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We aimed to search for new circulating angiogenic biomarkers for improvement.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>This case-control study compared 73 singleton pregnancies with early or late-onset FGR based on Delphi consensus and 73 matched normal controls. Their maternal serum samples stored during 11\u201313 weeks were retrieved for measurement of 36 angiogenic biomarkers by MILLIPLEX<jats:sup>\u00ae<\/jats:sup> human angiogenesis magnetic bead panels. Those biomarkers that showed significant differences between the study groups were further analysed with receiver operating characteristic (ROC) curve.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>In the early-onset FGR group, log<jats:sub>10<\/jats:sub>MoM of soluble neuropilin-1 (sNRP-1: 0.08\u2009\u00b1\u20090.11 vs. 0.00\u2009\u00b1\u20090.09, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) and log<jats:sub>10<\/jats:sub>MoM of soluble platelet and endothelial cell adhesion molecule 1 (sPECAM-1: 0.05\u2009\u00b1\u20090.06 vs. 0.00\u2009\u00b1\u20090.09, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) were significantly higher than the control group, while log<jats:sub>10<\/jats:sub>MoM of platelet-derived growth factor AB\/BB (PDGF-AB\/BB: -0.08\u2009\u00b1\u20090.13 vs. 0.00\u2009\u00b1\u20090.16, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) and PAPP-A (-0.15\u2009\u00b1\u20090.28 vs. 0.05\u2009\u00b1\u20090.23, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) were lower. Their combination achieved the highest area under the ROC curve (AUC) of 0.83 (95% CI: 0.74\u20130.95) with a higher sensitivity than that of PAPP-A alone (61.5% vs. 30.8% at 10% false positive rate, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Concerning the late-onset FGR group, only log<jats:sub>10<\/jats:sub>MoMs of sFlt-1 (-0.12 vs. 0.00, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) and PAPP-A (-0.07 vs. 0.05, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) were lower than the control group, but their AUC was only 0.68 (95% CI:0.59\u20130.78).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>Three new first trimester biomarkers, sNRP-1, sPECAM-1 and PDGF-AB\/BB are predictive of subsequent development of early-onset FGR.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/s12884-025-07558-4","type":"journal-article","created":{"date-parts":[[2025,5,10]],"date-time":"2025-05-10T11:08:02Z","timestamp":1746875282000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["New first trimester circulating angiogenic biomarkers in predicting early-onset and late-onset fetal growth restriction: a case-control study"],"prefix":"10.1186","volume":"25","author":[{"given":"Xiaoyi","family":"Bai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjing","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oi Ka","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maran Bo Wah","family":"Leung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"So Ling","family":"Lau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daljit Singh","family":"Sahota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi Chiu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tak Yeung","family":"Leung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,5,10]]},"reference":[{"issue":"6","key":"7558_CR1","first-page":"430","volume":"28","author":"GPG Fung","year":"2022","unstructured":"Fung GPG, Lau SL, Hui ASY, Wong STK, Tse WT, Ng PC, et al. 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Ultrasound Obstet Gynecol. 2024;63(3):331\u201341.","journal-title":"Ultrasound Obstet Gynecol"}],"container-title":["BMC Pregnancy and Childbirth"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12884-025-07558-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12884-025-07558-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12884-025-07558-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,10]],"date-time":"2025-05-10T11:08:05Z","timestamp":1746875285000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcpregnancychildbirth.biomedcentral.com\/articles\/10.1186\/s12884-025-07558-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,10]]},"references-count":43,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["7558"],"URL":"https:\/\/doi.org\/10.1186\/s12884-025-07558-4","relation":{},"ISSN":["1471-2393"],"issn-type":[{"value":"1471-2393","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,10]]},"assertion":[{"value":"6 February 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 April 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 May 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the Joint Chinese University of Hong Kong - New Territories East Cluster Clinical Research Ethics Committee (CREC reference No.2020.313) on July 20, 2020. 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