{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T04:04:48Z","timestamp":1783051488173,"version":"3.54.6"},"reference-count":13,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,10,9]],"date-time":"2020-10-09T00:00:00Z","timestamp":1602201600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,10,9]],"date-time":"2020-10-09T00:00:00Z","timestamp":1602201600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Pregnancy Childbirth"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Persistent right umbilical vein (PRUV) is characterized by atresia of the left umbilical vein while the right umbilical vein remains open. Given the limited sample size of most studies, the incidence of PRUV and the status of concomitant anomalies may not be fully reflected. Thus, we studied the incidence of fetal PRUV and its concomitant anomalies on a larger scale using our hospital database. This study hoped to address the following questions: Does PRUV increase the risk of fetal anomalies? If the PRUV fetus also has a single umbilical artery (SUA), does the risk of fetal anomaly increase further? What is the positive predictive value of PRUV for fetal anomalies?<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective study analyzed 756 cases of fetal PRUV at our hospital from January 2007 to April 2017. Prenatal ultrasound and color Doppler images were assessed. All PRUV fetuses underwent echocardiography and detailed ultrasound examinations of other systems. Newborn status was obtained via the database or by telephone follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 435,428 pregnant women underwent prenatal ultrasonography at 16\u201340\u2009weeks, the incidence of fetal PRUV was 0.17%, and 102 fetuses (13.5%) developed other anomalies. Two complicated cases had trisomy 18. PRUV was associated with a higher incidence of fetal anomalies. When fetal anomalies were classified by body systems, PRUV was associated with a higher incidence of cardiovascular, nervous, urinary, skeletal, digestive, and respiratory system anomalies. The positive predictive values of a PRUV for any fetal anomalies and cardiovascular anomalies were 13.5% (95%CI, 11.2\u201316.2%) and 5.4% (95%CI, 4.0\u20137.3%), respectively. SUA further increases the risk of PRUV fetuses with other anomalies and cardiovascular anomalies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Detailed prenatal ultrasonography and echocardiography should be performed in fetuses with PRUV to rule out anomalies in other systems. When the PRUV is combined with SUA, echocardiography is particularly important. Fetuses with complicated PRUV should undergo chromosomal examination. Although isolated fetal PRUV prognosis is good, complicated PRUV prognosis depends on the type and severity of the concomitant anomalies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12884-020-03310-2","type":"journal-article","created":{"date-parts":[[2020,10,9]],"date-time":"2020-10-09T09:03:00Z","timestamp":1602234180000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Ultrasonic detection of fetal persistent right umbilical vein and incidence and significance of concomitant anomalies"],"prefix":"10.1186","volume":"20","author":[{"given":"Jingyu","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeyu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0636-9215","authenticated-orcid":false,"given":"Bin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,10,9]]},"reference":[{"key":"3310_CR1","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1046\/j.1469-0705.2002.00678.x","volume":"19","author":"I Wolman","year":"2002","unstructured":"Wolman I, Gull I, Fait G, Amster R, Kupferminc MJ, Lessing JB, et al. Persistent right umbilical vein: incidence and significance. Ultrasound Obstet Gynecol. 2002;19:562\u20134.","journal-title":"Ultrasound Obstet Gynecol"},{"key":"3310_CR2","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.ejogrb.2012.12.019","volume":"168","author":"R Martinez","year":"2013","unstructured":"Martinez R, Gamez F, Bravo C, S\u00e1nchez P, Orizales C, Ortiz L, et al. Perinatal outcome after ultrasound prenatal diagnosis of persistent right umbilical vein. Eur J Obstet Gynecol Reprod Biol. 2013;168:36\u20139.","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"3310_CR3","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1002\/uog.7618","volume":"35","author":"S Yagel","year":"2010","unstructured":"Yagel S, Kivilevitch Z, Cohen SM, Valsky DV, Messing B, Shen O, et al. The fetal venous system, part I: normal embryology, anatomy, hemodynamics, ultrasound evaluation and Doppler investigation. 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The study was approved by the Hospital Human Subjects Ethics Committee and any consent to participate was obtained from those who were contacted via telephone. Consent obtained from all participants was verbal and the ethics committee approved this procedure, because this study was a retrospective study based on database, it will not affect the routine procedures of the examination, nor will it cause any harm to pregnant women and fetuses. This article does not contain any studies with animals performed by any of the authors.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not Applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"610"}}