{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T00:01:29Z","timestamp":1724889689340},"reference-count":12,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,8,18]],"date-time":"2021-08-18T00:00:00Z","timestamp":1629244800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,8,18]],"date-time":"2021-08-18T00:00:00Z","timestamp":1629244800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Pregnancy Childbirth"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Coronavirus disease 2019 (COVID-19) still is a global emergency. According to the studies, pregnant women are of the at risk populations and any underlying disease(s) might even worsen their condition. The aim of this study is reporting a complex case of immune thrombocytopenic purpura (ITP) during pregnancy who has been diagnosed with COVID-19 as well as suspicion of HELLP syndrome.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>A 24-year-old woman with a platelet count of 6000\/mL and resistance to conventional therapies was referred. A day after starting 0.5\u2009g\/day of methylprednisolone for her, fever and a decrease in SpO2 presented. According to the paraclinical investigations, COVID-19 was diagnosed and the conventional COVID-19 treatments started for her (the methylprednisolone pulse stopped). Due to the increased liver enzymes and low platelet count, with suspicion of HELLP syndrome, cesarean section surgery was performed which resulted in a healthy neonate. Then, the methylprednisolone pulse was restarted for and she developed an increase in the platelet count.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>It is not clear how COVID-19 and pregnancy affected the patient\u2019s condition and the underlying disease; however, it seems the delivery and\/or restarting the methylprednisolone pulses caused improvement in her condition.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12884-021-04030-x","type":"journal-article","created":{"date-parts":[[2021,8,18]],"date-time":"2021-08-18T14:04:30Z","timestamp":1629295470000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Coronavirus disease 2019 (COVID-19) in a pregnant women with treatment resistance thrombocytopenic purpura with and suspicion to HELLP syndrome: a case report"],"prefix":"10.1186","volume":"21","author":[{"given":"Amir Hossein","family":"Norooznezhad","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maryam","family":"Nurzadeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad Hasan","family":"Darabi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahsa","family":"Naemi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,8,18]]},"reference":[{"issue":"2","key":"4030_CR1","doi-asserted-by":"publisher","first-page":"834","DOI":"10.4269\/ajtmh.20-0512","volume":"103","author":"AH Norooznezhad","year":"2020","unstructured":"Norooznezhad AH, Najafi F, Riahi P, Moradinazar M, Shakiba E, Mostafaei S. Primary symptoms, comorbidities, and outcomes of 431 hospitalized patients with confirmative RT-PCR results for COVID-19. Am J Trop Med Hyg. 2020;103(2):834\u20137.","journal-title":"Am J Trop Med Hyg"},{"key":"4030_CR2","doi-asserted-by":"publisher","first-page":"m3320","DOI":"10.1136\/bmj.m3320","volume":"370","author":"J Allotey","year":"2020","unstructured":"Allotey J, Stallings E, Bonet M, Yap M, Chatterjee S, Kew T, et al. Clinical manifestations, risk factors, and maternal and perinatal outcomes of coronavirus disease 2019 in pregnancy: living systematic review and meta-analysis. BMJ. 2020;370:m3320.","journal-title":"BMJ."},{"issue":"7","key":"4030_CR3","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1002\/ajh.25829","volume":"95","author":"E Terpos","year":"2020","unstructured":"Terpos E, Ntanasis-Stathopoulos I, Elalamy I, Kastritis E, Sergentanis TN, Politou M, et al. Hematological findings and complications of COVID-19. Am J Hematol. 2020;95(7):834\u201347.","journal-title":"Am J Hematol"},{"key":"4030_CR4","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.cca.2020.03.022","volume":"506","author":"G Lippi","year":"2020","unstructured":"Lippi G, Plebani M, Henry BM. Thrombocytopenia is associated with severe coronavirus disease 2019 (COVID-19) infections: a meta-analysis. Clin Chim Acta. 2020;506:145\u20138.","journal-title":"Clin Chim Acta"},{"key":"4030_CR5","doi-asserted-by":"publisher","unstructured":"Nesr G, Garnett C, Bailey C, Arami S. ITP flare with mild COVID-19 infection in pregnancy: a case report. Br J Haematol. 2020. https:\/\/doi.org\/10.1111\/bjh.16928.","DOI":"10.1111\/bjh.16928"},{"key":"4030_CR6","doi-asserted-by":"crossref","unstructured":"Rodeghiero F, Cantoni S, Carli G, Carpenedo M, Carrai V, Chiurazzi F, et al. Practical recommendations for the management of patients with ITP during the COVID-19 pandemic. Mediterr J Hematol Infect Dis. 2021;13(1):e2021032.","DOI":"10.4084\/MJHID.2021.032"},{"issue":"1","key":"4030_CR7","first-page":"55","volume":"11","author":"AM Ciobanu","year":"2016","unstructured":"Ciobanu AM, Colibaba S, Cimpoca B, Peltecu G, Panaitescu AM. Thrombocytopenia in pregnancy. Maedica. 2016;11(1):55\u201360.","journal-title":"Maedica."},{"issue":"1","key":"4030_CR8","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1182\/blood-2012-08-448944","volume":"121","author":"T Gernsheimer","year":"2013","unstructured":"Gernsheimer T, James AH, Stasi R. How I treat thrombocytopenia in pregnancy. Blood. 2013;121(1):38\u201347.","journal-title":"Blood."},{"key":"4030_CR9","doi-asserted-by":"publisher","unstructured":"Papageorghiou AT, Deruelle P, Gunier RB, Rauch S, Garc\u00eda-May PK, Mhatre M, et al. Preeclampsia and COVID-19: results from the INTERCOVID prospective longitudinal study. Am J Obstet Gynecol. 2021. https:\/\/doi.org\/10.1016\/j.ajog.2021.05.014.","DOI":"10.1016\/j.ajog.2021.05.014"},{"issue":"02","key":"4030_CR10","doi-asserted-by":"publisher","first-page":"e179","DOI":"10.1055\/s-0040-1712978","volume":"10","author":"I Futterman","year":"2020","unstructured":"Futterman I, Toaff M, Navi L, Clare CA. COVID-19 and HELLP: overlapping clinical pictures in two gravid patients. Am J Perinatol Rep. 2020;10(02):e179\u2013e82.","journal-title":"Am J Perinatol Rep"},{"issue":"1","key":"4030_CR11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12884-020-03172-8","volume":"20","author":"L Ronnje","year":"2020","unstructured":"Ronnje L, L\u00e4nsberg J-K, Vikhareva O, Hansson SR, Herbst A, Zaigham M. Complicated COVID-19 in pregnancy: a case report with severe liver and coagulation dysfunction promptly improved by delivery. BMC Pregnancy Childbirth. 2020;20(1):1\u20138.","journal-title":"BMC Pregnancy Childbirth"},{"issue":"9","key":"4030_CR12","doi-asserted-by":"publisher","first-page":"577","DOI":"10.7326\/M20-0504","volume":"172","author":"SA Lauer","year":"2020","unstructured":"Lauer SA, Grantz KH, Bi Q, Jones FK, Zheng Q, Meredith HR, et al. The incubation period of coronavirus disease 2019 (COVID-19) from publicly reported confirmed cases: estimation and application. Ann Intern Med. 2020;172(9):577\u201382.","journal-title":"Ann Intern Med"}],"container-title":["BMC Pregnancy and Childbirth"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12884-021-04030-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12884-021-04030-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12884-021-04030-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,18]],"date-time":"2021-08-18T14:05:17Z","timestamp":1629295517000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcpregnancychildbirth.biomedcentral.com\/articles\/10.1186\/s12884-021-04030-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,18]]},"references-count":12,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["4030"],"URL":"https:\/\/doi.org\/10.1186\/s12884-021-04030-x","relation":{},"ISSN":["1471-2393"],"issn-type":[{"value":"1471-2393","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,18]]},"assertion":[{"value":"16 March 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 August 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 August 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Authors declare their adhered to the 1975 declaration of Helsinki and its next revisions. This case belongs to a research proposal with the ethical approval code of the Medical Ethics Committee of Tehran University of Medical Sciences (IRB: IR.TUMS.VCR.1398.1082).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Patient kindly signed a written consent form freely for publishing\/using of her medical data.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Authors declare no actual or potential conflict of interests related to this study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"567"}}