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The research comprised univariable and multivariable MR analyses, with a prime focus on individual and combined effects of lipid-related traits. Statistical techniques included the fixed-effect inverse variance weighted (IVW) method and supplementary methods such as MR-Egger for comprehensive assessment.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Our findings revealed the following significant associations: apoA-I and HDL cholesterol were inversely correlated with GDM risk, while triglycerides showed a positive correlation. In multivariable analysis, apoA-I consistently exhibited a strong causal link with GDM, even after adjusting for other lipids and Body Mass Index (BMI).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>The study demonstrates a significant causal relationship between apoA-I and GDM risk.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12884-024-06556-2","type":"journal-article","created":{"date-parts":[[2024,5,6]],"date-time":"2024-05-06T11:02:19Z","timestamp":1714993339000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Lipids, apolipoproteins and gestational diabetes mellitus: a Mendelian randomization study"],"prefix":"10.1186","volume":"24","author":[{"given":"Dan","family":"Shan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,5,6]]},"reference":[{"issue":"11","key":"6556_CR1","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1016\/j.tem.2018.09.004","volume":"29","author":"EC Johns","year":"2018","unstructured":"Johns EC, Denison FC, Norman JE, Reynolds RM. 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