{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T08:24:19Z","timestamp":1765355059234},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T00:00:00Z","timestamp":1725321600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T00:00:00Z","timestamp":1725321600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Wenzhou Key Laboratory of Precision General Practice and Health Management"},{"name":"the Obstetrics and gynecology of combine traditional Chinese and Western medicine of Zhejiang Province","award":["2017-XK-A42"],"award-info":[{"award-number":["2017-XK-A42"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Pregnancy Childbirth"],"DOI":"10.1186\/s12884-024-06793-5","type":"journal-article","created":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T08:02:23Z","timestamp":1725350543000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Association of phthalates exposure and sex steroid hormones with late-onset preeclampsia: a case-control study"],"prefix":"10.1186","volume":"24","author":[{"given":"Xiaomin","family":"Zhao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anjian","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinyue","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baoyi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Hua","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanyan","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,9,3]]},"reference":[{"key":"6793_CR1","first-page":"e1","volume":"1","author":"ACOG","year":"2019","unstructured":"ACOG. ACOG practice bulletin 202: gestational hypertension and preeclampsia. Obstet Gynecol. 2019;1:e1\u201325.","journal-title":"Obstet Gynecol"},{"issue":"1","key":"6793_CR2","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1186\/s12958-020-0569-5","volume":"18","author":"K-C Lan","year":"2020","unstructured":"Lan K-C, Lai Y-J, Cheng H-H, et al. Levels of sex steroid hormones and their receptors in women with preeclampsia. Reprod Biol Endocrinol. 2020;18(1):12.","journal-title":"Reprod Biol Endocrinol"},{"issue":"11","key":"6793_CR3","doi-asserted-by":"publisher","first-page":"1389","DOI":"10.1111\/1471-0528.15042","volume":"125","author":"AS Cerdeira","year":"2018","unstructured":"Cerdeira AS, Agrawal S, Staff AC, et al. Angiogenic factors: potential to change clinical practice in preeclampsia? BJOG. 2018;125(11):1389\u201395.","journal-title":"BJOG"},{"key":"6793_CR4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.reprotox.2021.05.001","volume":"103","author":"R Genoa","year":"2021","unstructured":"Genoa R, Warner, Raquel S, Dettogni, Indrani C, Bagchi, et al. Placental outcomes of phthalate exposure. Reprod Toxicol. 2021;103:1\u201317.","journal-title":"Reprod Toxicol"},{"key":"6793_CR5","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.envres.2019.02.001","volume":"172","author":"J Park","year":"2019","unstructured":"Park J, Park C, Gye MC, et al. Assessment of endocrine-disrupting activities of alternative chemicals for bis (2-ethylhexyl) phthalate. Environ Res. 2019;172:10\u20137.","journal-title":"Environ Res"},{"issue":"8","key":"6793_CR6","doi-asserted-by":"publisher","first-page":"e0135601","DOI":"10.1371\/journal.pone.0135601","volume":"10","author":"KK Ferguson","year":"2015","unstructured":"Ferguson KK, McElrath TF, Mukherjee B, et al. Associations between maternal biomarkers of phthalate exposure and inflammation using repeated measurements across pregnancy. PLoS ONE. 2015;10(8):e0135601.","journal-title":"PLoS ONE"},{"issue":"10","key":"6793_CR7","doi-asserted-by":"publisher","first-page":"1651","DOI":"10.1289\/EHP188","volume":"124","author":"DE Cantonwine","year":"2016","unstructured":"Cantonwine DE, Meeker JD, Ferg uson KK, et al. Urinary concentrations of bisphenol A and phthalate metabolites measured during pregnancy and risk of preeclampsia. Environ Health Perspect. 2016;124(10):1651\u20135.","journal-title":"Environ Health Perspect"},{"issue":"20","key":"6793_CR8","doi-asserted-by":"publisher","first-page":"10627","DOI":"10.3390\/ijerph182010627","volume":"18","author":"SM Bedell","year":"2021","unstructured":"Bedell SM, Lyden GR, Sathyanarayana S, et al. First- and third-trimester urinary phthalate metabolites in the development of Hypertensive diseases of pregnancy. Int J Environ Res Public Health. 2021;18(20):10627.","journal-title":"Int J Environ Res Public Health"},{"issue":"1","key":"6793_CR9","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1515\/hmbci-2016-0038","volume":"27","author":"GCD Renzo","year":"2016","unstructured":"Renzo GCD, Giardina I, Clerici G, Brillo E. Sandro Gerli. Progesterone in normal and pathological pregnancy. Horm Mol Biol Clin Investig. 2016;27(1):35\u201348.","journal-title":"Horm Mol Biol Clin Investig"},{"key":"6793_CR10","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.preghy.2017.12.003","volume":"11","author":"Z Jiayi Wana","year":"2018","unstructured":"Jiayi Wana Z, Hub K, Zenga, et al. The reduction in circulating levels of estrogen and progesterone in women with preeclampsia. Pregnancy Hypertens. 2018;11:18\u201325.","journal-title":"Pregnancy Hypertens"},{"issue":"5","key":"6793_CR11","first-page":"2943","volume":"41","author":"MEE-NA PARK","year":"2018","unstructured":"MEE-NA PARK, KYUNG-HEE PARK, JAE-EON LEE, et al. The expression and activation of sex steroid receptors in the preeclamptic placenta. Int J Mol Med. 2018;41(5):2943\u201351.","journal-title":"Int J Mol Med"},{"key":"6793_CR12","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1016\/j.envint.2018.12.021","volume":"123","author":"RM Shaffer","year":"2019","unstructured":"Shaffer RM, Ferguson KK, Sheppard L, et al. Maternal urinary phthalate metabolites in relation to gestational diabetes and glucose intolerance during pregnancy. Environ Int. 2019;123:588\u201396.","journal-title":"Environ Int"},{"key":"6793_CR13","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.reprotox.2017.10.001","volume":"75","author":"M Yujing Huang, Jose","year":"2018","unstructured":"Yujing Huang, Jose M, Garcia W, Shu, et al. Peroxisome proliferator activated receptor gamma in human placenta may mediate the adverse effects of phthalates exposure in pregnancy. Reprod Toxicol. 2018;75:121\u20136.","journal-title":"Reprod Toxicol"},{"issue":"1","key":"6793_CR14","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1186\/s12940-015-0062-3","volume":"14","author":"EF Werner","year":"2015","unstructured":"Werner EF, Braun JM, Yolton K, et al. The association between maternal urinary phthalate concentrations and blood pressure in pregnancy: the HOME Study. Environ Health. 2015;14(1):75.","journal-title":"Environ Health"},{"issue":"2","key":"6793_CR15","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1093\/humrep\/dey364","volume":"34","author":"EM Philips","year":"2019","unstructured":"Philips EM, Trasande L, Kahn LG, et al. Early pregnancy bisphenol and phthalate metabolite levels, maternal hemodynamics and gestational hypertensive disorders. Hum Reprod. 2019;34(2):365\u201373.","journal-title":"Hum Reprod"},{"key":"6793_CR16","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1016\/j.scitotenv.2018.06.112","volume":"642","author":"Y Zhang","year":"2018","unstructured":"Zhang Y, Huang B, Thomsen M, et al. One overlooked source of phthalate exposure - oral intake from vegetables produced in plastic greenhouses in China. Sci Total Environ. 2018;642:1127\u201335.","journal-title":"Sci Total Environ"},{"issue":"11","key":"6793_CR17","first-page":"739","volume":"40","author":"X Wang","year":"2005","unstructured":"Wang X, Xiong Q, Wang C, et al. Study of estradiol on treatment of preeclampsia in rat model. Zhonghua Fu Chan Ke Za Zhi. 2005;40(11):739\u201342.","journal-title":"Zhonghua Fu Chan Ke Za Zhi"},{"issue":"8","key":"6793_CR18","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1080\/09513590.2019.1706085","volume":"36","author":"V Tskhay","year":"2020","unstructured":"Tskhay V, Schindler A, Shestakova M, et al. The role of progestogen supplementation (dydrogesterone) in the prevention of preeclampsia. Gynecol Endocrinol. 2020;36(8):698\u2013701.","journal-title":"Gynecol Endocrinol"},{"issue":"1","key":"6793_CR19","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.rbmo.2015.10.005","volume":"32","author":"MA Costa","year":"2016","unstructured":"Costa MA. The endocrine function of human placenta: an overview. Reprod Biomed Online. 2016;32(1):14\u201343.","journal-title":"Reprod Biomed Online"},{"key":"6793_CR20","doi-asserted-by":"crossref","unstructured":"Schumacher A, Dauven D, Zenclussen AC. Progesterone-driven local regulatory T cell induction does not prevent fetal loss in the CBA\/JxDBA\/2J abortion-prone model. Am J Reprod Immunol, 2017. 77(3).","DOI":"10.1111\/aji.12626"},{"key":"6793_CR21","doi-asserted-by":"crossref","unstructured":"Furcron A-E, Romero R, Plazyo O et al. Vaginal progesterone, but not 17alpha-hydroxyprogesterone caproate, has antiinflammatory effects at the murine maternal-fetal interface. Am J Obstet Gynecol, 2015.213(6): p. 846 e1\u2013846 e19.","DOI":"10.1016\/j.ajog.2015.08.010"},{"key":"6793_CR22","doi-asserted-by":"publisher","first-page":"106254","DOI":"10.1016\/j.jsbmb.2023.106254","volume":"May","author":"D Kenichiro Motomura","year":"2023","unstructured":"Kenichiro Motomura D, Miller J, Galaz, et al. The effects of progesterone on immune cellular function at the maternal-fetal interface and in maternal circulation. J Steroid Biochem Mol Biol. 2023;May:229:106254.","journal-title":"J Steroid Biochem Mol Biol"},{"key":"6793_CR23","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.jri.2013.06.002","volume":"101\u2013102","author":"S Saito","year":"2014","unstructured":"Saito S, Nakashima A. A review of the mechanism for poor placentation in earlyonset preeclampsia: the role of autophagy in trophoblast invasion and vascular remodeling. J Reprod Immunol. 2014;101\u2013102:80\u20138.","journal-title":"J Reprod Immunol"},{"issue":"12","key":"6793_CR24","doi-asserted-by":"publisher","first-page":"e0143190","DOI":"10.1371\/journal.pone.0143190","volume":"10","author":"N Nora Kl\u00f6ting","year":"2015","unstructured":"Nora Kl\u00f6ting N, Hesselbarth M, Gericke, et al. Di-(2-Ethylhexyl)-Phthalate (DEHP) causes impaired adipocyte function and alters serum metabolites. PLoS ONE. 2015;10(12):e0143190.","journal-title":"PLoS ONE"},{"key":"6793_CR25","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1016\/j.cbi.2011.12.008","volume":"195","author":"K Yuan","year":"2012","unstructured":"Yuan K, Zhao B, Li XW, et al. Effects of phthalates on 3beta-hydroxysteroid dehydrogenase and 17beta-hydroxysteroid dehydrogenase 3 activities in human and rat testes. Chem Biol Interact. 2012;195:180\u20138.","journal-title":"Chem Biol Interact"},{"key":"6793_CR26","doi-asserted-by":"crossref","unstructured":"Xu RA, Mao B, Li S et al. Structure-activity relationships of phthalates in inhibition of human placental 3beta-hydroxysteroid dehydrogenase 1 and aromatase. Reprod Toxicol 2016, 151\u201361.","DOI":"10.1016\/j.reprotox.2016.04.004"},{"key":"6793_CR27","doi-asserted-by":"crossref","unstructured":"Matsuda S, Kobayashi M, Kitagishi Y. Expression and function of PPARs in placenta. PPAR Res 2013:256508.","DOI":"10.1155\/2013\/256508"},{"issue":"8","key":"6793_CR28","doi-asserted-by":"publisher","first-page":"1558","DOI":"10.3390\/molecules24081558","volume":"24","author":"D-H Kim","year":"2019","unstructured":"Kim D-H, Park CG, Kim SH, et al. The effects of Mono-(2-Ethylhexyl) phthalate (MEHP) on human estrogen receptor (hER) and androgen receptor (hAR) by YES\/YAS in Vitro Assay. Molecules. 2019;24(8):1558.","journal-title":"Molecules"},{"key":"6793_CR29","doi-asserted-by":"publisher","first-page":"267","DOI":"10.2217\/epi.11.22","volume":"3","author":"JA Alegr\u00eda-Torres","year":"2011","unstructured":"Alegr\u00eda-Torres JA, Baccarelli A, Bollati V. Epigenetics and lifestyle. Epigenomics. 2011;3:267\u201377.","journal-title":"Epigenomics"},{"key":"6793_CR30","doi-asserted-by":"crossref","unstructured":"Machtinger R, Zhong J, Mansur A et al. Placental lncRNA expression is associated with prenatal phthalate exposure. Toxicol Sci 2018: 116\u201322.","DOI":"10.1093\/toxsci\/kfy013"},{"issue":"1","key":"6793_CR31","doi-asserted-by":"publisher","first-page":"6086","DOI":"10.1038\/s41598-018-24505-w","volume":"8","author":"NM Grindler","year":"2018","unstructured":"Grindler NM, Vanderlinden L, Karthikraj R, et al. Exposure to Phthalate, an endocrine disrupting Chemical, alters the first trimester placental methylome and transcriptome in women. Sci Rep. 2018;8(1):6086.","journal-title":"Sci Rep"}],"container-title":["BMC Pregnancy and Childbirth"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12884-024-06793-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12884-024-06793-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12884-024-06793-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T08:05:31Z","timestamp":1725350731000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcpregnancychildbirth.biomedcentral.com\/articles\/10.1186\/s12884-024-06793-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,3]]},"references-count":31,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["6793"],"URL":"https:\/\/doi.org\/10.1186\/s12884-024-06793-5","relation":{},"ISSN":["1471-2393"],"issn-type":[{"value":"1471-2393","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,3]]},"assertion":[{"value":"15 June 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 August 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 September 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the Research Ethics Committee of the Second Affiliated Hospital of Wenzhou Medical University (NO. LCKY2019-288). Informed consent was obtained from all the participants.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"We ensured our manuscript reporting adhered to CONSORT guidelines.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Statement"}}],"article-number":"577"}}