{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T15:31:02Z","timestamp":1781969462138,"version":"3.54.5"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T00:00:00Z","timestamp":1759104000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T00:00:00Z","timestamp":1759104000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Neurol"],"DOI":"10.1186\/s12883-025-04426-8","type":"journal-article","created":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T14:34:45Z","timestamp":1759156485000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Lymphomatosis cerebri presenting with rapidly progressive parkinsonism and Holmes tremor: a case report"],"prefix":"10.1186","volume":"25","author":[{"given":"Tsukika","family":"Iguchi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsuyoshi","family":"Furuya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Koinuma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asuka","family":"Nakajima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsuhito","family":"Fuse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroto","family":"Eguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasunori","family":"Sugiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasushi","family":"Shimo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,9,29]]},"reference":[{"key":"4426_CR1","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1038\/s41572-023-00439-0","volume":"9","author":"AJM Ferreri","year":"2023","unstructured":"Ferreri AJM, Calimeri T, Cwynarski K, Dietrich J, Grommes C, Hoang-Xuan K, et al. Primary central nervous system lymphoma. Nat Rev Dis Primers. 2023;9:29. https:\/\/doi.org\/10.1038\/s41572-023-00439-0.","journal-title":"Nat Rev Dis Primers"},{"key":"4426_CR2","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1017\/CBO9781139175845.020","volume-title":"Movement disorders in neurologic and systemic disease","author":"T Hatano","year":"2014","unstructured":"Hatano T, Kubo S, Hattori N, Mizuno Y. Movement disorders in neoplastic brain disease. In: Poewe W, Jankovic J, editors. Movement disorders in neurologic and systemic disease. Cambridge: Medicine; 2014. pp. 279\u201392."},{"key":"4426_CR3","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1093\/brain\/27.3.327","volume":"27","author":"G Holmes","year":"1904","unstructured":"Holmes G. On certain tremors in organic cerebral lesions. Brain. 1904;27:327\u201375.","journal-title":"Brain"},{"key":"4426_CR4","doi-asserted-by":"publisher","first-page":"6731","DOI":"10.1007\/s10072-022-06352-w","volume":"43","author":"ES Pyrgelis","year":"2022","unstructured":"Pyrgelis ES, Agapiou E, Angelopoulou E. Holmes tremor: an updated review. Neurol Sci. 2022;43:6731\u201340. https:\/\/doi.org\/10.1007\/s10072-022-06352-w.","journal-title":"Neurol Sci"},{"key":"4426_CR5","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1159\/000017116","volume":"10","author":"R Bakshi","year":"1999","unstructured":"Bakshi R, Mazziotta JC, Mischel PS, Jahan R, Seligson DB, Vinters HV. Lymphomatosis cerebri presenting as a rapidly progressive dementia: clinical, neuroimaging and pathologic findings. Dement Geriatr Cogn Disord. 1999;10:152\u20137. https:\/\/doi.org\/10.1159\/000017116.","journal-title":"Dement Geriatr Cogn Disord"},{"key":"4426_CR6","doi-asserted-by":"publisher","first-page":"1463","DOI":"10.3892\/ol.2018.8839","volume":"16","author":"L Li","year":"2018","unstructured":"Li L, Rong JH, Feng J. Neuroradiological features of lymphomatosis cerebri: A systematic review of the english literature with a new case report. Oncol Lett. 2018;16:1463\u201374. https:\/\/doi.org\/10.3892\/ol.2018.8839.","journal-title":"Oncol Lett"},{"key":"4426_CR7","doi-asserted-by":"publisher","first-page":"934","DOI":"10.1007\/s004150050485","volume":"246","author":"PP Pramstaller","year":"1999","unstructured":"Pramstaller PP, Salerno A, Bhatia KP, Prugger M, Marsden CD. Primary central nervous system lymphoma presenting with a parkinsonian syndrome of pure akinesia. J Neurol. 1999;246:934\u20138. https:\/\/doi.org\/10.1007\/s004150050485.","journal-title":"J Neurol"},{"key":"4426_CR8","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1007\/s002340000451","volume":"43","author":"M S\u00e1nchez-Guerra","year":"2001","unstructured":"S\u00e1nchez-Guerra M, Cerezal L, Leno C, D\u00edez C, Figols J, Berciano J. Primary brain lymphoma presenting as parkinson\u2019s disease. Neuroradiology. 2001;43:36\u201340. https:\/\/doi.org\/10.1007\/s002340000451.","journal-title":"Neuroradiology"},{"key":"4426_CR9","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1620\/tjem.220.187","volume":"220","author":"CM Lin","year":"2010","unstructured":"Lin CM, Hong K. Cerebral infratentorial large B-cell lymphoma presenting as parkinsonism. Tohoku J Exp Med. 2010;220:187\u201390. https:\/\/doi.org\/10.1620\/tjem.220.187.","journal-title":"Tohoku J Exp Med"},{"key":"4426_CR10","doi-asserted-by":"publisher","first-page":"95","DOI":"10.3892\/mco.2021.2257","volume":"14","author":"R Okano","year":"2021","unstructured":"Okano R, Suzuki K, Nakano Y, Yamamoto J. Primary central nervous system lymphoma presenting with parkinsonism as an initial manifestation: a case report and literature review. Mol Clin Oncol. 2021;14:95. https:\/\/doi.org\/10.3892\/mco.2021.2257.","journal-title":"Mol Clin Oncol"},{"key":"4426_CR11","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1002\/mdc3.13415","volume":"9","author":"C Fearon","year":"2022","unstructured":"Fearon C, Rawal S, Olszewska D, Alcaide-Leon P, Kern DS, Sharma S, et al. Neuroimaging pearls from the MDS congress video challenge. Part 2: acquired disorders. Mov Disord Clin Pract. 2022;9:311\u201325. https:\/\/doi.org\/10.1002\/mdc3.13415.","journal-title":"Mov Disord Clin Pract"},{"key":"4426_CR12","doi-asserted-by":"publisher","first-page":"962","DOI":"10.1002\/mds.1193","volume":"16","author":"P Haussermann","year":"2001","unstructured":"Haussermann P, Wilhelm T, Keinath S, St\u00f6lzle C, Conrad B, Ceballos-Baumann A. Primary central nervous system lymphoma in the SMA presenting as rapidly progressive parkinsonism. Mov Disord. 2001;16:962\u20135. https:\/\/doi.org\/10.1002\/mds.1193.","journal-title":"Mov Disord"},{"key":"4426_CR13","doi-asserted-by":"publisher","first-page":"2239","DOI":"10.1007\/s00415-020-09819-y","volume":"267","author":"S Merrill","year":"2020","unstructured":"Merrill S, Mauler DJ, Richter KR, Raghunathan A, Leis JF, Mrugala MM. Parkinsonism as a late presentation of lymphomatosis cerebri following high-dose chemotherapy with autologous stem cell transplantation for primary central nervous system lymphoma. J Neurol. 2020;267:2239\u201344. https:\/\/doi.org\/10.1007\/s00415-020-09819-y.","journal-title":"J Neurol"},{"key":"4426_CR14","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1002\/mds.27121","volume":"33","author":"KP Bhatia","year":"2018","unstructured":"Bhatia KP, Bain P, Bajaj N, Elble RJ, Hallett M, Louis ED, et al. Consensus statement on the classification of tremors. From the task force on tremor of the international Parkinson and movement disorder society. Mov Disord. 2018;33:75\u201387. https:\/\/doi.org\/10.1002\/mds.27121.","journal-title":"Mov Disord"},{"key":"4426_CR15","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1212\/WNL.0000000000002440","volume":"86","author":"GB Raina","year":"2016","unstructured":"Raina GB, Cersosimo MG, Folgar SS, Giugni JC, Calandra C, Paviolo JP, et al. Holmes tremor: clinical description, lesion localization, and treatment in a series of 29 cases. Neurology. 2016;86:931\u20138. https:\/\/doi.org\/10.1212\/WNL.0000000000002440.","journal-title":"Neurology"},{"key":"4426_CR16","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1002\/mds.20795","volume":"21","author":"JH Tan","year":"2006","unstructured":"Tan JH, Chan BPL, Wilder-Smith EP, Ong BKC. A unique case of reversible hyperglycemic Holmes\u2019 tremor. Mov Disord. 2006;21:707\u20139. https:\/\/doi.org\/10.1002\/mds.20795.","journal-title":"Mov Disord"},{"key":"4426_CR17","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2017-220348","volume":"2017","author":"RS Iyer","year":"2017","unstructured":"Iyer RS, Wattamwar P, Thomas B. Reversible holmes\u2019 tremor due to spontaneous intracranial hypotension. BMJ Case Rep. 2017;2017:bcr2017220348. https:\/\/doi.org\/10.1136\/bcr-2017-220348.","journal-title":"BMJ Case Rep"},{"key":"4426_CR18","doi-asserted-by":"publisher","first-page":"1557","DOI":"10.1212\/01.wnl.0000034256.20173.ea","volume":"59","author":"R Lai","year":"2002","unstructured":"Lai R, Rosenblum MK, DeAngelis LM. Primary CNS lymphoma: a whole-brain disease? Neurology. 2002;59:1557\u201362. https:\/\/doi.org\/10.1212\/01.wnl.0000034256.20173.ea.","journal-title":"Neurology"},{"key":"4426_CR19","doi-asserted-by":"publisher","first-page":"e67577","DOI":"10.7759\/cureus.67577","volume":"16","author":"A Okazaki","year":"2024","unstructured":"Okazaki A, Yamasaki T, Kataoka E, Fujihiro M, Kurozumi K. Clinical benefits of arterial spin-labeling magnetic resonance","journal-title":"Cureus."}],"container-title":["BMC Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12883-025-04426-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12883-025-04426-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12883-025-04426-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T14:34:46Z","timestamp":1759156486000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcneurol.biomedcentral.com\/articles\/10.1186\/s12883-025-04426-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,29]]},"references-count":19,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["4426"],"URL":"https:\/\/doi.org\/10.1186\/s12883-025-04426-8","relation":{},"ISSN":["1471-2377"],"issn-type":[{"value":"1471-2377","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,29]]},"assertion":[{"value":"11 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 August 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 September 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"declaration: Written informed consent for publication of their clinical details and clinical images was obtained from the patient relative.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publish"}}],"article-number":"392"}}