]],"date-time":"2022-01-10T11:03:16Z","timestamp":1641812596000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Recurrent amnesia caused by early seizures after hippocampal infarction: a case report"],"prefix":"10.1186","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5729-2935","authenticated-orcid":false,"given":"Eckhard","family":"Schlemm","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tim","family":"Magnus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leander D.","family":"Rimmele","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justine","family":"M\u00fcnsterberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maxim","family":"Bester","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon S.","family":"Kessner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathias","family":"Gelderblom","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Gerloff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,1,10]]},"reference":[{"key":"2543_CR1","doi-asserted-by":"publisher","first-page":"299","DOI":"10.3233\/BEN-2011-0340","volume":"24","author":"CR Butler","year":"2011","unstructured":"Butler CR, Zeman A. The causes and consequences of transient epileptic amnesia. Behav Neurol. 2011;24:299\u2013305. https:\/\/doi.org\/10.3233\/BEN-2011-0340.","journal-title":"Behav Neurol"},{"key":"2543_CR2","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1159\/000332036","volume":"33","author":"A F\u00f6rster","year":"2012","unstructured":"F\u00f6rster A, Griebe M, Gass A, Kern R, Hennerici MG, Szabo K. Diffusion-weighted imaging for the differential diagnosis of disorders affecting the hippocampus. Cerebrovasc Dis. 2012;33:104\u201315. https:\/\/doi.org\/10.1159\/000332036.","journal-title":"Cerebrovasc Dis"},{"key":"2543_CR3","doi-asserted-by":"publisher","first-page":"2165","DOI":"10.1212\/01.WNL.0000130504.88404.C9","volume":"62","author":"OL Sedlaczek","year":"2004","unstructured":"Sedlaczek OL, Hirsch JG, Grips E, Peters CNA, Gass A, W\u00f6hrle J, et al. Detection of delayed focal MR changes in the lateral hippocampus in transient global amnesia. Neurology. 2004;62:2165\u201370. https:\/\/doi.org\/10.1212\/01.WNL.0000130504.88404.C9.","journal-title":"Neurology."},{"key":"2543_CR4","doi-asserted-by":"publisher","first-page":"59","DOI":"10.3988\/jcn.2008.4.2.59","volume":"4","author":"Y Yang","year":"2008","unstructured":"Yang Y, Kim SY, Kim JH. Ischemic evidence of transient global amnesia: location of the lesion in the hippocampus. J Clin Neurol. 2008;4:59\u201366. https:\/\/doi.org\/10.3988\/jcn.2008.4.2.59.","journal-title":"J Clin Neurol"},{"key":"2543_CR5","doi-asserted-by":"publisher","first-page":"1640","DOI":"10.1093\/BRAIN\/AWL105","volume":"129","author":"P Quinette","year":"2006","unstructured":"Quinette P, Guillery-Girard B, Dayan J, Sayette V d l, Marquis S, Viader F, et al. What does transient global amnesia really mean? Review of the literature and thorough study of 142 cases. Brain. 2006;129:1640\u201358. https:\/\/doi.org\/10.1093\/BRAIN\/AWL105.","journal-title":"Brain."},{"key":"2543_CR6","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1111\/ene.14099","volume":"27","author":"D Paech","year":"2020","unstructured":"Paech D, Kuder TA, Ro\u00dfmanith C, Griebe M, Eisele P, Platten M, et al. What remains after transient global amnesia (TGA)? An ultra-high field 7 T magnetic resonance imaging study of the hippocampus. Eur J Neurol. 2020;27:406\u20139. https:\/\/doi.org\/10.1111\/ene.14099.","journal-title":"Eur J Neurol"}],"container-title":["BMC Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12883-021-02543-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12883-021-02543-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12883-021-02543-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,10]],"date-time":"2022-05-10T06:04:19Z","timestamp":1652162659000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcneurol.biomedcentral.com\/articles\/10.1186\/s12883-021-02543-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,10]]},"references-count":6,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["2543"],"URL":"https:\/\/doi.org\/10.1186\/s12883-021-02543-8","relation":{},"ISSN":["1471-2377"],"issn-type":[{"type":"electronic","value":"1471-2377"}],"subject":[],"published":{"date-parts":[[2022,1,10]]},"assertion":[{"value":"29 August 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 December 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 January 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 May 2022","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Update","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Open Access funding statement has been added to this article.","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent for publication was obtained from the patient discussed in the report.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"18"}}