{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T05:32:00Z","timestamp":1791955920589,"version":"4.3.4"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T00:00:00Z","timestamp":1721174400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T00:00:00Z","timestamp":1721174400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Guangzhou fundamental research project jointly funded by School (Institution","award":["202102010131"],"award-info":[{"award-number":["202102010131"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Pregnancy Childbirth"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Hypercalcemia can be a rare contributor to acute pancreatitis (AP) in pregnancy. This is primarily due to primary hyperparathyroidism (PHPT), resulting from parathyroid carcinoma. We exhibited a case report to analyze the diagnosis and treatment during the onset of hypercalcemia-induced AP.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>A 32-year-old primigravida presented with acute pancreatitis near full-term gestation. Following a cesarean delivery, there was a reduction in serum amylase and peripancreatic exudate, but her serum calcium concentrations persistently elevated over 4.0 mmol\/L. Interventions to lower the hypercalcemia were only temporarily effective, until a high serum parathyroid hormone (PTH) concentration of 1404 pg\/mL was detected. Ultrasound revealed a 31\u00a0mm \u00d7 24\u00a0mm hypoechoic oval nodule in the left lower lobe of the thyroid gland. She underwent a parathyroidectomy, resulting in a dramatic decrease in serum PTH level, from preoperative levels of 2051 pg\/mL to 299 pg\/mL just 20 minutes after removal. Similarly, her serum calcium declined from 3.82 mmol\/L to 1.73 mmol\/L within 24 hours postoperatively. The final histopathology suggested parathyroid carcinoma.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>When refractory hypercalcemia is present, serum PTH levels should be measured to determine PHPT. Parathyroidectomy is the optimal strategy for alleviating hypercalcemia and clarifying the underlying pathology.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12884-024-06636-3","type":"journal-article","created":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T05:02:10Z","timestamp":1721192530000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Acute pancreatitis and refractory hypercalcemia in the third trimester caused by parathyroid carcinoma"],"prefix":"10.1186","volume":"24","author":[{"given":"Qingwen","family":"Nie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunlin","family":"Ouyang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,7,17]]},"reference":[{"key":"6636_CR1","doi-asserted-by":"crossref","unstructured":"M\u0105dro A. Pancreatitis in pregnancy-comprehensive Review[J]. Int J Environ Res Public Health,2022,19(23).","DOI":"10.3390\/ijerph192316179"},{"issue":"2","key":"6636_CR2","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1111\/j.1445-2197.1998.tb04719.x","volume":"68","author":"B Carnaille","year":"1998","unstructured":"Carnaille B, Oudar C, Pattou F, Combemale F, Rocha J, Proye C. Pancreatitis and primary hyperparathyroidism: forty cases[J]. Aust N Z J Surg. 1998;68(2):117\u20139.","journal-title":"Aust N Z J Surg"},{"issue":"8","key":"6636_CR3","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1097\/MCG.0b013e31825c446c","volume":"46","author":"HX Bai","year":"2012","unstructured":"Bai HX, Giefer M, Patel M, Orabi AI, Husain SZ. The association of primary hyperparathyroidism with pancreatitis[J]. J Clin Gastroenterol. 2012;46(8):656\u201361.","journal-title":"J Clin Gastroenterol"},{"key":"6636_CR4","doi-asserted-by":"crossref","unstructured":"Dandurand K, Ali DS, Khan AA. Hypercalcemia in Pregnancy[J]. Endocrinol Metab Clin North Am 2021,50(4):753\u201368.","DOI":"10.1016\/j.ecl.2021.07.009"},{"issue":"2","key":"6636_CR5","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/S0002-9343(97)00270-2","volume":"104","author":"RA Wermers","year":"1998","unstructured":"Wermers RA, Khosla S, Atkinson EJ, Grant CS, Hodgson SF, O\u2019Fallon WM, et al. Survival after the diagnosis of hyperparathyroidism: a population-based study[J]. Am J Med. 1998;104(2):115\u201322.","journal-title":"Am J Med"},{"issue":"8","key":"6636_CR6","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1002\/hed.20049","volume":"26","author":"NL Busaidy","year":"2004","unstructured":"Busaidy NL, Jimenez C, Habra MA, Schultz PN, El-Naggar AK, Clayman GL, et al. Parathyroid carcinoma: a 22-year experience[J]. Head Neck. 2004;26(8):716\u201326.","journal-title":"Head Neck"},{"key":"6636_CR7","doi-asserted-by":"crossref","unstructured":"Haiyan Z, Na P, Jialin H, Qingjian L, Jianying B, Xiumei B. Acute pancreatitis in pregnancy: a ten-year noninterventional, retrospective cohort Experience[J]. Gastroenterol Res Pract,2022,2022:3663079.","DOI":"10.1155\/2022\/3663079"},{"key":"6636_CR8","doi-asserted-by":"crossref","unstructured":"Misgar RA, Bhat MH, Rather TA, Masoodi SR, Wani AI, Bashir MI et al. Primary hyperparathyroidism and pancreatitis[J]. J Endocrinol Invest 2020,43(10):1493\u20138.","DOI":"10.1007\/s40618-020-01233-5"},{"key":"6636_CR9","doi-asserted-by":"crossref","unstructured":"Devgan Y, Mayilvaganan S, Mishra A, Chand G, Agarwal G, Mohindra S et al. PHPT with pancreatitis: atypical presentation of PHPT[J]. Indian J Endocrinol Metab 2023,27(6):513\u20138.","DOI":"10.4103\/ijem.ijem_169_23"},{"key":"6636_CR10","doi-asserted-by":"crossref","unstructured":"Zhou Y, Wang Q, Zou L, Wu X, Yang A. Parathyroid carcinoma-related severe acute pancreatitis during pregnancy: a case report and literature review[J]. Gastroenterol Rep (Oxf),2023,11:c87.","DOI":"10.1093\/gastro\/goac087"},{"issue":"25","key":"6636_CR11","doi-asserted-by":"publisher","first-page":"1863","DOI":"10.1056\/NEJM200012213432508","volume":"343","author":"SJ Marx","year":"2000","unstructured":"Marx SJ. Hyperparathyroid and hypoparathyroid disorders[J]. N Engl J Med. 2000;343(25):1863\u201375.","journal-title":"N Engl J Med"},{"key":"6636_CR12","doi-asserted-by":"crossref","unstructured":"Toyoda M, Suganuma N, Takahashi A, Masuda T, Goda M, Yoshida T et al. Parathyroid carcinoma with pancreatitis causing hypercalcaemic emergency treated with extracorporeal membrane oxygenation-assisted parathyroid resection[J]. Endocrinol Diabetes Metab Case Rep,2023,2023(1).","DOI":"10.1530\/EDM-22-0323"},{"key":"6636_CR13","doi-asserted-by":"crossref","unstructured":"Zelano L, Locantore P, Rota CA, Policola C, Corsello A, Rossi ED et al. Parathyroid carcinoma All-In-One, a Rare Life-threatening case with multiple systemic manifestations: Case Report and Review of the Literature[J]. Front Endocrinol (Lausanne),2022,13:881225.","DOI":"10.3389\/fendo.2022.881225"},{"key":"6636_CR14","unstructured":"Mignini I, Pizzoferrato M, Larosa L, Gasbarrini A, Rapaccini GL, Armuzzi A. Acute pancreatitis and parathyroid carcinoma: a case report and literature review[J]. Eur Rev Med Pharmacol Sci 2021,25(19):5972\u20137."},{"key":"6636_CR15","doi-asserted-by":"crossref","unstructured":"Imam Z, Hanna A, Jomaa D, Khasawneh M, Abonofal A, Murad MH. Hypercalcemia Malignancy Acute Pancreatitis[J] Pancreas 2021,50(2):206\u201313.","DOI":"10.1097\/MPA.0000000000001741"},{"key":"6636_CR16","doi-asserted-by":"crossref","unstructured":"Jiajue R, Song A, Wang O, Li W. Persistent Hypercalcemia Crisis and recurrent Acute Pancreatitis due to multiple ectopic parathyroid carcinomas: Case Report and Literature Review of Mediastinal parathyroid Carcinoma[J]. Front Endocrinol (Lausanne),2020,11:647.","DOI":"10.3389\/fendo.2020.00647"},{"key":"6636_CR17","doi-asserted-by":"crossref","unstructured":"Givi B, Shah JP. Parathyroid carcinoma[J]. Clin Oncol (R Coll Radiol),2010,22(6):498\u2013507.","DOI":"10.1016\/j.clon.2010.04.007"},{"key":"6636_CR18","doi-asserted-by":"crossref","unstructured":"Erickson LA, Mete O, Juhlin CC, Perren A, Gill AJ. Overview of the 2022 WHO classification of parathyroid Tumors[J]. Endocr Pathol 2022,33(1):64\u201389.","DOI":"10.1007\/s12022-022-09709-1"},{"issue":"5","key":"6636_CR19","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1016\/j.amjsurg.2010.09.025","volume":"202","author":"M Schaapveld","year":"2011","unstructured":"Schaapveld M, Jorna FH, Aben KK, Haak HR, Plukker JT, Links TP. Incidence and prognosis of parathyroid gland carcinoma: a population-based study in the Netherlands estimating the preoperative diagnosis[J]. Am J Surg. 2011;202(5):590\u20137.","journal-title":"Am J Surg"},{"key":"6636_CR20","doi-asserted-by":"crossref","unstructured":"Sabbah N, Demar M, Sogbo F, Zappa M, Alsibai KD, Amroun H et al. Recurrent vomiting and confusion in pregnancy: hypercalcaemia due to parathyroid adenoma[J]. Lancet 2023,402(10395):62\u20133.","DOI":"10.1016\/S0140-6736(23)01050-4"},{"key":"6636_CR21","doi-asserted-by":"crossref","unstructured":"Kong SH, Kim JH, Park MY, Kim SW, Shin CS. Epidemiology and prognosis of parathyroid carcinoma: real-world data using nationwide cohort[J]. J Cancer Res Clin Oncol 2021,147(10):3091\u20137.","DOI":"10.1007\/s00432-021-03576-9"},{"key":"6636_CR22","doi-asserted-by":"crossref","unstructured":"Harari A, Waring A, Fernandez-Ranvier G, Hwang J, Suh I, Mitmaker E et al. Parathyroid carcinoma: a 43-year outcome and survival analysis[J]. J Clin Endocrinol Metab 2011,96(12):3679\u201386.","DOI":"10.1210\/jc.2011-1571"},{"key":"6636_CR23","doi-asserted-by":"crossref","unstructured":"Wynne AG, van Heerden J, Carney JA, Fitzpatrick LA. Parathyroid carcinoma: clinical and pathologic features in 43 patients[J]. Med (Baltimore) 1992,71(4):197\u2013205.","DOI":"10.1097\/00005792-199207000-00002"}],"container-title":["BMC Pregnancy and Childbirth"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12884-024-06636-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12884-024-06636-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12884-024-06636-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T05:03:30Z","timestamp":1721192610000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcpregnancychildbirth.biomedcentral.com\/articles\/10.1186\/s12884-024-06636-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,17]]},"references-count":23,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["6636"],"URL":"https:\/\/doi.org\/10.1186\/s12884-024-06636-3","relation":{},"ISSN":["1471-2393"],"issn-type":[{"value":"1471-2393","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,17]]},"assertion":[{"value":"7 April 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 June 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 July 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent for publication was obtained from the patient.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"483"}}