{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T03:45:29Z","timestamp":1776224729459,"version":"3.50.1"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,11,23]],"date-time":"2020-11-23T00:00:00Z","timestamp":1606089600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,11,23]],"date-time":"2020-11-23T00:00:00Z","timestamp":1606089600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"no funding"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Pregnancy Childbirth"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n<jats:title>Background<\/jats:title>\n<jats:p>To evaluate if women with a history of myomectomy have a modified preterm birth risk compared to women with myomas during pregnancy.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>Retrospective cohort study including all women with a history of myomectomy (operated group) or uterine myomas during pregnancy (unoperated group) who delivered in a tertiary center between January, 2011 and December, 2017. The operated group included women who had a myomectomy history with or without myomas during the ongoing pregnancy. The unoperated group included women with uterine myoma(s) seen on at least one ultrasound during pregnancy without history of myomectomy. The primary outcome was preterm birth &lt;\u200937\u2009weeks, and the secondary outcome spontaneous preterm birth &lt;\u200937\u2009weeks. To control for confounding factors, a propensity score approach was used. Two sensitivity analysis were performed, one repeating the analysis using the propensity score after excluding operated women with persistent myomas and one using a classical multivariable logistic regression model.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>The cohort included 576 women: 283 operated women and 293 unoperated women. The rate of preterm birth was similar in the two groups: 12.6% in the unoperated group and 12.0% in the operated group (<jats:italic>p<\/jats:italic>\u2009=\u20090.82). No difference in preterm birth risk was shown between unoperated and operated women in the cohort matched on the propensity score: OR 0.86; 95%CI [0.47\u20131.59]. These results were consistent for spontaneous preterm birth (OR 1.61; 95%CI [0.61\u20134.23]) and for the sensitivity analyses.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Conclusion<\/jats:title>\n<jats:p>In women with a leiomyomatous uterus, a history of myomectomy is not associated with a reduced preterm birth risk.<\/jats:p>\n<\/jats:sec>","DOI":"10.1186\/s12884-020-03413-w","type":"journal-article","created":{"date-parts":[[2020,11,23]],"date-time":"2020-11-23T15:10:21Z","timestamp":1606144221000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Impact of history of myomectomy on preterm birth risk in women with a leiomyomatous uterus: a propensity score analysis"],"prefix":"10.1186","volume":"20","author":[{"given":"Emmanuel","family":"Rault","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Delorme","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fran\u00e7ois","family":"Goffinet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6101-1200","authenticated-orcid":false,"given":"Aude","family":"Girault","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,11,23]]},"reference":[{"key":"3413_CR1","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/1472-6874-12-6","volume":"12","author":"A Zimmermann","year":"2012","unstructured":"Zimmermann A, Bernuit D, Gerlinger C, Schaefers M, Geppert K. Prevalence, symptoms and management of uterine fibroids: an international internet-based survey of 21,746 women. BMC Womens Health. 2012;12:6. https:\/\/doi.org\/10.1186\/1472-6874-12-6.","journal-title":"BMC Womens Health"},{"issue":"2 Pt 1","key":"3413_CR2","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1097\/01.AOG.0000196806.25897.7c","volume":"107","author":"GI Qidwai","year":"2006","unstructured":"Qidwai GI, Caughey AB, Jacoby AF. Obstetric outcomes in women with sonographically identified uterine leiomyomata. Obstet Gynecol. 2006;107(2 Pt 1):376\u201382. https:\/\/doi.org\/10.1097\/01.AOG.0000196806.25897.7c.","journal-title":"Obstet Gynecol"},{"issue":"3","key":"3413_CR3","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1097\/AOG.0b013e318197bbaf","volume":"113","author":"SK Laughlin","year":"2009","unstructured":"Laughlin SK, Baird DD, Savitz DA, Herring AH, Hartmann KE. Prevalence of uterine leiomyomas in the first trimester of pregnancy: an ultrasound-screening study. Obstet Gynecol. 2009;113(3):630\u20135. https:\/\/doi.org\/10.1097\/AOG.0b013e318197bbaf.","journal-title":"Obstet Gynecol"},{"issue":"5","key":"3413_CR4","doi-asserted-by":"publisher","first-page":"1056","DOI":"10.1097\/AOG.0b013e3181f7496d","volume":"116","author":"MJ Stout","year":"2010","unstructured":"Stout MJ, Odibo AO, Graseck AS, Macones GA, Crane JP, Cahill AG. Leiomyomas at routine second-trimester ultrasound examination and adverse obstetric outcomes. Obstet Gynecol. 2010;116(5):1056\u201363. https:\/\/doi.org\/10.1097\/AOG.0b013e3181f7496d.","journal-title":"Obstet Gynecol"},{"issue":"4","key":"3413_CR5","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/j.ajog.2007.12.039","volume":"198","author":"PC Klatsky","year":"2008","unstructured":"Klatsky PC, Tran ND, Caughey AB, Fujimoto VY. Fibroids and reproductive outcomes: a systematic literature review from conception to delivery. Am J Obstet Gynecol. 2008;198(4):357\u201366. https:\/\/doi.org\/10.1016\/j.ajog.2007.12.039.","journal-title":"Am J Obstet Gynecol"},{"issue":"12","key":"3413_CR6","doi-asserted-by":"publisher","first-page":"3049","DOI":"10.1093\/humrep\/dep320","volume":"24","author":"Y-H Chen","year":"2009","unstructured":"Chen Y-H, Lin H-C, Chen S-F, Lin H-C. Increased risk of preterm births among women with uterine leiomyoma: a nationwide population-based study. Hum Reprod Oxf Engl. 2009;24(12):3049\u201356. https:\/\/doi.org\/10.1093\/humrep\/dep320.","journal-title":"Hum Reprod Oxf Engl"},{"issue":"11","key":"3413_CR7","doi-asserted-by":"publisher","first-page":"e0187821","DOI":"10.1371\/journal.pone.0187821","volume":"12","author":"R Zhao","year":"2017","unstructured":"Zhao R, Wang X, Zou L, et al. Adverse obstetric outcomes in pregnant women with uterine fibroids in China: a multicenter survey involving 112,403 deliveries. PLoS One. 2017;12(11):e0187821. https:\/\/doi.org\/10.1371\/journal.pone.0187821.","journal-title":"PLoS One"},{"issue":"4","key":"3413_CR8","doi-asserted-by":"publisher","first-page":"410.e1","DOI":"10.1016\/j.ajog.2018.08.033","volume":"219","author":"A Girault","year":"2018","unstructured":"Girault A, Le Ray C, Chapron C, Goffinet F, Marcellin L. Leiomyomatous uterus and preterm birth: an exposed\/unexposed monocentric cohort study. Am J Obstet Gynecol. 2018;219(4):410.e1\u20137. https:\/\/doi.org\/10.1016\/j.ajog.2018.08.033.","journal-title":"Am J Obstet Gynecol"},{"issue":"3","key":"3413_CR9","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/j.jmig.2005.03.011","volume":"12","author":"J Kumakiri","year":"2005","unstructured":"Kumakiri J, Takeuchi H, Kitade M, et al. Pregnancy and delivery after laparoscopic myomectomy. J Minim Invasive Gynecol. 2005;12(3):241\u20136. https:\/\/doi.org\/10.1016\/j.jmig.2005.03.011.","journal-title":"J Minim Invasive Gynecol"},{"issue":"1","key":"3413_CR10","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.fertnstert.2005.11.075","volume":"86","author":"R Seracchioli","year":"2006","unstructured":"Seracchioli R, Manuzzi L, Vianello F, et al. Obstetric and delivery outcome of pregnancies achieved after laparoscopic myomectomy. Fertil Steril. 2006;86(1):159\u201365. https:\/\/doi.org\/10.1016\/j.fertnstert.2005.11.075.","journal-title":"Fertil Steril"},{"issue":"1","key":"3413_CR11","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.ajog.2004.01.046","volume":"191","author":"J Goldberg","year":"2004","unstructured":"Goldberg J, Pereira L, Berghella V, et al. Pregnancy outcomes after treatment for fibromyomata: uterine artery embolization versus laparoscopic myomectomy. Am J Obstet Gynecol. 2004;191(1):18\u201321. https:\/\/doi.org\/10.1016\/j.ajog.2004.01.046.","journal-title":"Am J Obstet Gynecol"},{"issue":"3","key":"3413_CR12","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1111\/jog.12532","volume":"41","author":"Y Tian","year":"2015","unstructured":"Tian Y, Long T, Dai Y. Pregnancy outcomes following different surgical approaches of myomectomy. J Obstet Gynaecol Res. 2015;41(3):350\u20137. https:\/\/doi.org\/10.1111\/jog.12532.","journal-title":"J Obstet Gynaecol Res"},{"issue":"4","key":"3413_CR13","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1159\/000355098","volume":"76","author":"M Fukuda","year":"2013","unstructured":"Fukuda M, Tanaka T, Kamada M, et al. Comparison of the perinatal outcomes after laparoscopic myomectomy versus abdominal myomectomy. Gynecol Obstet Investig. 2013;76(4):203\u20138. https:\/\/doi.org\/10.1159\/000355098.","journal-title":"Gynecol Obstet Investig"},{"issue":"4","key":"3413_CR14","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1093\/humrep\/15.4.869","volume":"15","author":"JB Dubuisson","year":"2000","unstructured":"Dubuisson JB, Fauconnier A, Deffarges JV, Norgaard C, Kreiker G, Chapron C. Pregnancy outcome and deliveries following laparoscopic myomectomy. Hum Reprod Oxf Engl. 2000;15(4):869\u201373.","journal-title":"Hum Reprod Oxf Engl"},{"issue":"1","key":"3413_CR15","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.fertnstert.2011.10.009","volume":"97","author":"VI Shavell","year":"2012","unstructured":"Shavell VI, Thakur M, Sawant A, et al. Adverse obstetric outcomes associated with sonographically identified large uterine fibroids. Fertil Steril. 2012;97(1):107\u201310. https:\/\/doi.org\/10.1016\/j.fertnstert.2011.10.009.","journal-title":"Fertil Steril"},{"issue":"4","key":"3413_CR16","doi-asserted-by":"publisher","first-page":"484","DOI":"10.3109\/14767058.2014.921675","volume":"28","author":"A Ciavattini","year":"2015","unstructured":"Ciavattini A, Clemente N, Delli Carpini G, Di Giuseppe J, Giannubilo SR, Tranquilli AL. Number and size of uterine fibroids and obstetric outcomes. J Matern-Fetal Neonatal Med Off J Eur Assoc Perinat Med Fed Asia Ocean Perinat Soc Int Soc Perinat Obstet. 2015;28(4):484\u20138. https:\/\/doi.org\/10.3109\/14767058.2014.921675.","journal-title":"J Matern-Fetal Neonatal Med Off J Eur Assoc Perinat Med Fed Asia Ocean Perinat Soc Int Soc Perinat Obstet"},{"issue":"4","key":"3413_CR17","doi-asserted-by":"publisher","first-page":"395.e1","DOI":"10.1016\/j.ajog.2014.03.066","volume":"211","author":"S-J Lam","year":"2014","unstructured":"Lam S-J, Best S, Kumar S. The impact of fibroid characteristics on pregnancy outcome. Am J Obstet Gynecol. 2014;211(4):395.e1\u20135. https:\/\/doi.org\/10.1016\/j.ajog.2014.03.066.","journal-title":"Am J Obstet Gynecol"},{"issue":"7 Suppl","key":"3413_CR18","first-page":"5S10","volume":"31","author":"PY Ancel","year":"2002","unstructured":"Ancel PY. Preterm labor: pathophysiology, risk factors and outcomes. J Gynecol Obstet Biol Reprod (Paris). 2002;31(7 Suppl):5S10\u201321.","journal-title":"J Gynecol Obstet Biol Reprod (Paris)"},{"issue":"8","key":"3413_CR19","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1016\/j.jgyn.2011.09.025","volume":"40","author":"CNGOF","year":"2011","unstructured":"CNGOF. Update of myoma management: guidelines for clinical practice - text of the guidelines. J Gynecol Obstet Biol Reprod (Paris). 2011;40(8):953\u201361. https:\/\/doi.org\/10.1016\/j.jgyn.2011.09.025.","journal-title":"J Gynecol Obstet Biol Reprod (Paris)"},{"issue":"11","key":"3413_CR20","doi-asserted-by":"publisher","first-page":"1772","DOI":"10.1111\/1471-0528.13683","volume":"123","author":"LF Wong","year":"2016","unstructured":"Wong LF, Wilkes J, Korgenski K, Varner MW, Manuck TA. Risk factors associated with preterm birth after a prior term delivery. BJOG Int J Obstet Gynaecol. 2016;123(11):1772\u20138. https:\/\/doi.org\/10.1111\/1471-0528.13683.","journal-title":"BJOG Int J Obstet Gynaecol"},{"issue":"4","key":"3413_CR21","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1016\/j.fertnstert.2007.01.093","volume":"87","author":"WH Parker","year":"2007","unstructured":"Parker WH. Etiology, symptomatology, and diagnosis of uterine myomas. Fertil Steril. 2007;87(4):725\u201336. https:\/\/doi.org\/10.1016\/j.fertnstert.2007.01.093.","journal-title":"Fertil Steril"},{"issue":"14","key":"3413_CR22","doi-asserted-by":"publisher","first-page":"1344","DOI":"10.1056\/NEJMra1209993","volume":"369","author":"SE Bulun","year":"2013","unstructured":"Bulun SE. Uterine fibroids. N Engl J Med. 2013;369(14):1344\u201355. https:\/\/doi.org\/10.1056\/NEJMra1209993.","journal-title":"N Engl J Med"},{"issue":"1","key":"3413_CR23","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1093\/humupd\/dmv044","volume":"22","author":"S Vannuccini","year":"2016","unstructured":"Vannuccini S, Clifton VL, Fraser IS, et al. Infertility and reproductive disorders: impact of hormonal and inflammatory mechanisms on pregnancy outcome. Hum Reprod Update. 2016;22(1):104\u201315. https:\/\/doi.org\/10.1093\/humupd\/dmv044.","journal-title":"Hum Reprod Update"},{"issue":"6","key":"3413_CR24","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1042\/CS20150702","volume":"130","author":"AC Harmon","year":"2016","unstructured":"Harmon AC, Cornelius DC, Amaral LM, et al. The role of inflammation in the pathology of preeclampsia. Clin Sci Lond Engl 1979. 2016;130(6):409\u201319. https:\/\/doi.org\/10.1042\/CS20150702.","journal-title":"Clin Sci Lond Engl 1979"},{"issue":"10","key":"3413_CR25","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1016\/j.jogoh.2017.09.002","volume":"46","author":"B Blondel","year":"2017","unstructured":"Blondel B, Coulm B, Bonnet C, Goffinet F, Le Ray C. Trends in perinatal health in metropolitan France from 1995 to 2016: results from the French National Perinatal Surveys. J Gynecol Obstet Hum Reprod. 2017;46(10):701\u201313. https:\/\/doi.org\/10.1016\/j.jogoh.2017.09.002.","journal-title":"J Gynecol Obstet Hum Reprod"}],"container-title":["BMC Pregnancy and Childbirth"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12884-020-03413-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12884-020-03413-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12884-020-03413-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,23]],"date-time":"2020-11-23T15:27:46Z","timestamp":1606145266000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcpregnancychildbirth.biomedcentral.com\/articles\/10.1186\/s12884-020-03413-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,23]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["3413"],"URL":"https:\/\/doi.org\/10.1186\/s12884-020-03413-w","relation":{},"ISSN":["1471-2393"],"issn-type":[{"value":"1471-2393","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,23]]},"assertion":[{"value":"23 July 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 November 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 November 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This study was approved by the National Data Protection Authority (Commission Nationale de l\u2019Informatique et des Libert\u00e9s, CNIL n\u00b0 1755849). Under French regulations, this study is exempt from Institutional Review Board (IRB) review because it was an observational study using anonymized data from medical records. Women were informed that their records can be used for the evaluation of medical practices and were allowed to opt out of these studies. The study\u2019s exempt status was confirmed by the Institutional Review Board Ile-de-France.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors report no conflict of interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"720"}}