{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T08:40:21Z","timestamp":1793868021392,"version":"4.6.1"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T00:00:00Z","timestamp":1750723200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T00:00:00Z","timestamp":1750723200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82101355"],"award-info":[{"award-number":["82101355"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Neurol"],"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:p>Primary central nervous system lymphoma (PCNSL) is a malignant tumor known to cause direct mass effects and various paraneoplastic syndromes. However, paraneoplastic vasculitic peripheral neuropathy is rarely associated with PCNSL. In this case report, we describe a patient with PCNSL who presented with probable paraneoplastic vasculitic peripheral neuropathy. The patient initially experienced recurrent pain and weakness in bilateral lower limbs for two years, followed by a sudden decline in consciousness over two days. A biopsy of the right sural nerve revealed probable vasculitic peripheral neuropathy, and the diagnosis of PCNSL was confirmed through brain biopsy.<\/jats:p>","DOI":"10.1186\/s12883-025-04285-3","type":"journal-article","created":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T08:56:04Z","timestamp":1751360164000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Clinically probable paraneoplastic vasculitic peripheral neuropathy in primary central nervous system lymphoma: a case report"],"prefix":"10.1186","volume":"25","author":[{"given":"Zhuangzhuang","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Ling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingshuang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiping","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoxia","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingchao","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,6,24]]},"reference":[{"key":"4285_CR1","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1038\/nrneurol.2017.42","volume":"13","author":"MP Collins","year":"2017","unstructured":"Collins MP, Hadden RD. The nonsystemic vasculitic neuropathies. Nat Rev Neurol. 2017;13:302\u201316.","journal-title":"Nat Rev Neurol."},{"key":"4285_CR2","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1055\/s-0039-1688990","volume":"39","author":"N Beachy","year":"2019","unstructured":"Beachy N, Satkowiak K, Gwathmey KG. Vasculitic neuropathies. Semin Neurol. 2019;39:608\u201319.","journal-title":"Semin Neurol"},{"key":"4285_CR3","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1097\/WCO.0b013e32834a87b7","volume":"24","author":"H Koike","year":"2011","unstructured":"Koike H, Tanaka F, Sobue G. Paraneoplastic neuropathy: wide-ranging clinicopathological manifestations. Curr Opin Neurol. 2011;24:504\u201310.","journal-title":"Curr Opin Neurol"},{"key":"4285_CR4","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1111\/bjh.15661","volume":"184","author":"CP Fox","year":"2019","unstructured":"Fox CP, Phillips EH, Smith J, Linton K, Gallop-Evans E, Hemmaway C, et al. Guidelines for the diagnosis and management of primary central nervous system diffuse large B-cell lymphoma. Br J Haematol. 2019;184:348\u201363.","journal-title":"Br J Haematol."},{"key":"4285_CR5","doi-asserted-by":"publisher","first-page":"1414","DOI":"10.1038\/bjc.2011.357","volume":"105","author":"JL Villano","year":"2011","unstructured":"Villano JL, Koshy M, Shaikh H, Dolecek TA, McCarthy BJ. Age, gender, and racial differences in incidence and survival in primary CNS lymphoma. Br J Cancer. 2011;105:1414\u20138.","journal-title":"Br J Cancer."},{"key":"4285_CR6","doi-asserted-by":"publisher","first-page":"1797","DOI":"10.1038\/leu.2011.169","volume":"25","author":"M Deckert","year":"2011","unstructured":"Deckert M, Engert A, Br\u00fcck W, Ferreri AJM, Finke J, Illerhaus G, et al. Modern concepts in the biology, diagnosis, differential diagnosis and treatment of primary central nervous system lymphoma. Leukemia. 2011;25:1797\u2013807.","journal-title":"Leukemia."},{"key":"4285_CR7","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1007\/BF01059956","volume":"23","author":"DM Ficker","year":"1995","unstructured":"Ficker DM, Hammack JE. Primary central nervous system lymphoma presenting as autonomic dysfunction. J Neurooncol. 1995;23:245\u20138.","journal-title":"J Neurooncol."},{"key":"4285_CR8","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1159\/000070859","volume":"50","author":"EK Tan","year":"2003","unstructured":"Tan EK, Chan LL, Auchus AP, Wong MC. Reversible choreoathetosis in primary cerebral lymphoma: clinicoradiologic correlation. Eur Neurol. 2003;50:53\u20134.","journal-title":"Eur Neurol."},{"key":"4285_CR9","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1007\/s12185-010-0503-2","volume":"91","author":"R Masroujeh","year":"2010","unstructured":"Masroujeh R, Otrock ZK, Yamout B, Jabbour MN, Bazarbachi A. Myasthenia gravis developing in a patient with CNS lymphoma. Int J Hematol. 2010;91:522\u20134.","journal-title":"Int J Hematol."},{"key":"4285_CR10","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1097\/WCO.0000000000000475","volume":"30","author":"J Antoine","year":"2017","unstructured":"Antoine J, Camdessanch\u00e9 J. Paraneoplastic neuropathies. Curr Opin Neurol. 2017;30:513\u201320.","journal-title":"Curr Opin Neurol"},{"key":"4285_CR11","doi-asserted-by":"publisher","first-page":"2563","DOI":"10.1093\/brain\/awt193","volume":"136","author":"M Tomita","year":"2013","unstructured":"Tomita M, Koike H, Kawagashira Y, Iijima M, Adachi H, Taguchi J, et al. Clinicopathological features of neuropathy associated with lymphoma. Brain. 2013;136:2563\u201378.","journal-title":"Brain"},{"key":"4285_CR12","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1097\/WNO.0000000000000359","volume":"36","author":"J Grubbs","year":"2016","unstructured":"Grubbs J Jr, Trobe JD, Fisher-Hubbard A. Opsoclonus-Myoclonus Syndrome in Primary Central Nervous System Lymphoma. J Neuroophthalmol. 2016;36:408\u201311.","journal-title":"J Neuroophthalmol"},{"key":"4285_CR13","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1111\/j.1365-2141.2011.08928.x","volume":"156","author":"A Baraniskin","year":"2012","unstructured":"Baraniskin A, Deckert M, Schulte-Altedorneburg G, Schlegel U, Schroers R. Current strategies in the diagnosis of diffuse large B-cell lymphoma of the central nervous system. Br J Haematol. 2012;156:421\u201332.","journal-title":"Br J Haematol"},{"key":"4285_CR14","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1038\/s41572-023-00445-2","volume":"9","author":"AJM Ferreri","year":"2023","unstructured":"Ferreri AJM, Calimeri T, Cwynarski K, Dietrich J, Grommes C, Hoang-Xuan K, et al. Primary central nervous system lymphoma. Nat Rev Dis Primers. 2023;9:29.","journal-title":"Nat Reviews Disease Primers"},{"key":"4285_CR15","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1111\/j.1529-8027.2010.00281.x","volume":"15","author":"MP Collins","year":"2010","unstructured":"Collins MP, Dyck PJB, Gronseth GS, Guillevin L, Hadden RDM, Heuss D, et al. Peripheral nerve society guideline on the classification, diagnosis, investigation, and immunosuppressive therapy of non-systemic vasculitic neuropathy: executive summary. J Peripher Nerv Syst. 2010;15:176\u201384.","journal-title":"J Peripher Nerv Syst"},{"key":"4285_CR16","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1097\/00005792-199203000-00001","volume":"71","author":"J Dalmau","year":"1992","unstructured":"Dalmau J, Graus F, Rosenblum MK, Posner JB. Anti-Hu\u2013associated paraneoplastic encephalomyelitis\/sensory neuronopathy. A clinical study of 71 patients. Med (Baltim). 1992;71:59\u201372.","journal-title":"Med (Baltim)"},{"key":"4285_CR17","doi-asserted-by":"publisher","first-page":"1138","DOI":"10.1093\/brain\/124.6.1138","volume":"124","author":"F Graus","year":"2001","unstructured":"Graus F, Keime-Guibert F, Re\u00f1e R, Benyahia B, Ribalta T, Ascaso C, et al. Anti-Hu-associated paraneoplastic encephalomyelitis: analysis of 200 patients. Brain. 2001;124:1138\u201348.","journal-title":"Brain"},{"key":"4285_CR18","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1111\/j.1468-1331.2010.03220.x","volume":"18","author":"MJ Titulaer","year":"2011","unstructured":"Titulaer MJ, Soffietti R, Dalmau J, Gilhus NE, Giometto B, Graus F, et al. Screening for tumours in paraneoplastic syndromes: report of an EFNS task force. Eur J Neurol. 2011;18:19\u2013e3.","journal-title":"Eur J Neurol"},{"key":"4285_CR19","doi-asserted-by":"publisher","first-page":"435","DOI":"10.2169\/internalmedicine.3228-19","volume":"59","author":"Y Fukami","year":"2020","unstructured":"Fukami Y, Koike H, Iijima M, Hagita J, Niwa H, Nishi R, et al. Demyelinating Neuropathy Due to Intravascular Large B-cell Lymphoma. Intern Med. 2020;59:435\u20138.","journal-title":"Intern Med"}],"container-title":["BMC Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12883-025-04285-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12883-025-04285-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12883-025-04285-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T08:56:04Z","timestamp":1751360164000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcneurol.biomedcentral.com\/articles\/10.1186\/s12883-025-04285-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,24]]},"references-count":19,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["4285"],"URL":"https:\/\/doi.org\/10.1186\/s12883-025-04285-3","relation":{},"ISSN":["1471-2377"],"issn-type":[{"value":"1471-2377","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,24]]},"assertion":[{"value":"21 September 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 June 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 June 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Ethical approval is not required for this case report in accordance with local guidelines.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"<!--Emphasis Type='Bold' removed-->Ethics approval and consent to participate"}},{"value":"Written, informed consent was obtained from the patient for publication of this case report and accompanying images.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"<!--Emphasis Type='Bold' removed-->Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"<!--Emphasis Type='Bold' removed-->Competing interests"}}],"article-number":"252"}}