{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,13]],"date-time":"2026-11-13T01:58:54Z","timestamp":1794535134676,"version":"4.9.1"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,12,14]],"date-time":"2022-12-14T00:00:00Z","timestamp":1670976000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,12,14]],"date-time":"2022-12-14T00:00:00Z","timestamp":1670976000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"national natural science foundation of china","doi-asserted-by":"publisher","award":["NO.82000729"],"award-info":[{"award-number":["NO.82000729"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"national natural science foundation of china","doi-asserted-by":"publisher","award":["NO.81670512"],"award-info":[{"award-number":["NO.81670512"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Neurol"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Schwannomas are benign tumors deriving from the sheath of cranial and peripheral nerves. The vagus nerve is comprised of a complex neuro-endocrine-immune network that maintains homeostasis, most tracts of it play a role in parasympathetic activity. We present an example of a rare cervical vagal schwannoma case accompanied by arrhythmia.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>A 35-year-old female patient with a left cervical vagus schwannoma and ventricular arrhythmia underwent schwannoma resection in the operating room. The patient\u2019s suppressed heart rate increased after tumor removal, and the cardiac rhythm returned to normal postoperatively. Pathological examination demonstrated the diagnosis of schwannoma.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>This case explains the link between the vagus nerve and the cardiovascular system, proving that a damaged cervical vagus nerve can inhibit the heart rate and lead to arrhythmias, and eventually requiring surgical intervention.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12883-022-03016-2","type":"journal-article","created":{"date-parts":[[2022,12,14]],"date-time":"2022-12-14T08:03:09Z","timestamp":1671004989000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Cervical vagal nerve schwannoma induced arrhythmia: a rare case report and literature review"],"prefix":"10.1186","volume":"22","author":[{"given":"Pin","family":"Ye","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changhuai","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunfei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongxiao","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiqing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9182-5478","authenticated-orcid":false,"given":"Chuanqi","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"L\u00fc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,12,14]]},"reference":[{"key":"3016_CR1","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1186\/s13256-016-0812-z","volume":"10","author":"T Adouly","year":"2016","unstructured":"Adouly T, Adnane C, Oubahmane T, Rouadi S, Abada R, Roubal M, et al. An unusual giant schwannoma of cervical sympathetic chain: a case report. J Med Case Rep. 2016;10:26.","journal-title":"J Med Case Rep"},{"key":"3016_CR2","first-page":"33","volume":"29","author":"MG Chiofalo","year":"2009","unstructured":"Chiofalo MG, Longo F, Marone U, Franco R, Petrillo A, Pezzullo L. Cervical Vagal Schwannoma. A case report. Acta Otorhinolaryngol. Acta Otorhinolaryngol Ital. 2009;29:33\u20135.","journal-title":"Acta Otorhinolaryngol Ital"},{"key":"3016_CR3","unstructured":"Kenny BJ, Bordoni B. Neuroanatomy, Cranial Nerve 10 (Vagus Nerve). In: StatPearls. Treasure Island: StatPearls Publishing; 2021."},{"key":"3016_CR4","doi-asserted-by":"publisher","first-page":"rjac084","DOI":"10.1093\/jscr\/rjac084","volume":"2022","author":"L Pankratjevaite","year":"2022","unstructured":"Pankratjevaite L, Dreyer NS, Dauksa A, Sarauskas V. Challenging diagnosis of cervical vagal nerve schwannoma. J Surg Case Rep. 2022;2022:rjac084. https:\/\/doi.org\/10.1093\/jscr\/rjac084.","journal-title":"J Surg Case Rep"},{"key":"3016_CR5","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1186\/s12957-015-0541-6","volume":"13","author":"G Cavallaro","year":"2015","unstructured":"Cavallaro G, Pattaro G, Iorio O, Avallone M, Silecchia G. A literature review on surgery for cervical vagal schwannomas. World J Surg Oncol. 2015;13:130.","journal-title":"World J Surg Oncol"},{"key":"3016_CR6","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1007\/s12070-011-0276-9","volume":"63","author":"SK Awasthi","year":"2011","unstructured":"Awasthi SK, Dutta A. Cervical sympathetic chain schwannoma: a case report. Indian J Otolaryngol Head Neck Surg. 2011;63:292\u20134.","journal-title":"Indian J Otolaryngol Head Neck Surg"},{"key":"3016_CR7","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1007\/s12105-014-0577-x","volume":"9","author":"V Mahajan","year":"2015","unstructured":"Mahajan V, Rao S, Gupta P, Munjal M, Agrawal S. Angiosarcoma developing in a vagal schwannoma: A rare case report. Head Neck Pathol. 2015;9:405\u201311.","journal-title":"Head Neck Pathol"},{"key":"3016_CR8","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.ijsu.2016.03.020","volume":"29","author":"G Illuminati","year":"2016","unstructured":"Illuminati G, Pizzardi G, Minni A, Masci F, Ciamberlano B, Pasqua R, et al. Superiority of resection over enucleation for schwannomas of the cervical vagus nerve: A retrospective cohort study of 22 consecutive patients. Int J Surg. 2016;29:74\u20138.","journal-title":"Int J Surg"},{"key":"3016_CR9","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.ijscr.2017.09.025","volume":"41","author":"C Carroll","year":"2017","unstructured":"Carroll C, Jagatiya M, Kamel D, Siddiqi J. A parapharyngeal space schwannoma arising from the vagus nerve: A case report. Int J Surg Case Rep. 2017;41:22\u20135.","journal-title":"Int J Surg Case Rep"},{"key":"3016_CR10","doi-asserted-by":"publisher","first-page":"254","DOI":"10.4103\/0259-1162.183163","volume":"11","author":"S Saini","year":"2017","unstructured":"Saini S, Sabharwal N, Agrawal N, Singh B. Cervical vagal schwannoma: anesthetic concerns. Anesth Essays Res. 2017;11:254\u20136.","journal-title":"Anesth Essays Res"},{"key":"3016_CR11","doi-asserted-by":"publisher","first-page":"460.e9","DOI":"10.1016\/j.avsg.2019.09.021","volume":"63","author":"G Keshelava","year":"2020","unstructured":"Keshelava G, Robakidze Z. Cervical vagal schwannoma causing asymptomatic internal carotid artery compression. Ann Vasc Surg. 2020;63:460.e9\u2013460.e11.","journal-title":"Ann Vasc Surg"},{"issue":"76","key":"3016_CR12","first-page":"103475","volume":"2022","author":"M Harhar","year":"2012","unstructured":"Harhar M, Harouachi A, Bouhout T, Serji B, El Harroudi T. A rare association of Vagus nerve schwannoma and Pheochromocytoma: A case report. Annals Med Surg. 2012;2022(76):103475.","journal-title":"Annals Med Surg"},{"key":"3016_CR13","doi-asserted-by":"publisher","first-page":"e28760","DOI":"10.1097\/MD.0000000000028760","volume":"101","author":"T Xu","year":"2022","unstructured":"Xu T, Liu Y, Li S, Zheng L. Pre-operative embolization and excision of vagal schwannoma with rich vascular supply: A case report and literature review. Med. 2022;101:e28760.","journal-title":"Med"},{"key":"3016_CR14","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1213\/XAA.0000000000000771","volume":"11","author":"CB Walters","year":"2018","unstructured":"Walters CB, Kynes JM, Tucker R, Netterville J. Central sleep apnea post vagal nerve manipulation and stimulation during neck tumor resection: A case report. A&A practice. 2018;11:160\u20131.","journal-title":"A&A practice"},{"key":"3016_CR15","doi-asserted-by":"publisher","first-page":"190","DOI":"10.4103\/ijabmr.IJABMR_439_16","volume":"8","author":"KP Kumar","year":"2018","unstructured":"Kumar KP, Alam MS. \"collateral damage:\" Horner's syndrome following excision of a Cervical vagal schwannoma. Int J Appl Basic Med Res. 2018;8:190\u20132.","journal-title":"Int J Appl Basic Med Res"},{"key":"3016_CR16","doi-asserted-by":"publisher","first-page":"e827","DOI":"10.1097\/SCS.0000000000005006","volume":"29","author":"O Cukic","year":"2018","unstructured":"Cukic O, Jovanovic MB. Vagus nerve schwannoma mimicking a lateral neck cyst. J Craniofac Surg. 2018;29:e827\u20138.","journal-title":"J Craniofac Surg"},{"key":"3016_CR17","first-page":"4074905","volume":"2018","author":"I Ansari","year":"2018","unstructured":"Ansari I, Ansari A, Graison AA, Patil AJ, Joshi H. Head and neck schwannomas: A surgical challenge-A series of 5 cases. Case Rep Otolaryngol. 2018;2018:4074905.","journal-title":"Case Rep Otolaryngol"},{"key":"3016_CR18","first-page":"Md03\u20134","volume":"10","author":"PM Kamath","year":"2016","unstructured":"Kamath PM, Dosemane D, Sreedharan SS, Majeed NA, Shenoy VS. Vagal schwannoma: A rare Parapharyngeal tumour. J Clin Diagn Res. 2016;10:Md03\u20134.","journal-title":"J Clin Diagn Res"},{"key":"3016_CR19","first-page":"Zd17\u20139","volume":"10","author":"Y Shinohara","year":"2016","unstructured":"Shinohara Y, Matsumoto T, Kiga N, Tojyo I, Fujita S. Neurilemmoma of the Vagus nerve in the Poststyloid Parapharyngeal space. J Clin Diagn Res. 2016;10:Zd17\u20139.","journal-title":"J Clin Diagn Res"},{"key":"3016_CR20","doi-asserted-by":"publisher","first-page":"E146","DOI":"10.1002\/hed.25793","volume":"41","author":"ML Sandler","year":"2019","unstructured":"Sandler ML, Sims JR, Sinclair C, Ho R, Yue LE, T\u00e9llez MJ, et al. A novel approach to neurologic function sparing surgical management of vagal schwannomas: continuous intraoperative nerve monitoring of the laryngeal adductor reflex. Head neck. 2019;41:E146\u2013e152.","journal-title":"Head neck"},{"key":"3016_CR21","doi-asserted-by":"publisher","first-page":"1130","DOI":"10.1111\/j.1365-2044.1986.tb12963.x","volume":"41","author":"BM Wood","year":"1986","unstructured":"Wood BM, McNeil WT. Schwannoma of the vagus nerve. Anaesthesia. 1986;41:1130\u20132.","journal-title":"Anaesthesia"},{"key":"3016_CR22","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1113\/eph8602146","volume":"86","author":"GA Ng","year":"2001","unstructured":"Ng GA, Brack KE, Coote JH. Effects of direct sympathetic and vagus nerve stimulation on the physiology of the whole heart--a novel model of isolated Langendorff perfused rabbit heart with intact dual autonomic innervation. Exp Physiol. 2001;86:319\u201329.","journal-title":"Exp Physiol"},{"key":"3016_CR23","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1017\/S0022215100086928","volume":"93","author":"DK Mukherjee","year":"1979","unstructured":"Mukherjee DK. Neurilemmoma of the vagus nerve: a case report. J Laryngol Otol. 1979;93:187\u201392.","journal-title":"J Laryngol Otol"}],"container-title":["BMC Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12883-022-03016-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12883-022-03016-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12883-022-03016-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,14]],"date-time":"2022-12-14T08:06:06Z","timestamp":1671005166000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcneurol.biomedcentral.com\/articles\/10.1186\/s12883-022-03016-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,14]]},"references-count":23,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,12]]}},"alternative-id":["3016"],"URL":"https:\/\/doi.org\/10.1186\/s12883-022-03016-2","relation":{},"ISSN":["1471-2377"],"issn-type":[{"value":"1471-2377","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,14]]},"assertion":[{"value":"2 August 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 December 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 December 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study has been approved by the Ethical Committee of Wuhan Union Hospital. Informed consent was obtained from this patient. The informed consent of the participant was acquired.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent to publish this case was obtained from study participant. Proof of consent to publish from study participant can be requested at any time.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing of interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"480"}}