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The objective of this study was to compare magnesium citrate with placebo in the prevention of adverse perinatal and maternal outcomes among women at higher risk.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>This multicenter, double-masked, placebo-controlled randomized superiority clinical trial compared oral magnesium citrate 300\u2009mg to matched placebo, from 12 to 20\u2009weeks\u2019 gestation until delivery. This trial was completed in three centers in northeastern Brazil. Eligible women were those with a singleton pregnancy and\u2009\u2265\u20091 risk factor, such as prior preterm birth or preeclampsia, or current chronic hypertension or pre-pregnancy diabetes mellitus, age\u2009&gt;\u200935\u2009years or elevated body mass index. The primary perinatal composite outcome comprised preterm birth\u2009&lt;\u200937\u2009weeks\u2019 gestation, stillbirth\u2009&gt;\u200920\u2009weeks, neonatal death\u2009or NICU admission &lt;\u200928\u2009days after birth, or small for gestational age birthweight &lt;\u20093rd percentile. The co-primary maternal composite outcome comprised preeclampsia or eclampsia\u2009&lt;\u200937\u2009weeks, severe gestational hypertension\u2009&lt;\u200937\u2009weeks, placental abruption, or maternal stroke or death during pregnancy or\u2009\u2264\u20097\u2009days after delivery.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Analyses comprised 407 women who received magnesium citrate and 422 who received placebo. The perinatal composite outcome occurred among 75 (18.4%) in the magnesium arm and 76 (18.0%) in the placebo group \u2013 an adjusted odds ratio (aOR) of 1.10 (95% CI 0.72\u20131.68). The maternal composite outcome occurred among 49 (12.0%) women in the magnesium arm and 41 women (9.7%) in the placebo group \u2013 an aOR of 1.29 (95% CI 0.83\u20132.00).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Oral magnesium citrate supplementation did not appear to reduce adverse perinatal or maternal outcomes in high-risk singleton pregnancies.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Trial registration<\/jats:title>\n                <jats:p>ClinicalTrials.gov <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT02032186\">NCT02032186<\/jats:ext-link>, registered January 9, 2014.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12884-020-02935-7","type":"journal-article","created":{"date-parts":[[2020,4,21]],"date-time":"2020-04-21T16:10:49Z","timestamp":1587485449000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["BRAzil magnesium (BRAMAG) trial: a double-masked randomized clinical trial of oral magnesium supplementation in pregnancy"],"prefix":"10.1186","volume":"20","author":[{"given":"Carla Adriane Leal","family":"de Ara\u00fajo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel Geoffrey","family":"Ray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Natal","family":"Figueiroa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o Guilherme","family":"Alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,4,21]]},"reference":[{"key":"2935_CR1","unstructured":"WHO. 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