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This study was part of the investigation into risk factors for phenoconversion and also had been approved by the committee (R2017-160). Written informed consent to participate was obtained from all patients.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Hiroshi Kadotani was supported by donations from Fukuda Life Tech Co., Ltd., Fukuda Life Tech Keiji Co., Ltd., and Kadotani Kids Clinic to the Shiga University of Medical Science. Hiroshi Kadotani received Merck Sharp and Dohme Corp\/MSD K.K. (the Investigator-initiated Studies Program), Eisai Co., Ltd., and the SECOM Science and Technology Foundation. The opinions expressed in this paper are those of the authors and do not necessarily represent those of Merck Sharp and Dohme Corp\/MSD K.K.  The other authors declare no conflicts of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"317"}}