{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T12:07:48Z","timestamp":1766059668397,"version":"3.48.0"},"reference-count":64,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T00:00:00Z","timestamp":1766016000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T00:00:00Z","timestamp":1766016000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Shandong Second Medical University Graduate Research Innovation Fund Project","award":["2022-25"],"award-info":[{"award-number":["2022-25"]}]},{"name":"Shandong Medical and Health Science and Technology Development Project","award":["202204040712"],"award-info":[{"award-number":["202204040712"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Neurol"],"DOI":"10.1186\/s12883-025-04372-5","type":"journal-article","created":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T10:33:40Z","timestamp":1766054020000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A computational analysis of programmed cell death-associated LncRNA signatures in glioma and drug prediction"],"prefix":"10.1186","volume":"25","author":[{"given":"Xingyu","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongliang","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Di","family":"Tian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liyan","family":"Jia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,12,18]]},"reference":[{"issue":"7","key":"4372_CR1","doi-asserted-by":"publisher","first-page":"1176","DOI":"10.1080\/15548627.2017.1320634","volume":"13","author":"L Ding","year":"2017","unstructured":"Ding L, Wang Q, Shen M, Sun Y, Zhang X, Huang C, et al. Thermoresponsive nanocomposite gel for local drug delivery to suppress the growth of glioma by inducing autophagy. Autophagy. 2017;13(7):1176\u201390.","journal-title":"Autophagy"},{"issue":"8","key":"4372_CR2","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.1093\/neuonc\/noab106","volume":"23","author":"DN Louis","year":"2021","unstructured":"Louis DN, Perry A, Wesseling P, Brat DJ, Cree IA, Figarella-Branger D, et al. The 2021 WHO classification of tumors of the central nervous system: a summary. Neuro Oncol. 2021;23(8):1231\u201351.","journal-title":"Neuro Oncol"},{"issue":"9","key":"4372_CR3","doi-asserted-by":"publisher","first-page":"1251","DOI":"10.1093\/neuonc\/not089","volume":"15","author":"O Heese","year":"2013","unstructured":"Heese O, Vogeler E, Martens T, Schnell O, Tonn JC, Simon M, et al. End-of-life caregivers\u2019 perception of medical and psychological support during the final weeks of glioma patients: a questionnaire-based survey. Neuro Oncol. 2013;15(9):1251\u20136.","journal-title":"Neuro Oncol"},{"issue":"3","key":"4372_CR4","doi-asserted-by":"publisher","first-page":"455","DOI":"10.3390\/genes12030455","volume":"12","author":"P Mahinfar","year":"2021","unstructured":"Mahinfar P, Baradaran B, Davoudian S, Vahidian F, Cho WC, Mansoori B. Long Non-Coding RNAs in multidrug resistance of glioblastoma. Genes (Basel). 2021;12(3):455.","journal-title":"Genes (Basel)"},{"issue":"20","key":"4372_CR5","doi-asserted-by":"publisher","first-page":"1954","DOI":"10.1056\/NEJMoa1707358","volume":"377","author":"W Wick","year":"2017","unstructured":"Wick W, Gorlia T, Bendszus M, Taphoorn M, Sahm F, Harting I, et al. Lomustine and bevacizumab in progressive glioblastoma. N Engl J Med. 2017;377(20):1954\u201363.","journal-title":"N Engl J Med"},{"issue":"7120","key":"4372_CR6","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1038\/nature05236","volume":"444","author":"S Bao","year":"2006","unstructured":"Bao S, Wu Q, McLendon RE, Hao Y, Shi Q, Hjelmeland AB, et al. Glioma stem cells promote radioresistance by Preferential activation of the DNA damage response. Nature. 2006;444(7120):756\u201360.","journal-title":"Nature"},{"key":"4372_CR7","doi-asserted-by":"publisher","first-page":"921","DOI":"10.3389\/fneur.2018.00921","volume":"9","author":"C Chu","year":"2018","unstructured":"Chu C, Liu G, Janowski M, Bulte JWM, Li S, Pearl M, et al. Real-Time MRI guidance for reproducible hyperosmolar opening of the Blood-Brain barrier in mice. Front Neurol. 2018;9:921.","journal-title":"Front Neurol"},{"key":"4372_CR8","doi-asserted-by":"publisher","first-page":"1379365","DOI":"10.3389\/fimmu.2024.1379365","volume":"15","author":"Y Gao","year":"2024","unstructured":"Gao Y, Liu S, Huang Y, Li F, Zhang Y. Regulation of anti-tumor immunity by metal ion in the tumor microenvironment. Front Immunol. 2024;15:1379365.","journal-title":"Front Immunol"},{"issue":"9","key":"4372_CR9","first-page":"1100","volume":"21","author":"EQ Lee","year":"2019","unstructured":"Lee EQ, Chukwueke UN, Hervey-Jumper SL, de Groot JF, Leone JP, Armstrong TS, et al. Barriers to accrual and enrollment in brain tumor trials. Neuro Oncol. 2019;21(9):1100\u201317.","journal-title":"Neuro Oncol"},{"issue":"9","key":"4372_CR10","doi-asserted-by":"publisher","first-page":"1186","DOI":"10.1093\/neuonc\/nou043","volume":"16","author":"NK Gerber","year":"2014","unstructured":"Gerber NK, Goenka A, Turcan S, Reyngold M, Makarov V, Kannan K, et al. Transcriptional diversity of long-term glioblastoma survivors. Neuro Oncol. 2014;16(9):1186\u201395.","journal-title":"Neuro Oncol"},{"issue":"5","key":"4372_CR11","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1038\/cr.2015.46","volume":"25","author":"J Wu","year":"2015","unstructured":"Wu J, Sun Y, Zhao Y, Zhang J, Luo L, Li M, et al. Deficient plastidic fatty acid synthesis triggers cell death by modulating mitochondrial reactive oxygen species. Cell Res. 2015;25(5):621\u201333.","journal-title":"Cell Res"},{"key":"4372_CR12","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1146\/annurev-immunol-111319-023800","volume":"38","author":"X Liu","year":"2020","unstructured":"Liu X, Lieberman J. Knocking \u2018em dead: Pore-Forming proteins in immune defense. Annu Rev Immunol. 2020;38:455\u201385.","journal-title":"Annu Rev Immunol"},{"issue":"4","key":"4372_CR13","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1038\/cr.2013.2","volume":"23","author":"Y Zhao","year":"2013","unstructured":"Zhao Y, Li X, Cai MY, Ma K, Yang J, Zhou J, et al. XBP-1u suppresses autophagy by promoting the degradation of FoxO1 in cancer cells. Cell Res. 2013;23(4):491\u2013507.","journal-title":"Cell Res"},{"issue":"12","key":"4372_CR14","doi-asserted-by":"publisher","first-page":"2622","DOI":"10.1038\/s41418-019-0323-8","volume":"26","author":"M Cao","year":"2019","unstructured":"Cao M, Wu Z, Lou Q, Lu W, Zhang J, Li Q, et al. Dectin-1-induced RIPK1 and RIPK3 activation protects host against Candida albicans infection. Cell Death Differ. 2019;26(12):2622\u201336.","journal-title":"Cell Death Differ"},{"issue":"7","key":"4372_CR15","doi-asserted-by":"publisher","first-page":"1304","DOI":"10.1038\/s41418-017-0041-z","volume":"25","author":"Y Li","year":"2018","unstructured":"Li Y, Guo X, Hu C, Du Y, Guo C, Di W, et al. Type I IFN operates pyroptosis and necroptosis during multidrug-resistant A. baumannii infection. Cell Death Differ. 2018;25(7):1304\u201318.","journal-title":"Cell Death Differ"},{"issue":"7784","key":"4372_CR16","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1038\/s41586-019-1770-6","volume":"575","author":"M Fritsch","year":"2019","unstructured":"Fritsch M, G\u00c3\u00bcnther SD, Schwarzer R, Albert MC, Schorn F, Werthenbach JP, et al. Caspase-8 is the molecular switch for apoptosis, necroptosis and pyroptosis. Nature. 2019;575(7784):683\u20137.","journal-title":"Nature"},{"issue":"2","key":"4372_CR17","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/j.cell.2017.09.021","volume":"171","author":"BR Stockwell","year":"2017","unstructured":"Stockwell BR, Friedmann Angeli JP, Bayir H, Bush AI, Conrad M, Dixon SJ, et al. Ferroptosis: A regulated cell death nexus linking metabolism, redox biology, and disease. Cell. 2017;171(2):273\u201385.","journal-title":"Cell"},{"issue":"7","key":"4372_CR18","doi-asserted-by":"publisher","first-page":"2331","DOI":"10.1172\/JCI42601","volume":"120","author":"G Mari\u00c3\u00b1o","year":"2010","unstructured":"Mari\u00c3\u00b1o G, Fern\u00c3\u00a1ndez AF, Cabrera S, Lundberg YW, Cabanillas R, Rodr\u00c3\u00adguez F, et al. Autophagy is essential for mouse sense of balance. J Clin Invest. 2010;120(7):2331\u201344.","journal-title":"J Clin Invest"},{"issue":"10","key":"4372_CR19","doi-asserted-by":"publisher","first-page":"1931","DOI":"10.1080\/15548627.2016.1196317","volume":"12","author":"J Wang","year":"2016","unstructured":"Wang J, Zhang J, Lee YM, Koh PL, Ng S, Bao F, et al. Quantitative chemical proteomics profiling of de Novo protein synthesis during starvation-mediated autophagy. Autophagy. 2016;12(10):1931\u201344.","journal-title":"Autophagy"},{"issue":"7","key":"4372_CR20","doi-asserted-by":"publisher","first-page":"996","DOI":"10.4161\/auto.24407","volume":"9","author":"WJ Guo","year":"2013","unstructured":"Guo WJ, Zhang YM, Zhang L, Huang B, Tao FF, Chen W, et al. Novel monofunctional platinum (II) complex Mono-Pt induces apoptosis-independent autophagic cell death in human ovarian carcinoma cells, distinct from cisplatin. Autophagy. 2013;9(7):996\u20131008.","journal-title":"Autophagy"},{"issue":"1","key":"4372_CR21","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1186\/s12943-019-1019-x","volume":"18","author":"JL Hu","year":"2019","unstructured":"Hu JL, Wang W, Lan XL, Zeng ZC, Liang YS, Yan YR, et al. CAFs secreted exosomes promote metastasis and chemotherapy resistance by enhancing cell stemness and epithelial-mesenchymal transition in colorectal cancer. Mol Cancer. 2019;18(1):91.","journal-title":"Mol Cancer"},{"issue":"8","key":"4372_CR22","doi-asserted-by":"publisher","first-page":"1457","DOI":"10.1038\/s41418-017-0053-8","volume":"25","author":"M Luo","year":"2018","unstructured":"Luo M, Wu L, Zhang K, Wang H, Zhang T, Gutierrez L, et al. miR-137 regulates ferroptosis by targeting glutamine transporter SLC1A5 in melanoma. Cell Death Differ. 2018;25(8):1457\u201372.","journal-title":"Cell Death Differ"},{"issue":"6","key":"4372_CR23","doi-asserted-by":"publisher","first-page":"1164","DOI":"10.1080\/15548627.2020.1753001","volume":"16","author":"T Marsh","year":"2020","unstructured":"Marsh T, Debnath J. Autophagy suppresses breast cancer metastasis by degrading NBR1. Autophagy. 2020;16(6):1164\u20135.","journal-title":"Autophagy"},{"issue":"7","key":"4372_CR24","doi-asserted-by":"publisher","first-page":"1008","DOI":"10.1001\/jamaoncol.2019.0393","volume":"5","author":"Y Wang","year":"2019","unstructured":"Wang Y, Zhou S, Yang F, Qi X, Wang X, Guan X, et al. Treatment-Related adverse events of PD-1 and PD-L1 inhibitors in clinical trials: A systematic review and Meta-analysis. JAMA Oncol. 2019;5(7):1008\u201319.","journal-title":"JAMA Oncol"},{"issue":"12","key":"4372_CR25","doi-asserted-by":"publisher","first-page":"e0167094","DOI":"10.1371\/journal.pone.0167094","volume":"11","author":"Y Cheng","year":"2016","unstructured":"Cheng Y, Zhao G, Zhang S, Nigim F, Zhou G, Yu Z, et al. AS1411-Induced growth Inhibition of glioma cells by Up-Regulation of p53 and Down-Regulation of Bcl-2 and Akt1 via nucleolin. PLoS ONE. 2016;11(12):e0167094.","journal-title":"PLoS ONE"},{"issue":"6","key":"4372_CR26","first-page":"715","volume":"53","author":"Y Mo","year":"2024","unstructured":"Mo Y, Zou Z, Chen E. [Research progress on ferroptosis regulation in tumor immunity of hepatocellular carcinoma]. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2024;53(6):715\u201325.","journal-title":"Zhejiang Da Xue Xue Bao Yi Xue Ban"},{"issue":"10","key":"4372_CR27","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1038\/nchem.2778","volume":"9","author":"TT Mai","year":"2017","unstructured":"Mai TT, Hama\u00c3\u00af A, Hienzsch A, Ca\u00c3\u00b1eque T, M\u00c3\u00bcller S, Wicinski J, et al. Salinomycin kills cancer stem cells by sequestering iron in lysosomes. Nat Chem. 2017;9(10):1025\u201333.","journal-title":"Nat Chem"},{"issue":"4","key":"4372_CR28","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1016\/j.trecan.2017.03.002","volume":"3","author":"A Najafov","year":"2017","unstructured":"Najafov A, Chen H, Yuan J. Necroptosis and cancer. Trends Cancer. 2017;3(4):294\u2013301.","journal-title":"Trends Cancer"},{"key":"4372_CR29","doi-asserted-by":"publisher","first-page":"4492608","DOI":"10.1155\/2022\/4492608","volume":"2022","author":"Q Liu","year":"2022","unstructured":"Liu Q, Chen N, Liu L, Zheng Q, Liao W, Zhao M, et al. Construction and validation of Pyroptosis-Related LncRNA prediction model for colon adenocarcinoma and immune infiltration analysis. Dis Markers. 2022;2022:4492608.","journal-title":"Dis Markers"},{"key":"4372_CR30","doi-asserted-by":"publisher","first-page":"6718443","DOI":"10.1155\/2021\/6718443","volume":"2021","author":"Z Zhao","year":"2021","unstructured":"Zhao Z, Liu H, Zhou X, Fang D, Ou X, Ye J, et al. Necroptosis-Related lncrnas: predicting prognosis and the distinction between the cold and hot tumors in gastric cancer. J Oncol. 2021;2021:6718443.","journal-title":"J Oncol"},{"key":"4372_CR31","doi-asserted-by":"publisher","first-page":"781427","DOI":"10.3389\/fmolb.2021.781427","volume":"8","author":"S Zhang","year":"2021","unstructured":"Zhang S, Li X, Zhang X, Zhang S, Tang C, Kuang W. The Pyroptosis-Related gene signature predicts the prognosis of hepatocellular carcinoma. Front Mol Biosci. 2021;8:781427.","journal-title":"Front Mol Biosci"},{"issue":"1","key":"4372_CR32","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1186\/s13059-016-1028-7","volume":"17","author":"B Li","year":"2016","unstructured":"Li B, Severson E, Pignon JC, Zhao H, Li T, Novak J, et al. Comprehensive analyses of tumor immunity: implications for cancer immunotherapy. Genome Biol. 2016;17(1):174.","journal-title":"Genome Biol"},{"issue":"6","key":"4372_CR33","doi-asserted-by":"publisher","first-page":"C1638","DOI":"10.1152\/ajpcell.00457.2024","volume":"327","author":"C Zhang","year":"2024","unstructured":"Zhang C, Wu S. ZNF197-AS1\/miR-425\/GABARAPL1 axis: a novel regulatory mechanism in uveal melanoma. Am J Physiol Cell Physiol. 2024;327(6):C1638\u201350.","journal-title":"Am J Physiol Cell Physiol"},{"issue":"1","key":"4372_CR34","first-page":"29","volume":"40","author":"C Lin","year":"2018","unstructured":"Lin C, Qin Y, Zhang H, Gao MY, Wang YF. EGF upregulates RFPL3 and hTERT via the MEK signaling pathway in non\u00e2\u20ac\u2018small cell lung cancer cells. Oncol Rep. 2018;40(1):29\u201338.","journal-title":"Oncol Rep"},{"key":"4372_CR35","doi-asserted-by":"publisher","first-page":"859730","DOI":"10.3389\/fimmu.2022.859730","volume":"13","author":"J Guo","year":"2022","unstructured":"Guo J, Wang S, Jiang Z, Tang L, Liu Z, Cao J, et al. Long Non-Coding RNA RFPL3S functions as a biomarker of prognostic and immunotherapeutic prediction in testicular germ cell tumor. Front Immunol. 2022;13:859730.","journal-title":"Front Immunol"},{"key":"4372_CR36","doi-asserted-by":"publisher","first-page":"1096792","DOI":"10.3389\/fgene.2023.1096792","volume":"14","author":"Q Liu","year":"2023","unstructured":"Liu Q, Bao H, Zhang S, Song T, Li C, Sun G, et al. Identification of a cellular senescence-related-lncRNA (SRlncRNA) signature to predict the overall survival of glioma patients and the tumor immune microenvironment. Front Genet. 2023;14:1096792.","journal-title":"Front Genet"},{"issue":"3","key":"4372_CR37","doi-asserted-by":"publisher","first-page":"755","DOI":"10.3390\/cancers15030775","volume":"15","author":"C Barbagallo","year":"2023","unstructured":"Barbagallo C, Stella M, Broggi G, Russo A, Caltabiano R, Ragusa M. Genetics and RNA regulation of uveal melanoma. Cancers (Basel). 2023;15(3):755.","journal-title":"Cancers (Basel)"},{"key":"4372_CR38","doi-asserted-by":"publisher","first-page":"1000396","DOI":"10.3389\/fimmu.2022.1000396","volume":"13","author":"S Tong","year":"2022","unstructured":"Tong S, Xia M, Xu Y, Sun Q, Ye L, Cai J, et al. Identification and validation of a 17-gene signature to improve the survival prediction of gliomas. Front Immunol. 2022;13:1000396.","journal-title":"Front Immunol"},{"issue":"4","key":"4372_CR39","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1084\/jem.190.4.555","volume":"190","author":"MD Denton","year":"1999","unstructured":"Denton MD, Geehan CS, Alexander SI, Sayegh MH, Briscoe DM. Endothelial cells modify the costimulatory capacity of transmigrating leukocytes and promote CD28-mediated CD4(+) T cell alloactivation. J Exp Med. 1999;190(4):555\u201366.","journal-title":"J Exp Med"},{"key":"4372_CR40","doi-asserted-by":"publisher","first-page":"577655","DOI":"10.3389\/fimmu.2020.577655","volume":"11","author":"B Soskic","year":"2020","unstructured":"Soskic B, Jeffery LE, Kennedy A, Gardner DH, Hou TZ, Halliday N, et al. CD80 on human T cells is associated with FoxP3 expression and supports Treg homeostasis. Front Immunol. 2020;11:577655.","journal-title":"Front Immunol"},{"key":"4372_CR41","doi-asserted-by":"publisher","first-page":"524826","DOI":"10.3389\/fimmu.2020.524826","volume":"11","author":"JT Schroeder","year":"2020","unstructured":"Schroeder JT, Adeosun AA, Bieneman AP. Epithelial cell-Associated Galectin-3 activates human dendritic cell subtypes for Pro-Inflammatory cytokines. Front Immunol. 2020;11:524826.","journal-title":"Front Immunol"},{"issue":"1","key":"4372_CR42","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1186\/s12964-024-01633-7","volume":"22","author":"SK Hsu","year":"2024","unstructured":"Hsu SK, Chou CK, Lin IL, Chang WT, Kuo IY, Chiu CC. Deubiquitinating enzymes: potential regulators of the tumor microenvironment and implications for immune evasion. Cell Commun Signal. 2024;22(1):259.","journal-title":"Cell Commun Signal"},{"issue":"66","key":"4372_CR43","doi-asserted-by":"publisher","first-page":"110693","DOI":"10.18632\/oncotarget.22690","volume":"8","author":"J Bai","year":"2017","unstructured":"Bai J, Gao Z, Li X, Dong L, Han W, Nie J. Regulation of PD-1\/PD-L1 pathway and resistance to PD-1\/PD-L1 Blockade. Oncotarget. 2017;8(66):110693\u2013707.","journal-title":"Oncotarget"},{"key":"4372_CR44","doi-asserted-by":"publisher","unstructured":"Ahmed F, Ahmed A, Tamoor T, Hassan T. Comment on Dual-Band Perfect Metamaterial Absorber Based on an Asymmetric H-Shaped Structure for Terahertz Waves [Materials] (2018) [2193; Materials (Basel). 2019;12(23):3914. https:\/\/doi.org\/10.3390\/ma12233914.","DOI":"10.3390\/ma12233914"},{"issue":"4","key":"4372_CR45","doi-asserted-by":"publisher","first-page":"e32","DOI":"10.4110\/in.2018.18.e32","volume":"18","author":"J Eom","year":"2018","unstructured":"Eom J, Yoo J, Kim JJ, Lee JB, Choi W, Park CG, et al. Viperin deficiency promotes polarization of macrophages and secretion of M1 and M2 cytokines. Immune Netw. 2018;18(4):e32.","journal-title":"Immune Netw"},{"issue":"3","key":"4372_CR46","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1097\/SHK.0000000000000495","volume":"45","author":"T Rimmel\u00c3\u00a9","year":"2016","unstructured":"Rimmel\u00c3\u00a9 T, Payen D, Cantaluppi V, Marshall J, Gomez H, Gomez A, et al. IMMUNE CELL PHENOTYPE AND FUNCTION IN SEPSIS. Shock. 2016;45(3):282\u201391.","journal-title":"Shock"},{"issue":"6","key":"4372_CR47","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1097\/FJC.0000000000000827","volume":"75","author":"N Zhang","year":"2020","unstructured":"Zhang N, Shou B, Chen L, Lai X, Luo Y, Meng X, et al. Cardioprotective effects of latifolin against Doxorubicin-Induced cardiotoxicity by macrophage polarization in mice. J Cardiovasc Pharmacol. 2020;75(6):564\u201372.","journal-title":"J Cardiovasc Pharmacol"},{"key":"4372_CR48","first-page":"314620","volume":"2015","author":"L Gu\u00c3\u00a9ry","year":"2015","unstructured":"Gu\u00c3\u00a9ry L, Hugues S. Th17 cell plasticity and functions in cancer immunity. Biomed Res Int. 2015;2015:314620.","journal-title":"Biomed Res Int"},{"issue":"8","key":"4372_CR49","doi-asserted-by":"publisher","first-page":"e7334","DOI":"10.1590\/1414-431x20187334","volume":"51","author":"L Jiang","year":"2018","unstructured":"Jiang L, Tang C, Gong Y, Liu Y, Rao J, Chen S, et al. PD-1\/PD-L1 regulates Treg differentiation in pregnancy-induced hypertension. Braz J Med Biol Res. 2018;51(8):e7334.","journal-title":"Braz J Med Biol Res"},{"key":"4372_CR50","doi-asserted-by":"crossref","unstructured":"Louren\u00c3\u00a7o JD, Teodoro WR, Barbeiro DF, Velosa APP, Silva LEF, Kohler JB et al. Th17\/Treg-Related intracellular signaling in patients with chronic obstructive pulmonary disease: comparison between local and systemic responses. Cells. 2021;10(7):1569.","DOI":"10.3390\/cells10071569"},{"issue":"1","key":"4372_CR51","first-page":"15","volume":"53","author":"M Wang","year":"2024","unstructured":"Wang M, Xu P, Wu Q. Cell-to-cell communications of cGAS-STING pathway in tumor immune microenvironment. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2024;53(1):15\u201324.","journal-title":"Zhejiang Da Xue Xue Bao Yi Xue Ban"},{"issue":"3","key":"4372_CR52","first-page":"376","volume":"53","author":"J Gao","year":"2024","unstructured":"Gao J, Pi C, Pan J, Zhou W. Research progress on Hippo signaling pathway effector molecules in rheumatic immune system diseases. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2024;53(3):376\u201381.","journal-title":"Zhejiang Da Xue Xue Bao Yi Xue Ban"},{"issue":"18","key":"4372_CR53","doi-asserted-by":"publisher","first-page":"4753","DOI":"10.1016\/j.cell.2021.07.020","volume":"184","author":"K Koikawa","year":"2021","unstructured":"Koikawa K, Kibe S, Suizu F, Sekino N, Kim N, Manz TD, et al. Targeting Pin1 renders pancreatic cancer eradicable by synergizing with immunochemotherapy. Cell. 2021;184(18):4753\u2013e7127.","journal-title":"Cell"},{"key":"4372_CR54","doi-asserted-by":"publisher","first-page":"5181241","DOI":"10.1155\/2022\/5181241","volume":"2022","author":"QM Pang","year":"2022","unstructured":"Pang QM, Yang R, Zhang M, Zou WH, Qian NN, Xu QJ, et al. Peripheral Blood-Derived mesenchymal stem cells modulate macrophage plasticity through the IL-10\/STAT3 pathway. Stem Cells Int. 2022;2022:5181241.","journal-title":"Stem Cells Int"},{"key":"4372_CR55","doi-asserted-by":"crossref","unstructured":"Brauneck F, Fischer B, Witt M, Muschhammer J, Oelrich J, da Costa Avelar PH et al. TIGIT Blockade repolarizes AML-associated TIGIT(+) M2 macrophages to an M1 phenotype and increases CD47-mediated phagocytosis. J Immunother Cancer. 2022;10(12):e004794.","DOI":"10.1136\/jitc-2022-004794"},{"issue":"1","key":"4372_CR56","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1186\/s12915-021-01034-z","volume":"19","author":"YW Lim","year":"2021","unstructured":"Lim YW, Coles GL, Sandhu SK, Johnson DS, Adler AS, Stone EL. Single-cell transcriptomics reveals the effect of PD-L1\/TGF-\u00ce\u00b2 Blockade on the tumor microenvironment. BMC Biol. 2021;19(1):107.","journal-title":"BMC Biol"},{"issue":"6","key":"4372_CR57","first-page":"785","volume":"53","author":"N Du","year":"2024","unstructured":"Du N, Wan H, Guo H, Zhang X, Wu X. [Myeloid-derived suppressor cells as important factors and potential targets for breast cancer progression]. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2024;53(6):785\u201395.","journal-title":"Zhejiang Da Xue Xue Bao Yi Xue Ban"},{"key":"4372_CR58","doi-asserted-by":"publisher","first-page":"113187","DOI":"10.1016\/j.biopha.2022.113187","volume":"151","author":"S Chen","year":"2022","unstructured":"Chen S, Li R, Chen Y, Chou CK, Zhang Z, Yang Y, et al. Scutellarin enhances anti-tumor immune responses by reducing TNFR2-expressing CD4(+)Foxp3(+) regulatory T cells. Biomed Pharmacother. 2022;151:113187.","journal-title":"Biomed Pharmacother"},{"issue":"3","key":"4372_CR59","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/j.stem.2014.01.005","volume":"14","author":"A Pietras","year":"2014","unstructured":"Pietras A, Katz AM, Ekstr\u00c3\u00b6m EJ, Wee B, Halliday JJ, Pitter KL, et al. Osteopontin-CD44 signaling in the glioma perivascular niche enhances cancer stem cell phenotypes and promotes aggressive tumor growth. Cell Stem Cell. 2014;14(3):357\u201369.","journal-title":"Cell Stem Cell"},{"issue":"1","key":"4372_CR60","doi-asserted-by":"publisher","first-page":"4520","DOI":"10.1038\/s41467-020-18298-8","volume":"11","author":"DH Peng","year":"2020","unstructured":"Peng DH, Rodriguez BL, Diao L, Chen L, Wang J, Byers LA, et al. Collagen promotes anti-PD-1\/PD-L1 resistance in cancer through LAIR1-dependent CD8(+) T cell exhaustion. Nat Commun. 2020;11(1):4520.","journal-title":"Nat Commun"},{"issue":"5","key":"4372_CR61","first-page":"567","volume":"52","author":"L Wang","year":"2023","unstructured":"Wang L, Zhang W, Zhang J, Zheng M, Pan X, Guo H, et al. Inhibitory effect of adenosine on adaptive antitumor immunity and intervention strategies. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2023;52(5):567\u201377.","journal-title":"Zhejiang Da Xue Xue Bao Yi Xue Ban"},{"issue":"17","key":"4372_CR62","doi-asserted-by":"publisher","first-page":"23212","DOI":"10.18632\/oncotarget.6745","volume":"7","author":"E Zhang","year":"2016","unstructured":"Zhang E, Yin D, Han L, He X, Si X, Chen W, et al. E2F1-induced upregulation of long noncoding RNA LINC00668 predicts a poor prognosis of gastric cancer and promotes cell proliferation through epigenetically Silencing of CKIs. Oncotarget. 2016;7(17):23212\u201326.","journal-title":"Oncotarget"},{"key":"4372_CR63","doi-asserted-by":"crossref","unstructured":"Chen S, Morine Y, Tokuda K, Yamada S, Saito Y, Nishi M et al. Cancer\u00e2\u20ac\u2018associated fibroblast\u00e2\u20ac\u2018induced M2\u00e2\u20ac\u2018polarized macrophages promote hepatocellular carcinoma progression via the plasminogen activator inhibitor\u00e2\u20ac\u20181 pathway. Int J Oncol. 2021;59(2):59.","DOI":"10.3892\/ijo.2021.5239"},{"issue":"16","key":"4372_CR64","doi-asserted-by":"publisher","first-page":"2904","DOI":"10.1158\/0008-5472.CAN-21-4141","volume":"82","author":"L Jenkins","year":"2022","unstructured":"Jenkins L, Jungwirth U, Avgustinova A, Iravani M, Mills A, Haider S, et al. Cancer-Associated fibroblasts suppress CD8\u2009+\u2009T-cell infiltration and confer resistance to Immune-Checkpoint Blockade. Cancer Res. 2022;82(16):2904\u201317.","journal-title":"Cancer Res"}],"container-title":["BMC Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12883-025-04372-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12883-025-04372-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12883-025-04372-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T12:01:55Z","timestamp":1766059315000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12883-025-04372-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,18]]},"references-count":64,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["4372"],"URL":"https:\/\/doi.org\/10.1186\/s12883-025-04372-5","relation":{},"ISSN":["1471-2377"],"issn-type":[{"type":"electronic","value":"1471-2377"}],"subject":[],"published":{"date-parts":[[2025,12,18]]},"assertion":[{"value":"28 September 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 July 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 December 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.This study follows the Helsinki Declaration and the usage specification of public databases, and all data are from anonymous data sets of TCGA and CGGA. TCGA and CGGA belong to public databases. The patients involved in the database have obtained ethical approval. Users can download relevant data for research and publish relevant articles for free. Our research is based on open source data, so there are no ethical issues and other conflicts of interest. Such secondary data analysis does not require additional ethical approval.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"509"}}