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We matched 16 PCVT patients with 64 pregnant and puerperal women without PCVT to explore risk factors and clinical susceptibility to PCVT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      PCVT occurred commonly during the first trimester (43.75%) and the puerperium (37.5%). The frequency of anemia, thrombocytosis and thrombocytopenia during pregnancy, dehydration, and pre-pregnancy anemia was significantly higher in women with PCVT than in those without PCVT (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05). Among the 16 patients, five were diagnosed with antiphospholipid syndrome and one was diagnosed with systemic lupus erythematosus. Three patients had distinct protein S deficiency and one had protein C deficiency. Whole Exome Sequencing (WES) was performed for five patients and revealed likely pathogenic mutations associated with CVT, including heterozygous PROC c.1218G\u2009&gt;\u2009A (p. Met406Ile), heterozygous PROS1 c.301C\u2009&gt;\u2009T (p. Arg101Cys), composite heterozygous mutation in the F8 gene (c.144-1259C\u2009&gt;\u2009T; c.6724G\u2009&gt;\u2009A (p. Val2242Met)) and homozygous MTHFR c.677C\u2009&gt;\u2009T (p. Ala222Val).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The occurrence of anemia, thrombocytopenia and thrombocytosis during pregnancy, dehydration and pre-pregnancy anemia suggested a greater susceptibility to PCVT. For confirmed PCVT patients, autoimmune diseases, hereditary thrombophilia, and hematological disorders were common causes. Screening for potential etiologies should be paid more attention, as it has implications for treatment and long-term management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12883-024-03676-2","type":"journal-article","created":{"date-parts":[[2024,5,31]],"date-time":"2024-05-31T01:01:44Z","timestamp":1717117304000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["The risk profiles of pregnancy-related cerebral venous thrombosis: a retrospective study in a comprehensive hospital"],"prefix":"10.1186","volume":"24","author":[{"given":"Shaoying","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juntao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,5,31]]},"reference":[{"issue":"2","key":"3676_CR1","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/S1474-4422(07)70029-7","volume":"6","author":"MG Bousser","year":"2007","unstructured":"Bousser MG, Ferro JM. 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