{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T04:15:11Z","timestamp":1772165711550,"version":"3.50.1"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T00:00:00Z","timestamp":1734566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T00:00:00Z","timestamp":1734566400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Changzhou Science and Technology planning project","award":["CJ20230068"],"award-info":[{"award-number":["CJ20230068"]}]},{"name":"National Natural Science Foundation of China Youth Project","award":["82100728"],"award-info":[{"award-number":["82100728"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Neurol"],"DOI":"10.1186\/s12883-024-03985-6","type":"journal-article","created":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T03:16:22Z","timestamp":1734578182000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Alterations in spontaneous brain activity of maintenance hemodialysis patients with restless legs syndrome: a cross-sectional case-control study"],"prefix":"10.1186","volume":"24","author":[{"given":"Di","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenqing","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yushang","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wanfen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tongqiang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haifeng","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,12,19]]},"reference":[{"key":"3985_CR1","doi-asserted-by":"publisher","first-page":"1982","DOI":"10.1093\/ndt\/gfab290","volume":"37","author":"JJ Chen","year":"2022","unstructured":"Chen JJ, et al. Pharmacological and non-pharmacological treatments for restless legs syndrome in end-stage kidney disease: a systematic review and component network meta-analysis. Nephrol Dial Transpl. 2022;37:1982\u201392.","journal-title":"Nephrol Dial Transpl"},{"key":"3985_CR2","doi-asserted-by":"publisher","first-page":"1275","DOI":"10.1038\/ki.2013.394","volume":"85","author":"CD Giannaki","year":"2014","unstructured":"Giannaki CD, et al. Epidemiology, impact, and treatment options of restless legs syndrome in end-stage renal disease patients: an evidence-based review. Kidney Int. 2014;85:1275\u201382.","journal-title":"Kidney Int"},{"key":"3985_CR3","doi-asserted-by":"publisher","first-page":"8171","DOI":"10.7150\/thno.35387","volume":"9","author":"YF Wang","year":"2019","unstructured":"Wang YF, et al. The gut microbiota-inflammation-brain axis in end-stage renal disease: perspectives from default mode network. Theranostics. 2019;9:8171\u201381.","journal-title":"Theranostics"},{"key":"3985_CR4","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.jneumeth.2008.04.012","volume":"172","author":"QH Zou","year":"2008","unstructured":"Zou QH, et al. An improved approach to detection of amplitude of low-frequency fluctuation (ALFF) for resting-state fMRI: fractional ALFF. J Neurosci Methods. 2008;172:137\u201341.","journal-title":"J Neurosci Methods"},{"key":"3985_CR5","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.pnpbp.2017.02.001","volume":"75","author":"M Zhou","year":"2017","unstructured":"Zhou M, et al. Intrinsic cerebral activity at resting state in adults with major depressive disorder: a meta-analysis. Prog Neuropsychopharmacol Biol Psychiatry. 2017;75:157\u201364.","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"3985_CR6","doi-asserted-by":"publisher","first-page":"1170","DOI":"10.1007\/s11682-020-00317-3","volume":"15","author":"P Chen","year":"2021","unstructured":"Chen P, et al. Abnormal degree centrality in end-stage renal disease (ESRD) patients with cognitive impairment: a resting-state functional MRI study. Brain Imaging Behav. 2021;15:1170\u201380.","journal-title":"Brain Imaging Behav"},{"key":"3985_CR7","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.sleep.2017.06.033","volume":"38","author":"Y Zhuo","year":"2017","unstructured":"Zhuo Y, et al. Combined resting state functional magnetic resonance imaging and diffusion tensor imaging study in patients with idiopathic restless legs syndrome. Sleep Med. 2017;38:96\u2013103.","journal-title":"Sleep Med"},{"key":"3985_CR8","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1016\/j.sleep.2023.08.014","volume":"110","author":"J Zhang","year":"2023","unstructured":"Zhang J, et al. Cerebellum drives functional dysfunctions in restless leg syndrome. Sleep Med. 2023;110:172\u20138.","journal-title":"Sleep Med"},{"key":"3985_CR9","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1016\/j.sleep.2014.12.029","volume":"16","author":"C Liu","year":"2015","unstructured":"Liu C, et al. Mapping intrinsic functional brain changes and repetitive transcranial magnetic stimulation neuromodulation in idiopathic restless legs syndrome: a resting-state functional magnetic resonance imaging study. Sleep Med. 2015;16:785\u201391.","journal-title":"Sleep Med"},{"key":"3985_CR10","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1007\/s11682-018-9968-z","volume":"14","author":"J Mu","year":"2020","unstructured":"Mu J, et al. The variation of motor-related brain structure and its relation to abnormal motor behaviors in end-stage renal disease patients with restless legs syndrome. Brain Imaging Behav. 2020;14:42\u201350.","journal-title":"Brain Imaging Behav"},{"key":"3985_CR11","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1016\/j.sleep.2014.03.025","volume":"15","author":"RP Allen","year":"2014","unstructured":"Allen RP, et al. Restless legs syndrome\/Willis-Ekbom disease diagnostic criteria: updated International Restless Legs Syndrome Study Group (IRLSSG) consensus criteria\u2013history, rationale, description, and significance. Sleep Med. 2014;15:860\u201373.","journal-title":"Sleep Med"},{"key":"3985_CR12","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1016\/j.acra.2022.06.019","volume":"30","author":"J Zheng","year":"2023","unstructured":"Zheng J, et al. Brain micro-structural and functional alterations for cognitive function prediction in the end-stage renal disease patients undergoing maintenance hemodialysis. Acad Radiol. 2023;30:1047\u201355.","journal-title":"Acad Radiol"},{"key":"3985_CR13","doi-asserted-by":"publisher","first-page":"e3378","DOI":"10.1002\/brb3.3378","volume":"14","author":"XH Zhou","year":"2024","unstructured":"Zhou XH, et al. Global prevalence of restless legs syndrome among hemodialysis patients: a systematic review and meta-analysis. Brain Behav. 2024;14:e3378.","journal-title":"Brain Behav"},{"key":"3985_CR14","doi-asserted-by":"publisher","first-page":"2375","DOI":"10.1016\/j.clinph.2020.06.024","volume":"131","author":"K Pacheco-Barrios","year":"2020","unstructured":"Pacheco-Barrios K, et al. Structural and functional motor cortex asymmetry in unilateral lower limb amputation with phantom limb pain. Clin Neurophysiol. 2020;131:2375\u201382.","journal-title":"Clin Neurophysiol"},{"key":"3985_CR15","doi-asserted-by":"publisher","first-page":"101735","DOI":"10.1016\/j.smrv.2022.101735","volume":"67","author":"G Lanza","year":"2023","unstructured":"Lanza G, et al. Repetitive transcranial magnetic stimulation in primary sleep disorders. Sleep Med Rev. 2023;67:101735.","journal-title":"Sleep Med Rev"},{"key":"3985_CR16","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1038\/s41572-021-00311-z","volume":"7","author":"M Manconi","year":"2021","unstructured":"Manconi M, et al. Restless legs syndrome. Nat Rev Dis Primers. 2021;7:80.","journal-title":"Nat Rev Dis Primers"},{"key":"3985_CR17","doi-asserted-by":"publisher","first-page":"1288","DOI":"10.1016\/j.sleep.2014.05.009","volume":"15","author":"CJ Earley","year":"2014","unstructured":"Earley CJ, et al. Altered brain iron homeostasis and dopaminergic function in restless legs syndrome (Willis-Ekbom Disease). Sleep Med. 2014;15:1288\u2013301.","journal-title":"Sleep Med"},{"key":"3985_CR18","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1007\/s13311-021-01019-4","volume":"18","author":"TR Gossard","year":"2021","unstructured":"Gossard TR, Trotti LM, Videnovic A, St Louis, EK. Restless legs syndrome: contemporary diagnosis and treatment. Neurotherapeutics. 2021;18:140\u201355.","journal-title":"Neurotherapeutics"},{"key":"3985_CR19","doi-asserted-by":"publisher","first-page":"1105463","DOI":"10.3389\/fneur.2023.1105463","volume":"14","author":"M Tang","year":"2023","unstructured":"Tang M, et al. Circadian rhythm in restless legs syndrome. Front Neurol. 2023;14:1105463.","journal-title":"Front Neurol"},{"key":"3985_CR20","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1002\/ajh.23397","volume":"88","author":"RP Allen","year":"2013","unstructured":"Allen RP, et al. The prevalence and impact of restless legs syndrome on patients with iron deficiency anemia. Am J Hematol. 2013;88:261\u20134.","journal-title":"Am J Hematol"},{"key":"3985_CR21","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1113\/JP279237","volume":"598","author":"J Duffin","year":"2020","unstructured":"Duffin J, et al. A mathematical model of cerebral blood flow control in anaemia and hypoxia. J Physiol. 2020;598:717\u201330.","journal-title":"J Physiol"},{"key":"3985_CR22","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1007\/s10863-009-9247-1","volume":"41","author":"C Carvalho","year":"2009","unstructured":"Carvalho C, et al. Role of mitochondrial-mediated signaling pathways in Alzheimer disease and hypoxia. J Bioenerg Biomembr. 2009;41:433\u201340.","journal-title":"J Bioenerg Biomembr"},{"key":"3985_CR23","doi-asserted-by":"publisher","first-page":"1856","DOI":"10.1212\/WNL.0000000000000454","volume":"82","author":"AV Salminen","year":"2014","unstructured":"Salminen AV, Rimpil\u00e4 V, Polo O. Peripheral hypoxia in restless legs syndrome (Willis-Ekbom disease). Neurology. 2014;82:1856\u201361.","journal-title":"Neurology"},{"key":"3985_CR24","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1016\/j.semnephrol.2015.06.006","volume":"35","author":"M Novak","year":"2015","unstructured":"Novak M, et al. Restless legs syndrome in patients with chronic kidney disease. Semin Nephrol. 2015;35:347\u201358.","journal-title":"Semin Nephrol"},{"key":"3985_CR25","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/j.jsmc.2015.05.006","volume":"10","author":"F Provini","year":"2015","unstructured":"Provini F, Chiaro G. Neuroimaging in restless legs syndrome. Sleep Med Clin. 2015;10:215\u201326.","journal-title":"Sleep Med Clin"},{"key":"3985_CR26","doi-asserted-by":"publisher","first-page":"1250","DOI":"10.1002\/mds.22074","volume":"23","author":"A Unrath","year":"2008","unstructured":"Unrath A, et al. Cerebral white matter alterations in idiopathic restless legs syndrome, as measured by diffusion tensor imaging. Mov Disord. 2008;23:1250\u20135.","journal-title":"Mov Disord"},{"key":"3985_CR27","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1186\/s12883-024-03636-w","volume":"24","author":"C Li","year":"2024","unstructured":"Li C, et al. Cerebral blood flow changes in maintenance hemodialysis patients with restless legs syndrome and their clinical significance:a cross-sectional case-control study. BMC Neurol. 2024;24:128.","journal-title":"BMC Neurol"},{"key":"3985_CR28","doi-asserted-by":"publisher","first-page":"356","DOI":"10.4103\/ijri.IJRI_326_19","volume":"29","author":"S Vyas","year":"2019","unstructured":"Vyas S, et al. Evaluation of cerebral microstructural changes in adult patients with obstructive sleep apnea by MR diffusion kurtosis imaging using a whole-brain atlas. Indian J Radiol Imaging. 2019;29:356\u201363.","journal-title":"Indian J Radiol Imaging"},{"key":"3985_CR29","doi-asserted-by":"publisher","first-page":"7643","DOI":"10.1038\/s41598-020-64641-w","volume":"10","author":"J Ku","year":"2020","unstructured":"Ku J, et al. Alterations in salience network functional connectivity in individuals with restless legs syndrome. Sci Rep. 2020;10:7643.","journal-title":"Sci Rep"},{"key":"3985_CR30","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1053\/ajkd.2001.27419","volume":"38","author":"MJ Smogorzewski","year":"2001","unstructured":"Smogorzewski MJ. Central nervous dysfunction in uremia. Am J Kidney Dis. 2001;38:122\u20138.","journal-title":"Am J Kidney Dis"},{"key":"3985_CR31","first-page":"e1834","volume":"90","author":"BY Lee","year":"2018","unstructured":"Lee BY, et al. Involvement of the central somatosensory system in restless legs syndrome: a neuroimaging study. Neurology. 2018;90:e1834\u201341.","journal-title":"Neurology"},{"key":"3985_CR32","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1148\/radiol.2015141913","volume":"278","author":"S Luo","year":"2016","unstructured":"Luo S, et al. Abnormal intrinsic brain activity patterns in patients with end-stage renal disease undergoing peritoneal dialysis: a resting-state functional MR imaging study. Radiology. 2016;278:181\u20139.","journal-title":"Radiology"},{"key":"3985_CR33","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.sleep.2019.12.009","volume":"71","author":"R Nardone","year":"2020","unstructured":"Nardone R, et al. Contribution of transcranial magnetic stimulation in restless legs syndrome: pathophysiological insights and therapeutical approaches. Sleep Med. 2020;71:124\u201334.","journal-title":"Sleep Med"},{"key":"3985_CR34","first-page":"265","volume":"101","author":"C Ma","year":"2021","unstructured":"Ma C, et al. Study on the changes of spontaneous brain activity in maintenance hemodialysis patients with end-stage renal disease based on three different resting state-functional magnetic resonance low-frequency amplitude algorithms. Zhonghua Yi Xue Za Zhi. 2021;101:265\u201370.","journal-title":"Zhonghua Yi Xue Za Zhi"},{"key":"3985_CR35","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1007\/s11325-023-02943-9","volume":"28","author":"BS Park","year":"2024","unstructured":"Park BS, et al. Difference in functional connectivity between end-stage renal disease patients with and without restless legs syndrome: a prospective study. Sleep Breath. 2024;28:673\u201381.","journal-title":"Sleep Breath"},{"key":"3985_CR36","doi-asserted-by":"crossref","unstructured":"Stefani A et al. Multimodal magnetic resonance imaging reveals alterations of sensorimotor circuits in restless legs syndrome. Sleep. 2019;42.","DOI":"10.1093\/sleep\/zsz171"}],"container-title":["BMC Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12883-024-03985-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12883-024-03985-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12883-024-03985-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T04:04:39Z","timestamp":1734581079000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcneurol.biomedcentral.com\/articles\/10.1186\/s12883-024-03985-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,19]]},"references-count":36,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["3985"],"URL":"https:\/\/doi.org\/10.1186\/s12883-024-03985-6","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-4998380\/v1","asserted-by":"object"}]},"ISSN":["1471-2377"],"issn-type":[{"value":"1471-2377","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,19]]},"assertion":[{"value":"29 August 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 November 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 December 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the Ethics Committee of the Third Affiliated Hospital of Nanjing Medical University, Changzhou, Jiangsu, China ([2022]KY005-01). The study was conducted in accordance with the Declaration of Helsinki and its later amendments. Informed consent was obtained from all participants and their legal guardians in the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval and consent to participate"}},{"value":"Not Applicable. All of our identifying images and other personal or clinical details of participants are presented that compromise anonymity.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"486"}}