{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T18:55:51Z","timestamp":1781636151001,"version":"3.54.5"},"reference-count":15,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T00:00:00Z","timestamp":1771459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T00:00:00Z","timestamp":1774483200000},"content-version":"vor","delay-in-days":35,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Neurol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>We report a compelling case of neurosarcoidosis in a 74-year-old Japanese woman. She initially presented with a clinical course that closely mimicked Guillain-Barr\u00e9 syndrome (GBS), and the definitive diagnosis of neurosarcoidosis was eventually made through a skin biopsy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>The patient presented with progressive limb weakness and sensory disturbances and was initially treated for a presumptive diagnosis of GBS. Although her condition showed an initial temporary improvement, her symptoms subsequently relapsed and worsened. This atypical and relapsing clinical pattern prompted a comprehensive systemic workup to find an alternative diagnosis. Based on the histological findings on skin biopsy and the clinical presentation, a diagnosis of probable neurosarcoidosis was made.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This case highlights the importance of considering neurosarcoidosis in the differential diagnosis of GBS with an atypical course. A comprehensive systemic workup is crucial for such cases. It further emphasizes that a thorough systemic evaluation is essential for accurate diagnosis, as a simple and accessible procedure like a skin biopsy can provide essential histological evidence to support the diagnosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12883-026-04753-4","type":"journal-article","created":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T05:04:00Z","timestamp":1771477440000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A case report of neurosarcoidosis mimicking Guillain-Barr\u00e9 syndrome: the diagnostic utility of skin biopsy in neurosarcoidosis"],"prefix":"10.1186","volume":"26","author":[{"given":"Kaede","family":"Ishikawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiro","family":"Horiuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sho","family":"Saika","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuntaro","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumire","family":"Nunomura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuki","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaaki","family":"Yoshikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruki","family":"Koike","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ichiro","family":"Yabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,19]]},"reference":[{"key":"4753_CR1","doi-asserted-by":"publisher","first-page":"103323","DOI":"10.1016\/j.jaut.2024.103323","volume":"149","author":"P Spagnolo","year":"2024","unstructured":"Spagnolo P, Kouranos V, Singh-Curry V, et al. Extrapulmonary sarcoidosis. J Autoimmun. 2024;149:103323. https:\/\/doi.org\/10.1016\/j.jaut.2024.103323.","journal-title":"J Autoimmun"},{"key":"4753_CR2","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1097\/00019052-200406000-00013","volume":"17","author":"BJ Stern","year":"2004","unstructured":"Stern BJ. Neurological complications of sarcoidosis. Curr Opin Neurol. 2004;17:311\u20136. https:\/\/doi.org\/10.1097\/00019052-200406000-00013.","journal-title":"Curr Opin Neurol"},{"key":"4753_CR3","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.jns.2006.01.014","volume":"244","author":"TM Burns","year":"2006","unstructured":"Burns TM, Dyck PJ, Aksamit AJ, et al. The natural history and long-term outcome of 57 limb sarcoidosis neuropathy cases. 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Ethical approval was waived because this is a single case report that does not include any experimental interventions. Written informed consent was obtained from the patient for participation in this study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained from the patient for publication of this case report and any accompanying images.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"193"}}