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To better understand this issue, a study was conducted to identify the factors contributing to neonatal jaundice among newborns admitted to Dessie and Woldia comprehensive specialized hospitals in northeast Ethiopia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The study took place from April 1 to May 30, 2022, using unmatched case-control design. A total of 320 neonates paired with their mothers were involved, including 64 cases and 256 controls. Data were collected through a structured interviewer-administered questionnaire and a review of medical records. The collected data were analyzed using SPSS Version 23, and a multivariate logistic regression model was employed to understand the relationship between independent factors and the occurrence of neonatal jaundice. Statistical significance was determined at a threshold of\n                      <jats:italic>P<\/jats:italic>\n                      \u2009value less than 0.05.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The study findings revealed that maternal age over 35 years, residing in urban areas [adjusted odds ratio (AOR)\u2009=\u20092.4, 95% confidence interval (CI): 1.23, 4.82], male gender (AOR\u2009=\u20094.3, 95% CI: 1.90, 9.74), prematurity (AOR\u2009=\u20093.9, 95% CI: 1.88, 8.09), and ABO incompatibility (AOR\u2009=\u20092.6, 95% CI: 1.16, 5.96) were significant determinants of neonatal jaundice. Conversely, the study indicated that cesarean birth was associated with a 76% lower likelihood of infant jaundice compared to vaginal delivery (AOR\u2009=\u20090.24, 95% CI: 0.08, 0.72).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>To prevent, diagnose, and treat neonatal jaundice effectively, efforts should primarily focus on managing ABO incompatibility and early detection of prematurity. Additionally, special attention should be given to neonates born through vaginal delivery, those with mothers over 35 years old, and those residing in urban areas, as they are at higher risk of developing newborn jaundice. Close monitoring of high-risk mother-infant pairs during the antenatal and postnatal periods, along with early intervention, is crucial for reducing the severity of neonatal jaundice in this study setting.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12884-024-06352-y","type":"journal-article","created":{"date-parts":[[2024,2,21]],"date-time":"2024-02-21T03:03:09Z","timestamp":1708484589000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Factors associated with neonatal jaundice among neonates admitted at referral hospitals in northeast Ethiopia: a facility-based unmatched case-control study"],"prefix":"10.1186","volume":"24","author":[{"given":"Tsedale","family":"Ayalew","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asressie","family":"Molla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bereket","family":"Kefale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tilahun Dessie","family":"Alene","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gebremeskel Kibret","family":"Abebe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Habtamu Setegn","family":"Ngusie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alemu Birara","family":"Zemariam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,2,21]]},"reference":[{"issue":"8","key":"6352_CR1","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1016\/j.mpsur.2020.06.008","volume":"38","author":"RR Ravindran","year":"2020","unstructured":"Ravindran RR. 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Verbal informed consent was obtained from each mother\/caregiver or legal guardians of the child after they were informed of the objective and benefits of the study. Due to the time to survey and the illiteracy level, it was deemed non-viable to obtain written consent from each participant\u2019s mother or caregiver or legal guardians, and the ethical review board of the College of Medicine and Health Science, Wollo University approved this procedure. To keep the confidentiality of information provided by the study subjects, the data collection procedure was anonymous. Likewise, this study was conducted by the standard Declaration of Helsinki.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"150"}}