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Intolerance of uncertainty was recently identified as a significant risk factor for postpartum anxiety symptoms and is a key trait of non-perinatal anxiety disorders. The present study aimed to validate the Intolerance of Uncertainty Scale (IUS) in a perinatal population and evaluate its use as a screening tool for anxiety disorders.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Psychiatric diagnoses were assessed in a sample of perinatal women (<jats:italic>n<\/jats:italic>\u2009=\u2009198), in addition to completing a self-report battery of questionnaires. Psychometric properties including internal consistency and convergent and discriminant validity were assessed. Determination of an optimal clinical cut-off score was measured through a ROC analysis in which the area under the curve, sensitivity, specificity, as well as positive and negative predictive values were calculated.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The IUS demonstrated excellent internal consistency (\u03b1\u2009=\u20090.95) and an optimal clinical cut-off score of 64 or greater was established, yielding a sensitivity of 89%. The IUS also demonstrated very good positive (79%) and negative (80%) predictive values.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>These findings suggest that the IUS represents a clinically useful screening tool to be used as an aid for the early and accurate detection of perinatal anxiety.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12884-021-04296-1","type":"journal-article","created":{"date-parts":[[2021,12,14]],"date-time":"2021-12-14T04:41:05Z","timestamp":1639456865000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Validation of the intolerance of uncertainty scale as a screening tool for perinatal anxiety"],"prefix":"10.1186","volume":"21","author":[{"given":"Melissa","family":"Furtado","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benicio N.","family":"Frey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheryl M.","family":"Green","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,12,14]]},"reference":[{"issue":"7","key":"4296_CR1","doi-asserted-by":"publisher","first-page":"e00497","DOI":"10.1002\/brb3.497","volume":"6","author":"O Remes","year":"2016","unstructured":"Remes O, Brayne C, van der Linde R, Lafortune L. 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