{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T11:32:08Z","timestamp":1791977528283,"version":"4.4.0"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,1,14]],"date-time":"2025-01-14T00:00:00Z","timestamp":1736812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,1,14]],"date-time":"2025-01-14T00:00:00Z","timestamp":1736812800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Neurol"],"DOI":"10.1186\/s12883-025-04027-5","type":"journal-article","created":{"date-parts":[[2025,1,14]],"date-time":"2025-01-14T01:28:58Z","timestamp":1736818138000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Euglycemic diabetic ketoacidosis associated metabolic encephalopathy caused by dapagliflozin: a rare case report"],"prefix":"10.1186","volume":"25","author":[{"given":"Lulu","family":"Chu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenhua","family":"Xi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Runzhi","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiliang","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoshen","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,14]]},"reference":[{"key":"4027_CR1","doi-asserted-by":"publisher","DOI":"10.1186\/s12902-023-01339-w","author":"M 1 Sitina","year":"2023","unstructured":"Sitina M, Lukes M, Sramek V. Empagliflozin-associated postoperative mixed metabolic acidosis. Case report and review of pathogenesis. BMC Endocr Disorders. 2023;23(1):81. https:\/\/doi.org\/10.1186\/s12902-023-01339-w.","journal-title":"BMC Endocr Disorders"},{"key":"4027_CR2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcjd.2020","author":"A 2 Clark","year":"2021","unstructured":"Clark A, Mohammed AS, Raut A, et al. Prevalence and clinical characteristics of adults presenting with sodium-glucose Cotransporter-2 inhibitor-Associated Diabetic Ketoacidosis at a Canadian academic Tertiary Care Hospital. Can J Diabetes. 2021;45(3):214-9. https:\/\/doi.org\/10.1016\/j.jcjd.2020.08.100.","journal-title":"Can J Diabetes"},{"key":"4027_CR3","doi-asserted-by":"publisher","unstructured":"Sampani E, Sarafidis P, Dimitriadis C et al. Severe euglycemic diabetic ketoacidosis of multifactorial etiology in a type 2 diabetic patient treated with empagliflozin: case report and literature review. BMC Nephrology. 2020;21(1):276. https:\/\/doi.org\/10.1186\/s12882-020-01930-6.","DOI":"10.1186\/s12882-020-01930-6"},{"key":"4027_CR4","doi-asserted-by":"publisher","unstructured":"Secinaro E, Ciavarella S, Rizzo G, et al. SGLT2-inhibitors and euglycemic diabetic ketoacidosis in COVID-19 pandemic era: a case report. Acta Diabetol. 2022;59(10):1391\u20134. https:\/\/doi.org\/10.1007\/s00592-022-01909-9.","DOI":"10.1007\/s00592-022-01909-9"},{"key":"4027_CR5","doi-asserted-by":"publisher","DOI":"10.1016\/j.amsu.2022.104879","author":"WM 5 Altowayan","year":"2022","unstructured":"Altowayan WM. Empagliflozin induced euglycemic diabetic ketoacidosis. A case reports. Annals Med Surg. 2022;84:104879. https:\/\/doi.org\/10.1016\/j.amsu.2022.104879.","journal-title":"Annals Med Surg"},{"key":"4027_CR6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2021.02.015","author":"B 6 Long","year":"2021","unstructured":"Long B, Lentz S, Koyfman A, et al. Euglycemic diabetic ketoacidosis: etiologies, evaluation, and management. Am J Emerg Med. 2021;44:157-60.\u00a0https:\/\/doi.org\/10.1016\/j.ajem.2021.02.015.","journal-title":"Am J Emerg Med"},{"key":"4027_CR7","doi-asserted-by":"publisher","unstructured":"Barski L, Eshkoli T, Brandstaetter E et al. Euglycemic diabetic ketoacidosis. Eur J Intern Med. 2019; 63:9-14. https:\/\/doi.org\/10.1016\/j.ejim.2019.03.014.","DOI":"10.1016\/j.ejim.2019.03.014"},{"key":"4027_CR8","doi-asserted-by":"publisher","DOI":"10.4183\/aeb.2021.266","author":"S 8 Sethi","year":"2021","unstructured":"Sethi S. Euglycemic Diabetic Ketoacidosis (EDKA) in a patient receiving Dapagliflozin. Acta Endocrinol (Bucharest). 2021;17(2):266-9. https:\/\/doi.org\/10.4183\/aeb.2021.266.","journal-title":"Acta Endocrinol (Bucharest)"},{"key":"4027_CR9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2018.08.054","author":"Z 9 Karakaya","year":"2018","unstructured":"Karakaya Z, Topal FE, Firdes Topal UP, et al. Euglisemic diabetic ketoacidotic coma caused by dapagliflozin. Am J Emerg Med. 2018;6(11):2136.e1-2036.e2. https:\/\/doi.org\/10.1016\/j.ajem. 2018.08.054.","journal-title":"Am J Emerg Med"},{"key":"4027_CR10","doi-asserted-by":"publisher","unstructured":"Banakh I, Kung R, Gupta S, et al. Euglycemic diabetic ketoacidosis in association with dapagliflozin use after gastric sleeve surgery in a patient with type II diabetes mellitus. Clin Case Rep. 2019;7(5):1087-90. https:\/\/doi.org\/10.1002\/ccr3.2147.","DOI":"10.1002\/ccr3.2147"},{"key":"4027_CR11","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.6089","author":"I 11 Iqbal","year":"2019","unstructured":"Iqbal I, Hamid M, Khan MAA, et al. Dapagliflozin-induced late-onset Euglycemic Diabetic Ketoacidosis. Cureus. 2019;11(11):e6089. https:\/\/doi.org\/10.7759\/cureus.6089.","journal-title":"Cureus"},{"key":"4027_CR12","doi-asserted-by":"publisher","DOI":"10.1186\/s12902-019-0398-8","author":"M 12 Tomkins","year":"2019","unstructured":"Tomkins M, McCormack R, O Connell K, et al. Metabolic encephalopathy secondary to diabetic ketoacidosis: a case report. BMC Endocr Disorders. 2019;19(1):71. https:\/\/doi.org\/10.1186\/s 12902-019-0398-8.","journal-title":"BMC Endocr Disorders"},{"key":"4027_CR13","doi-asserted-by":"publisher","DOI":"10.1111\/pedi.12362","author":"R 13 Jones","year":"2017","unstructured":"Jones R, Redler K, Witherick J, et al. Posterior reversible encephalopathy syndrome complicating diabetic ketoacidosis; an important treatable complication. Pediatr Diabetes. 2017;18(2):159-62. https:\/\/doi.org\/10.1111\/pedi. 12362.","journal-title":"Pediatr Diabetes"},{"key":"4027_CR14","doi-asserted-by":"publisher","DOI":"10.1007\/s11892-020-01307-x","author":"BM 14 Bonora","year":"2020","unstructured":"Bonora BM, Avogaro A, Fadini GP. Euglycemic Ketoacidosis. Curr Diab Rep. 2020;20(7)25. https:\/\/doi.org\/10.1007\/s11892-020-01307-x.","journal-title":"Curr Diab Rep"},{"key":"4027_CR15","doi-asserted-by":"publisher","DOI":"10.1136\/bmjdrc-2023-003666","author":"E 15 Chow","year":"2023","unstructured":"Chow E, Clement S, Garg R. Euglycemic diabetic ketoacidosis in the era of SGLT-2 inhibitors. BMJ Open Diabetes Res Care. 2023;11(5). https:\/\/doi.org\/10.1136\/bmjdrc-2023-003666.","journal-title":"BMJ Open Diabetes Res Care"},{"key":"4027_CR16","doi-asserted-by":"publisher","DOI":"10.4103\/jfmpc.jfmpc_644_21","author":"S 16 Dutta","year":"2022","unstructured":"Dutta S, Kumar T, Singh S, et al. Euglycemic diabetic ketoacidosis associated with SGLT2 inhibitors: a systematic review and quantitative analysis. J Family Med Prim Care. 2022;11(3):927-40. https:\/\/doi.org\/10.4103\/jfmpc.jfmpc_644_21.","journal-title":"J Family Med Prim Care"},{"key":"4027_CR17","doi-asserted-by":"publisher","unstructured":"Koksel Y, McKinney AM. Potentially reversible and recognizable Acute Encephalopathic syndromes: Disease categorization and MRI appearances. AJNR Am J Neuroradiol. 2020;41(8):1328-38. https:\/\/doi.org\/10.3174\/ajnr.A6634.","DOI":"10.3174\/ajnr.A6634"},{"key":"4027_CR18","doi-asserted-by":"publisher","DOI":"10.15441\/ceem.22.410","author":"PRE Jarvis","year":"2023","unstructured":"Jarvis PRE. Euglycemic diabetic ketoacidosis: a potential pitfall for the emergency physician. Clin Experimental Emerg Med. 2023;10(1):110-3. https:\/\/doi.org\/10.15441\/ceem.22.410.","journal-title":"Clin Experimental Emerg Med"},{"key":"4027_CR19","doi-asserted-by":"publisher","DOI":"10.5811\/westjem.60361","author":"J 19 Sell","year":"2023","unstructured":"Sell J, Haas NL, Korley FK, et al. Euglycemic Diabetic Ketoacidosis: experience with 44 patients and comparison to Hyperglycemic Diabetic Ketoacidosis. West J Emerg Med. 2023;24(6):1049-55. https:\/\/doi.org\/10.5811\/westjem.60361.","journal-title":"West J Emerg Med"},{"key":"4027_CR20","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v14.i8.1314","author":"D 20 Juneja","year":"2023","unstructured":"Juneja D, Nasa P, Jain R, et al. Sodium-glucose Cotransporter-2 inhibitors induced euglycemic diabetic ketoacidosis: a meta summary of case reports. World J Diabetes. 2023;14(8):1314-22. https:\/\/doi.org\/10.4239\/wjd.v14.i8.1314.","journal-title":"World J Diabetes"}],"container-title":["BMC Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12883-025-04027-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12883-025-04027-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12883-025-04027-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,14]],"date-time":"2025-01-14T01:29:00Z","timestamp":1736818140000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcneurol.biomedcentral.com\/articles\/10.1186\/s12883-025-04027-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,14]]},"references-count":20,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["4027"],"URL":"https:\/\/doi.org\/10.1186\/s12883-025-04027-5","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-4723882\/v1","asserted-by":"object"}]},"ISSN":["1471-2377"],"issn-type":[{"value":"1471-2377","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,14]]},"assertion":[{"value":"10 July 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 January 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 January 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The patient gave written consent for their personal or clinical details along with any identifying images to be published in this study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"20"}}