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All participants provided written, informed, consent to take part in the study in accordance with the Declaration of Helsinki.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Martin Underwood is chief investigator or co-investigator on multiple previous and current research grants from the UK National Institute for Health Research and is a co-investigator on grants funded by the Australian NHMRC and Norwegian Research Council. He is a director and shareholder of Clinvivo Ltd that provides electronic data collection for health services research. He has accepted honoraria for examining theses and performing peer review. He receives some salary support from University Hospitals Coventry and Warwickshire. He is a co-investigator on two current and one completed NIHR funded studies that have, or have had, additional support from Stryker Ltd. He has accepted travel expenses and accommodation for speaking at academic meetings. Martin Underwood is chief investigator or co-investigator on multiple previous and current research grants from the UK National Institute for Health Research, and is a co-investigator on grants funded by the Australian NHMRC and Norwegian Research Council. He is a director and shareholder of Clinvivo Ltd that provides electronic data collection for health services research. He has accepted honoraria for examining theses, and performing peer review. He receives some salary support from University Hospitals Coventry and Warwickshire. He is a co-investigator on two current and one completed NIHR funded studies that have, or have had, additional support from Stryker Ltd. He has accepted travel expenses and accommodation for speaking at academic meetings.Manjit Matharu reports grants, personal fees, and honorarium for serving on advisory board from Allergan, honorarium for serving on advisory board from Novartis, personal fees and honorarium for serving on advisory board from Eli Lilly, personal fees and honorarium for serving on advisory board from TEVA, grants from Abbott, grants from Medtronic, grants from electroCore, and personal fees and honorarium for serving on advisory board from Salvia, outside the submitted work; In addition, MSM has a patent WO2018051103A1 issued.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"21"}}