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<jats:p>Parkinson\u2019s disease (PD) is the second most common neurodegenerative disorder and, according to the Global Burden of Disease estimates in 2015, was the fastest growing neurological disorder globally with respect to associated prevalence, disability, and deaths. Information regarding the awareness, diagnosis, phenotypic characteristics, epidemiology, prevalence, risk factors, treatment, economic impact and lived experiences of people with PD from the African perspective is relatively sparse in contrast to the developed world, and much remains to be learned from, and about, the continent.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Transforming Parkinson\u2019s Care in Africa (TraPCAf) is a multi-faceted, mixed-methods, multi-national research grant. The study design includes multiple sub-studies, combining observational (qualitative and quantitative) approaches for the epidemiological, clinical, risk factor and lived experience components, as appropriate, and interventional methods (clinical trial component). The aim of TraPCAf is to describe and gain a better understanding of the current situation of PD in Africa. The countries included in this National Institute for Health and Care Research (NIHR) Global Health Research Group (Egypt, Ethiopia, Ghana, Kenya, Nigeria, South Africa and Tanzania) represent diverse African geographies and genetic profiles, with differing resources, healthcare systems, health and social protection schemes, and policies. The research team is composed of experts in the field with vast experience in PD, jointly led by a UK-based and Africa-based investigator.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Discussion<\/jats:title>\n                <jats:p>Despite the increasing prevalence of PD globally, robust data on the disease from Africa are lacking. Existing data point towards the poor awareness of PD and other neurological disorders on the continent and subsequent challenges with stigma, and limited access to affordable services and medication. This multi-site study will be the first of its kind in Africa. The data collected across the proposed sub-studies will provide novel and conclusive insights into the situation of PD. The selected country sites will allow for useful comparisons and make results relevant to other low- and middle-income countries. This grant is timely, as global recognition of PD and the public health challenge it poses builds. The work will contribute to broader initiatives, including the World Health Organization\u2019s Intersectoral global action plan on epilepsy and other neurological disorders.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Trial registration<\/jats:title>\n                <jats:p><jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/doi.org\/10.1186\/ISRCTN77014546\">https:\/\/doi.org\/10.1186\/ISRCTN77014546<\/jats:ext-link>.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12883-023-03414-0","type":"journal-article","created":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T06:01:53Z","timestamp":1697695313000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Transforming Parkinson's Care in Africa (TraPCAf): protocol for a multimethodology\u00a0National Institute for Health and Care Research Global Health Research Group project"],"prefix":"10.1186","volume":"23","author":[{"given":"R.","family":"Walker","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Fothergill-Misbah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Kariuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Ojo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Cilia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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In-country ethics approvals are either in place or in process at the time of publication. All methods will be carried out in accordance with relevant guidelines and regulations. Informed consent will be obtained from all subjects prior to their participation in any study aspect.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Roberto Cilia has received speaking honoraria from Zambon Italia; Zambon SAU; Bial Italia Srl; Advisory board fees from Bial; Research support from the Italian Ministry of Health (Principal Investigator of the project GR-2018\u201312366771 and Co- Principal Investigator of the project PNRR-MR1-2022\u201312376921); Editor-in-chief of the neuromuscular and movement disorders section of Brain Sciences; Associate Editor of Parkinsonism and Related Disorders, Frontiers in Neuroscience section Neurodegeneration and Frontiers in Aging Neuroscience.Silvia Del Din reports consultancy activity with Hoffmann-La Roche Ltd. outside of this study. SDD was also supported by the Mobilise-D project that has received funding from the Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No. 820820. This JU receives support from the European Union's Horizon 2020 research and innovation program and the European Federation of Pharmaceutical Industries and Associations (EFPIA). SDD was also supported by the Innovative Medicines Initiative 2 Joint Undertaking (IMI2 JU) project IDEA-FAST\u2014Grant Agreement 853981. SDD was supported by the National Institute for Health Research (NIHR) Newcastle Biomedical Research Centre (BRC) based at The Newcastle upon Tyne Hospital NHS Foundation Trust, Newcastle University and the Cumbria, Northumberland and Tyne and Wear (CNTW) NHS Foundation Trust. SDD and LR were supported by the NIHR\/Wellcome Trust Clinical Research Facility (CRF) infrastructure at Newcastle upon Tyne Hospitals NHS Foundation Trust.Oluwadamilola Ojo receives Honoraria from the International Parkinson and Movement Disorder Society (MDS) for educational courses on Movement Disorders as Faculty and support for attending meetings and\/or travel, and funding for a leadership or fiduciary role in other board, society, committee or advocacy group, paid or unpaid\u2014Member, Executive Committee, MDS African Section.Njideka Okubadejo receives research grants from the Michael J Fox Foundation for Parkinson's Research (Parkinson Progression Markers Initiative and PD Genetic Diversity in Africa) and Honorarium from the International Parkinson and Movement Disorder Society (IPMDS).Lynn Rochester is a member of Endpoints Advisory Group\u2014MJ Fox Foundation and receives consultancy for the role.All other authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"373"}}