{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T02:30:08Z","timestamp":1786415408366,"version":"build-2736575974"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T00:00:00Z","timestamp":1780704000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T00:00:00Z","timestamp":1786406400000},"content-version":"vor","delay-in-days":66,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Neurol"],"DOI":"10.1186\/s12883-026-05042-w","type":"journal-article","created":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T03:42:02Z","timestamp":1780717322000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prognostic value of C-reactive protein to albumin ratio for in-hospital mortality in acute stroke patients"],"prefix":"10.1186","volume":"26","author":[{"given":"Tuba","family":"G\u00fcl","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasemin","family":"Kaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmet","family":"Kaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u015e\u00fckran","family":"Kayg\u0131s\u0131z","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatih","family":"Akkaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7340-8187","authenticated-orcid":false,"given":"G\u00f6kce","family":"Y\u00fcce Onur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,6]]},"reference":[{"key":"5042_CR1","doi-asserted-by":"publisher","first-page":"E52","DOI":"10.5888\/pcd16.180411","volume":"16","author":"X Tong","year":"2019","unstructured":"Tong X, Yang Q, Ritchey MD, George MG, Jackson SL, Gillespie C, et al. The Burden of Cerebrovascular Disease in the United States. Prev Chronic Dis. 2019;16:E52.","journal-title":"Prev Chronic Dis"},{"issue":"9913","key":"5042_CR2","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/S0140-6736(13)61953-4","volume":"383","author":"VL Feigin","year":"2014","unstructured":"Feigin VL, Forouzanfar MH, Krishnamurthi R, Mensah GA, Connor M, Bennett DA, et al. Global and regional burden of stroke during 1990\u20132010: findings from the Global Burden of Disease Study 2010. Lancet. 2014;383(9913):245\u201354.","journal-title":"Lancet"},{"issue":"10","key":"5042_CR3","doi-asserted-by":"publisher","first-page":"e146","DOI":"10.1161\/CIR.0000000000000485","volume":"135","author":"EJ Benjamin","year":"2017","unstructured":"Benjamin EJ, Blaha MJ, Chiuve SE, Cushman M, Das SR, Deo R, et al. Heart disease and stroke statistics \u2014 2017 update: a report from the American Heart Association. Circulation. 2017;135(10):e146\u2013603.","journal-title":"Circulation"},{"issue":"35","key":"5042_CR4","doi-asserted-by":"publisher","first-page":"933","DOI":"10.15585\/mmwr.mm6635e1","volume":"66","author":"Q Yang","year":"2017","unstructured":"Yang Q, Tong X, Schieb L, Vaughan A, Gillespie C, Wiltz JL, et al. Vital signs: recent trends in stroke death rates \u2014 United States, 2000\u20132015. MMWR Morb Mortal Wkly Rep. 2017;66(35):933\u20139.","journal-title":"MMWR Morb Mortal Wkly Rep"},{"issue":"6","key":"5042_CR5","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1001\/jamaneurol.2017.0020","volume":"74","author":"MG George","year":"2017","unstructured":"George MG, Tong X, Bowman BA. Prevalence of cardiovascular risk factors and strokes in younger adults. JAMA Neurol. 2017;74(6):695\u2013703. https:\/\/doi.org\/10.1001\/jamaneurol.2017.0020.","journal-title":"JAMA Neurol"},{"issue":"4","key":"5042_CR6","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1007\/s13311-016-0483-x","volume":"13","author":"J Anrather","year":"2016","unstructured":"Anrather J, Iadecola C. Inflammation and Stroke: An Overview. Neurotherapeutics. 2016;13(4):661\u201370. https:\/\/doi.org\/10.1007\/s13311-016-0483-x.","journal-title":"Neurotherapeutics"},{"key":"5042_CR7","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1001\/archneurol.2011.3590","volume":"69","author":"H Kamel","year":"2012","unstructured":"Kamel H, Iadecola C. Brain-immune interactions and ischemic stroke: clinical implications. Arch Neurol. 2012;69:576.","journal-title":"Arch Neurol"},{"key":"5042_CR8","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1001\/archneur.58.4.669","volume":"58","author":"GJ del Zoppo","year":"2001","unstructured":"del Zoppo GJ, Becker KJ, Hallenbeck JM. Inflammation after stroke: is it harmful? Arch Neurol. 2001;58:669.","journal-title":"Arch Neurol"},{"key":"5042_CR9","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1016\/S1474-4422(11)70066-7","volume":"10","author":"R Macrez","year":"2011","unstructured":"Macrez R, Ali C, Toutirais O, et al. Stroke and the immune system: from pathophysiology to new therapeutic strategies. Lancet Neurol. 2011;10:471.","journal-title":"Lancet Neurol"},{"key":"5042_CR10","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1002\/ana.25665","volume":"87","author":"AM Kollikowski","year":"2020","unstructured":"Kollikowski AM, Schuhmann MK, Nieswandt B, et al. Local Leukocyte Invasion during Hyperacute Human Ischemic Stroke. Ann Neurol. 2020;87:466.","journal-title":"Ann Neurol"},{"key":"5042_CR11","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1161\/01.CIR.0000079160.07364.6A","volume":"108","author":"JJ Cao","year":"2003","unstructured":"Cao JJ, Thach C, Manolio TA, Psaty BM, Kuller LH, Chaves PH, et al. C-Reactive protein, carotid intima-media thickness, and incidence of ischemic stroke in the elderly: the cardiovascular health study. Circulation. 2003;108:166\u201370.","journal-title":"Circulation"},{"issue":"47","key":"5042_CR12","doi-asserted-by":"publisher","first-page":"48487","DOI":"10.1074\/jbc.R400025200","volume":"279","author":"S Black","year":"2004","unstructured":"Black S, Kushner I, Samols D. C-reactive Protein. J Biol Chem. 2004;279(47):48487\u201390.","journal-title":"J Biol Chem"},{"key":"5042_CR13","doi-asserted-by":"publisher","first-page":"989769","DOI":"10.3389\/fneur.2022.989769","volume":"13","author":"Y Du","year":"2022","unstructured":"Du Y, Zhang J, Li N, Guo J, Liu X, Bian L, et al. Association between the C-reactive protein to albumin ratio and adverse clinical prognosis in patients with young stroke. Front Neurol. 2022;13:989769.","journal-title":"Front Neurol"},{"issue":"1","key":"5042_CR14","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1186\/s12957-021-02253-y","volume":"19","author":"CK Liao","year":"2021","unstructured":"Liao CK, Yu YL, Lin YC, Hsu YJ, Chern YJ, Chiang JM, et al. Prognostic value of the C-reactive protein to albumin ratio in colorectal cancer: an updated systematic review and meta-analysis. World J Surg Oncol. 2021;19(1):139.","journal-title":"World J Surg Oncol"},{"key":"5042_CR15","doi-asserted-by":"publisher","first-page":"718329","DOI":"10.1155\/2015\/718329","volume":"2015","author":"E Ammirati","year":"2015","unstructured":"Ammirati E, Moroni F, Norata GD, Magnoni M, Camici PG. Markers of inflammation associated with plaque progression and instability in patients with carotid atherosclerosis. Mediators Inflamm. 2015;2015:718329. https:\/\/doi.org\/10.1155\/2015\/718329.","journal-title":"Mediators Inflamm"},{"issue":"3","key":"5042_CR16","doi-asserted-by":"publisher","first-page":"e59321","DOI":"10.1371\/journal.pone.0059321","volume":"8","author":"OT Ranzani","year":"2013","unstructured":"Ranzani OT, Zampieri FG, Forte DN, Azevedo LC, Park M. C-reactive protein\/albumin ratio predicts 90-day mortality of septic patients. PLoS ONE. 2013;8(3):e59321.","journal-title":"PLoS ONE"},{"key":"5042_CR17","doi-asserted-by":"publisher","first-page":"e937842","DOI":"10.12659\/MSM.937842","volume":"28","author":"A Glapa-Nowak","year":"2022","unstructured":"Glapa-Nowak A, Szczepanik M, Banaszkiewicz A, Kwiecie\u0144 J, Szaflarska-Pop\u0142awska A, et al. C-Reactive Protein\/Albumin Ratio at Diagnosis of Pediatric Inflammatory Bowel Disease: A Retrospective Multi-Center Study. Med Sci Monit. 2022;28:e937842.","journal-title":"Med Sci Monit"},{"key":"5042_CR18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ijcard.2017.04.003","volume":"241","author":"SC Chien","year":"2017","unstructured":"Chien SC, Chen CY, Leu HB, Su CH, Yin WH, et al. Association of low serum albumin concentration and adverse cardiovascular events in stable coronary heart disease. Int J Cardiol. 2017;241:1\u20135.","journal-title":"Int J Cardiol"},{"key":"5042_CR19","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/j.ahj.2010.05.022","volume":"160","author":"DM Gopal","year":"2010","unstructured":"Gopal DM, Kalogeropoulos AP, Georgiopoulou VV, Tang WW, et al. Serum albumin concentration and heart failure risk the health, aging, and body composition study. Am Heart J. 2010;160:279\u201385.","journal-title":"Am Heart J"},{"issue":"2","key":"5042_CR20","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1207\/S15327914nc392_8","volume":"39","author":"DC McMillan","year":"2001","unstructured":"McMillan DC, Watson WS, O\u2019Gorman P, Preston T, Scott HR, et al. Albumin concentrations are primarily determined by the body cell mass and the systemic inflammatory response in cancer patients with weight loss. Nutr Cancer. 2001;39(2):210\u20133.","journal-title":"Nutr Cancer"},{"issue":"4","key":"5042_CR21","doi-asserted-by":"publisher","first-page":"S143","DOI":"10.1097\/01.mcg.0000155514.17715.39","volume":"39","author":"M Chojkier","year":"2005","unstructured":"Chojkier M. Inhibition of albumin synthesis in chronic diseases: molecular mechanisms. J Clin Gastroenterol. 2005;39(4):S143\u20136.","journal-title":"J Clin Gastroenterol"},{"key":"5042_CR22","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1159\/000215938","volume":"28","author":"TT Idicula","year":"2009","unstructured":"Idicula TT, Waje-Andreassen U, Brogger J, Naess H, Thomassen L. Serum albumin in ischemic stroke patients: the higher the better. The Bergen Stroke Study. Cerebrovasc Dis. 2009;28:13\u20137.","journal-title":"Cerebrovasc Dis"},{"key":"5042_CR23","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.29175","author":"MY Tarar","year":"2022","unstructured":"Tarar MY, et al. Use of the C-Reactive Protein (CRP)\/Albumin Ratio as a Severity Tool in Acute Pancreatitis. Syst Rev Cureus. 2022. https:\/\/doi.org\/10.7759\/cureus.29175.","journal-title":"Syst Rev Cureus"},{"issue":"3","key":"5042_CR24","doi-asserted-by":"publisher","first-page":"174","DOI":"10.5543\/tkda.2022.27741","volume":"51","author":"MR Sons\u00f6z","year":"2023","unstructured":"Sons\u00f6z MR, Karadamar N, Y\u0131lmaz H\u00c7, Ero\u011flu Z, \u015eahin KK, \u00d6zate\u015f Y, et al. C-Reactive Protein to Albumin Ratio Predicts In-hospital Mortality in Patients with Acute Heart Failure. Turk Kardiyol Dern Ars. 2023;51(3):174\u201381.","journal-title":"Turk Kardiyol Dern Ars"},{"key":"5042_CR25","doi-asserted-by":"publisher","first-page":"4867974","DOI":"10.1155\/2020\/4867974","volume":"2020","author":"N Lin","year":"2020","unstructured":"Lin N, Li J, Ke Q, Wang L, Cao Y, Liu J. Clinical Significance of C-Reactive Protein to Albumin Ratio in Patients with Hepatocellular Carcinoma: A Meta-Analysis. Dis Markers. 2020;2020:4867974.","journal-title":"Dis Markers"},{"key":"5042_CR26","doi-asserted-by":"publisher","first-page":"39","DOI":"10.3390\/jcm7030039","volume":"7","author":"TK Oh","year":"2018","unstructured":"Oh TK, Ji E, Na HS, Min B, Jeon YT, Do SH, et al. C-reactive protein to albumin ratio predicts 30-day and 1-year mortality in postoperative patients after admission to the intensive care unit. J Clin Med. 2018;7:39.","journal-title":"J Clin Med"},{"key":"5042_CR27","doi-asserted-by":"publisher","first-page":"1200","DOI":"10.3389\/fonc.2019.01200","volume":"9","author":"D Martin","year":"2019","unstructured":"Martin D, R\u00f6del F, Balermpas P, Winkelmann R, Fokas E, et al. C-Reactive protein-to-albumin ratio as prognostic marker for anal squamous cell carcinoma treated with chemoradiotherapy. Front Oncol. 2019;9:1200.","journal-title":"Front Oncol"},{"key":"5042_CR28","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1177\/0003319717743325","volume":"70","author":"M Cagdas","year":"2019","unstructured":"Cagdas M, Rencuzogullari I, Karakoyun S, Karabag Y, Yesin M, et al. Assessment of relationship between c-reactive protein to albumin ratio and coronary artery disease severity in patients with acute coronary syndrome. Angiology. 2019;70:361\u20138.","journal-title":"Angiology"},{"key":"5042_CR29","doi-asserted-by":"publisher","first-page":"4393","DOI":"10.12659\/MSM.897460","volume":"22","author":"G Qin","year":"2016","unstructured":"Qin G, Tu J, Liu L, Luo L, Wu J, Tao L, et al. Serum albumin and c-reactive protein\/albumin ratio are useful biomarkers of crohn\u2019s disease activity. Med Sci Monit. 2016;22:4393\u2013400.","journal-title":"Med Sci Monit"},{"key":"5042_CR30","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.cca.2019.10.009","volume":"500","author":"Y He","year":"2020","unstructured":"He Y, Tang J, Wu B, Yang B, Ou Q, Lin J. Correlation between albumin to fibrinogen ratio, C-reactive protein to albumin ratio and Th17 cells in patients with rheumatoid arthritis. Clin Chim Acta. 2020;500:149\u201354.","journal-title":"Clin Chim Acta"},{"issue":"8","key":"5042_CR31","doi-asserted-by":"publisher","first-page":"e13550","DOI":"10.1111\/eci.13550","volume":"51","author":"G \u00c7inier","year":"2021","unstructured":"\u00c7inier G, Hay\u0131ro\u011flu M\u0130, Kolak Z, et al. The value of C-reactive protein-to-albumin ratio in predicting long-term mortality among HFrEF patients with implantable cardiac defibrillators. Eur J Clin Investig. 2021;51(8):e13550.","journal-title":"Eur J Clin Investig"},{"key":"5042_CR32","doi-asserted-by":"publisher","unstructured":"Binyang W, Jing Z, Lu S, Shuochen F, Shiping W et al. The C-Reactive Protein-to-Albumin Ratio (CAR) and All-Cause Mortality in Critically Ill Ischemic Stroke Patients: A Retrospective Analysis of the MIMIC-IV and eICU-CRD Databases Research Square (Preprint) \u2014 BMC Neurology DOI: https:\/\/doi.org\/10.21203\/rs.3.rs-7185510\/v1","DOI":"10.21203\/rs.3.rs-7185510\/v1"},{"issue":"3","key":"5042_CR33","doi-asserted-by":"publisher","first-page":"158","DOI":"10.62210\/ClinSciNutr.2025.120","volume":"7","author":"T Tatar","year":"2025","unstructured":"Tatar T, Zengin FH, R\u00fcmeysa Y\u00fcksel, Afacan EN. Association of C-Reactive Protein Albumin Ratio with Disease Severity and Nutritional Risk in Patients with Acute Ischemic Stroke. Clin Sci Nutr. 2025;7(3):158\u201368.","journal-title":"Clin Sci Nutr"},{"key":"5042_CR34","doi-asserted-by":"publisher","unstructured":"Duan T, Zou C, Yang M, Xu J, Wu Z. C-reactive protein to albumin ratio as a novel predictor of stroke-associated pneumonia: a retrospective cohort study revealing non-linear threshold effects. Front Neurol. 2026;17. https:\/\/doi.org\/10.3389\/fneur.2026.1786925.","DOI":"10.3389\/fneur.2026.1786925"},{"key":"5042_CR35","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1055\/s-2007-1007106","volume":"19","author":"G Ramadori","year":"1999","unstructured":"Ramadori G, Christ B. Cytokines and the hepatic acute-phase response. Semin Liver Dis. 1999;19:141\u201355.","journal-title":"Semin Liver Dis"},{"key":"5042_CR36","doi-asserted-by":"publisher","first-page":"1194","DOI":"10.1161\/01.CIR.103.9.1194","volume":"103","author":"TP Zwaka","year":"2001","unstructured":"Zwaka TP, Hombach V, Torzewski J. C-reactive protein-mediated low density lipoprotein uptake by macrophages: implications for atherosclerosis. Circulation. 2001;103:1194\u20137.","journal-title":"Circulation"},{"issue":"4","key":"5042_CR37","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1136\/hrt.2004.037317","volume":"91","author":"D Skowasch","year":"2005","unstructured":"Skowasch D, Jabs A, Andri\u00e9 R, L\u00fcderitz B, Bauriedel G. Progression of native coronary plaques and in-stent restenosis are associated and predicted by increased pre-procedural C reactive protein. Heart. 2005;91(4):535\u20136.","journal-title":"Heart"},{"issue":"2","key":"5042_CR38","first-page":"75","volume":"20","author":"V Aslan","year":"2003","unstructured":"Aslan V, Akay OM, G\u00fclba\u015f Z. C-Reactive Protein in the Follow-up and Estimation of Infections in Acute Leukemic Patients. Turk J Haematol. 2003;20(2):75\u201380.","journal-title":"Turk J Haematol"},{"issue":"1","key":"5042_CR39","first-page":"22","volume":"54","author":"A Bircan","year":"2006","unstructured":"Bircan A, Kaya O, G\u00f6kirmak M, Ozt\u00fcrk O, Sahin U, Akkaya A. [C-reactive protein, leukocyte count and ESR in the assessment of severity of community-acquired pneumonia]. Ulus Travma Acil Cerrahi Derg. 2006;54(1):22\u20139.","journal-title":"Ulus Travma Acil Cerrahi Derg"},{"issue":"2","key":"5042_CR40","first-page":"83","volume":"10","author":"G G\u00fcrleyik","year":"2004","unstructured":"G\u00fcrleyik G, Zahidullaho\u011flu Cirpici O, Aktekin A, Sa\u011flam A. [The value of Ranson and APACHE II scoring systems, and serum levels of interleukin-6 and C-reactive protein in the early diagnosis of the severity of acute pancreatitis]. Ulus Travma Acil Cerrahi Derg. 2004;10(2):83\u20138.","journal-title":"Ulus Travma Acil Cerrahi Derg"},{"key":"5042_CR41","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1161\/hs0402.105555","volume":"33","author":"L Belayev","year":"2002","unstructured":"Belayev L, Pinard E, Nallet H, Seylaz J, Liu Y, et al. Albumin therapy of transient focal cerebral ischemia: in vivo analysis of dynamic microvascular responses. Stroke. 2002;33:1077\u201384.","journal-title":"Stroke"},{"key":"5042_CR42","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1016\/0006-2952(88)90126-8","volume":"37","author":"B Halliwell","year":"1988","unstructured":"Halliwell B. Albumin\u2013an important extracellular antioxidant? Biochem Pharmacol. 1988;37:569\u201371.","journal-title":"Biochem Pharmacol"},{"issue":"4","key":"5042_CR43","doi-asserted-by":"publisher","first-page":"300","DOI":"10.2133\/dmpk.24.300","volume":"24","author":"GJ van der Vusse","year":"2009","unstructured":"van der Vusse GJ. Albumin as fatty acid transporter. Drug Metab Pharmacokinet. 2009;24(4):300\u20137.","journal-title":"Drug Metab Pharmacokinet"},{"key":"5042_CR44","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1056\/NEJM199902113400607","volume":"340","author":"C Gabay","year":"1999","unstructured":"Gabay C, Kushner I. Acute-phase proteins and other systemic responses to inflammation. N Engl J Med. 1999;340:448\u201354.","journal-title":"N Engl J Med"},{"issue":"4","key":"5042_CR45","first-page":"580","volume":"26","author":"Y \u015eahiner","year":"2020","unstructured":"\u015eahiner Y, Y\u0131ld\u0131r\u0131m MB. Can the C-reactive protein-to-plasma albumin ratio be an alternative scoring to show mortality and morbidity in patients with colorectal cancer? Ulus Travma Acil Cerrahi Derg. 2020;26(4):580\u20135.","journal-title":"Ulus Travma Acil Cerrahi Derg"},{"issue":"1","key":"5042_CR46","first-page":"67","volume":"27","author":"P \u00d6z\u00e7iftci Y\u0131lmaz","year":"2021","unstructured":"\u00d6z\u00e7iftci Y\u0131lmaz P, Karacan E. The effects of C-reactive protein\/albumin ratio and hematologic parameters on predicting the prognosis for emergency surgical patients in intensive care. Ulus Travma Acil Cerrahi Derg. 2021;27(1):67\u201372.","journal-title":"Ulus Travma Acil Cerrahi Derg"},{"key":"5042_CR47","doi-asserted-by":"publisher","first-page":"489","DOI":"10.2217\/bmm-2020-0705","volume":"15","author":"T Omar","year":"2021","unstructured":"Omar T, Karakayali M, Yesin M, Alaydin HC, Karabag Y, et al. Monocyte to high-density lipoprotein cholesterol ratio is associated with the presence of carotid artery disease in acute ischemic stroke. Biomark Med. 2021;15:489\u201395. https:\/\/doi.org\/10.2217\/bmm-2020-0705.","journal-title":"Biomark Med"},{"issue":"8","key":"5042_CR48","doi-asserted-by":"publisher","first-page":"e43258","DOI":"10.7759\/cureus.43258","volume":"15","author":"ED Demirel","year":"2023","unstructured":"Demirel ED, T\u00fcrel CA. The Role of the Multi-Inflammatory Index as a Novel Predictor of Hospital Mortality in Acute Ischemic Stroke. Cureus. 2023;15(8):e43258. https:\/\/doi.org\/10.7759\/cureus.43258.","journal-title":"Cureus"},{"issue":"8","key":"5042_CR49","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1136\/neurintsurg-2013-010780","volume":"6","author":"SD Brooks","year":"2014","unstructured":"Brooks SD, Spears C, Cummings C, VanGilder RL, Stinehart KR, Gutmann L, et al. Admission neutrophil-lymphocyte ratio predicts 90\u00a0day outcome after endovascular stroke therapy. J Neurointerv Surg. 2014;6(8):578\u201383.","journal-title":"J Neurointerv Surg"},{"issue":"1","key":"5042_CR50","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1177\/17085381251330370","volume":"34","author":"\u00c7 Tunca","year":"2026","unstructured":"Tunca \u00c7, Ta\u015f A, \u0130nci SD. The role of the HALP score in determining the severity of lower extremity peripheral arterial disease. Vascular. 2026;34(1):240\u20137. https:\/\/doi.org\/10.1177\/17085381251330370.","journal-title":"Vascular"},{"issue":"18","key":"5042_CR51","doi-asserted-by":"publisher","first-page":"e38030","DOI":"10.1016\/j.heliyon.2024.e38030","volume":"10","author":"A Eren","year":"2024","unstructured":"Eren A, Giray S. Value of the red blood cell distribution width (RDW) and neutrophil lymphocyte ratio (NLR) in the prediction of functional recovery and 3-month mortality following endovascular treatment for acute anterior circulation ischemic stroke. Heliyon. 2024;10(18):e38030. https:\/\/doi.org\/10.1016\/j.heliyon.2024.e38030.","journal-title":"Heliyon"},{"issue":"1","key":"5042_CR52","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.hipert.2023.10.002","volume":"41","author":"RF C\u00e1ceda-Samam\u00e9","year":"2024","unstructured":"C\u00e1ceda-Samam\u00e9 RF, Vela-Salazar MR, Alejandro-Salinas R, Llamo-Vilcherrez AP, Toro-Huamanchumo CJ. Prognostic performance of neutrophil\/lymphocyte ratio and platelet\/lymphocyte ratio for mortality in patients with acute stroke. Hipertens Riesgo Vasc. 2024;41(1):26\u201334. https:\/\/doi.org\/10.1016\/j.hipert.2023.10.002.","journal-title":"Hipertens Riesgo Vasc"}],"container-title":["BMC Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12883-026-05042-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12883-026-05042-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12883-026-05042-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T02:02:26Z","timestamp":1786413746000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12883-026-05042-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,6]]},"references-count":52,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["5042"],"URL":"https:\/\/doi.org\/10.1186\/s12883-026-05042-w","relation":{},"ISSN":["1471-2377"],"issn-type":[{"value":"1471-2377","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,6]]},"assertion":[{"value":"17 March 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 June 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This study was approved by the Clinical Research Ethics Committee of Ordu University under decision number 2023\/212, dated August 18, 2023. Written informed consent was obtained from all participants prior to enrollment. The researchers protected participant data through complete anonymity while following all confidentiality guidelines, and the study was conducted in accordance with the principles of the Declaration of Helsinki.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"505"}}