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This study aims to evaluate the diagnostic performance of serum microRNA-130a-3p (miR-130a-3p) in cerebral AS patients, and construct a logistic risk model for 2-year cerebrovascular events on the basis of the prognostic potential of miR-130a-3p.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Serum samples were collected from 74 cerebral AS patients and 62 control individuals, and miR-130a-3p expression was investigated using reverse transcription quantitative PCR. Risk factors related with cerebral AS were assessed using a logistic regression analysis, and the receiver operating characteristic analysis was performed to evaluate the diagnostic value of miR-130a-3p. The relationship between miR-130a-3p and cerebrovascular events was analyzed using a Kaplan\u2013Meier method, and a logistic risk model was constructed for 2-year cerebrovascular events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Cerebral AS patients had elevated serum miR-130a-3p compared with controls (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Serum miR-130a-3p had diagnostic value (AUC\u2009=\u20090.899), and could significantly improve the diagnostic accuracy of total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) in cerebral AS patients (AUC\u2009=\u20090.992). High serum miR-130a-3p was independently related with high probability of cerebrovascular events (HR\u2009=\u20091.993, 95% CI\u2009=\u20091.205\u20132.897,<jats:italic>P<\/jats:italic>\u2009=\u20090.006), and a logistic risk model was constructed based on serum miR-130a-3p, hs-CRP, TC and LDL-C.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>All the findings indicated that high serum miR-130a-3p had diagnostic potential to screen cerebral AS, and predicted the probability of cerebrovascular events after AS. The logistic risk model based on miR-130a-3p may provide an efficient method to predict 2-year cerebrovascular events in AS patients.<\/jats:p><\/jats:sec>","DOI":"10.1186\/s12883-022-02829-5","type":"journal-article","created":{"date-parts":[[2022,8,22]],"date-time":"2022-08-22T13:06:14Z","timestamp":1661173574000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Circulating miR-130a-3p is elevated in patients with cerebral atherosclerosis and predicts 2-year risk of cerebrovascular events"],"prefix":"10.1186","volume":"22","author":[{"given":"Jialei","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengchao","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,8,22]]},"reference":[{"issue":"8 Suppl","key":"2829_CR1","doi-asserted-by":"publisher","first-page":"C7","DOI":"10.1016\/j.jacc.2005.09.068","volume":"47","author":"E Falk","year":"2006","unstructured":"Falk E. 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