{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:53:30Z","timestamp":1791161610354,"version":"4.1.0"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T00:00:00Z","timestamp":1783641600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:00:00Z","timestamp":1791158400000},"content-version":"vor","delay-in-days":87,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"NIH\/NINDS","award":["K23NS124986"],"award-info":[{"award-number":["K23NS124986"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Neurol"],"DOI":"10.1186\/s12883-026-05162-3","type":"journal-article","created":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T05:05:29Z","timestamp":1783659929000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cluster Analysis of Migraine-Associated Symptoms (CAMS) across the lifespan: a cross-sectional study"],"prefix":"10.1186","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4996-2457","authenticated-orcid":false,"given":"Carlyn","family":"Patterson Gentile","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9750-2434","authenticated-orcid":false,"given":"Eric","family":"Kaiser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4786-8889","authenticated-orcid":false,"given":"Christina L.","family":"Szperka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1598-7536","authenticated-orcid":false,"given":"Andrew D.","family":"Hershey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4028-3100","authenticated-orcid":false,"given":"Geoffrey K.","family":"Aguirre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,10]]},"reference":[{"key":"5162_CR1","doi-asserted-by":"publisher","first-page":"p1","DOI":"10.1177\/0333102417738202","volume":"38","author":"S International Headache","year":"2018","unstructured":"International Headache S. The international classification of headache disorders, 3rd edition. Cephalalgia: Int J headache. 2018;38:p1\u2013211.","journal-title":"Cephalalgia: Int J headache"},{"issue":"10","key":"5162_CR2","doi-asserted-by":"publisher","first-page":"p1288","DOI":"10.1111\/j.1526-4610.2005.00260.x","volume":"45","author":"AD Hershey","year":"2005","unstructured":"Hershey AD, et al. Use of the ICHD-II Criteria in the Diagnosis of Pediatric Migraine. Headache: J Head Face Pain. 2005;45(10):p1288\u20131297.","journal-title":"Headache: J Head Face Pain"},{"issue":"10","key":"5162_CR3","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.1177\/0333102420921855","volume":"40","author":"A Iljazi","year":"2020","unstructured":"Iljazi A, et al. Dizziness and vertigo during the prodromal phase and headache phase of migraine: A systematic review and meta-analysis. Cephalalgia. 2020;40(10):1095\u2013103.","journal-title":"Cephalalgia"},{"issue":"1","key":"5162_CR4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3233\/VES-201644","volume":"32","author":"T Lempert","year":"2022","unstructured":"Lempert T, et al. Vestibular migraine: Diagnostic criteria (Update)1. J Vestib Res. 2022;32(1):1\u20136.","journal-title":"J Vestib Res"},{"issue":"8","key":"5162_CR5","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.1111\/head.12189","volume":"53","author":"M Levin","year":"2013","unstructured":"Levin M. The International Classification of Headache Disorders, 3rd Edition (ICHD III) \u2013 Changes and Challenges. Headache: J Head Face Pain. 2013;53(8):1383\u201395.","journal-title":"Headache: J Head Face Pain"},{"issue":"9","key":"5162_CR6","doi-asserted-by":"publisher","first-page":"1393","DOI":"10.1111\/j.1526-4610.2011.01934.x","volume":"51","author":"JM Cohen","year":"2011","unstructured":"Cohen JM, Bigal ME, Newman LC. Migraine and Vestibular Symptoms\u2014Identifying Clinical Features That Predict Vestibular Migraine. Headache: J Head Face Pain. 2011;51(9):1393\u20137.","journal-title":"Headache: J Head Face Pain"},{"issue":"3","key":"5162_CR7","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1111\/head.14484","volume":"63","author":"MT Gerstein","year":"2023","unstructured":"Gerstein MT, et al. Patient-reported experiences with migraine\u2010related cognitive symptoms: Results of the MiCOAS qualitative study. Headache: J Head Face Pain. 2023;63(3):441\u201354.","journal-title":"Headache: J Head Face Pain"},{"key":"5162_CR8","doi-asserted-by":"crossref","unstructured":"Patterson Gentile C, et al. Symptoms associated with headache in youth. Cephalalgia. 2023;43(7):03331024231187162.","DOI":"10.1177\/03331024231187162"},{"issue":"10","key":"5162_CR9","doi-asserted-by":"publisher","first-page":"1230","DOI":"10.1111\/head.14859","volume":"64","author":"C Patterson Gentile","year":"2024","unstructured":"Patterson Gentile C, Szperka CL, Hershey AD. Cluster Analysis of Migraine-associated Symptoms (CAMS) in youth: A retrospective cross\u2010sectional multicenter study. Headache: J Head Face Pain. 2024;64(10):1230\u201343.","journal-title":"Headache: J Head Face Pain"},{"issue":"10","key":"5162_CR10","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.1111\/head.14858","volume":"64","author":"C Patterson Gentile","year":"2024","unstructured":"Patterson Gentile C, Hershey AD, Szperka CL. A critical appraisal of the International Classification of Headache Disorders migraine diagnostic criteria based on a retrospective multicenter cross-sectional headache registry study in youth. Headache: J Head Face Pain. 2024;64(10):1217\u201329.","journal-title":"Headache: J Head Face Pain"},{"issue":"2","key":"5162_CR11","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1111\/head.14069","volume":"61","author":"JS McGinley","year":"2021","unstructured":"McGinley JS, et al. Systematic review of outcomes and endpoints in preventive migraine clinical trials. Headache: J Head Face Pain. 2021;61(2):253\u201362.","journal-title":"Headache: J Head Face Pain"},{"issue":"10","key":"5162_CR12","doi-asserted-by":"publisher","first-page":"1257","DOI":"10.1177\/0333102419847749","volume":"39","author":"EA Kaiser","year":"2019","unstructured":"Kaiser EA, et al. A web-based, branching logic questionnaire for the automated classification of migraine. Cephalalgia. 2019;39(10):1257\u201366.","journal-title":"Cephalalgia"},{"key":"5162_CR13","doi-asserted-by":"publisher","first-page":"103208","DOI":"10.1016\/j.jbi.2019.103208","volume":"95","author":"PA Harris","year":"2019","unstructured":"Harris PA, et al. The REDCap consortium: Building an international community of software platform partners. J Biomed Inform. 2019;95:103208\u2013103208.","journal-title":"J Biomed Inform"},{"issue":"2","key":"5162_CR14","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/j.jbi.2008.08.010","volume":"42","author":"PA Harris","year":"2009","unstructured":"Harris PA, et al. Research electronic data capture (REDCap)\u2014A metadata-driven methodology and workflow process for providing translational research informatics support. J Biomed Inform. 2009;42(2):377\u201381.","journal-title":"J Biomed Inform"},{"issue":"10","key":"5162_CR15","doi-asserted-by":"publisher","first-page":"1359","DOI":"10.1111\/head.14643","volume":"63","author":"CL Szperka","year":"2023","unstructured":"Szperka CL, et al. Patient headache questionnaires can improve headache diagnosis and treatment in children. Headache: J Head Face Pain. 2023;63(10):1359\u201371.","journal-title":"Headache: J Head Face Pain"},{"issue":"4","key":"5162_CR16","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1046\/j.1526-4610.2003.03068.x","volume":"43","author":"ME Bigal","year":"2003","unstructured":"Bigal ME, et al. Assessment of migraine disability using the Migraine Disability Assessment (MIDAS) Questionnaire: A comparison of chronic migraine with episodic migraine. Headache. 2003;43(4):336\u201342.","journal-title":"Headache"},{"issue":"2","key":"5162_CR17","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1002\/ana.21211","volume":"63","author":"RB Lipton","year":"2008","unstructured":"Lipton RB, et al. Cutaneous allodynia in the migraine population. Ann Neurol. 2008;63(2):148\u201358.","journal-title":"Ann Neurol"},{"key":"5162_CR18","unstructured":"Trujillo-Ortiz A. Multiple Correspondence Analysis Based on the Indicator Matrix. 2021. Available from: https:\/\/www.mathworks.com\/matlabcentral\/fileexchange\/22154-multiple-correspondence-analysis-based-on-the-indicator-matrix.\u00a0Cited 2023."},{"key":"5162_CR19","doi-asserted-by":"publisher","first-page":"75","DOI":"10.6339\/JDS.2004.02(1).122","volume":"2","author":"DB Panagiotakos","year":"2004","unstructured":"Panagiotakos DB, Pitsavos C. Interpretation of epidemiological data using multiple correspondence analysis and log-linear models. J Data Sci. 2004;2:75\u201386.","journal-title":"J Data Sci"},{"issue":"6","key":"5162_CR20","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1007\/s11916-008-0073-7","volume":"12","author":"BB Vargas","year":"2008","unstructured":"Vargas BB. Tension-type headache and migraine: Two points on a continuum? Curr Pain Headache Rep. 2008;12(6):433\u20136.","journal-title":"Curr Pain Headache Rep"},{"issue":"7","key":"5162_CR21","doi-asserted-by":"publisher","first-page":"1200","DOI":"10.1097\/j.pain.0000000000000157","volume":"156","author":"DP Turner","year":"2015","unstructured":"Turner DP, et al. Are migraine and tension-type headache diagnostic types or points on a severity continuum? An exploration of the latent taxometric structure of headache. Pain. 2015;156(7):1200\u20137.","journal-title":"Pain"},{"key":"5162_CR22","doi-asserted-by":"publisher","first-page":"S27","DOI":"10.1212\/WNL.58.9_suppl_6.S27","volume":"58","author":"RB Lipton","year":"2002","unstructured":"Lipton RB, et al. Diagnostic lessons from the Spectrum Study. Neurology. 2002;58:S27\u201331. Issue 9, Supplement 6.","journal-title":"Neurology"},{"key":"5162_CR23","doi-asserted-by":"crossref","unstructured":"Charles A. The pathophysiology of migraine: implications for clinical management, in The Lancet Neurology. 2018. pp. 174\u2013182.","DOI":"10.1016\/S1474-4422(17)30435-0"},{"issue":"17","key":"5162_CR24","doi-asserted-by":"publisher","first-page":"6619","DOI":"10.1523\/JNEUROSCI.0373-15.2015","volume":"35","author":"R Burstein","year":"2015","unstructured":"Burstein R, Noseda R, Borsook D. Migraine: Multiple Processes, Complex Pathophysiology. J Neurosci. 2015;35(17):6619\u201329.","journal-title":"J Neurosci"},{"issue":"2","key":"5162_CR25","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/S0304-3959(00)00478-4","volume":"89","author":"R Burstein","year":"2001","unstructured":"Burstein R. Deconstructing migraine headache into peripheral and central sensitization. Pain. 2001;89(2):107\u201310.","journal-title":"Pain"},{"issue":"1","key":"5162_CR26","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1186\/s10194-021-01294-8","volume":"22","author":"K Suzuki","year":"2021","unstructured":"Suzuki K, et al. Investigating the relationships between the burden of multiple sensory hypersensitivity symptoms and headache-related disability in patients with migraine. J Headache Pain. 2021;22(1):77\u201377.","journal-title":"J Headache Pain"},{"issue":"9","key":"5162_CR27","doi-asserted-by":"publisher","first-page":"1418","DOI":"10.1111\/head.12651","volume":"56","author":"G Demarquay","year":"2016","unstructured":"Demarquay G, Maugui\u00e8re F. Central Nervous System Underpinnings of Sensory Hypersensitivity in Migraine: Insights from Neuroimaging and Electrophysiological Studies. Headache: J Head Face Pain. 2016;56(9):1418\u201338.","journal-title":"Headache: J Head Face Pain"},{"issue":"4","key":"5162_CR28","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1177\/0333102419877661","volume":"40","author":"A Terrin","year":"2020","unstructured":"Terrin A, et al. A prospective study on osmophobia in migraine versus tension-type headache in a large series of attacks. Cephalalgia. 2020;40(4):337\u201346.","journal-title":"Cephalalgia"},{"key":"5162_CR29","doi-asserted-by":"crossref","unstructured":"Maniyar FH, et al. The origin of nausea in migraine\u2013A PET study. J Headache Pain. 2014;15(1):84.","DOI":"10.1186\/1129-2377-15-84"},{"issue":"2\u20133","key":"5162_CR30","doi-asserted-by":"publisher","first-page":"45","DOI":"10.3233\/VES-190655","volume":"29","author":"HA Kim","year":"2019","unstructured":"Kim HA, et al. Hemodynamic orthostatic dizziness\/vertigo: Diagnostic criteria. J Vestib Res. 2019;29(2\u20133):45\u201356.","journal-title":"J Vestib Res"},{"issue":"10","key":"5162_CR31","doi-asserted-by":"publisher","first-page":"1687","DOI":"10.1177\/0333102417738251","volume":"38","author":"G Demarquay","year":"2018","unstructured":"Demarquay G, et al. Migraine with brainstem aura: Why not a cortical origin? Cephalalgia. 2018;38(10):1687\u201395.","journal-title":"Cephalalgia"},{"key":"5162_CR32","doi-asserted-by":"crossref","unstructured":"Schwedt TJ, et al. Allodynia and descending pain modulation in migraine: A resting state functional connectivity analysis. Pain Medicine (United States). 2014;15(1):154\u201365.","DOI":"10.1111\/pme.12267"},{"issue":"1","key":"5162_CR33","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1186\/s10194-023-01651-9","volume":"24","author":"JA Pijpers","year":"2023","unstructured":"Pijpers JA, et al. Cutaneous allodynia as predictor for treatment response in chronic migraine: a cohort study. J Headache Pain. 2023;24(1):118\u2013118.","journal-title":"J Headache Pain"},{"issue":"7","key":"5162_CR34","doi-asserted-by":"publisher","first-page":"1026","DOI":"10.1111\/head.13115","volume":"57","author":"RB Lipton","year":"2017","unstructured":"Lipton RB, et al. Allodynia Is Associated With Initial and Sustained Response to Acute Migraine Treatment: Results from the American Migraine Prevalence and Prevention Study. Headache: J Head Face Pain. 2017;57(7):1026\u201340.","journal-title":"Headache: J Head Face Pain"},{"issue":"11","key":"5162_CR35","doi-asserted-by":"publisher","first-page":"3489","DOI":"10.1093\/brain\/awt251","volume":"136","author":"MA Louter","year":"2013","unstructured":"Louter MA, et al. Cutaneous allodynia as a predictor of migraine chronification. Brain. 2013;136(11):3489\u201396.","journal-title":"Brain"},{"key":"5162_CR36","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.pediatrneurol.2024.03.026","volume":"156","author":"N Karsan","year":"2024","unstructured":"Karsan N, Prabhakar P, Goadsby PJ. Extended Phenotyping of Migraine in Children: A Cross-Sectional Study in a Specialist Children\u2019s Headache Clinic. Pediatr Neurol. 2024;156:33\u201340.","journal-title":"Pediatr Neurol"},{"issue":"1","key":"5162_CR37","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1186\/s12883-022-02610-8","volume":"22","author":"D Danno","year":"2022","unstructured":"Danno D, et al. Cranial autonomic symptoms in migraine are related to central sensitization: a prospective study of 164 migraine patients at a tertiary headache center. BMC Neurol. 2022;22(1):89\u201389.","journal-title":"BMC Neurol"},{"key":"5162_CR38","doi-asserted-by":"crossref","unstructured":"Patterson Gentile C, Szperka CL, Hershey AD. Migraine-associated symptoms change with improvement in youth with migraine: A cohort study. Cephalalgia Rep. 2025;8:10.1177\/25158163251371152.","DOI":"10.1177\/25158163251371152"},{"issue":"2","key":"5162_CR39","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1111\/head.14067","volume":"61","author":"CR Houts","year":"2021","unstructured":"Houts CR, et al. Systematic review of outcomes and endpoints in acute migraine clinical trials. Headache: J Head Face Pain. 2021;61(2):263\u201375.","journal-title":"Headache: J Head Face Pain"},{"key":"5162_CR40","doi-asserted-by":"publisher","first-page":"395","DOI":"10.3389\/fneur.2018.00395","volume":"9","author":"R Teggi","year":"2018","unstructured":"Teggi R, et al. Clinical Features of Headache in Patients With Diagnosis of Definite Vestibular Migraine: The VM-Phenotypes Projects. Front Neurol. 2018;9:395.","journal-title":"Front Neurol"},{"issue":"3","key":"5162_CR41","doi-asserted-by":"publisher","first-page":"215","DOI":"10.14639\/0392-100X-847","volume":"36","author":"R Teggi","year":"2016","unstructured":"Teggi R, et al. Point prevalence of vertigo and dizziness in a sample of 2672 subjects and correlation with headaches. Acta otorhinolaryngologica Italica: organo ufficiale della Soc italiana di otorinolaringologia e chirurgia cervico-facciale. 2016;36(3):215\u20139.","journal-title":"Acta otorhinolaryngologica Italica: organo ufficiale della Soc italiana di otorinolaringologia e chirurgia cervico-facciale"},{"issue":"1","key":"5162_CR42","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1086\/504814","volume":"79","author":"V Anttila","year":"2006","unstructured":"Anttila V, et al. Trait Components Provide Tools to Dissect the Genetic Susceptibility of Migraine. Am J Hum Genet. 2006;79(1):85\u201399.","journal-title":"Am J Hum Genet"},{"issue":"2","key":"5162_CR43","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1038\/s41588-021-00990-0","volume":"54","author":"H Hautakangas","year":"2022","unstructured":"Hautakangas H, et al. Genome-wide analysis of 102,084 migraine cases identifies 123 risk loci and subtype-specific risk alleles. Nat Genet. 2022;54(2):152\u201360.","journal-title":"Nat Genet"},{"issue":"6","key":"5162_CR44","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1177\/0333102419828967","volume":"39","author":"H-C Diener","year":"2019","unstructured":"Diener H-C, et al. Guidelines of the International Headache Society for controlled trials of acute treatment of migraine attacks in adults: Fourth edition. Cephalalgia. 2019;39(6):687\u2013710.","journal-title":"Cephalalgia"}],"container-title":["BMC Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12883-026-05162-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12883-026-05162-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12883-026-05162-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:28:28Z","timestamp":1791160108000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12883-026-05162-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,10]]},"references-count":44,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["5162"],"URL":"https:\/\/doi.org\/10.1186\/s12883-026-05162-3","relation":{},"ISSN":["1471-2377"],"issn-type":[{"value":"1471-2377","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,10]]},"assertion":[{"value":"29 April 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 July 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The study was conducted in accordance with the Declaration of Helsinki. Adult data collection via an anonymized online survey was approved by the University of Pennsylvania IRB and deemed the study exempt from consent collection due to minimal risk. For the pediatric dataset, The Children\u2019s Hospital of Philadelphia (CHOP) IRB approved extracting data from the electronic health record and entering it into a research registry, with a waiver of consent and assent to maximize generalizability.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The requirement for informed consent was waived by The University of Pennsylvania and CHOP IRBs for adult and pediatric datasets, respectively due to the minimal risk nature of this study and the use of de-identified participant data to ensure no adverse effects on participant rights.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"C. Patterson Gentile: Dr. Patterson Gentile is currently or was recently funded by the National Institutes of Health\/National Institute of Neurological Disorders and Stroke and the CHOP Foerderer Institutional grant. E. Kaiser: Dr. Kaiser was recently funded by the National Institutes of Health\/ National Institute of Neurological Disorders and Stroke. C.L. Szperka.: Dr. Szperka is currently receiving research\/grant support from PCORI. Dr. Szperka or her institution have received compensation for her consulting work for Eli Lilly; Teva Pharmaceutical Industries Ltd; Upsher-Smith Laboratories, LLC; and Abbvie. A.D. Hershey: Dr. Hershey or his institution have received compensation for serving as a consultant for AbbVie, Amgen, Biohaven, Eli Lilly, Lundbeck, Supernus, Teva, Theranica and Upsher-Smith. His institution has also received research support from Amgen, Biohaven, Eli Lilly, Theranica, Upsher-Smith, and the NIH NINDS\/NICHDS. G.K. Aguirre: Dr. Aguirre receives funding\/grant support from the National Institute of Neurological Disorders and Stroke, the National Eye Institute, and the Binational Science Foundation.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"622"}}