{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T17:07:27Z","timestamp":1779210447422,"version":"3.51.4"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T00:00:00Z","timestamp":1775433600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T00:00:00Z","timestamp":1779148800000},"content-version":"vor","delay-in-days":43,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Science and Technology Innovation 2030\u2014Major Project","award":["2021ZD0201805"],"award-info":[{"award-number":["2021ZD0201805"]}]},{"name":"Tianjin Key Medical Discipline (Specialty) Construction Project","award":["TJYXZDXK-004A"],"award-info":[{"award-number":["TJYXZDXK-004A"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Neurol"],"DOI":"10.1186\/s12883-026-04861-1","type":"journal-article","created":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T10:17:20Z","timestamp":1775470640000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Case report: anti-NMDAR encephalitis with cerebellar ataxia as the initial manifestation"],"prefix":"10.1186","volume":"26","author":[{"given":"Yidi","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linyang","family":"Cui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,4,6]]},"reference":[{"key":"4861_CR1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2021.577753","volume":"361","author":"H Ren","year":"2021","unstructured":"Ren H, Fan S, Zhao Y, Guan H. The changing spectrum of antibody-mediated encephalitis in China. J Neuroimmunol. 2021;361:577753.","journal-title":"J Neuroimmunol"},{"key":"4861_CR2","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1002\/ana.21050","volume":"61","author":"J Dalmau","year":"2007","unstructured":"Dalmau J, T\u00fcz\u00fcn E, Wu H, et al. Paraneoplastic anti\u2013 N -methyl\u2010 <Emphasis Type=\"SmallCaps\">D<\/Emphasis> \u2010aspartate receptor encephalitis associated with ovarian teratoma. Ann Neurol. 2007;61:25\u201336.","journal-title":"Ann Neurol"},{"key":"4861_CR3","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1016\/S1474-4422(19)30244-3","volume":"18","author":"J Dalmau","year":"2019","unstructured":"Dalmau J, Armangu\u00e9 T, Planagum\u00e0 J, et al. An update on anti-NMDA receptor encephalitis for neurologists and psychiatrists: mechanisms and models. Lancet Neurol. 2019;18:1045\u201357.","journal-title":"Lancet Neurol"},{"key":"4861_CR4","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/S1474-4422(12)70310-1","volume":"12","author":"MJ Titulaer","year":"2013","unstructured":"Titulaer MJ, McCracken L, Gabilondo I, et al. Treatment and prognostic factors for long-term outcome in patients with anti-NMDA receptor encephalitis: an observational cohort study. Lancet Neurol. 2013;12:157\u201365.","journal-title":"Lancet Neurol"},{"key":"4861_CR5","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1016\/S1474-4422(15)00401-9","volume":"15","author":"F Graus","year":"2016","unstructured":"Graus F, Titulaer MJ, Balu R, et al. A clinical approach to diagnosis of autoimmune encephalitis. Lancet Neurol. 2016;15:391\u2013404.","journal-title":"Lancet Neurol"},{"key":"4861_CR6","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.1016\/S1474-4422(08)70224-2","volume":"7","author":"J Dalmau","year":"2008","unstructured":"Dalmau J, Gleichman AJ, Hughes EG, et al. Anti-NMDA-receptor encephalitis: case series and analysis of the effects of antibodies. Lancet Neurol. 2008;7:1091\u20138.","journal-title":"Lancet Neurol"},{"key":"4861_CR7","doi-asserted-by":"publisher","first-page":"e633","DOI":"10.1212\/NXI.0000000000000633","volume":"7","author":"X Xu","year":"2020","unstructured":"Xu X, Lu Q, Huang Y, et al. Anti-NMDAR encephalitis: A single-center, longitudinal study in China. Neurol Neuroimmunol Neuroinflammation. 2020;7:e633.","journal-title":"Neurol Neuroimmunol Neuroinflammation"},{"key":"4861_CR8","doi-asserted-by":"publisher","first-page":"3495","DOI":"10.1007\/s00018-018-2868-y","volume":"75","author":"JL Ransdell","year":"2018","unstructured":"Ransdell JL, Nerbonne JM. Voltage-gated sodium currents in cerebellar Purkinje neurons: functional and molecular diversity. Cell Mol Life Sci. 2018;75:3495\u2013505.","journal-title":"Cell Mol Life Sci"},{"key":"4861_CR9","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1002\/ana.24195","volume":"76","author":"EH Moscato","year":"2014","unstructured":"Moscato EH, Peng X, Jain A, Parsons TD, Dalmau J, Balice-Gordon RJ. Acute mechanisms underlying antibody effects in anti\u2013N\u2010methyl\u2010D\u2010aspartate receptor encephalitis. Ann Neurol. 2014;76:108\u201319.","journal-title":"Ann Neurol"},{"key":"4861_CR10","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1113\/jphysiol.2007.141531","volume":"585","author":"M Renzi","year":"2007","unstructured":"Renzi M, Farrant M, Cull-Candy SG. Climbing\u2010fibre activation of NMDA receptors in Purkinje cells of adult mice. J Physiol. 2007;585:91\u2013101.","journal-title":"J Physiol"},{"key":"4861_CR11","first-page":"71","volume":"151","author":"M Guasp","year":"2018","unstructured":"Guasp M, Dalmau J. Encephalitis associated with antibodies against the NMDA receptor. Med Clin (Engl Ed). 2018;151:71\u20139.","journal-title":"Med Clin (Engl Ed)"},{"key":"4861_CR12","doi-asserted-by":"crossref","unstructured":"Slemmer JE, De Zeeuw CI, Weber JT. Don\u2019t get too excited: mechanisms of glutamate-mediated Purkinje cell death. Prog Brain Res [online]. Elsevier; 2005. pp. 367\u2013390. Accessed at: https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0079612304480297. Accessed September 19, 2024.","DOI":"10.1016\/S0079-6123(04)48029-7"},{"key":"4861_CR13","unstructured":"Chinese Society of Neuroinfectious Diseases and Cerebrospinal Fluid Cytology, Wang J, Guan H, Zhao G. [Chinese expert consensus on the diagnosis and management of autoimmune encephalitis (2022 edition).]. Chin J Neurol [online serial]. 2022;55. Accessed at: https:\/\/rs.yiigle.com\/cmaid\/1423359"},{"key":"4861_CR14","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1136\/jnnp-2020-325300","volume":"92","author":"H Abboud","year":"2021","unstructured":"Abboud H, Probasco JC, Irani S, et al. Autoimmune encephalitis: proposed best practice recommendations for diagnosis and acute management. J Neurol Neurosurg Psychiatry. 2021;92:757\u201368.","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"4861_CR15","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000001052","volume":"8","author":"M Nosadini","year":"2021","unstructured":"Nosadini M, Thomas T, Eyre M, et al. International consensus recommendations for the treatment of pediatric NMDAR antibody encephalitis. Neurol(R) Neuroimmunol Neuroinflammation. 2021;8:e1052.","journal-title":"Neurol(R) Neuroimmunol Neuroinflammation"},{"key":"4861_CR16","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/S1474-4422(10)70253-2","volume":"10","author":"J Dalmau","year":"2011","unstructured":"Dalmau J, Lancaster E, Martinez-Hernandez E, Rosenfeld MR, Balice-Gordon R. Clinical experience and laboratory investigations in patients with anti-NMDAR encephalitis. Lancet Neurol. 2011;10:63\u201374.","journal-title":"Lancet Neurol"},{"key":"4861_CR17","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1369587","volume":"15","author":"M Reda","year":"2024","unstructured":"Reda M, Jabbour R, Haydar A, et al. Case report: rapid recovery after intrathecal rituximab administration in refractory anti-NMDA receptor encephalitis: report of two cases. Front Immunol. 2024;15:1369587.","journal-title":"Front Immunol"},{"key":"4861_CR18","doi-asserted-by":"publisher","DOI":"10.1212\/CPJ.0000000000200218","volume":"14","author":"KM Barter","year":"2024","unstructured":"Barter KM, Fuchs C, Graham TB, Pagano LM, Vater M. Anti-NMDAR encephalitis clinical practice guideline: improving time to diagnosis, treatment, and hospital length of stay. Neurol, Clin Pract. 2024;14:e200218.","journal-title":"Neurol, Clin Pract"},{"key":"4861_CR19","doi-asserted-by":"crossref","unstructured":"Chang C-K, Guo Y-H, Kuan T-S, Hsieh P-C, Lien W-C, Lin Y-C. Rehabilitation for a child with recalcitrant anti-N-methyl-D-aspartate receptor encephalitis: case report and literature review. Neuropsychiatr Dis Treat. Epub 2014 Nov.:2263.","DOI":"10.2147\/NDT.S74205"},{"key":"4861_CR20","doi-asserted-by":"publisher","first-page":"863","DOI":"10.3233\/NRE-141176","volume":"35","author":"LJ Bach","year":"2014","unstructured":"Bach LJ. Long term rehabilitation management and outcome of anti-NMDA receptor encephalitis: case reports. Neurorehabil. 2014;35:863\u201375.","journal-title":"Neurorehabil"}],"container-title":["BMC Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12883-026-04861-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12883-026-04861-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12883-026-04861-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T16:22:21Z","timestamp":1779207741000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12883-026-04861-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,6]]},"references-count":20,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["4861"],"URL":"https:\/\/doi.org\/10.1186\/s12883-026-04861-1","relation":{},"ISSN":["1471-2377"],"issn-type":[{"value":"1471-2377","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,6]]},"assertion":[{"value":"3 November 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 March 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 April 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study involved a human participant and the study was approved by the Tianjin Medical University General Hospital.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The patient provided written informed consent for the publication of this case report and any accompanying images.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Clinical trial number"}}],"article-number":"330"}}