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Faecal samples were collected and sequenced using 16S rRNA gene sequencing to analyse the microbial composition.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>(1) Pregnant patients exhibited an increase in the abundance of <jats:italic>Streptococcus<\/jats:italic> (P<jats:sub>normal<\/jats:sub>\u2009=\u20090.01286, P<jats:sub>GD<\/jats:sub>\u2009=\u20090.002965) and <jats:italic>Blautia<\/jats:italic> (P<jats:sub>normal<\/jats:sub>\u2009=\u20090.0003924, P<jats:sub>GD<\/jats:sub>\u2009=\u20090.000246) but a decrease in the abundance of <jats:italic>Roseburia<\/jats:italic> (P<jats:sub>normal<\/jats:sub>\u2009=\u20090.0361, P<jats:sub>GD<\/jats:sub>\u2009=\u20090.007075), <jats:italic>Phascolarctobacterium<\/jats:italic> (P<jats:sub>normal<\/jats:sub>\u2009=\u20090.0003906, P<jats:sub>GD<\/jats:sub>\u2009=\u20090.02499) and <jats:italic>Lachnoclostridium<\/jats:italic> (P<jats:sub>normal<\/jats:sub>\u2009=\u20090.0003906, P<jats:sub>GD<\/jats:sub>\u2009=\u20090.03866). (2) Compared with healthy pregnant women, GD patients had an excessive increase in <jats:italic>Streptococcus<\/jats:italic> abundance and decrease in <jats:italic>Roseburia<\/jats:italic> abundance. The increase in <jats:italic>Blautia<\/jats:italic> abundance and the decrease in <jats:italic>Phascolarctobacterium<\/jats:italic> and <jats:italic>Lachnoclostridium<\/jats:italic> abundance in GD patients were less than those in healthy pregnant women. (3) The abundance of <jats:italic>Faecalibacterium prausnitzii<\/jats:italic> decreased significantly in GD patients (P<jats:sub>GD<\/jats:sub>\u2009=\u20090.02985) but not in healthy pregnant patients (P<jats:sub>normal<\/jats:sub>\u2009=\u20090.1643).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Abnormal increases and decreases in the abundances of gut microbiota components, especially <jats:italic>Faecalibacterium prausnitzii<\/jats:italic>, were observed in GD patients.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Trial registration<\/jats:title>\n                <jats:p>The cross-sectional research was conducted in accordance with the Declaration of Helsinki, and approved by Sir Run Run Shaw Hospital Clinical Trials and Biomedical Ethics Committee. 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