{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T03:49:45Z","timestamp":1790653785972,"version":"4.1.0"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Neurol"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>\u03b22-microglobulin has been showing to be vital that associated with brain function and neurological diseases. This study aimed to explore the expressions of \u03b22-microglobulin in blood and urine of the patients with brain injury, and the effect of hyperbaric oxygen therapy on the content of \u03b22-microglobulin.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>This prospective study included 54 patients with brain injury and 11 healthy controls. The patients were further assigned to two groups: the conscious disturbance group (<jats:italic>n<\/jats:italic>\u2009=\u200932) and the non-conscious disturbance group (<jats:italic>n<\/jats:italic>\u2009=\u200922) depending on the Glasgow Coma Scale (GCS). The patients received routine treatment and two courses of hyperbaric oxygen therapy (2.0ATA, 60\u2009min, once a day, 10\u2009days for a course). In the brain injury group, blood \u03b22-microglobulin (\u03b22MG) and urine \u03b22-microglobulin (\u03b22MU) were detected respectively before and after hyperbaric oxygen therapy (HBOT). Consciousness and cognitive scores were performed, correspondingly.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Compared with those of the control group, levels of \u03b22MG and \u03b22MU in the brain injury group were significantly increased before HBOT (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Whether it was before or after HBOT, \u03b22MG\u2019s content in the conscious disturbance group was higher than that in the non-conscious disturbance group, while \u03b22MU\u2019s content was obviously higher than that of the non-conscious disturbance group only before HBOT (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Besides, the \u03b22MU\u2019s content in the conscious disturbance group was negatively correlated with GCS score (<jats:italic>R<\/jats:italic>\u2009=\u2009-0.351, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) and \u03b22MG\u2019s content in the non-conscious disturbance group was positively correlated with the MMSE score grade (<jats:italic>R<\/jats:italic>\u2009=\u20090.598, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). The ROC curve was used to assess the evaluation of \u03b22MG and \u03b22MU for patients with impaired consciousness with the area under the curve (AUC) of \u03b22MG and \u03b22MU were 0.775 and 0.796, respectively.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>The concentrations of blood \u03b22-microglobulin and urinary \u03b22-microglobulin were significantly increased in patients with brain injury. The concentrations of \u03b22-microglobulin were correlated with the degree of consciousness and cognitive function. The changes tendency of \u03b22-microglobulin may be considered as clinical monitoring index to evaluate the patient\u2019s disturbance of consciousness and cognitive degree, and provide a basis for early assessment of prognosis.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12883-022-02850-8","type":"journal-article","created":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T07:03:44Z","timestamp":1662015824000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Effect of \u03b22-microglobulin in evaluating the severity and prognosis of brain injury: a clinical study"],"prefix":"10.1186","volume":"22","author":[{"given":"Qiqi","family":"Huo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenshuo","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuehua","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ding","family":"Nan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,9,1]]},"reference":[{"issue":"15","key":"2850_CR1","doi-asserted-by":"publisher","first-page":"4095","DOI":"10.1016\/S0021-9258(18)93284-9","volume":"243","author":"I Berggard","year":"1968","unstructured":"Berggard I, Bearn AG. 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All ethical rules and regulations were followed while conducting this study. Laboratory indicators, such as \u03b22-microglobulin, serum creatine and blood urea nitrogen, were included in routine inpatient examination and all enrolled patients had signed informed consent.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"327"}}