{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T05:13:31Z","timestamp":1792300411415,"version":"4.4.0"},"reference-count":14,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,1,22]],"date-time":"2021-01-22T00:00:00Z","timestamp":1611273600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,1,22]],"date-time":"2021-01-22T00:00:00Z","timestamp":1611273600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["COV20\/00188"],"award-info":[{"award-number":["COV20\/00188"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Pregnancy Childbirth"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>The Coronavirus Disease 2019 (COVID-19) is a novel disease which has been having a worldwide affect since December 2019. Evidence regarding the effects of SARS-CoV-2 during pregnancy is conflicting. The presence of SARS-CoV-2 has been demonstrated in biological samples during pregnancy (placenta, umbilical cord or amniotic fluid); however, maternal and fetal effects of the virus are not well known.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Descriptive, multicentre, longitudinal, observational study in eight tertiary care hospitals throughout Spain, that are referral centres for pregnant women with COVID-19. All pregnant women with positive SARS-CoV-2 real-time reverse transcriptase polymerase chain reaction during their pregnancy or 14\u2009days preconception and newborns born to mothers infected with SARS-CoV-2 will be included. They will continue to be followed up until 4 weeks after delivery. The aim of the study is to investigate both the effect of COVID-19 on the pregnancy, and the effect of the pregnancy status with the evolution of the SARS-CoV-2 disease. Other samples (faeces, urine, serum, amniotic fluid, cord and peripheral blood, placenta and breastmilk) will be collected in order to analyse whether or not there is a risk of vertical transmission and to describe the behaviour of the virus in other fluids. Neonates will be followed until 6\u2009months after delivery to establish the rate of neonatal transmission. We aim to include 150 pregnant women and their babies. Ethics approval will be obtained from all the participating centres.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Discussion<\/jats:title>\n                <jats:p>There is little information known about COVID-19 and its unknown effects on pregnancy. This study will collect a large number of samples in pregnant women which will allow us to demonstrate the behaviour of the virus in pregnancy and postpartum in a representative cohort of the Spanish population.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12884-021-03572-4","type":"journal-article","created":{"date-parts":[[2021,1,22]],"date-time":"2021-01-22T11:09:43Z","timestamp":1611313783000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Gestation and COVID-19: clinical and microbiological observational study (Gesta-COVID19)"],"prefix":"10.1186","volume":"21","author":[{"name":"On behalf of the Gesta-COVID19 Collaboration Group","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Suy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Itziar","family":"Garcia-Ruiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melchor","family":"Carbonell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Garcia-Manau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlota","family":"Rodo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8261-6383","authenticated-orcid":false,"given":"Nerea","family":"Maiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Sulleiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andres","family":"Anton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana","family":"Esperalba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuria","family":"Fern\u00e1ndez-Hidalgo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie Antoinette","family":"Frick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatima","family":"Camba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomas","family":"Pumarola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Carreras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,1,22]]},"reference":[{"key":"3572_CR1","unstructured":"COVID-19 situation reports [Internet]. [cited 2020 Apr 18]. Available from: https:\/\/www.who.int\/emergencies\/diseases\/novel-coronavirus-2019\/situation-reports."},{"issue":"2","key":"3572_CR2","doi-asserted-by":"publisher","first-page":"100118","DOI":"10.1016\/j.ajogmf.2020.100118","volume":"2","author":"N Breslin","year":"2020","unstructured":"Breslin N, Baptiste C, Gyamfi-Bannerman C, Miller R, Martinez R, Bernstein K, et al. Coronavirus disease 2019 infection among asymptomatic and symptomatic pregnant women: two weeks of confirmed presentations to an affiliated pair of New York City hospitals. Am J Obstet Gynecol MFM. 2020;2(2):100118. https:\/\/doi.org\/10.1016\/j.ajogmf.2020.100118.","journal-title":"Am J Obstet Gynecol MFM."},{"key":"3572_CR3","doi-asserted-by":"crossref","unstructured":"Badr DA, Mattern J, Carlin A, Cordier A-G, Maillart E, El Hachem L, et al. Are clinical outcomes worse for pregnant women at \u226520 weeks\u2019 gestation infected with coronavirus disease 2019? A multicenter case-control study with propensity score matching. Am J Obstet Gynecol. 2020; [cited 2020 Oct 1]; Available from: https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002937820307766.","DOI":"10.1016\/j.ajog.2020.07.045"},{"key":"3572_CR4","doi-asserted-by":"crossref","unstructured":"Mendoza M, Garcia-Ruiz I, Maiz N, Rodo C, Garcia-Manau P, Serrano B, et al. Preeclampsia-like syndrome induced by severe COVID-19: a prospective observational study. BJOG Int J Obstet Gynaecol. 2020; [cited 2020 Jun 2]; Available from: https:\/\/onlinelibrary.wiley.com\/doi\/abs\/10.1111\/1471-0528.16339.","DOI":"10.1111\/1471-0528.16339"},{"key":"3572_CR5","doi-asserted-by":"crossref","unstructured":"Garcia-Manau P, Garcia-Ruiz I, Rodo C, Sulleiro E, Maiz N, Catalan M, et al. Fetal Transient Skin Edema in Two Pregnant Women With Coronavirus Disease 2019 (COVID-19). Obstet Gynecol. 2020; [cited 2020 Oct 1]; Publish Ahead of Print. Available from: https:\/\/journals.lww.com\/10.1097\/AOG.0000000000004059.","DOI":"10.1097\/AOG.0000000000004059"},{"key":"#cr-split#-3572_CR6.1","doi-asserted-by":"crossref","unstructured":"Vivanti AJ, Vauloup-Fellous C, Prevot S, Zupan V, Suffee C, Do Cao J, et al. Transplacental transmission of SARS-CoV-2 infection. Nat Commun. 2020;11","DOI":"10.1038\/s41467-020-17436-6"},{"key":"#cr-split#-3572_CR6.2","unstructured":"(1) [cited 2020 Oct 1]. Available from: http:\/\/www.nature.com\/articles\/s41467-020-17436-6."},{"key":"3572_CR7","doi-asserted-by":"crossref","unstructured":"Schwartz DA, Morotti D, Beigi B, Moshfegh F, Zafaranloo N, Patan\u00e8 L. Confirming Vertical Fetal Infection with COVID-19: Neonatal and Pathology Criteria for Early Onset and Transplacental Transmission of SARS-CoV-2 from Infected Pregnant Mothers. Arch Pathol Lab Med. 2020; [cited 2020 Oct 1]; Available from: http:\/\/meridian.allenpress.com\/aplm\/article\/doi\/10.5858\/arpa.2020-0442-SA\/441323\/Confirming-Vertical-Fetal-Infection-with-COVID19.","DOI":"10.5858\/arpa.2020-0442-SA"},{"issue":"10","key":"3572_CR8","doi-asserted-by":"publisher","first-page":"1430","DOI":"10.1016\/j.cmi.2020.05.027","volume":"26","author":"S Costa","year":"2020","unstructured":"Costa S, Posteraro B, Marchetti S, Tamburrini E, Carducci B, Lanzone A, et al. Excretion of SARS-CoV-2 in human breast milk. Clin Microbiol Infect. 2020;26(10):1430\u20132.","journal-title":"Clin Microbiol Infect"},{"issue":"1","key":"3572_CR9","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1002\/uog.22088","volume":"56","author":"J Juan","year":"2020","unstructured":"Juan J, Gil MM, Rong Z, Zhang Y, Yang H, Poon LC. Effect of coronavirus disease 2019 (COVID-19) on maternal, perinatal and neonatal outcome: systematic review. 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Available from: https:\/\/scientiasalut.gencat.cat\/handle\/11351\/4786."}],"container-title":["BMC Pregnancy and Childbirth"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12884-021-03572-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12884-021-03572-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12884-021-03572-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,22]],"date-time":"2021-01-22T11:12:31Z","timestamp":1611313951000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcpregnancychildbirth.biomedcentral.com\/articles\/10.1186\/s12884-021-03572-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,22]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["3572"],"URL":"https:\/\/doi.org\/10.1186\/s12884-021-03572-4","relation":{},"ISSN":["1471-2393"],"issn-type":[{"value":"1471-2393","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,22]]},"assertion":[{"value":"27 April 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 January 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 January 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The Vall d\u2019Hebron University Hospital Ethics Committee (EC), as the reference Ethics Committee, first approved this study. The reference number is PR(AMI)181\u20132020. All of the participating centres also obtained their own EC approval.The protocol, informed consent form, participant information sheet and any applicable documents were submitted to the respective Ethics Committees and regulatory authorities, and written approval was obtained. All substantial amendments to the originally approved documents will be sent to the respective authorities for approval. The study did not begin until the approval of the EC and Director\u2019s consent was obtained. Given the current pandemic and public health concerns, it was accepted to obtain oral consent from the patients and to record it in their medical history.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"78"}}