{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:39:03Z","timestamp":1790743143404,"version":"4.1.0"},"reference-count":14,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,1,27]],"date-time":"2023-01-27T00:00:00Z","timestamp":1674777600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,1,27]],"date-time":"2023-01-27T00:00:00Z","timestamp":1674777600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100002701","name":"Ministry of Education","doi-asserted-by":"publisher","award":["2021R1I1A3056006"],"award-info":[{"award-number":["2021R1I1A3056006"]}],"id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003625","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Neurol"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Ramsay-Hunt syndrome (RHS) due to varicella zoster virus (VZV) infection is commonly reported in individuals aged at least 50\u00a0years or immunocompromised individuals. VZV infection may invade the central nervous system (CNS) and cause meningitis or encephalitis, which are more likely to occur in patients with chronic diseases such as diabetes and chronic renal failure. However, cases with VZV-induced concurrent RHS and CNS infections are rare.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>Two young male patients, aged 32 and 43\u00a0years, with no underlying disease developed VZV meningitis, followed by RHS involving cranial nerves VII and VIII. Both patients presented with symptoms of peripheral facial palsy, and dizziness accompanied by tinnitus and hearing loss, which appeared several days after the onset of fever and headache. These symptoms were documented as facial neuropathy and sensorineural hearing loss in the electrophysiologic studies. Lymphocyte-dominant pleocytosis and VZV positivity were confirmed from cerebrospinal fluid examination and polymerase chain reaction, respectively. The patients were treated with intravenous acyclovir and oral steroids simultaneously. Following the treatment completion, both patients were relieved of their headaches and fever; however, facial palsy, dizziness, and tinnitus persisted. They were followed up at the outpatient clinic.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>These cases confirmed that RHS and CNS infections can co-exist even in young adults with normal immune function and more importantly, that CNS infection can precede RHS. Since early detection and treatment of RHS improve the prognosis, it is critical to closely monitor patients with VZV meningitis or encephalitis considering the possible superimposition of RHS.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12883-023-03074-0","type":"journal-article","created":{"date-parts":[[2023,1,27]],"date-time":"2023-01-27T07:03:42Z","timestamp":1674803022000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Two cases of Ramsay-Hunt syndrome following varicella zoster viral meningitis in young immunocompetent men: case reports"],"prefix":"10.1186","volume":"23","author":[{"given":"Yun Su","family":"Hwang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Seo","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byoung-Soo","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5443-3635","authenticated-orcid":false,"given":"Hyun Goo","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,1,27]]},"reference":[{"key":"3074_CR1","doi-asserted-by":"crossref","unstructured":"Gaudin M, The\u00efs C, Mrozek N, et al. Varicella zoster virus and meningitis in immunocompetent patients: Specificity and questions. Clin Infect Pract. 2022;13:100125.","DOI":"10.1016\/j.clinpr.2021.100125"},{"key":"3074_CR2","doi-asserted-by":"crossref","unstructured":"Lee JH, Kang J, Seo YD, Kim HC, Shin KJ. Delayed facial palsy in a patient with varicella zoster virus encephalitis. J Clin Neurol. 2021;17:604\u20136.","DOI":"10.3988\/jcn.2021.17.4.604"},{"key":"3074_CR3","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.idcr.2015.02.003","volume":"2","author":"T Shinha","year":"2015","unstructured":"Shinha T, Krishna P. Ramsay Hunt syndrome and zoster laryngitis with multiple cranial nerve involvement. IDCases. 2015;2:47\u20138.","journal-title":"IDCases"},{"key":"3074_CR4","doi-asserted-by":"publisher","first-page":"60","DOI":"10.15584\/ejcem.2018.1.10","volume":"16","author":"K B\u0142ochowiak","year":"2018","unstructured":"B\u0142ochowiak K, Kami\u0144ski B. Ramsay Hunt syndrome with deep hearing loss and meningitis. Eur J Clin Exp Med. 2018;16:60\u20132.","journal-title":"Eur J Clin Exp Med"},{"key":"3074_CR5","first-page":"149","volume":"40","author":"C Bienkowski","year":"2019","unstructured":"Bienkowski C, Kowalczyk M, Talarek E, Pokorska-Spiewak M, Kierdaszuk B, Marczynska M. Meningitis and Ramsay-Hunt syndrome in a 17-year old girl. Neuro Endocrinol Lett. 2019;40:149\u201351.","journal-title":"Neuro Endocrinol Lett"},{"key":"3074_CR6","first-page":"OD05","volume":"10","author":"V Ganesan","year":"2016","unstructured":"Ganesan V, Bandyopadhyay D, Kar SS, Choudhury C, Choudhary V. Herpes Zoster infection involving mandibular division of trigeminal nerve and Ramsay Hunt Syndrome with meningitis in an immunocompetent patient: A rare association. 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