{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T04:15:10Z","timestamp":1772165710217,"version":"3.50.1"},"reference-count":9,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,1,24]],"date-time":"2024-01-24T00:00:00Z","timestamp":1706054400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,1,24]],"date-time":"2024-01-24T00:00:00Z","timestamp":1706054400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100009687","name":"Uniwersytet Medyczny im. Piast\u00f3w Slaskich we Wroclawiu","doi-asserted-by":"publisher","award":["SUBZ.C220.23.073"],"award-info":[{"award-number":["SUBZ.C220.23.073"]}],"id":[{"id":"10.13039\/501100009687","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009687","name":"Uniwersytet Medyczny im. Piast\u00f3w Slaskich we Wroclawiu","doi-asserted-by":"publisher","award":["SUBZ.C220.23.073"],"award-info":[{"award-number":["SUBZ.C220.23.073"]}],"id":[{"id":"10.13039\/501100009687","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009687","name":"Uniwersytet Medyczny im. Piast\u00f3w Slaskich we Wroclawiu","doi-asserted-by":"publisher","award":["SUBZ.C220.23.073"],"award-info":[{"award-number":["SUBZ.C220.23.073"]}],"id":[{"id":"10.13039\/501100009687","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Neurol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Spinal adhesive arachnoiditis is a chronic inflammatory process of the leptomeninges and intrathecal neural elements. The possible causes of arachnoiditis are: infections, injuries of spinal cord, surgical procedures and intrathecal administration of therapeutic substances or contrast.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>We present a case of 56-old woman with spinal muscular atrophy type 3 who developed a severe back pain in the lumbosacral region after the fifth dose of nusinersen given intrathecally. Magnetic resonance of lumbosacral spine showed spinal adhesive arachnoiditis. She received high doses of methylprednisolone intravenously, and later non-steroidal anti-inflammatory drugs, alpha lipoic acid, vitamins and rehabilitation with slight improvement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The authors summarize that scheduled resonance imaging of the lumbosacral spine may be an important element of the algorithm in the monitoring of novel, intrathecal therapy in patients with spinal muscular atrophy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12883-024-03543-0","type":"journal-article","created":{"date-parts":[[2024,1,24]],"date-time":"2024-01-24T01:02:22Z","timestamp":1706058142000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Spinal adhesive arachnoiditis in an adult patient with spinal muscular atrophy type 3 treated with intrathecal therapy"],"prefix":"10.1186","volume":"24","author":[{"given":"Jakub","family":"Ubysz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magdalena","family":"Koszewicz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna","family":"Bladowska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Slawomir","family":"Budrewicz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,1,24]]},"reference":[{"key":"3543_CR1","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1017\/S0317167100044486","volume":"10","author":"SI Esses","year":"1983","unstructured":"Esses SI, Morley TP. Spinal arachnoiditis. Can J Neurol Sci. 1983;10:2\u201310. https:\/\/doi.org\/10.1017\/S0317167100044486.","journal-title":"Can J Neurol Sci"},{"key":"3543_CR2","doi-asserted-by":"publisher","first-page":"1194","DOI":"10.1016\/j.wneu.2018.05.219","volume":"116","author":"T Kr\u00e4tzig","year":"2018","unstructured":"Kr\u00e4tzig T, Dreimann M, Mende KC, K\u00f6nigs I, Westphal M, Eicker SO. Extensive spinal adhesive arachnoiditis after extradural spinal infection-spinal dura mater is no barrier to inflammation. World Neurosurg. 2018;116:1194\u2013203. https:\/\/doi.org\/10.1016\/j.wneu.2018.05.219.","journal-title":"World Neurosurg"},{"key":"3543_CR3","doi-asserted-by":"publisher","first-page":"176","DOI":"10.3109\/15360288.2012.671239","volume":"26","author":"J Kalina","year":"2012","unstructured":"Kalina J, Arachnoiditis J, Pain Palliat. Care Pharmacother. 2012;26:176\u20137. https:\/\/doi.org\/10.3109\/15360288.2012.671239.","journal-title":"Care Pharmacother"},{"key":"3543_CR4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1515\/tnsci-2017-0001","volume":"8","author":"EW Ottesen","year":"2017","unstructured":"Ottesen EW. ISS-N1 makes the first FDA-approved drug for spinal muscular atrophy. Transl Neurosci. 2017;8:1\u20136. https:\/\/doi.org\/10.1515\/tnsci-2017-0001.","journal-title":"Transl Neurosci"},{"key":"3543_CR5","doi-asserted-by":"publisher","first-page":"453","DOI":"10.3233\/JND-190416","volume":"6","author":"MC Walter","year":"2019","unstructured":"Walter MC, Wenninger S, Thiele S, Stauber J, Hiebeler M, Greckl E, et al. Safety and treatment effects of nusinersen in longstanding adult 5q-SMA type 3 - a prospective observational study. J Neuromuscul Dis. 2019;6:453\u201365. https:\/\/doi.org\/10.3233\/JND-190416.","journal-title":"J Neuromuscul Dis"},{"key":"3543_CR6","doi-asserted-by":"publisher","unstructured":"Coratti G, Cutrona C, Pera MC, Bovis F, Ponzano M, Chieppa F et al. (2021) Motor function in type 2 and 3 SMA patients treated with Nusinersen: a critical review and meta-analysis. Orphanet J Rare Dis 2021;16:430\u2013442, https:\/\/doi.org\/10.1186\/s13023-021-02065-z.","DOI":"10.1186\/s13023-021-02065-z"},{"key":"3543_CR7","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1097\/00007632-197803000-00006","volume":"3","author":"CV Burton","year":"1978","unstructured":"Burton CV, Lumbosacral arachnoiditis. Spine. 1978;3:24\u201330. https:\/\/doi.org\/10.1097\/00007632-197803000-00006.","journal-title":"Spine"},{"key":"3543_CR8","doi-asserted-by":"publisher","first-page":"1201","DOI":"10.1148\/rg.2018170178","volume":"38","author":"VK Kunam","year":"2018","unstructured":"Kunam VK, Velayudhan V, Chaudhry ZA, Bobinski M, Smoker WRK, Reede DL. Incomplete cord syndromes: clinical and imaging review. Radiographics. 2018;38:1201\u201322. https:\/\/doi.org\/10.1148\/rg.2018170178.","journal-title":"Radiographics"},{"issue":"1","key":"3543_CR9","doi-asserted-by":"publisher","first-page":"e33697","DOI":"10.7759\/cureus.33697","volume":"15","author":"J Maillard","year":"2023","unstructured":"Maillard J, Batista S, Medeiros F, et al. Spinal Adhesive Arachnoiditis: A literature review. Cureus. 2023;15(1):e33697. https:\/\/doi.org\/10.7759\/cureus.33697.","journal-title":"Cureus"}],"container-title":["BMC Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12883-024-03543-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12883-024-03543-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12883-024-03543-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,24]],"date-time":"2024-01-24T01:02:35Z","timestamp":1706058155000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcneurol.biomedcentral.com\/articles\/10.1186\/s12883-024-03543-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,24]]},"references-count":9,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["3543"],"URL":"https:\/\/doi.org\/10.1186\/s12883-024-03543-0","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-3783744\/v1","asserted-by":"object"}]},"ISSN":["1471-2377"],"issn-type":[{"value":"1471-2377","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,24]]},"assertion":[{"value":"20 December 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 January 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 January 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Written informed consent for publication of their clinical details and\/or clinical images was obtained from the patient. A copy of the consent form is available for review by the Editor of this journal.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"From the patient described written informed consent for publication has been obtained.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"43"}}