{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T05:33:49Z","timestamp":1769751229062,"version":"3.49.0"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,2,14]],"date-time":"2024-02-14T00:00:00Z","timestamp":1707868800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,2,14]],"date-time":"2024-02-14T00:00:00Z","timestamp":1707868800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"the First Affiliated Hospital of Chongqing Medical University PhD Innovation Program","award":["No. CYYY-BSYJSCXXM-202314"],"award-info":[{"award-number":["No. CYYY-BSYJSCXXM-202314"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No. 82071337"],"award-info":[{"award-number":["No. 82071337"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Chongqing Innovation Support Program for Returned Overseas Chinese Scholars","award":["No. cx2020002"],"award-info":[{"award-number":["No. cx2020002"]}]},{"name":"Chongqing Science Fund for Distinguished Young Scholars","award":["No.cstc2021jcyj-jqX0029"],"award-info":[{"award-number":["No.cstc2021jcyj-jqX0029"]}]},{"name":"Research Fund of Anhui Institute of translational medicine","award":["No.2022zhyx-C38"],"award-info":[{"award-number":["No.2022zhyx-C38"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Neurol"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>The implementation of a care bundle might improve functional outcome for patients with intracerebral hemorrhage (ICH). However, the impact of anti-hypertensive treatment on ICH outcomes remains uncertain. Our objective is to examine whether early blood pressure (BP) lowering therapy within first 12\u00a0h is associated with good outcome in ICH patients.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>We included acute ICH patients who had baseline computed tomography (CT) scans within 6\u00a0h after onset of symptoms between October 2013 and December 2021. Early BP reduction was defined as use of anti-hypertensive agents within 12\u00a0h after onset of symptom. The clinical characteristics were compared between patients who received early BP lowering therapy and those without. The associations between early BP lowering and good outcome and functional independence at 3\u00a0months were assessed by using multivariable logistic regression analyses.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>A total of 377 patients were finally included in this study for outcome analysis. Of those, 212 patients received early BP reduction within 12\u00a0h after ICH. A total of 251 (66.6%) patients had good outcome. After adjustment for age, admission systolic BP, admission GCS score, baseline hematoma volume, hematoma expansion, and presence of intraventricular hemorrhage, early BP lowering therapy was associated with functional independence (adjusted odd ratio:1.72, 95% confidence interval:1.03\u20132.87; <jats:italic>P<\/jats:italic>\u2009=\u20090.039) and good outcome (adjusted odd ratio: 2.02, 95% confidence interval:1.08\u20133.76; <jats:italic>P<\/jats:italic>\u2009=\u20090.027).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>In ICH patients presenting within 6\u00a0h after symptom onset, early BP reduction within first 12 h is associated with good outcome and functional independence when compared to those who do not undergo such early intervention. Implementation of quality measures to ensure early BP reduction is crucial for management of ICH.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12883-024-03561-y","type":"journal-article","created":{"date-parts":[[2024,2,14]],"date-time":"2024-02-14T06:03:11Z","timestamp":1707890591000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Early blood pressure lowering therapy is associated with good functional outcome in patients with intracerebral hemorrhage"],"prefix":"10.1186","volume":"24","author":[{"given":"Xinni","family":"Lv","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xueyun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zicheng","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lan","family":"Deng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zuoqiao","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingjun","family":"Pu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9144-148X","authenticated-orcid":false,"given":"Qi","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,2,14]]},"reference":[{"key":"3561_CR1","doi-asserted-by":"publisher","first-page":"1632","DOI":"10.1016\/S0140-6736(09)60371-8","volume":"373","author":"AI Qureshi","year":"2009","unstructured":"Qureshi AI, Mendelow AD, Hanley DF. Intracerebral haemorrhage. Lancet. 2009;373:1632\u201344.","journal-title":"Lancet"},{"key":"3561_CR2","doi-asserted-by":"publisher","first-page":"1182","DOI":"10.1212\/01.wnl.0000208400.08722.7c","volume":"66","author":"ML Flaherty","year":"2006","unstructured":"Flaherty ML, Haverbusch M, Sekar P, Kissela B, Kleindorfer D, Moomaw CJ, et al. Long-term mortality after intracerebral hemorrhage. Neurology. 2006;66:1182\u20136.","journal-title":"Neurology"},{"key":"3561_CR3","doi-asserted-by":"publisher","first-page":"3","DOI":"10.5853\/jos.2016.00864","volume":"19","author":"SJ An","year":"2017","unstructured":"An SJ, Kim TJ, Yoon BW. Epidemiology, risk factors, and clinical features of intracerebral hemorrhage: an update. J Stroke. 2017;19:3\u201310.","journal-title":"J Stroke"},{"key":"3561_CR4","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1161\/CIRCULATIONAHA.107.723874","volume":"118","author":"AI Qureshi","year":"2008","unstructured":"Qureshi AI. 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Informed consent was waived due to the retrospective nature of this study (the Ethics Committee of the First Affiliated Hospital of Chongqing Medical University). The study was conducted in accordance with the declaration of Helsink.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"63"}}