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PSPRS and MDS-UPDRS scores were collected virtually or during routine clinical visits.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Between November, 2021- November, 2022, 27 participants were screened of whom 3 were excluded because of technological difficulties. Eleven PSP and 12 PD participants enrolled, of whom 10 from each group had complete analyzable data. Demographics were well-matched (PSP mean age\u2009=\u200967.6\u2009\u00b1\u20091.3\u00a0years, 40% female; PD mean age\u2009=\u200970.3\u2009\u00b1\u20091.8\u00a0years, 40% female) while disease duration was significantly shorter in PSP (PSP 14\u2009\u00b1\u20093.5\u00a0months vs PD 87.9\u2009\u00b1\u200916.9\u00a0months). Gait parameters showed significant group differences with effect sizes ranging from <jats:italic>d<\/jats:italic>\u2009=\u20091.0 to 2.27. Gait speed was significantly slower in PSP: 0.45\u2009\u00b1\u20090.06\u00a0m\/s vs. 0.79\u2009\u00b1\u20090.06\u00a0m\/s in PD (<jats:italic>d<\/jats:italic>\u2009=\u20091.78, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Our study demonstrates the feasibility of measuring gait in PSP and PD remotely using wearable sensors. The study provides insight into digital biomarkers for both neurodegenerative diseases.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Trial registration<\/jats:title>\n                <jats:p>ClinicalTrials.gov Identifier: NCT04753320, first posted Febuary 15, 2021.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12883-023-03466-2","type":"journal-article","created":{"date-parts":[[2023,12,11]],"date-time":"2023-12-11T08:01:52Z","timestamp":1702281712000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Remote at-home wearable-based gait assessments in Progressive Supranuclear Palsy compared to Parkinson\u2019s Disease"],"prefix":"10.1186","volume":"23","author":[{"given":"Mansi","family":"Sharma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ram kinker","family":"Mishra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna J.","family":"Hall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose","family":"Casado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rylee","family":"Cole","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adonay S.","family":"Nunes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory","family":"Barchard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashkan","family":"Vaziri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6427-7485","authenticated-orcid":false,"given":"Alexander","family":"Pantelyat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0901-4711","authenticated-orcid":false,"given":"Anne-Marie","family":"Wills","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,12,11]]},"reference":[{"issue":"Suppl 1","key":"3466_CR1","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1159\/000512500","volume":"4","author":"D Stephenson","year":"2020","unstructured":"Stephenson D, et al. 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The protocol and consent forms were approved by the Mass General Brigham Human Research Committee (protocol# 2021P000431) and the Johns Hopkins Medicine Institutional Review Board. All procedures were in accordance with the ethical standards of the responsible institutional committees on human experimentation or in accordance with the Helsinki Declaration of 1975, as revised in 1983 (ClinicalTrials.gov Identifier: NCT04753320).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent for publication of the supplementary video was obtained from the participant and their caregiver.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"MS has received salary support from NIA\/NIH SBIR Award R44AG080861.RMK, JC, RC, ASN, GB and AV are all employees of BioSensics LLC.AJH has received salary support from NIA\/NIH SBIR Award R44AG080861.AP has received salary support from NIA\/NIH SBIR Award R44AG080861, NIH\/NIA K23AG059891, NIH\/NIA grant AG059891 and NIH\/NINDS grant NS102035; he has received honoraria for his role on the Scientific Advisory Board of MedRhythms, Inc.AMW has research funding from NIA\/NIH SBIR Award R44AG080861, from the Parkinson\u2019s Foundation, has participated in clinical trials funded by Sanofi\/Genzyme, Roche\/Genentech, Biogen\/Denali, Bial, Transposon therapeutics and received consultant payments from Accordant, CVS\/Caremark, Genentech, Amylyx Pharmaceuticals and Ono Pharmaceuticals.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"434"}}