{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T10:56:03Z","timestamp":1792061763227,"version":"4.4.0"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,10,29]],"date-time":"2020-10-29T00:00:00Z","timestamp":1603929600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,10,29]],"date-time":"2020-10-29T00:00:00Z","timestamp":1603929600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81801414"],"award-info":[{"award-number":["81801414"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Key Research and Development Program of Shaanxi Province","award":["2018SF-253"],"award-info":[{"award-number":["2018SF-253"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Pregnancy Childbirth"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Ectopic pregnancy is a major life- and fertility-threatening women\u2019s health concern. As a result of advances in examination technology, an increasing number of ectopic pregnancies can be diagnosed early and treated with medical methods instead of surgery. The aim of this study was to summarize the clinical features and identify the predictors of success of methotrexate (MTX) treatment of ectopic pregnancy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a retrospective study of 238 ectopic pregnancies treated with MTX in the Department of Gynecology of Shaanxi Provincial People\u2019s Hospital from January 2017 to December 2017.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Patients were divided into two groups: the successful treatment group (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009166) and the failed treatment group (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200972). The overall success rate of MTX therapy for ectopic pregnancy was 69.75%. The mean initial beta-human chorionic gonadotropin (\u03b2-hCG) level was significantly lower in the successful treatment group than in the failed treatment group (2538.08\u2009IU\/L versus 3533.17\u2009IU\/L,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.000). The treatment success rate of the group with an initial \u03b2-hCG concentration less than 4000\u2009IU\/L was significantly higher than that of the group with an initial \u03b2-hCG concentration greater than 4000\u2009IU\/L. However, the success rate of the group with an initial \u03b2-hCG concentration greater than 4000\u2009IU\/L was still relatively high (54.55%). \u03b2-hCG levels were significantly increased on the 4th day in the failed treatment group (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.000). Compared to the initial \u03b2-hCG level, the day-4 \u03b2-hCG level increased by more than 8.21%, indicating that the treatment was effective. The diagnostic sensitivity was 88.6%, the specificity was 74.5%, and the area under the receiver operating characteristic (ROC) curve was 0.863 (95% confidence interval (CI): 0.805\u20130.920).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>MTX therapy as a treatment option is safe and effective for asymptomatic, hemodynamically stable patients with ectopic pregnancies who are interested in conservative treatment, regardless of the serum \u03b2-hCG level or adnexal mass size. The change in the \u03b2-hCG level between the initial day and the 4th day is an effective and early predictive tool for the success of MTX therapy for ectopic pregnancy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12884-020-03350-8","type":"journal-article","created":{"date-parts":[[2020,10,29]],"date-time":"2020-10-29T09:03:09Z","timestamp":1603962189000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Predictors and clinical features of methotrexate (MTX) therapy for ectopic pregnancy"],"prefix":"10.1186","volume":"20","author":[{"given":"Jing","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Gan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-ying","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan-ping","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,10,29]]},"reference":[{"issue":"2","key":"3350_CR1","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1097\/AOG.0000000000002499","volume":"131","author":"Committee on Practice Bulletins-Gynecology","year":"2018","unstructured":"Committee on Practice Bulletins-Gynecology. 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All procedures were in accordance with the ethical standards of the National Research Committee and with the 1964 Helsinki declaration and its later amendments. All participants provided written informed consent.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"654"}}