{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T16:15:44Z","timestamp":1759335344116},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,4,20]],"date-time":"2024-04-20T00:00:00Z","timestamp":1713571200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,4,20]],"date-time":"2024-04-20T00:00:00Z","timestamp":1713571200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"National High Level Hospital Clinical Research Funding","award":["2022-PUMCH-A-263"],"award-info":[{"award-number":["2022-PUMCH-A-263"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Pregnancy Childbirth"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Vitamin D deficiency is common in pregnancy, however, its effects has not been fully elucidated. Here, we conducted targeted metabolomics profiling to study the relationship.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>This study enrolled 111 pregnant women, including sufficient group (<jats:italic>n<\/jats:italic>\u2009=\u20099), inadequate group (<jats:italic>n<\/jats:italic>\u2009=\u200949) and deficient group (<jats:italic>n<\/jats:italic>\u2009=\u200953). Ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS\/MS)-based targeted metabonomics were used to characterize metabolite profiles associated with vitamin D deficiency in pregnancy.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Many metabolites decreased in the inadequate and deficient group, including lipids, amino acids and others. The lipid species included fatty acyls (FA 14:3, FA 26:0; O), glycerolipids (MG 18:2), glycerophospholipids (LPG 20:5, PE-Cer 40:1; O2, PG 29:0), sterol lipids (CE 20:5, ST 28:0; O4, ST 28:1; O4). Decreased amino acids included aromatic amino acids (tryptophan, phenylalanine, tyrosine) and branched-chain amino acids (valine, isoleucine, leucine), proline, methionine, arginine, lysine, alanine, L-kynurenine,5-hydroxy-L-tryptophan, allysine.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>This targeted metabolomics profiling indicated that vitamin D supplementation can significantly affect lipids and amino acids metabolism in pregnancy.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12884-024-06454-7","type":"journal-article","created":{"date-parts":[[2024,4,20]],"date-time":"2024-04-20T07:02:08Z","timestamp":1713596528000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Targeted metabolomics profiling in pregnancy associated with vitamin D deficiency"],"prefix":"10.1186","volume":"24","author":[{"given":"Xiaogang","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhuoling","family":"An","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aimin","family":"Yao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suhan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Songlin","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liangkun","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanping","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,4,20]]},"reference":[{"key":"6454_CR1","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1530\/EJE-11-0984","volume":"166","author":"E Lerchbaum","year":"2012","unstructured":"Lerchbaum E, Obermayer-Pietsch B. Vitamin D and fertility:a systematic review. Eur J Endocrinol. 2012;166:765\u201378.","journal-title":"Eur J Endocrinol"},{"issue":"8","key":"6454_CR2","doi-asserted-by":"publisher","first-page":"1649","DOI":"10.3390\/nu14081649","volume":"14","author":"S V\u00e1rb\u00edr\u00f3","year":"2022","unstructured":"V\u00e1rb\u00edr\u00f3 S, Tak\u00e1cs I, T\u0171\u0171 L, Nas K, Sziva RE, Hetth\u00e9ssy JR, T\u00f6r\u00f6k M. Effects of vitamin D on fertility, pregnancy and polycystic ovary Syndrome-A review. Nutrients. 2022;14(8):1649.","journal-title":"Nutrients"},{"key":"6454_CR3","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1016\/j.fertnstert.2017.05.037","volume":"108","author":"JL Fung","year":"2017","unstructured":"Fung JL, Hartman TJ, Schleicher RL, Goldman MB. Association of Vitamin D intake and serum levels with fertility: results from the Lifestyle and Fertility Study. Fertil Steril. 2017;108:302\u201311.","journal-title":"Fertil Steril"},{"key":"6454_CR4","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1016\/j.fertnstert.2013.10.008","volume":"101","author":"BJ Rudick","year":"2014","unstructured":"Rudick BJ, Ingles SA, Chung K, Stanczyk FZ, Paulson RJ, Bendikson KA. Influence of vitamin D levels on in vitro fertilization outcomes in donor-recipient cycles. Fertil Steril. 2014;101:447\u201352.","journal-title":"Fertil Steril"},{"key":"6454_CR5","first-page":"361","volume":"13","author":"L Farzadi","year":"2015","unstructured":"Farzadi L, Khayatzadeh Bidgoli H, Ghojazadeh M, Bahrami Z, Fattahi A, Latifi Z, Shahnazi V, Nouri M. Correlation between follicular fluid 25-OH vitamin D and assisted reproductive outcomes. 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The Ethics Committee of Peking Union Medical College Hospital approved the current research (Approval number: HS-1646;\u00a0ZS-1997;\u00a0ChiCTR 1900024080). All subjects provided a written informed consent form before inclusion and were requested to adhere to issued study restrictions.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"295"}}