{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T19:21:37Z","timestamp":1773861697034,"version":"3.50.1"},"reference-count":87,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T00:00:00Z","timestamp":1770854400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T00:00:00Z","timestamp":1773792000000},"content-version":"vor","delay-in-days":34,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82101538"],"award-info":[{"award-number":["82101538"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"the Clinical and Translational Research Project of Anhui Province","award":["202427b10020083"],"award-info":[{"award-number":["202427b10020083"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Neurol"],"DOI":"10.1186\/s12883-026-04725-8","type":"journal-article","created":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T04:34:44Z","timestamp":1770870884000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Transcriptomic signatures of gray matter volume loss in cerebral small vessel disease"],"prefix":"10.1186","volume":"26","author":[{"given":"Rui","family":"Qin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kunpeng","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liangping","family":"Ni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dai","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Longsheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,2,12]]},"reference":[{"key":"4725_CR1","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.neuroscience.2024.11.014","volume":"564","author":"Z Fang","year":"2025","unstructured":"Fang Z, Chen X, Zhao Y, Zhou X, Cai X, Deng J, et al. Quantitative assessments of white matter hyperintensities and plasma biomarkers can predict cognitive impairment and cerebral microbleeds in cerebral small vessel disease patients. Neuroscience. 2025;564:41\u201351.","journal-title":"Neuroscience"},{"issue":"24","key":"4725_CR2","doi-asserted-by":"publisher","first-page":"1146","DOI":"10.1212\/WNL.0000000000007654","volume":"92","author":"RJ Cannistraro","year":"2019","unstructured":"Cannistraro RJ, Badi M, Eidelman BH, Dickson DW, Middlebrooks EH, Meschia JF. CNS small vessel disease: a clinical review. Neurology. 2019;92(24):1146\u201356.","journal-title":"Neurology"},{"issue":"10","key":"4725_CR3","doi-asserted-by":"publisher","first-page":"3007","DOI":"10.1161\/STROKEAHA.120.029517","volume":"51","author":"K Rannikm\u00e4e","year":"2020","unstructured":"Rannikm\u00e4e K, Henshall DE, Thrippleton S, Ginj Kong Q, Chong M, Grami N, et al. Beyond the brain: systematic review of extracerebral phenotypes associated with Monogenic cerebral small vessel disease. Stroke. 2020;51(10):3007\u201317.","journal-title":"Stroke"},{"issue":"8","key":"4725_CR4","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1016\/S1474-4422(13)70124-8","volume":"12","author":"JM Wardlaw","year":"2013","unstructured":"Wardlaw JM, Smith EE, Biessels GJ, Cordonnier C, Fazekas F, Frayne R, et al. Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration. Lancet Neurol. 2013;12(8):822\u201338.","journal-title":"Lancet Neurol"},{"issue":"4","key":"4725_CR5","doi-asserted-by":"publisher","first-page":"36303","DOI":"10.31083\/JIN36303","volume":"24","author":"D Fan","year":"2025","unstructured":"Fan D, Wang T, Zhao H, Liu C, Liu C, Liu T, et al. Association between white matter hyperintensity and cognitive impairment in cerebral small vessel disease: the Frequency-dependent role of brain functional activity. J Integr Neurosci. 2025;24(4):36303.","journal-title":"J Integr Neurosci"},{"issue":"4","key":"4725_CR6","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1161\/STROKEAHA.109.570044","volume":"41","author":"S Debette","year":"2010","unstructured":"Debette S, Beiser A, DeCarli C, Au R, Himali JJ, Kelly-Hayes M, et al. Association of MRI markers of vascular brain injury with incident stroke, mild cognitive impairment, dementia, and mortality: the Framingham offspring study. Stroke. 2010;41(4):600\u20136.","journal-title":"Stroke"},{"issue":"1","key":"4725_CR7","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1136\/jnnp.70.1.9","volume":"70","author":"F De Leeuw","year":"2001","unstructured":"De Leeuw F, de Groot JC, Achten E, Oudkerk M, Ramos L, Heijboer R, et al. Prevalence of cerebral white matter lesions in elderly people: a population based magnetic resonance imaging study. The Rotterdam scan study. J Neurol Neurosurg Psychiatry. 2001;70(1):9\u201314.","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"4","key":"4725_CR8","doi-asserted-by":"publisher","first-page":"1136","DOI":"10.1093\/brain\/aww009","volume":"139","author":"C Lambert","year":"2016","unstructured":"Lambert C, Benjamin P, Zeestraten E, Lawrence AJ, Barrick TR, Markus HS. Longitudinal patterns of leukoaraiosis and brain atrophy in symptomatic small vessel disease. Brain. 2016;139(4):1136\u201351.","journal-title":"Brain"},{"issue":"3","key":"4725_CR9","doi-asserted-by":"publisher","first-page":"754","DOI":"10.1093\/cercor\/bhac099","volume":"33","author":"H Huang","year":"2023","unstructured":"Huang H, Zheng S, Yang Z, Wu Y, Li Y, Qiu J, et al. Voxel-based morphometry and a deep learning model for the diagnosis of early alzheimer\u2019s disease based on cerebral Gray matter changes. Cereb Cortex. 2023;33(3):754\u201363.","journal-title":"Cereb Cortex"},{"issue":"3","key":"4725_CR10","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1016\/j.neuroimage.2008.09.053","volume":"44","author":"CL Tardif","year":"2009","unstructured":"Tardif CL, Collins DL, Pike GB. Sensitivity of voxel-based morphometry analysis to choice of imaging protocol at 3 T. NeuroImage. 2009;44(3):827\u201338.","journal-title":"NeuroImage"},{"key":"4725_CR11","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.neubiorev.2015.03.011","volume":"53","author":"TT van Sloten","year":"2015","unstructured":"van Sloten TT, Protogerou AD, Henry RM, Schram MT, Launer LJ, Stehouwer CD. Association between arterial stiffness, cerebral small vessel disease and cognitive impairment: a systematic review and meta-analysis. Neurosci Biobehav Rev. 2015;53:121.","journal-title":"Neurosci Biobehav Rev"},{"key":"4725_CR12","doi-asserted-by":"publisher","first-page":"819055","DOI":"10.3389\/fneur.2022.819055","volume":"13","author":"J Li","year":"2022","unstructured":"Li J, Wen H, Wang S, Che Y, Zhang N, Guo L. Altered brain morphometry in cerebral small vessel disease with cerebral microbleeds: an investigation combining univariate and multivariate pattern analyses. Front Neurol. 2022;13:819055.","journal-title":"Front Neurol"},{"issue":"7416","key":"4725_CR13","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1038\/nature11405","volume":"489","author":"MJ Hawrylycz","year":"2012","unstructured":"Hawrylycz MJ, Lein ES, Guillozet-Bongaarts AL, Shen EH, Ng L, Miller JA, et al. An anatomically comprehensive atlas of the adult human brain transcriptome. Nature. 2012;489(7416):391\u20139.","journal-title":"Nature"},{"key":"4725_CR14","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1016\/j.neuroimage.2019.01.011","volume":"189","author":"A Arnatkeviciute","year":"2019","unstructured":"Arnatkeviciute A, Fulcher BD, Fornito A. A practical guide to linking brain-wide gene expression and neuroimaging data. NeuroImage. 2019;189:353\u201367.","journal-title":"NeuroImage"},{"issue":"1","key":"4725_CR15","doi-asserted-by":"publisher","first-page":"13","DOI":"10.31083\/j.jin2301013","volume":"23","author":"CI Colit\u0103","year":"2024","unstructured":"Colit\u0103 CI, Udristoiu I, Ancuta DL, Hermann DM, Colita D, Colita E, et al. Epigenetics of ageing and psychiatric disorders. J Integr Neurosci. 2024;23(1):13.","journal-title":"J Integr Neurosci"},{"issue":"6","key":"4725_CR16","doi-asserted-by":"publisher","first-page":"136","DOI":"10.31083\/j.jin2206136","volume":"22","author":"L Su","year":"2023","unstructured":"Su L, Zhang Y, Wang Y, Wei H. Identification of a lncRNA\/circRNA-miRNA-mRNA CeRNA network in alzheimer\u2019s disease. J Integr Neurosci. 2023;22(6):136.","journal-title":"J Integr Neurosci"},{"issue":"3","key":"4725_CR17","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/j.biopsych.2019.12.005","volume":"88","author":"R Romero-Garcia","year":"2020","unstructured":"Romero-Garcia R, Seidlitz J, Whitaker KJ, Morgan SE, Fonagy P, Dolan RJ, et al. Schizotypy-Related magnetization of cortex in healthy adolescence is colocated with expression of Schizophrenia-Related genes. Biol Psychiatry. 2020;88(3):248\u201359.","journal-title":"Biol Psychiatry"},{"issue":"2","key":"4725_CR18","doi-asserted-by":"publisher","first-page":"351","DOI":"10.2214\/ajr.149.2.351","volume":"149","author":"F Fazekas","year":"1987","unstructured":"Fazekas F, Chawluk JB, Alavi A, Hurtig HI, Zimmerman RA. MR signal abnormalities at 1.5 T in alzheimer\u2019s dementia and normal aging. Am J Roentgenol. 1987;149(2):351\u20136.","journal-title":"Am J Roentgenol"},{"key":"4725_CR19","doi-asserted-by":"crossref","unstructured":"Duering M, Biessels GJ, Brodtmann A, Chen C, Cordonnier C, de Leeuw FE et al. Neuroimaging standards for research into small vessel disease-advances since 2013. 2023;22(7):602\u201318.","DOI":"10.1016\/S1474-4422(23)00131-X"},{"issue":"4","key":"4725_CR20","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1111\/j.1532-5415.2005.53221.x","volume":"53","author":"ZS Nasreddine","year":"2005","unstructured":"Nasreddine ZS, Phillips NA, B\u00e9dirian V, Charbonneau S, Whitehead V, Collin I, et al. The Montreal cognitive Assessment, moca: a brief screening tool for mild cognitive impairment. J Am Geriatr Soc. 2005;53(4):695\u20139.","journal-title":"J Am Geriatr Soc"},{"issue":"12","key":"4725_CR21","doi-asserted-by":"publisher","first-page":"e285","DOI":"10.1111\/jgs.14530","volume":"64","author":"KL Chen","year":"2016","unstructured":"Chen KL, Xu Y, Chu AQ, Ding D, Liang XN, Nasreddine ZS, et al. Validation of the Chinese version of Montreal cognitive assessment basic for screening mild cognitive impairment. J Am Geriatr Soc. 2016;64(12):e285\u201390.","journal-title":"J Am Geriatr Soc"},{"issue":"1","key":"4725_CR22","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1097\/WAD.0b013e3182420bfe","volume":"27","author":"S Freitas","year":"2013","unstructured":"Freitas S, Sim\u00f5es MR, Alves L, Santana I. Montreal cognitive assessment: validation study for mild cognitive impairment and alzheimer disease. Alzheimer Dis Assoc Disord. 2013;27(1):37\u201343.","journal-title":"Alzheimer Dis Assoc Disord"},{"key":"4725_CR23","doi-asserted-by":"crossref","unstructured":"Gaser C, Dahnke R, Thompson PM, Kurth F, Luders E. The Alzheimer\u2019s Disease Neuroimaging I. CAT: a computational anatomy toolbox for the analysis of structural MRI data. Gigascience. 2024;13.","DOI":"10.1093\/gigascience\/giae049"},{"issue":"1","key":"4725_CR24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.neuroimage.2010.06.010","volume":"53","author":"C Destrieux","year":"2010","unstructured":"Destrieux C, Fischl B, Dale A, Halgren E. Automatic parcellation of human cortical gyri and sulci using standard anatomical nomenclature. NeuroImage. 2010;53(1):1\u201315.","journal-title":"NeuroImage"},{"key":"4725_CR25","doi-asserted-by":"publisher","first-page":"117038","DOI":"10.1016\/j.neuroimage.2020.117038","volume":"220","author":"JB Burt","year":"2020","unstructured":"Burt JB, Helmer M, Shinn M, Anticevic A, Murray JD. Generative modeling of brain maps with Spatial autocorrelation. NeuroImage. 2020;220:117038.","journal-title":"NeuroImage"},{"issue":"1","key":"4725_CR26","doi-asserted-by":"publisher","first-page":"1523","DOI":"10.1038\/s41467-019-09234-6","volume":"10","author":"Y Zhou","year":"2019","unstructured":"Zhou Y, Zhou B, Pache L, Chang M, Khodabakhshi AH, Tanaseichuk O, et al. Metascape provides a biologist-oriented resource for the analysis of systems-level datasets. Nat Commun. 2019;10(1):1523.","journal-title":"Nat Commun"},{"issue":"9","key":"4725_CR27","doi-asserted-by":"publisher","first-page":"R183","DOI":"10.1186\/gb-2007-8-9-r183","volume":"8","author":"DW Huang","year":"2007","unstructured":"Huang DW, Sherman BT, Tan Q, Collins JR, Alvord WG, Roayaei J, et al. The DAVID gene functional classification tool: a novel biological module-centric algorithm to functionally analyze large gene lists. Genome Biol. 2007;8(9):R183.","journal-title":"Genome Biol"},{"issue":"1","key":"4725_CR28","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1186\/s13104-018-3154-7","volume":"11","author":"H Ma","year":"2018","unstructured":"Ma H, Gao G, Weber GM. Use of DAVID algorithms for clustering custom annotated gene lists in a non-model organism, rainbow trout. BMC Res Notes. 2018;11(1):63.","journal-title":"BMC Res Notes"},{"key":"4725_CR29","volume-title":"Neuroanatomy, postcentral gyrus","author":"J DiGuiseppi","year":"2023","unstructured":"DiGuiseppi J, Tadi P. Neuroanatomy, postcentral gyrus. StatPearls [internet]: StatPearls Publishing; 2023."},{"key":"4725_CR30","doi-asserted-by":"publisher","first-page":"854","DOI":"10.1016\/j.nicl.2013.06.006","volume":"2","author":"R Righart","year":"2013","unstructured":"Righart R, Duering M, Gonik M, Jouvent E, Reyes S, Herv\u00e9 D, et al. Impact of regional cortical and subcortical changes on processing speed in cerebral small vessel disease. NeuroImage: Clin. 2013;2:854\u201361.","journal-title":"NeuroImage: Clin"},{"key":"4725_CR31","doi-asserted-by":"publisher","first-page":"731585","DOI":"10.3389\/fnagi.2021.731585","volume":"13","author":"M Feng","year":"2021","unstructured":"Feng M, Wen H, Xin H, Zhang N, Liang C, Guo L. Altered spontaneous brain activity related to neurologic dysfunction in patients with cerebral small vessel disease. Front Aging Neurosci. 2021;13:731585.","journal-title":"Front Aging Neurosci"},{"issue":"2","key":"4725_CR32","doi-asserted-by":"publisher","first-page":"fcae064","DOI":"10.1093\/braincomms\/fcae064","volume":"6","author":"JH Shin","year":"2024","unstructured":"Shin JH, Kim H, Lee SY, Yoon WT, Park SW, Park S, et al. Impaired cognitive flexibility and disrupted cognitive cerebellum in degenerative cerebellar ataxias. Brain Commun. 2024;6(2):fcae064.","journal-title":"Brain Commun"},{"key":"4725_CR33","doi-asserted-by":"publisher","first-page":"857","DOI":"10.3389\/fnins.2019.00857","volume":"13","author":"N Cera","year":"2019","unstructured":"Cera N, Esposito R, Cieri F, Tartaro A. Altered cingulate cortex functional connectivity in normal aging and mild cognitive impairment. Front NeuroSci. 2019;13:857.","journal-title":"Front NeuroSci"},{"key":"4725_CR34","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.nicl.2014.05.011","volume":"5","author":"MA Parvaz","year":"2014","unstructured":"Parvaz MA, Maloney T, Moeller SJ, Malaker P, Konova AB, Alia-Klein N, et al. Multimodal evidence of regional midcingulate Gray matter volume underlying conflict monitoring. Neuroimage Clin. 2014;5:10\u20138.","journal-title":"Neuroimage Clin"},{"issue":"4","key":"4725_CR35","doi-asserted-by":"publisher","first-page":"1144","DOI":"10.1016\/j.neuropsychologia.2009.12.020","volume":"48","author":"G Pourtois","year":"2010","unstructured":"Pourtois G, Vocat R, N\u2019diaye K, Spinelli L, Seeck M, Vuilleumier P. Errors recruit both cognitive and emotional monitoring systems: simultaneous intracranial recordings in the dorsal anterior cingulate gyrus and amygdala combined with fMRI. Neuropsychologia. 2010;48(4):1144\u201359.","journal-title":"Neuropsychologia"},{"issue":"2","key":"4725_CR36","doi-asserted-by":"publisher","first-page":"fcac012","DOI":"10.1093\/braincomms\/fcac012","volume":"4","author":"P Cuesta","year":"2022","unstructured":"Cuesta P, Ochoa-Urrea M, Funke M, Hasan O, Zhu P, Marcos A, et al. Gamma band functional connectivity reduction in patients with amnestic mild cognitive impairment and epileptiform activity. Brain Commun. 2022;4(2):fcac012.","journal-title":"Brain Commun"},{"issue":"2","key":"4725_CR37","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.pscychresns.2010.09.001","volume":"192","author":"J Zhang","year":"2011","unstructured":"Zhang J, Tan Q, Yin H, Zhang X, Huan Y, Tang L, et al. Decreased Gray matter volume in the left hippocampus and bilateral calcarine cortex in coal mine flood disaster survivors with recent onset PTSD. Psychiatry Research: Neuroimaging. 2011;192(2):84\u201390.","journal-title":"Psychiatry Research: Neuroimaging"},{"key":"4725_CR38","doi-asserted-by":"publisher","first-page":"283","DOI":"10.3389\/fneur.2014.00283","volume":"5","author":"CC Piccinin","year":"2015","unstructured":"Piccinin CC, Piovesana LG, Santos MC, Guimar\u00e3es RP, De Campos BM, Rezende TJ, et al. Diffuse decreased Gray matter in patients with idiopathic craniocervical dystonia: a voxel-based morphometry study. Front Neurol. 2015;5:283.","journal-title":"Front Neurol"},{"issue":"5","key":"4725_CR39","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1136\/jnnp.50.5.607","volume":"50","author":"J Bogousslavsky","year":"1987","unstructured":"Bogousslavsky J, Miklossy J, Deruaz J-P, Assal G, Regli F. Lingual and fusiform gyri in visual processing: a clinico-pathologic study of superior altitudinal hemianopia. J Neurol Neurosurg Psychiatry. 1987;50(5):607\u201314.","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"4725_CR40","doi-asserted-by":"publisher","first-page":"1532","DOI":"10.3389\/fpsyg.2016.01532","volume":"7","author":"L Zhang","year":"2016","unstructured":"Zhang L, Qiao L, Chen Q, Yang W, Xu M, Yao X, et al. Gray matter volume of the lingual gyrus mediates the relationship between Inhibition function and divergent thinking. Front Psychol. 2016;7:1532.","journal-title":"Front Psychol"},{"key":"4725_CR41","doi-asserted-by":"publisher","first-page":"878758","DOI":"10.3389\/fnagi.2022.878758","volume":"14","author":"SH Kang","year":"2022","unstructured":"Kang SH, Park YH, Shin J, Kim H-R, Yun J, Jang H, et al. Cortical neuroanatomical changes related to specific Language impairments in primary progressive aphasia. Front Aging Neurosci. 2022;14:878758.","journal-title":"Front Aging Neurosci"},{"issue":"3","key":"4725_CR42","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/S2215-0366(20)30431-4","volume":"8","author":"U Clancy","year":"2021","unstructured":"Clancy U, Gilmartin D, Jochems AC, Knox L, Doubal FN, Wardlaw JM. Neuropsychiatric symptoms associated with cerebral small vessel disease: a systematic review and meta-analysis. Lancet Psychiatry. 2021;8(3):225\u201336.","journal-title":"Lancet Psychiatry"},{"key":"4725_CR43","doi-asserted-by":"publisher","first-page":"83","DOI":"10.3389\/fnins.2020.00083","volume":"14","author":"C Liu","year":"2020","unstructured":"Liu C, Shi L, Zhu W, Yang S, Sun P, Qin Y, et al. Fiber connectivity density in cerebral small-vessel disease patients with mild cognitive impairment and cerebral small-vessel disease patients with normal cognition. Front NeuroSci. 2020;14:83.","journal-title":"Front NeuroSci"},{"key":"4725_CR44","unstructured":"Palejwala AH, Dadario NB, Young IM, O\u2019Connor K. Briggs RG, Conner AK ."},{"issue":"1455","key":"4725_CR45","doi-asserted-by":"publisher","first-page":"1909","DOI":"10.1098\/rspb.2000.1229","volume":"267","author":"A Mechelli","year":"2000","unstructured":"Mechelli A, Humphreys GW, Mayall K, Olson A, Price CJ. Differential effects of word length and visual contrast in the fusiform and lingual gyri during reading. Proc Biol Sci. 2000;267(1455):1909\u201313.","journal-title":"Proc Biol Sci"},{"issue":"12","key":"4725_CR46","doi-asserted-by":"publisher","first-page":"e3279","DOI":"10.1002\/brb3.3279","volume":"13","author":"X Zhang","year":"2023","unstructured":"Zhang X, Wang Z, Zheng D, Cao X, Qi W, Yuan Q, et al. Aberrant spontaneous static and dynamic amplitude of low-frequency fluctuations in cerebral small vessel disease with or without mild cognitive impairment. Brain Behav. 2023;13(12):e3279.","journal-title":"Brain Behav"},{"issue":"12","key":"4725_CR47","doi-asserted-by":"publisher","first-page":"2767","DOI":"10.1093\/cercor\/bhp055","volume":"19","author":"JR Binder","year":"2009","unstructured":"Binder JR, Desai RH, Graves WW, Conant LL. Where is the semantic system? A critical review and Meta-Analysis of 120 functional neuroimaging studies. Cereb Cortex. 2009;19(12):2767\u201396.","journal-title":"Cereb Cortex"},{"issue":"6","key":"4725_CR48","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1016\/j.tins.2021.01.006","volume":"44","author":"GF Humphreys","year":"2021","unstructured":"Humphreys GF, Ralph MAL, Simons JS. A unifying account of angular gyrus contributions to episodic and semantic cognition. Trends Neurosci. 2021;44(6):452\u201363.","journal-title":"Trends Neurosci"},{"issue":"10","key":"4725_CR49","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1038\/nrn3338","volume":"13","author":"C Ranganath","year":"2012","unstructured":"Ranganath C, Ritchey M. Two cortical systems for memory-guided behaviour. Nat Rev Neurosci. 2012;13(10):713\u201326.","journal-title":"Nat Rev Neurosci"},{"issue":"2","key":"4725_CR50","doi-asserted-by":"publisher","first-page":"e26603","DOI":"10.1002\/hbm.26603","volume":"45","author":"AG Liuzzi","year":"2024","unstructured":"Liuzzi AG, Meersmans K, Peeters R, De Deyne S, Dupont P, Vandenberghe R. Semantic representations in inferior frontal and lateral Temporal cortex during picture naming, reading, and repetition. Hum Brain Mapp. 2024;45(2):e26603.","journal-title":"Hum Brain Mapp"},{"key":"4725_CR51","doi-asserted-by":"publisher","first-page":"107512","DOI":"10.1016\/j.clineuro.2022.107512","volume":"223","author":"P Suarez-Meade","year":"2022","unstructured":"Suarez-Meade P, Marenco-Hillembrand L, Sabsevitz D, Okromelidze L, Blake Perdikis BS, Sherman WJ, et al. Surgical resection of gliomas in the dominant inferior frontal gyrus: consecutive case series and anatomy review of broca\u2019s area. Clin Neurol Neurosurg. 2022;223:107512.","journal-title":"Clin Neurol Neurosurg"},{"issue":"23","key":"4725_CR52","doi-asserted-by":"publisher","first-page":"2316","DOI":"10.1001\/jama.2019.7437","volume":"321","author":"CR Jack","year":"2019","unstructured":"Jack CR, Wiste HJ, Therneau TM, Weigand SD, Knopman DS, Mielke MM, et al. Associations of amyloid, tau, and neurodegeneration biomarker profiles with rates of memory decline among individuals without dementia. JAMA. 2019;321(23):2316\u201325.","journal-title":"JAMA"},{"issue":"6","key":"4725_CR53","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1002\/hipo.23039","volume":"29","author":"EMC van Leijsen","year":"2019","unstructured":"van Leijsen EMC, Tay J, van Uden IWM, Kooijmans ECM, Bergkamp MI, van der Holst HM, et al. Memory decline in elderly with cerebral small vessel disease explained by Temporal interactions between white matter hyperintensities and hippocampal atrophy. Hippocampus. 2019;29(6):500\u201310.","journal-title":"Hippocampus"},{"issue":"2","key":"4725_CR54","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1007\/s12975-020-00847-4","volume":"12","author":"FCC Wong","year":"2021","unstructured":"Wong FCC, Yatawara C, Low A, Foo H, Wong BYX, Lim L, et al. Cerebral small vessel disease influences hippocampal subfield atrophy in mild cognitive impairment. Transl Stroke Res. 2021;12(2):284\u201392.","journal-title":"Transl Stroke Res"},{"issue":"22","key":"4725_CR55","doi-asserted-by":"publisher","first-page":"1785","DOI":"10.1212\/WNL.0b013e3182583070","volume":"78","author":"H Jokinen","year":"2012","unstructured":"Jokinen H, Lipsanen J, Schmidt R, Fazekas F, Gouw A, Van Der Flier W, et al. Brain atrophy accelerates cognitive decline in cerebral small vessel disease: the LADIS study. Neurology. 2012;78(22):1785\u201392.","journal-title":"Neurology"},{"issue":"1","key":"4725_CR56","doi-asserted-by":"publisher","first-page":"5694","DOI":"10.1038\/s41467-023-41380-w","volume":"14","author":"L Geissmann","year":"2023","unstructured":"Geissmann L, Coynel D, Papassotiropoulos A, de Quervain DJF. Neurofunctional underpinnings of individual differences in visual episodic memory performance. Nat Commun. 2023;14(1):5694.","journal-title":"Nat Commun"},{"issue":"3","key":"4725_CR57","doi-asserted-by":"publisher","first-page":"547","DOI":"10.3233\/JAD-2011-101782","volume":"24","author":"SW Scheff","year":"2011","unstructured":"Scheff SW, Price DA, Schmitt FA, Scheff MA, Mufson EJ. Synaptic loss in the inferior Temporal gyrus in mild cognitive impairment and alzheimer\u2019s disease. J Alzheimer\u2019s Disease. 2011;24(3):547\u201357.","journal-title":"J Alzheimer\u2019s Disease"},{"issue":"7","key":"4725_CR58","doi-asserted-by":"publisher","first-page":"2025","DOI":"10.1093\/brain\/awr119","volume":"134","author":"J Acosta-Cabronero","year":"2011","unstructured":"Acosta-Cabronero J, Patterson K, Fryer TD, Hodges JR, Pengas G, Williams GB, et al. Atrophy, hypometabolism and white matter abnormalities in semantic dementia tell a coherent story. Brain. 2011;134(7):2025\u201335.","journal-title":"Brain"},{"issue":"4","key":"4725_CR59","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1007\/s00234-025-03557-6","volume":"67","author":"W Wang","year":"2025","unstructured":"Wang W, Huang J, Cheng R, Liu X, Luo T. Concurrent brain structural and functional alterations related to cognition in patients with cerebral small vessel disease. Neuroradiology. 2025;67(4):833\u201344.","journal-title":"Neuroradiology"},{"key":"4725_CR60","doi-asserted-by":"crossref","unstructured":"Gao Y, Wang S, Xin H, Feng M, Zhang Q, Sui C et al. Disrupted Gray matter networks associated with cognitive dysfunction in cerebral small vessel disease. Brain Sci. 2023;13(10).","DOI":"10.3390\/brainsci13101359"},{"issue":"7","key":"4725_CR61","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1016\/j.tins.2023.04.004","volume":"46","author":"KE Bauer","year":"2023","unstructured":"Bauer KE, de Queiroz BR, Kiebler MA, Besse F. RNA granules in neuronal plasticity and disease. Trends Neurosci. 2023;46(7):525\u201338.","journal-title":"Trends Neurosci"},{"issue":"2","key":"4725_CR62","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1016\/j.neuron.2019.03.014","volume":"102","author":"JK Nussbacher","year":"2019","unstructured":"Nussbacher JK, Tabet R, Yeo GW, Lagier-Tourenne C. Disruption of RNA metabolism in neurological diseases and emerging therapeutic interventions. Neuron. 2019;102(2):294\u2013320.","journal-title":"Neuron"},{"issue":"1","key":"4725_CR63","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1186\/s13024-023-00642-3","volume":"18","author":"S Wang","year":"2023","unstructured":"Wang S, Sun S. Translation dysregulation in neurodegenerative diseases: a focus on ALS. Mol Neurodegeneration. 2023;18(1):58.","journal-title":"Mol Neurodegeneration"},{"issue":"3","key":"4725_CR64","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1038\/s44318-024-00352-6","volume":"44","author":"Y Li","year":"2025","unstructured":"Li Y, Sun S. RNA dysregulation in neurodegenerative diseases. EMBO J. 2025;44(3):613\u201338.","journal-title":"EMBO J"},{"issue":"3","key":"4725_CR65","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1016\/j.neuron.2013.10.036","volume":"80","author":"CE Holt","year":"2013","unstructured":"Holt CE, Schuman EM. The central dogma decentralized: new perspectives on RNA function and local translation in neurons. Neuron. 2013;80(3):648\u201357.","journal-title":"Neuron"},{"key":"4725_CR66","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1186\/1750-1326-9-31","volume":"9","author":"X Wang","year":"2014","unstructured":"Wang X, Huang T, Bu G, Xu H. Dysregulation of protein trafficking in neurodegeneration. Mol Neurodegener. 2014;9:31.","journal-title":"Mol Neurodegener"},{"key":"4725_CR67","doi-asserted-by":"publisher","first-page":"70","DOI":"10.3389\/fnmol.2014.00070","volume":"7","author":"NP Dantuma","year":"2014","unstructured":"Dantuma NP, Bott LC. The ubiquitin-proteasome system in neurodegenerative diseases: precipitating factor, yet part of the solution. Front Mol Neurosci. 2014;7:70.","journal-title":"Front Mol Neurosci"},{"issue":"2","key":"4725_CR68","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1038\/s41418-020-00706-7","volume":"28","author":"MF Schmidt","year":"2021","unstructured":"Schmidt MF, Gan ZY, Komander D, Dewson G. Ubiquitin signalling in neurodegeneration: mechanisms and therapeutic opportunities. Cell Death Differ. 2021;28(2):570\u201390.","journal-title":"Cell Death Differ"},{"issue":"3","key":"4725_CR69","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1523\/JNEUROSCI.3029-15.2016","volume":"36","author":"S Meier","year":"2016","unstructured":"Meier S, Bell M, Lyons DN, Rodriguez-Rivera J, Ingram A, Fontaine SN, et al. Pathological Tau promotes neuronal damage by impairing ribosomal function and decreasing protein synthesis. J Neurosci. 2016;36(3):1001\u20137.","journal-title":"J Neurosci"},{"key":"4725_CR70","unstructured":"Lim SM, Nahm M, Kim SH, Proteostasis. and Ribostasis Impairment as Common Cell Death Mechanisms in Neurodegenerative Diseases."},{"key":"4725_CR71","doi-asserted-by":"publisher","first-page":"13","DOI":"10.3390\/cells11132063","volume":"11","author":"P Jeon","year":"2022","unstructured":"Jeon P, Ham HJ, Park S, Lee JA. Regulation of cellular ribonucleoprotein granules: from assembly to degradation via Post-translational modification. Cells. 2022;11:13.","journal-title":"Cells"},{"key":"4725_CR72","doi-asserted-by":"crossref","unstructured":"Ivanov P, Kedersha N, Anderson P. Stress granules and processing bodies in translational control. Cold Spring Harb Perspect Biol. 2019;11(5).","DOI":"10.1101\/cshperspect.a032813"},{"key":"4725_CR73","doi-asserted-by":"crossref","unstructured":"Albeshri A, Bahieldin A, Ali HM. Transcriptomic Analysis Reveals the Molecular Relationship Between Common Respiratory Infections and Parkinson\u2019s Disease. Curr Issues Mol Biol. 2025;47(9).","DOI":"10.3390\/cimb47090727"},{"key":"4725_CR74","doi-asserted-by":"publisher","first-page":"970654","DOI":"10.3389\/fcell.2022.970654","volume":"10","author":"B Lu","year":"2022","unstructured":"Lu B. Translational regulation by ribosome-associated quality control in neurodegenerative disease, cancer, and viral infection. Front Cell Dev Biol. 2022;10:970654.","journal-title":"Front Cell Dev Biol"},{"issue":"4","key":"4725_CR75","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1038\/nrn3689","volume":"15","author":"C Hetz","year":"2014","unstructured":"Hetz C, Mollereau B. Disturbance of Endoplasmic reticulum proteostasis in neurodegenerative diseases. Nat Rev Neurosci. 2014;15(4):233\u201349.","journal-title":"Nat Rev Neurosci"},{"key":"4725_CR76","doi-asserted-by":"crossref","unstructured":"Sossin WS, Costa-Mattioli M. Translational control in the brain in health and disease. Cold Spring Harb Perspect Biol. 2019;11(8).","DOI":"10.1101\/cshperspect.a032912"},{"issue":"1","key":"4725_CR77","doi-asserted-by":"publisher","first-page":"a000745","DOI":"10.1101\/cshperspect.a000745","volume":"3","author":"G Giglia-Mari","year":"2011","unstructured":"Giglia-Mari G, Zotter A, Vermeulen W. DNA damage response. Cold Spring Harb Perspect Biol. 2011;3(1):a000745.","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"4725_CR78","doi-asserted-by":"publisher","first-page":"21","DOI":"10.3390\/cancers14215305","volume":"14","author":"K Khaddour","year":"2022","unstructured":"Khaddour K, Felipe Fernandez M, Khabibov M, Garifullin A, Dressler D, Topchu I, et al. The prognostic and therapeutic potential of DNA damage repair pathway alterations and homologous recombination deficiency in lung cancer. Cancers (Basel). 2022;14:21.","journal-title":"Cancers (Basel)"},{"key":"4725_CR79","doi-asserted-by":"publisher","first-page":"778","DOI":"10.3389\/fnins.2019.00778","volume":"13","author":"Y Li","year":"2019","unstructured":"Li Y, Xie L, Huang T, Zhang Y, Zhou J, Qi B, et al. Aging neurovascular unit and potential role of DNA damage and repair in combating vascular and neurodegenerative disorders. Front Neurosci. 2019;13:778.","journal-title":"Front Neurosci"},{"issue":"4","key":"4725_CR80","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1161\/CIRCULATIONAHA.112.104380","volume":"126","author":"M Durik","year":"2012","unstructured":"Durik M, Kavousi M, van der Pluijm I, Isaacs A, Cheng C, Verdonk K, et al. Nucleotide excision DNA repair is associated with age-related vascular dysfunction. Circulation. 2012;126(4):468\u201378.","journal-title":"Circulation"},{"issue":"6","key":"4725_CR81","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1038\/nrn3961","volume":"16","author":"FM Menzies","year":"2015","unstructured":"Menzies FM, Fleming A, Rubinsztein DC. Compromised autophagy and neurodegenerative diseases. Nat Rev Neurosci. 2015;16(6):345\u201357.","journal-title":"Nat Rev Neurosci"},{"key":"4725_CR82","doi-asserted-by":"publisher","first-page":"kvac011","DOI":"10.1093\/oons\/kvac011","volume":"1","author":"VD Bhat","year":"2022","unstructured":"Bhat VD, Jayaraj J, Babu K. RNA and neuronal function: the importance of post-transcriptional regulation. Oxf Open Neurosci. 2022;1:kvac011.","journal-title":"Oxf Open Neurosci"},{"issue":"6","key":"4725_CR83","doi-asserted-by":"publisher","first-page":"1124","DOI":"10.1038\/s41593-025-01953-y","volume":"28","author":"RNA dysregulation impairs","year":"2025","unstructured":"RNA dysregulation impairs. Stress resilience in aged neurons. Nat Neurosci. 2025;28(6):1124\u20135.","journal-title":"Nat Neurosci"},{"key":"4725_CR84","doi-asserted-by":"crossref","unstructured":"Rhine K, Li R, Kopalle HM, Rothamel K, Ge X, Epstein E et al. Neuronal aging causes mislocalization of splicing proteins and unchecked cellular stress. Nat Neurosci. 2025:1\u201311.","DOI":"10.1038\/s41593-025-01952-z"},{"key":"4725_CR85","doi-asserted-by":"publisher","first-page":"1075215","DOI":"10.3389\/fcell.2023.1075215","volume":"11","author":"CS Tseng","year":"2023","unstructured":"Tseng CS, Chao YW, Liu YH, Huang YS, Chao HW. Dysregulated proteostasis network in neuronal diseases. Front Cell Dev Biol. 2023;11:1075215.","journal-title":"Front Cell Dev Biol"},{"issue":"11","key":"4725_CR86","doi-asserted-by":"publisher","first-page":"1998","DOI":"10.1016\/j.ajpath.2025.07.011","volume":"195","author":"D Pytel","year":"2025","unstructured":"Pytel D, Fromm Longo J. The proteostasis network in proteinopathies: mechanisms and interconnections. Am J Pathol. 2025;195(11):1998\u20132014.","journal-title":"Am J Pathol"},{"issue":"3","key":"4725_CR87","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1016\/j.neuron.2017.09.057","volume":"96","author":"M Kapur","year":"2017","unstructured":"Kapur M, Monaghan CE, Ackerman SL. Regulation of mRNA translation in Neurons-A matter of life and death. Neuron. 2017;96(3):616\u201337.","journal-title":"Neuron"}],"container-title":["BMC Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12883-026-04725-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12883-026-04725-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12883-026-04725-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T12:02:48Z","timestamp":1773835368000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12883-026-04725-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,12]]},"references-count":87,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["4725"],"URL":"https:\/\/doi.org\/10.1186\/s12883-026-04725-8","relation":{},"ISSN":["1471-2377"],"issn-type":[{"value":"1471-2377","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,12]]},"assertion":[{"value":"30 September 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 February 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 February 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the Ethics Committee of the Second Affiliated Hospital of Anhui Medical University (Approval No. 2021065). All procedures were performed in accordance with the Declaration of Helsinki. Written informed consent was obtained from all participants prior to inclusion in the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"175"}}