{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T19:15:20Z","timestamp":1769973320516,"version":"3.49.0"},"reference-count":63,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2018,8,28]],"date-time":"2018-08-28T00:00:00Z","timestamp":1535414400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001824","name":"Grantov\u00e1 Agentura \u010cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["14-37368G"],"award-info":[{"award-number":["14-37368G"]}],"id":[{"id":"10.13039\/501100001824","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Pregnancy Childbirth"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1186\/s12884-018-1981-0","type":"journal-article","created":{"date-parts":[[2018,8,28]],"date-time":"2018-08-28T19:02:03Z","timestamp":1535482923000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Long-term significant seasonal differences in the numbers of new-borns with an orofacial cleft in the Czech Republic \u2013 a retrospective study"],"prefix":"10.1186","volume":"18","author":[{"given":"Miroslav","family":"Peterka","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zbynek","family":"Likovsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ales","family":"Panczak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renata","family":"Peterkova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,8,28]]},"reference":[{"key":"1981_CR1","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1007\/BF00888980","volume":"19","author":"RG Condon","year":"1991","unstructured":"Condon RG. Birth seasonality, photoperiod, and social change in the Central Canadian Arctic. Hum Ecol. 1991;19:287\u2013321.","journal-title":"Hum Ecol"},{"key":"1981_CR2","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1086\/418980","volume":"70","author":"FH Bronson","year":"1995","unstructured":"Bronson FH. Seasonal variation in human reproduction: environmental factors. Q Rev Biol. 1995;70:141\u201364.","journal-title":"Q Rev Biol"},{"key":"1981_CR3","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1111\/j.1749-6632.1994.tb30385.x","volume":"709","author":"DA Lam","year":"1994","unstructured":"Lam DA, Miron JA. Global patterns of seasonal variation in human fertility. Ann N Y Acad Sci. 1994;709:9\u201328.","journal-title":"Ann N Y Acad Sci"},{"key":"1981_CR4","doi-asserted-by":"publisher","first-page":"1149","DOI":"10.1073\/pnas.52.5.1149","volume":"52","author":"UM Cowgill","year":"1964","unstructured":"Cowgill UM. Recent variations in the season of birth in Puerto Rico. Proc N A S. 1964;52:1149\u201351.","journal-title":"Proc N A S"},{"key":"1981_CR5","doi-asserted-by":"publisher","first-page":"1512","DOI":"10.1093\/humrep\/16.7.1512","volume":"16","author":"M Bobak","year":"2001","unstructured":"Bobak M, Gjonca A. The seasonality of live birth is strongly influenced by socio-demographic factors. Hum Reprod. 2001;16:1512\u20137.","journal-title":"Hum Reprod"},{"key":"1981_CR6","doi-asserted-by":"publisher","first-page":"1801","DOI":"10.1289\/ehp.10779","volume":"115","author":"M Peterka","year":"2007","unstructured":"Peterka M, Peterkova R, Likovsky Z. Chernobyl: relationship between number of missing newborn boys and the level of radiation in the Czech regions. Environ Health Perspect. 2007;115:1801\u20136.","journal-title":"Environ Health Perspect"},{"key":"1981_CR7","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1093\/ije\/19.2.399","volume":"19","author":"EE Castilla","year":"1990","unstructured":"Castilla EE, Orioli IM, Lugarinho R, et al. Monthly and seasonal variations in the frequency of congenital anomalies. Int J Epidemiol. 1990;19:399\u2013404.","journal-title":"Int J Epidemiol"},{"key":"1981_CR8","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1002\/bdra.23006","volume":"94","author":"AR Caton","year":"2012","unstructured":"Caton AR. Exploring the seasonality of birth defects in the New York state congenital malformations registry. Birth Defects Res A Clin Mol Teratol. 2012;94:424\u201337.","journal-title":"Birth Defects Res A Clin Mol Teratol."},{"key":"1981_CR9","first-page":"1","volume":"18","author":"BC Slater","year":"1964","unstructured":"Slater BC, Watson GI, Mcdonald JC. Seasonal variation in congenital abnormalities. Preliminary report of a survey conducted by the research committee of council of the college of general practitioners. Br J Prev Soc Med. 1964;18:1\u20137.","journal-title":"Br J Prev Soc Med"},{"key":"1981_CR10","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1111\/j.1469-1809.1961.tb01502.x","volume":"25","author":"JH Edwards","year":"1961","unstructured":"Edwards JH. Seasonal incidence of congenital disease in Birmingham. Ann Hum Genet. 1961;25:89\u201393.","journal-title":"Ann Hum Genet"},{"key":"1981_CR11","first-page":"33","volume":"25","author":"MA Coupland","year":"1988","unstructured":"Coupland MA, Coupland AI. Seasonality, incidence and sex distribution of cleft lip and palate births in Trent region, 1973-1982. Cleft Palate J. 1988;25:33\u20137.","journal-title":"Cleft Palate J."},{"key":"1981_CR12","first-page":"24","volume":"24","author":"DA Wehrung","year":"1970","unstructured":"Wehrung DA, Hay S. A study of seasonal incidence of congenital malformations in the United States. Brit J Prev Soc Med. 1970;24:24\u201332.","journal-title":"Brit J Prev Soc Med"},{"key":"1981_CR13","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1597\/07-086.1","volume":"45","author":"RF Elliott","year":"2008","unstructured":"Elliott RF, Jovic G, Beveridge M. Seasonal variation and regional distribution of cleft lip and palate in Zambia. Cleft Palate Craniofac J. 2008;45:533\u20138.","journal-title":"Cleft Palate Craniofac J."},{"key":"1981_CR14","first-page":"343","volume":"25","author":"A De la Vega","year":"2006","unstructured":"De la Vega A, Martinez E. Seasonal variation in the incidence of cleft lip and palate based on the age of conception. P R Health Sci J. 2006;25:343\u20136.","journal-title":"P R Health Sci J"},{"key":"1981_CR15","doi-asserted-by":"publisher","first-page":"197","DOI":"10.3109\/02844318309013119","volume":"17","author":"A Rintala","year":"1983","unstructured":"Rintala A, P\u00f6nk\u00e4 A, Sarna S, et al. Cleft lip and palate in Finland in 1948-75: correlations to infections, seasonal and yearly variations. Scand J Plast Reconstr Surg. 1983;17:197\u2013201.","journal-title":"Scand J Plast Reconstr Surg"},{"key":"1981_CR16","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1097\/SCS.0b013e3182670045","volume":"24","author":"J Yin","year":"2013","unstructured":"Yin J, Yin N, Liu L, et al. Seasonal variation in birth months of patients with oral-facial clefts. J Craniofac Surg. 2013;24:18\u201321.","journal-title":"J Craniofac Surg"},{"key":"1981_CR17","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1002\/bdra.20207","volume":"73","author":"C Siffel","year":"2005","unstructured":"Siffel C, Alverson CJ, Correa A. Analysis of seasonal variation of birth defects in Atlanta. Birth Defects Res A Clin Mol Teratol. 2005;73:655\u201362.","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"key":"1981_CR18","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1111\/j.1754-4505.1994.tb01072.x","volume":"14","author":"RL Amidei","year":"1994","unstructured":"Amidei RL, Hamman RF, Kassebaum DK, et al. Birth prevalence of cleft lip and palate in Colorado by sex distribution, seasonality, race\/ethnicity, and geographic variation. Spec Care Dentist. 1994;14:233\u201340.","journal-title":"Spec Care Dentist"},{"key":"1981_CR19","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1597\/06-045.1","volume":"45","author":"TA Gregg","year":"2008","unstructured":"Gregg TA, Leonard AG, Hayden C, et al. Birth prevalence of cleft lip and palate in Northern Ireland (1981 to 2000). Cleft Palate Craniofac J. 2008;45:141\u20137.","journal-title":"Cleft Palate Craniofac J."},{"key":"1981_CR20","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/j.ijom.2005.08.007","volume":"35","author":"B Krost","year":"2006","unstructured":"Krost B, Schubert J. Influence of season on prevalence of cleft lip and palate. Int J Oral Maxillofac Surg. 2006;35:215\u20138.","journal-title":"Int J Oral Maxillofac Surg"},{"key":"1981_CR21","doi-asserted-by":"publisher","unstructured":"Brender JD, Weyer PJ. Agricultural compounds in water and birth defects.Curr Environ Health Rep 2016;3(2):144\u2013152. doi: \n                    https:\/\/doi.org\/10.1007\/s40572-016-0085-0\n                    \n                  . Review.","DOI":"10.1007\/s40572-016-0085-0"},{"key":"1981_CR22","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1597\/14-136","volume":"53","author":"HJ Sabbagh","year":"2016","unstructured":"Sabbagh HJ, Alamoudi NM, Abdulhameed FD, Innes NP, Al-Aama JY, Hummaida T, Almalik M, El Derwi DA, Mossey PA. Environmental risk factors in the etiology of nonsyndromic orofacial clefts in the western region of Saudi Arabia. Cleft Palate Craniofac J. 2016;53:435\u201343.","journal-title":"Cleft Palate Craniofac J"},{"key":"1981_CR23","doi-asserted-by":"publisher","first-page":"1853","DOI":"10.1093\/hmg\/8.10.1853","volume":"8","author":"BC Schutte","year":"1999","unstructured":"Schutte BC, Murray JC. The many faces and factors of orofacial clefts. Hum Mol Genet. 1999;8:1853\u20139. Review","journal-title":"Hum Mol Genet"},{"key":"1981_CR24","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1177\/1933719112466311","volume":"20","author":"MK Chung","year":"2013","unstructured":"Chung MK, Lao TT, Ting YH, et al. Environmental factors in the first trimester and risk of oral-facial clefts in the offspring. Reprod Sci. 2013;20:797\u2013803.","journal-title":"Reprod Sci"},{"key":"1981_CR25","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1002\/(SICI)1096-9926(199606)53:6<345::AID-TERA5>3.0.CO;2-Z","volume":"53","author":"AE Czeizel","year":"1996","unstructured":"Czeizel AE, T\u00f3th M, Rockenbauer M. Population-based case control study of folic acid supplementation during pregnancy. Teratology. 1996;53:345\u201351.","journal-title":"Teratology"},{"key":"1981_CR26","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1097\/00001648-200207000-00019","volume":"13","author":"LD Botto","year":"2002","unstructured":"Botto LD, Ericson JD, Mulinare J, et al. Maternal fever, multivitamin use, and selected birth defects: evidence of interaction? Epidemiology. 2002;13:485\u20138.","journal-title":"Epidemiology"},{"key":"1981_CR27","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1016\/j.ypmed.2004.02.036","volume":"39","author":"IA Van Rooij","year":"2004","unstructured":"Van Rooij IA, Ock\u00e9 MC, Straatman H, et al. Periconceptional folate intake by supplement and food reduces the risk of nonsyndromic cleft lip with or without cleft palate. Prev Med. 2004;39:689\u201394.","journal-title":"Prev Med"},{"key":"1981_CR28","volume-title":"Inheritance of harelip and cleft lip","author":"P Fogh-Andersen","year":"1942","unstructured":"Fogh-Andersen P. Inheritance of harelip and cleft lip. Nyt Nordisk Torlag: Copenhagen; 1942."},{"key":"1981_CR29","first-page":"57","volume":"38","author":"M Peterka","year":"1996","unstructured":"Peterka M, Peterkova R, Halaskova M, Tvrdek M, Fara M, Likovsky Z. Sex differences in the incidence of orofacial clefts and the question of primary prevention in families with genetic risk. Acta Chir Plast. 1996;38:57\u201360.","journal-title":"Acta Chir Plast"},{"key":"1981_CR30","unstructured":"Czech Statistical Office. http:\/\/(\n                    www.czso.cz\n                    \n                  )."},{"key":"1981_CR31","volume-title":"Introduction to statistical analysis","author":"WJ Dixon","year":"1969","unstructured":"Dixon WJ, Massey FJ. Introduction to statistical analysis. McGraw-hill book company; 1969."},{"key":"1981_CR32","unstructured":"WinPepi Portal . Version 11.65. \n                    http:\/\/www.brixtonhealth.com\n                    \n                  \/."},{"key":"1981_CR33","unstructured":"Social Science Statistics. \n                    http:\/\/www.socscistatistics.com\/Default.aspx\n                    \n                  ."},{"key":"1981_CR34","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.reprotox.2003.10.010","volume":"18","author":"M Peterka","year":"2004","unstructured":"Peterka M, Peterkov\u00e1 R, Likovsky Z. Chernobyl: prenatal loss of four hundred male fetuses in the Czech Republic. Reprod Toxicol. 2004;18:75\u20139.","journal-title":"Reprod Toxicol"},{"key":"1981_CR35","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1192\/bjp.131.4.339","volume":"131","author":"O Odegard","year":"1977","unstructured":"Odegard O. Season of birth in the population of Norway, with particular reference to the September birth maximum. Br J Psychiatry. 1977;131:339\u201344.","journal-title":"Br J Psychiatry"},{"key":"1981_CR36","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1111\/j.1552-6909.2002.tb00077.x","volume":"31","author":"SK Cesario","year":"2002","unstructured":"Cesario SK. The \u201cChristmas effect\u201d and other biometeorologic influences on childbearing and the health of women. J Obstet Gynecol Neonatal Nurs. 2002;31:526\u201335.","journal-title":"J Obstet Gynecol Neonatal Nurs"},{"key":"1981_CR37","first-page":"249","volume":"29","author":"O Polasek","year":"2005","unstructured":"Polasek O, Kolci\u0107 I, Vorko-Jovi\u0107 A, et al. Seasonality of births in Croatia. Coll Antropol. 2005;29:249\u201355.","journal-title":"Coll Antropol"},{"key":"1981_CR38","doi-asserted-by":"publisher","first-page":"1668","DOI":"10.1001\/jama.1988.03720110030030","volume":"259","author":"P Mastroiacovo","year":"1988","unstructured":"Mastroiacovo P, Spagnolo A, Marni E, et al. Birth defects in the Seveso area after TCDD contamination. JAMA. 1988;259:1668\u201372.","journal-title":"JAMA"},{"key":"1981_CR39","first-page":"69","volume":"34","author":"M Peterka","year":"1986","unstructured":"Peterka M, Havr\u00e1nek T, Jel\u00ednek R. Dose-response relationships in chick embryos exposed to embryotoxic agents. Folia Morphol (Warsz). 1986;34:69\u201377.","journal-title":"Folia Morphol (Warsz)"},{"key":"1981_CR40","doi-asserted-by":"crossref","unstructured":"Peterka M, Peterkova R, Likovsky Z. Environmental risk and sex ratio in newborns. In: Nicolopoulou-Stamati P, Hens L, Howard CV, editors. Congenital Diseases and the Environment. Springer, 2007b; p.295\u2013319.","DOI":"10.1007\/1-4020-4831-9_13"},{"key":"1981_CR41","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4684-2850-6","volume-title":"General principles and etiology","author":"JG Wilson","year":"1977","unstructured":"Wilson JG, Fraser FC. Handbook of teratology. Vol. I. In: General principles and etiology. New York: Plenum Press; 1977."},{"key":"1981_CR42","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1590\/S0102-311X2002000200007","volume":"18","author":"J Jarrell","year":"2002","unstructured":"Jarrell J. Rationale for the study of the human sex ratio in population studies of polluted environments. Cad Saude Publica. 2002;18:429\u201334. Review","journal-title":"Cad Saude Publica"},{"key":"1981_CR43","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1289\/ehp.021101","volume":"110","author":"PH Jongbloet","year":"2002","unstructured":"Jongbloet PH, Roeleveld N, Groenewoud HM. Where the boys aren't: dioxin and the sex ratio. Environ Health Perspect. 2002;110:1\u20133. Review","journal-title":"Environ Health Perspect"},{"key":"1981_CR44","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1016\/S0015-0282(99)00576-2","volume":"73","author":"MJ Nicolich","year":"2000","unstructured":"Nicolich MJ, Huebner WW, Schnatter AR. Influence of parental and biological factors on the male birth fraction in the United States: an analysis of birth certificate data from 1964 through 1988. Fertil Steril. 2000;73:487\u201392.","journal-title":"Fertil Steril"},{"key":"1981_CR45","doi-asserted-by":"publisher","first-page":"A699","DOI":"10.1289\/ehp.021100699","volume":"110","author":"JJ Ryan","year":"2002","unstructured":"Ryan JJ, Amirova Z, Carrier G. Sex ratios of children of Russian pesticide producers exposed to dioxin. Environ Health Perspect. 2002;110:A699\u2013701.","journal-title":"Environ Health Perspect"},{"key":"1981_CR46","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1136\/adc.60.6.521","volume":"60","author":"JR Owens","year":"1985","unstructured":"Owens JR, Jones JW, Harris F. Epidemiology of facial clefting. Arch Dis Child. 1985;60:521\u20134.","journal-title":"Arch Dis Child"},{"issue":"361","key":"1981_CR47","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/S0140-6736(03)12162-9","volume":"4","author":"T Heikkinen","year":"2003","unstructured":"Heikkinen T, J\u00e4rvinen A. The common cold. Lancet. 2003;4(361):51\u20139. Review","journal-title":"Lancet"},{"key":"1981_CR48","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.ejim.2004.01.006","volume":"15","author":"D Wat","year":"2004","unstructured":"Wat D. The common cold: a review of the literature. Eur J Intern Med. 2004;15:79\u201388.","journal-title":"Eur J Intern Med"},{"key":"1981_CR49","first-page":"469","volume":"93","author":"A Molnarova","year":"1992","unstructured":"Molnarova A, Brozman M, Schwanzerova I, et al. Prenatal virus infections and orofacial clefts. Bratisl Lek Listy. 1992;93:469\u201376.","journal-title":"Bratisl Lek Listy"},{"key":"1981_CR50","first-page":"114","volume":"36","author":"M Peterka","year":"1994","unstructured":"Peterka M, Tvrdek M, Likovsky Z, et al. Maternal hyperthermia and infection as one of possible causes of orofacial clefts. Acta Chir Plast. 1994;36:114\u20138.","journal-title":"Acta Chir Plast"},{"key":"1981_CR51","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1093\/ije\/4.1.37","volume":"4","author":"I Saxen","year":"1975","unstructured":"Saxen I. Associations between oral clefts and drugs taken during pregnancy. Int J Epidemiol. 1975;4:37\u201344.","journal-title":"Int J Epidemiol"},{"key":"1981_CR52","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1002\/bdra.20177","volume":"73","author":"J M\u00e9tneki","year":"2005","unstructured":"M\u00e9tneki J, Puh\u00f3 E, Czeizel AE. Maternal diseases and isolated orofacial clefts in Hungary. Birth Defects Res A Clin Mol Teratol. 2005;73:617\u201323.","journal-title":"Birth Defects Res A Clin Mol Teratol."},{"key":"1981_CR53","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1111\/j.1365-3016.2009.01025.x","volume":"23","author":"W Wang","year":"2009","unstructured":"Wang W, Guan P, Xu W, et al. Risk factors for oral clefts: a population-based case-control study in Shenyang, China. Paediatr Perinat Epidemiol. 2009;23:310\u201320.","journal-title":"Paediatr Perinat Epidemiol"},{"issue":"Suppl 2","key":"1981_CR54","doi-asserted-by":"publisher","first-page":"199","DOI":"10.2307\/3435010","volume":"109","author":"SM Bernard","year":"2001","unstructured":"Bernard SM, Samet JM, Grambsch A, et al. The potential impacts of climate variability and change on air pollution-related health effects in the United States. Environ Health Perspect. 2001;109(Suppl 2):199\u2013209. Review","journal-title":"Environ Health Perspect"},{"key":"1981_CR55","doi-asserted-by":"publisher","first-page":"1411","DOI":"10.1289\/ehp.11311","volume":"116","author":"BF Hwang","year":"2008","unstructured":"Hwang BF, Jaakkola JJ. Ozone and other air pollutants and the risk of oral clefts. Environ Health Perspect. 2008;116:1411\u20135.","journal-title":"Environ Health Perspect"},{"key":"1981_CR56","unstructured":"Czech Hydrometeorological Institute. \n                    http:\/\/portal.chmi.cz\/files\/portal\/docs\/uoco\/isko\/grafroc\/13groc\/gr13e\/IV4_O3_GB.html"},{"key":"1981_CR57","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1007\/978-94-011-4353-0_15","volume-title":"Chemistry and Radiation Changes in the Ozone Layer","author":"M Dubrovsky","year":"2000","unstructured":"Dubrovsky M. Variability of daily and annual cycles of mean erythemal solar irradiance related to total ozone variability. In: Zerefos CS, et al., editors. Chemistry and Radiation Changes in the Ozone Layer. Printed in the Netherlands: Kluwer Academic Publishers; 2000. p. 179\u201386."},{"key":"1981_CR58","volume-title":"Increase of annual and seasonal air temperatures in the Czech Republic during 1961-2010","author":"J Strestik","year":"2014","unstructured":"Strestik J, Roznovsky J, Stepanek P, et al. In: Ro\u017enovsk\u00fd J, Litschmann T, editors. Increase of annual and seasonal air temperatures in the Czech Republic during 1961-2010. Brno: Mendel a bioklimatologie; 2014."},{"key":"1981_CR59","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1210\/er.2013-1012","volume":"34","author":"T Braun","year":"2013","unstructured":"Braun T, Challis JR, Newnham JP, et al. Early-life glucocorticoid exposure: the hypothalamic-pituitary-adrenal Axis, placental function, and Longterm disease risk. Endocr Rev. 2013;34:885\u2013916.","journal-title":"Endocr Rev"},{"key":"1981_CR60","first-page":"245","volume":"19","author":"H Baxter","year":"1950","unstructured":"Baxter H, Fraser FC. The production of congenital defects in the offspring of female mice treated with cortisone. A preliminary report. McGill Med J. 1950;19:245\u20139.","journal-title":"McGill Med J"},{"key":"1981_CR61","first-page":"35","volume":"20","author":"M Peterka","year":"1983","unstructured":"Peterka M, Jelinek R. Origin of hydrocortisone induced orofacial clefts in the chick embryo. Cleft Palate J. 1983;20:35\u201346.","journal-title":"Cleft Palate J"},{"key":"1981_CR62","first-page":"103","volume":"72","author":"A S\u00edpek","year":"2007","unstructured":"S\u00edpek A, Gregor V, Hor\u00e1cek J. Birth defects in the Czech Republic in the period 1994\u20132005\u2014perinatology data. Ceska Gynekol. 2007;72:103\u20139.","journal-title":"Ceska Gynekol"},{"key":"1981_CR63","first-page":"39","volume":"54","author":"M Peterka","year":"2012","unstructured":"Peterka M, Hrudka J, Tvrdek M, et al. Extension of orofacial cleft size and gestational bleeding in early pregnancy. Acta Chir Plast. 2012;54:39\u201344.","journal-title":"Acta Chir Plast"}],"container-title":["BMC Pregnancy and Childbirth"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12884-018-1981-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12884-018-1981-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12884-018-1981-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T19:37:46Z","timestamp":1569958666000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcpregnancychildbirth.biomedcentral.com\/articles\/10.1186\/s12884-018-1981-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,28]]},"references-count":63,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["1981"],"URL":"https:\/\/doi.org\/10.1186\/s12884-018-1981-0","relation":{},"ISSN":["1471-2393"],"issn-type":[{"value":"1471-2393","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,28]]},"assertion":[{"value":"3 November 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 August 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 August 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This study only analysed historical anonymous birth rate data from the years 1964\u20132000 derived from both the archives of the Plastic Surgery Clinic in Prague and from the official database of the Czech Statistical Office (30), (Ethical Committee of the Institute of Experimental Medicine, CAS, agreement No. 2016\/01).","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"All the authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"348"}}