{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T20:00:08Z","timestamp":1779307208107,"version":"3.51.4"},"reference-count":8,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,11,25]],"date-time":"2024-11-25T00:00:00Z","timestamp":1732492800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,11,25]],"date-time":"2024-11-25T00:00:00Z","timestamp":1732492800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Pregnancy Childbirth"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Placental mesenchymal dysplasia (PMD) is a rare, benign, placental disorder characterised macroscopically by an enlarged multi-cystic placenta. It is a condition associated with a range of reported clinical outcomes and can be misdiagnosed as a molar or partial molar pregnancy given the similarities in clinical presentation. We present an unusual case of PMD complicated by fetal growth restriction and oligohydramnios in the second trimester.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>A 33 year old female was referred to our fetal medicine unit with a multi-cystic placenta at dating scan suspected initially to be a partial molar pregnancy. She opted for conservative management and declined invasive testing. At 16 weeks severe fetal growth restriction was present with an estimated fetal weight\u2009&lt;\u20093rd centile and associated with oligohydramnios. Whilst live births in cases of PMD have been reported in the literature, to our knowledge there are no reported successful outcomes in cases of early onset growth restriction at this gestation. The patient opted to proceed with termination of pregnancy given the suspected poor prognosis. Post mortem results confirmed a diagnosis of PMD and fetal growth restriction with normal genetic testing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Placental mesenchymal dysplasia can be a difficult condition to manage, particularly when counselling about prognosis and deciding whether to continue the pregnancy. More evidence is needed about prognostic factors in PMD associated with a successful outcome. Early onset fetal growth restriction and\/or oligohydramnios prior to 20 weeks are likely poor prognostic factors which should be considered in the antenatal counselling.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12884-024-06960-8","type":"journal-article","created":{"date-parts":[[2024,11,25]],"date-time":"2024-11-25T03:02:09Z","timestamp":1732503729000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Placental mesenchymal dysplasia: a rare case associated with second trimester fetal growth restriction"],"prefix":"10.1186","volume":"24","author":[{"given":"Thomas","family":"Chadwick","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Davis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wafa","family":"Bitar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susmita","family":"Pankaja","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,11,25]]},"reference":[{"issue":"2\u20133","key":"6960_CR1","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1016\/S0344-0338(11)80791-0","volume":"187","author":"G Moscoso","year":"1991","unstructured":"Moscoso G, Jauniaux E, Hustin J. Placental vascular anomaly with diffuse mesenchymal Stei Villuos Hyperplasia. Pathol Res Pract. 1991;187(2\u20133):324\u20138.","journal-title":"Pathol Res Pract"},{"issue":"6","key":"6960_CR2","doi-asserted-by":"publisher","first-page":"e3","DOI":"10.1016\/j.ajog.2011.08.019","volume":"205","author":"GW Woo","year":"2011","unstructured":"Woo GW, Rocha FG, Gaspar-Oishi M, Bartholomew ML, Thompson KS. Placental mesenchymal dysplasia. Am J Obstet Gynecol. 2011;205(6):e3\u20135.","journal-title":"Am J Obstet Gynecol"},{"issue":"4","key":"6960_CR3","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1002\/uog.12359","volume":"41","author":"UA Nayeri","year":"2013","unstructured":"Nayeri UA, West AB, Grossetta Nardini HK, Copel JA, Sfakianaki AK. Systematic review of sonographic findings of placental mesenchymal dysplasia and subsequent pregnancy outcome. Ultrasound Obstet Gynecol. 2013;41(4):366\u201374.","journal-title":"Ultrasound Obstet Gynecol"},{"key":"6960_CR4","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.ejogrb.2019.01.014","volume":"234","author":"C Guenot","year":"2019","unstructured":"Guenot C, Kingdom J, De Rham M, Osterheld M, Keating S, Vial Y, et al. Placental mesenchymal dysplasia: an underdiagnosed placental pathology with various clinical outcomes. Eur J Obstet Gynecol Reproductive Biology. 2019;234:155\u201364.","journal-title":"Eur J Obstet Gynecol Reproductive Biology"},{"issue":"3","key":"6960_CR5","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1002\/uog.15930","volume":"49","author":"C Marusik","year":"2017","unstructured":"Marusik C, Frykholm C, Ericson K, Wikstr\u00f6m J, Axelsson O. Diagnosis of placental mesenchymal dysplasia with magnetic resonance imaging. Ultrasound Obstet Gynecol. 2017;49(3):410\u20132.","journal-title":"Ultrasound Obstet Gynecol"},{"issue":"01","key":"6960_CR6","doi-asserted-by":"publisher","first-page":"62","DOI":"10.4103\/0971-3026.202949","volume":"27","author":"D Mittal","year":"2017","unstructured":"Mittal D, Anand R, Sisodia N, Singh S, Biswas R. Placental mesenchymal dysplasia: what every radiologist needs to know. Indian J Radiol Imaging. 2017;27(01):62\u20134.","journal-title":"Indian J Radiol Imaging"},{"issue":"2","key":"6960_CR7","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1148\/radiology.140.2.7255725","volume":"140","author":"P Naumoff","year":"1981","unstructured":"Naumoff P, Szulman AE, Weinstein B, Mazer J, Surti U. Ultrasonography of partial hydatidiform mole. Radiology. 1981;140(2):467\u201370.","journal-title":"Radiology"},{"issue":"1","key":"6960_CR8","doi-asserted-by":"publisher","first-page":"131","DOI":"10.5858\/2007-131-131-PMD","volume":"131","author":"Z Parveen","year":"2007","unstructured":"Parveen Z, Tongson-Ignacio JE, Fraser CR, Killeen JL, Thompson KS. Placental mesenchymal dysplasia. Arch Pathol Lab Med. 2007;131(1):131\u20137.","journal-title":"Arch Pathol Lab Med"}],"container-title":["BMC Pregnancy and Childbirth"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12884-024-06960-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12884-024-06960-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12884-024-06960-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,25]],"date-time":"2024-11-25T03:02:38Z","timestamp":1732503758000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcpregnancychildbirth.biomedcentral.com\/articles\/10.1186\/s12884-024-06960-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,25]]},"references-count":8,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["6960"],"URL":"https:\/\/doi.org\/10.1186\/s12884-024-06960-8","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-4177683\/v1","asserted-by":"object"}]},"ISSN":["1471-2393"],"issn-type":[{"value":"1471-2393","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,25]]},"assertion":[{"value":"27 March 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 November 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 November 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Written informed consent was obtained from the patient for publication.Ethical approval is not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent for participation"}},{"value":"Written informed consent was obtained from the patient for publication.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"786"}}