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Dyslipidemia in pregnancy is correlated with an increased risk of preeclampsia. However, the dynamic changes in lipid metabolic product, particularly fatty acid fraction, in preeclampsia maternal circulation, are not well understood. This study aimed to investigate fatty acid fraction in preeclampsia maternal blood compared with normotensive normal pregnancy.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>A total of 34 women who developed preeclampsia and 32 women with normotensive normal pregnancy were included in our case-control study. Maternal blood samples were collected for serum fatty acid fractions analysis and other biochemical parameters. Serum fatty acid fractions included long-chain polyunsaturated fatty acid (LCPUFA), monounsaturated fatty acid (MUFA), saturated fatty acid, and total fatty acid, measured with gas chromatography-mass spectrometry (GC-MS). The mean difference of fatty acid level was analysed using parametric and non-parametric bivariate analysis based on normality distributed data, while the risk of preeclampsia based on fatty acid fraction was analysed using a logistic regression model.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Women with preeclampsia have lower high-density lipoprotein (53.97\u2009\u00b1\u200912.82\u2009mg\/dL vs. 63.71\u2009\u00b1\u200915.20\u2009mg\/dL, <jats:italic>p<\/jats:italic>\u2009=\u20090.006), higher triglyceride (284.91\u2009\u00b1\u200997.68\u2009mg\/dL vs. 232.84\u2009\u00b1\u200973.69\u2009mg\/dL, <jats:italic>p<\/jats:italic>\u2009=\u20090.018) than that in the normotensive group. Higher palmitoleic acid was found in women with preeclampsia compared to normotensive normal pregnancy (422.94\u2009\u00b1\u2009195.99 vs. 325.71\u2009\u00b1\u2009111.03\u2009\u03bcmol\/L, <jats:italic>p\u2009=<\/jats:italic>\u00a00.037). The binary logistic regression model showed that pregnant women who had total omega-3 levels within the reference values had a higher risk of suffering preeclampsia than those with the higher reference value (odds ratio OR (95% CI): 8,5 (1.51\u201348.07), <jats:italic>p<\/jats:italic>\u2009=\u20090.015). Pregnant women who have saturated fatty acid within reference values had a lower risk for suffering preeclampsia than those in upper reference value (OR (95% CI): 0.21 (0.52\u20130.88), <jats:italic>p<\/jats:italic>\u2009=\u20090.032).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Overall, palmitoleic acid was higher in women with preeclampsia. Further analysis indicated that reference omega-3 in and high saturated fatty acid serum levels are characteristics of women with preeclampsia.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12884-021-04313-3","type":"journal-article","created":{"date-parts":[[2022,1,3]],"date-time":"2022-01-03T07:03:20Z","timestamp":1641193400000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Comprehensive fatty acid fractionation profilling in preeclampsia: a case control study with multivariable analysis"],"prefix":"10.1186","volume":"22","author":[{"given":"Herlambang","family":"Herlambang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anggelia","family":"Puspasari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Citra","family":"Maharani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rina Nofri","family":"Enis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Tarawifa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amelia Dwi","family":"Fitri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huntari","family":"Harahap","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asro Hayani","family":"Harahap","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erny","family":"Kusdiyah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mas Rizky Anggun Adipurna","family":"Syamsunarno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,1,3]]},"reference":[{"key":"4313_CR1","doi-asserted-by":"publisher","first-page":"6268276","DOI":"10.1155\/2018\/6268276","volume":"2018","author":"J Mayrink","year":"2018","unstructured":"Mayrink J, Costa M, Cecatti J. 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The ethical approval number was KE\/FK\/1189\/EC\/2020.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Due to personal subject data, all subjects who participated signed informed consent forms after receiving detailed information concerning the purpose of the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"We declared no conflict of interest associated with this publication, and there has been no significant financial support for this work that could have influenced its outcome.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"8"}}