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The serum Gal-1 level was detected using an enzyme-linked immunosorbent assay (ELISA), and Gal-1 expression in the placenta was detected by western blot.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The results revealed that, compared with the control group, the serum Gal-1 level decreased in the women with FGR without comorbidities, and the difference was statistically significant (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Compared with the control group, the difference in serum Gal-1 expression in the FGR-PE group was not statistically significant (<jats:italic>P<\/jats:italic>\u2009=\u20090.29). The peripheral serum Gal-1 level decreased in the FGR-GDM group compared with the control group, and the difference was statistically significant (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). The serum Gal-1 level was positively correlated with birth weight (r<jats:sup>2<\/jats:sup>\u2009=\u20090.172,<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01). Compared with the control group, the Gal-1 expression level decreased in the placenta of the pregnant women with FGR without comorbidities (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Gal-1 exhibits low expression in the serum and placenta of pregnant women with FGR. In addition, Gal-1 may be involved in the pathogenesis of FGR and could represent a new diagnostic marker of the disease.<\/jats:p><\/jats:sec>","DOI":"10.1186\/s12884-020-03477-8","type":"journal-article","created":{"date-parts":[[2021,1,6]],"date-time":"2021-01-06T17:13:16Z","timestamp":1609953196000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Galectin-1 expression in the serum and placenta of pregnant women with fetal growth restriction and its significance"],"prefix":"10.1186","volume":"21","author":[{"given":"Xiao-Xiao","family":"Jin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Ying","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7423-6732","authenticated-orcid":false,"given":"Min-Yue","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,1,6]]},"reference":[{"key":"3477_CR1","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1093\/aje\/kww109","volume":"185","author":"MS Kramer","year":"2017","unstructured":"Kramer MS, Zhang X, Dahhou M, Yang S, Martin RM, Oken E, Platt RW. 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