{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T20:39:59Z","timestamp":1784320799936,"version":"3.55.0"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,12,7]],"date-time":"2023-12-07T00:00:00Z","timestamp":1701907200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,12,7]],"date-time":"2023-12-07T00:00:00Z","timestamp":1701907200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Neurol"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Persistent primitive trigeminal artery variant (PPTAv) is a rare remnant of the primitive intracranial embryonic anastomotic arteries, and its persistence has an unknown etiology. Trigeminal neuralgia attributed to a PPTAv passing through Meckel\u2019s cavity is extremely uncommon.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>A 73-year-old woman presented with right-sided facial pain for 10 years that had failed to respond to medication. Magnetic resonance angiography suggested the presence of a PPTAv compressing the trigeminal nerve, as the abnormal artery originated from the right internal carotid artery. During microvascular decompression (MVD), the offending vessel was inferred to be a PPTAv, as it continued to become the anterior inferior cerebellar artery after passing through Meckel\u2019s cavity. Postoperative computed tomography angiography showed the PPTAv continuing posteriorly as the anterior inferior cerebellar artery and supplying the cerebellar hemisphere, which confirmed the intraoperative judgment. The pain resolved after MVD and has not recurred in 12 months of follow-up.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>MVD is the best surgical choice for trigeminal neuralgia combined with a PPTAv. For patients with neurovascular conflicts, particularly those with suspected vascular variations, preoperative imaging examinations play a critical role in meticulously evaluating the anatomical locations of the nerves and blood vessels. Semilunar puncture (for radiofrequency ablation or percutaneous balloon compression) is contraindicated in patients with a PPTAv.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12883-023-03483-1","type":"journal-article","created":{"date-parts":[[2023,12,7]],"date-time":"2023-12-07T08:02:32Z","timestamp":1701936152000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Trigeminal neuralgia caused by a persistent primitive trigeminal artery variant passing through Meckel\u2019s cavity: a case report"],"prefix":"10.1186","volume":"23","author":[{"given":"Zhengyan","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenpan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Risheng","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,12,7]]},"reference":[{"key":"3483_CR1","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1007\/s00234-006-0150-8","volume":"49","author":"BJ de Bondt","year":"2007","unstructured":"de Bondt BJ, Stokroos R, Casselman J. Persistent trigeminal artery associated with trigeminal neuralgia: hypothesis of neurovascular compression. Neuroradiology. 2007;49:23\u20136.","journal-title":"Neuroradiology"},{"key":"3483_CR2","doi-asserted-by":"publisher","first-page":"715","DOI":"10.21203\/rs.3.rs-1526010\/v1","volume":"44","author":"MA Deniz","year":"2022","unstructured":"Deniz MA, Turmak M, Hattapoglu S, Tekinhatun M. Persistent trigeminal artery detected on computed tomography angiography. Surg Radiol Anat. 2022;44:715\u201320. https:\/\/doi.org\/10.21203\/rs.3.rs-1526010\/v1.","journal-title":"Surg Radiol Anat"},{"issue":"3","key":"3483_CR3","doi-asserted-by":"publisher","first-page":"e22","DOI":"10.1136\/neurintsurg-2013-010703.rep","volume":"6","author":"TR Ladner","year":"2014","unstructured":"Ladner TR, Ehtesham M, Davis BJ, Khan IS, Ghiassi M, Ghiassi M, Singer RJ. Resolution of trigeminal neuralgia by coil embolization of a persistent primitive trigeminal artery Aneurysm. J Neurointerv Surg. 2014;6(3):e22.","journal-title":"J Neurointerv Surg"},{"key":"3483_CR4","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1097\/00006123-199809000-00082","volume":"43","author":"E Salas","year":"1998","unstructured":"Salas E, Ziyal IM, Sekhar LN, Wright DC. Persistent trigeminal artery: an anatomic study. Neurosurgery. 1998;43:557\u201361.","journal-title":"Neurosurgery"},{"key":"3483_CR5","doi-asserted-by":"publisher","first-page":"329","DOI":"10.3109\/00016925909171103","volume":"51","author":"GF Saltzman","year":"1959","unstructured":"Saltzman GF. Patent primitive trigeminal artery studied by cerebral angiography. Acta Radiol. 1959;51:329\u201336.","journal-title":"Acta Radiol"},{"key":"3483_CR6","doi-asserted-by":"publisher","first-page":"E746","DOI":"10.1227\/01.neu.0000317327.17225.f8","volume":"62","author":"S Ali","year":"2008","unstructured":"Ali S, Radaideh MM, Shaibani A, Russell EJ, Walker MT. Persistent trigeminal artery terminating in the posterior inferior cerebellar artery: Case report. Neurosurgery. 2008;62:E746\u20138.","journal-title":"Neurosurgery"},{"issue":"3","key":"3483_CR7","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1007\/s00276-023-03082-2","volume":"45","author":"MA Alnafie","year":"2023","unstructured":"Alnafie MA. New variant of persistent primitive trigeminal artery associated with duplicated basilar artery: a radiological case report. Surg Radiol Anat. 2023;45(3):321\u20136.","journal-title":"Surg Radiol Anat"},{"key":"3483_CR8","doi-asserted-by":"crossref","unstructured":"Chihara H, Kiyosue H, Tanoue S et al. Fenestration of the cavernous internal carotid artery associated with a persistent primitive trigeminal artery.Interv Neuroradiol. 2021; 27(6): 751\u20135.","DOI":"10.1177\/15910199211012261"},{"issue":"4","key":"3483_CR9","doi-asserted-by":"publisher","first-page":"194","DOI":"10.2176\/nmc.46.194","volume":"46","author":"Y Yamada","year":"2006","unstructured":"Yamada Y, Kondo A, Tanabe H. Trigeminal neuralgia associated with an anomalous artery originating from the persistent primitive trigeminal artery. Neurol Med Chir (Tokyo). 2006;46(4):194\u20137.","journal-title":"Neurol Med Chir (Tokyo)"},{"issue":"6","key":"3483_CR10","doi-asserted-by":"publisher","first-page":"1455","DOI":"10.1007\/s10072-012-0942-z","volume":"33","author":"R Conforti","year":"2012","unstructured":"Conforti R, Parlato RS, De Paulis D, et al. Trigeminal neuralgia and persistent trigeminal artery. Neurol Sci. 2012;33(6):1455\u20138.","journal-title":"Neurol Sci"},{"key":"3483_CR11","doi-asserted-by":"crossref","unstructured":"Tamura Y, Shimano H, Kuroiwa T, Miki Y. Trigeminal neuralgia associated with a primitive trigeminal artery variant: case report. Neurosurgery 52: 1217\u20139; discussion 1219\u20131220, 2003.","DOI":"10.1227\/01.NEU.0000058023.55777.44"},{"issue":"4","key":"3483_CR12","doi-asserted-by":"publisher","first-page":"101","DOI":"10.2176\/nmccrj.cr.2018-0279","volume":"6","author":"K Miki","year":"2019","unstructured":"Miki K, Natori Y, Mori M, Kai Y, Yamada T, Noguchi N. Trigeminal Neuralgia caused by a persistent primitive trigeminal artery variant and Superior Cerebellar Artery. NMC Case Rep J. 2019;6(4):101\u20133.","journal-title":"NMC Case Rep J"},{"key":"3483_CR13","first-page":"1229","volume":"14","author":"M Siqueira","year":"1993","unstructured":"Siqueira M, Piske R, Ono M, Marino J\u00fanior R. Cerebellar arteries originating from the internal carotid artery. AJNR Am J Neuroradiol. 1993;14:1229\u201335.","journal-title":"AJNR Am J Neuroradiol"},{"issue":"2","key":"3483_CR14","first-page":"209","volume":"18","author":"H Tokimura","year":"1990","unstructured":"Tokimura H, Atsuchi M, Kawasaki T, et al. Trigeminal neuralgia associated with primitive trigeminal artery: report of two cases. No Shinkei Geka. 1990;18(2):209\u201313.","journal-title":"No Shinkei Geka"},{"issue":"9","key":"3483_CR15","first-page":"1009","volume":"63","author":"I Kawahara","year":"2011","unstructured":"Kawahara I, Motokawa T, Umeno T, et al. Trigeminal neuralgia in an elderly patient associated with a variant of persistent primitive trigeminal artery. Brain Nerve. 2011;63(9):1009\u201312.","journal-title":"Brain Nerve"},{"issue":"1","key":"3483_CR16","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1007\/s00062-011-0114-1","volume":"23","author":"B Son","year":"2013","unstructured":"Son B, Yang S, Sung J, et al. Bilateral persistent primitive trigeminal arteries associated with trigeminal neuralgia. Clin Neuroradiol. 2013;23(1):45\u20139.","journal-title":"Clin Neuroradiol"},{"issue":"11","key":"3483_CR17","doi-asserted-by":"publisher","first-page":"2225","DOI":"10.1016\/j.radcr.2020.08.057","volume":"15","author":"MM Ling","year":"2020","unstructured":"Ling MM, Gupta M, Acharya J. Trigeminal neuralgia associated with a variant of persistent trigeminal artery. Radiol Case Rep. 2020;15(11):2225\u20138.","journal-title":"Radiol Case Rep"},{"key":"3483_CR18","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1136\/bmj.39085.614792.BE","volume":"334","author":"L Bennetto","year":"2007","unstructured":"Bennetto L, Patel NK, Fuller G. Trigeminal neuralgia and its management. BMJ. 2007;334:201\u20135.","journal-title":"BMJ"},{"issue":"6","key":"3483_CR19","doi-asserted-by":"publisher","first-page":"1144","DOI":"10.3171\/JNS-07\/12\/1144","volume":"107","author":"M Sindou","year":"2007","unstructured":"Sindou M, Leston J, Decullier E, Chapuis F. Microvascular decompression for primary trigeminal neuralgia: long-term effectiveness and prognostic factors in a series of 362 consecutive patients with clear-cut neurovascular conflicts who underwent pure decompression. J Neurosurg. 2007;107(6):1144\u201353.","journal-title":"J Neurosurg"},{"key":"3483_CR20","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.jocn.2023.01.002","volume":"109","author":"RFV Nascimento","year":"2023","unstructured":"Nascimento RFV, Pipek LZ, de Aguiar PHP. Is percutaneous balloon compression better than microvascular decompression to treat trigeminal neuralgia? A systematic review and meta-analysis. J Clin Neurosci. 2023;109:11\u201320.","journal-title":"J Clin Neurosci"},{"issue":"1","key":"3483_CR21","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1007\/s10143-022-01922-0","volume":"46","author":"DT Di Carlo","year":"2022","unstructured":"Di Carlo DT, Benedetto N, Perrini P. Clinical outcome after microvascular decompression for trigeminal neuralgia: a systematic review and meta-analysis. Neurosurg Rev. 2022;46(1):8.","journal-title":"Neurosurg Rev"}],"container-title":["BMC Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12883-023-03483-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12883-023-03483-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12883-023-03483-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,7]],"date-time":"2023-12-07T08:03:53Z","timestamp":1701936233000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcneurol.biomedcentral.com\/articles\/10.1186\/s12883-023-03483-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,7]]},"references-count":21,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,12]]}},"alternative-id":["3483"],"URL":"https:\/\/doi.org\/10.1186\/s12883-023-03483-1","relation":{},"ISSN":["1471-2377"],"issn-type":[{"value":"1471-2377","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,7]]},"assertion":[{"value":"8 October 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 November 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 December 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This research did not increase the risk and economic burden of the patient; the patient\u2019s rights were fully protected; the project design was conducted in line with scientific and ethical principles. The institutional review board approved this project.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained from the patient for publication of the case report and accompanying images.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"432"}}