{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T17:07:55Z","timestamp":1788368875257,"version":"build-2803163510"},"reference-count":58,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T00:00:00Z","timestamp":1754438400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T00:00:00Z","timestamp":1754438400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Pregnancy Childbirth"],"DOI":"10.1186\/s12884-025-07930-4","type":"journal-article","created":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T09:13:17Z","timestamp":1754471597000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["FSP1 and CoQ10 have the potential to serve as biomarkers for severe preeclampsia"],"prefix":"10.1186","volume":"25","author":[{"given":"Peishan","family":"LI","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunyun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingli","family":"Rao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Shang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenghua","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,8,6]]},"reference":[{"issue":"1","key":"7930_CR1","doi-asserted-by":"publisher","first-page":"2934","DOI":"10.1038\/s41598-022-07065-y","volume":"12","author":"T Liao","year":"2022","unstructured":"Liao T, Xu X, Ye X, Yan J. DJ-1 upregulates the Nrf2\/GPX4 signal pathway to inhibit trophoblast ferroptosis in the pathogenesis of preeclampsia. Sci Rep. 2022;12(1):2934. https:\/\/doi.org\/10.1038\/s41598-022-07065-y. Published 2022 Feb 21.","journal-title":"Sci Rep"},{"issue":"10","key":"7930_CR2","doi-asserted-by":"publisher","first-page":"e47951","DOI":"10.7759\/cureus.47951","volume":"15","author":"FR Garrote","year":"2023","unstructured":"Garrote FR, Perez-Viloria ME, Caltagirone C, De La Cuesta C. The conservative management of an uncommon case of postpartum HELLP (hemolysis, elevated liver enzymes, and low platelet count) syndrome complicated by liver hematoma causing gastric outlet obstruction: a case report. Cureus. 2023;15(10):e47951. https:\/\/doi.org\/10.7759\/cureus.47951. Published 2023 Oct 30.","journal-title":"Cureus"},{"key":"7930_CR3","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/j.preghy.2022.01.006","volume":"27","author":"V Sethuraman","year":"2022","unstructured":"Sethuraman V, Pu Y, Gingrich J, et al. Expression of ABC transporters during syncytialization in preeclampsia. Pregnancy Hypertens. 2022;27:181\u20138. https:\/\/doi.org\/10.1016\/j.preghy.2022.01.006.","journal-title":"Pregnancy Hypertens"},{"issue":"10","key":"7930_CR4","doi-asserted-by":"publisher","first-page":"1532","DOI":"10.4239\/wjd.v14.i10.1532","volume":"14","author":"Y Wang","year":"2023","unstructured":"Wang Y, Song M, Qi BR. Effects of insulin Aspart and Metformin on gestational diabetes mellitus and inflammatory markers. World J Diabetes. 2023;14(10):1532\u201340. https:\/\/doi.org\/10.4239\/wjd.v14.i10.1532.","journal-title":"World J Diabetes"},{"issue":"5","key":"7930_CR5","doi-asserted-by":"publisher","first-page":"100901","DOI":"10.1016\/j.accpm.2021.100901","volume":"40","author":"MP Bonnet","year":"2021","unstructured":"Bonnet MP, Garnier M, Keita H, et al. Guidelines for the management of women with severe preeclampsia. Anaesth Crit Care Pain Med. 2021;40(5):100901. https:\/\/doi.org\/10.1016\/j.accpm.2021.100901.","journal-title":"Anaesth Crit Care Pain Med"},{"issue":"1","key":"7930_CR6","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-021-04082-z","volume":"21","author":"H Shao","year":"2021","unstructured":"Shao H, Gao S, Dai D, Zhao X, Hua Y, Yu H. The association of antenatal D-dimer and fibrinogen with postpartum hemorrhage and intrauterine growth restriction in preeclampsia. BMC Pregnancy Childbirth. 2021;21(1): 605. https:\/\/doi.org\/10.1186\/s12884-021-04082-z.","journal-title":"BMC Pregnancy Childbirth"},{"key":"7930_CR7","doi-asserted-by":"publisher","first-page":"102426","DOI":"10.1016\/j.bpobgyn.2023.102426","volume":"92","author":"T de Ganzo Su\u00e1rez","year":"2024","unstructured":"de Ganzo Su\u00e1rez T, de Paco Matallana C, Plasencia W. Spiral, uterine artery doppler and placental ultrasound in relation to preeclampsia. Best Pract Res Clin Obstet Gynaecol. 2024;92:102426. https:\/\/doi.org\/10.1016\/j.bpobgyn.2023.102426.","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"issue":"1","key":"7930_CR8","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1186\/s12884-022-04820-x","volume":"22","author":"J Zheng","year":"2022","unstructured":"Zheng J, Zhang L, Zhou Y, Xu L, Zhang Z, Luo Y. Development and evaluation of a nomogram for adverse outcomes of preeclampsia in Chinese pregnant women. BMC Pregnancy Childbirth. 2022;22(1):504. https:\/\/doi.org\/10.1186\/s12884-022-04820-x. Published 2022 Jun 20.","journal-title":"BMC Pregnancy Childbirth"},{"issue":"7","key":"7930_CR9","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1038\/s41419-023-05972-0","volume":"14","author":"Y Liang","year":"2023","unstructured":"Liang Y, Wang Y, Zhang Y, et al. HSPB1 facilitates chemoresistance through inhibiting ferroptotic cancer cell death and regulating NF-\u03baB signaling pathway in breast cancer. Cell Death Dis. 2023;14(7):434. https:\/\/doi.org\/10.1038\/s41419-023-05972-0. Published 2023 Jul 15.","journal-title":"Cell Death Dis"},{"issue":"14","key":"7930_CR10","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21144908","volume":"21","author":"MM Capelletti","year":"2020","unstructured":"Capelletti MM, Manceau H, Puy H, Peoc\u2019h K. Ferroptosis in liver diseases: an overview. Int J Mol Sci. 2020;21(14): 4908. https:\/\/doi.org\/10.3390\/ijms21144908.","journal-title":"Int J Mol Sci"},{"issue":"3","key":"7930_CR11","doi-asserted-by":"publisher","first-page":"591","DOI":"10.3390\/nu15030591","volume":"15","author":"Y Chen","year":"2023","unstructured":"Chen Y, Li X, Wang S, Miao R, Zhong J. Targeting iron metabolism and ferroptosis as novel therapeutic approaches in cardiovascular diseases. Nutrients. 2023;15(3):591. https:\/\/doi.org\/10.3390\/nu15030591. Published 2023 Jan 23.","journal-title":"Nutrients"},{"key":"7930_CR12","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2023.1090338","volume":"10","author":"Z Cheng","year":"2023","unstructured":"Cheng Z, Chu H, Zhu Q, Yang L. Ferroptosis in non-alcoholic liver disease: molecular mechanisms and therapeutic implications. Front Nutr. 2023;10: 1090338. https:\/\/doi.org\/10.3389\/fnut.2023.1090338.","journal-title":"Front Nutr"},{"key":"7930_CR13","doi-asserted-by":"publisher","first-page":"4941","DOI":"10.2147\/JIR.S427505","volume":"16","author":"J Liu","year":"2023","unstructured":"Liu J, Han X, Zhou J, Leng Y. Molecular mechanisms of ferroptosis and their involvement in acute kidney injury. J Inflamm Res. 2023;16:4941\u201351. https:\/\/doi.org\/10.2147\/JIR.S427505. Published 2023 Nov 2.","journal-title":"J Inflamm Res"},{"issue":"4","key":"7930_CR14","doi-asserted-by":"publisher","DOI":"10.1016\/j.repbio.2023.100816","volume":"23","author":"SW Ng","year":"2023","unstructured":"Ng SW, Lee C, Ng A, et al. Ferroportin expression and regulation in human placenta\/fetal membranes: implications for ferroptosis and adverse pregnancy outcomes. Reprod Biol. 2023;23(4): 100816. https:\/\/doi.org\/10.1016\/j.repbio.2023.100816.","journal-title":"Reprod Biol"},{"issue":"1","key":"7930_CR15","doi-asserted-by":"publisher","first-page":"99","DOI":"10.3390\/cells12010099s","volume":"12","author":"H Yang","year":"2022","unstructured":"Yang H, Zhang X, Ding Y, et al., et al. Elabela: negative regulation of ferroptosis in trophoblasts via the ferritinophagy pathway implicated in the pathogenesis of preeclampsia. Cells. 2022;12(1):99. https:\/\/doi.org\/10.3390\/cells12010099s. Published 2022 Dec 26.","journal-title":"Cells"},{"issue":"23","key":"7930_CR16","doi-asserted-by":"publisher","first-page":"16681","DOI":"10.3390\/ijms242316681","volume":"24","author":"AHL Hirata","year":"2023","unstructured":"Hirata AHL, Camargo LAJR, Silva VAD, et al. Exploring the potential of olfactory receptor Circulating RNA measurement for preeclampsia prediction and its linkage to mild gestational hypothyroidism. Int J Mol Sci. 2023;24(23):16681. https:\/\/doi.org\/10.3390\/ijms242316681. Published 2023 Nov 24.","journal-title":"Int J Mol Sci"},{"key":"7930_CR17","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.115415","volume":"166","author":"M Liu","year":"2023","unstructured":"Liu M, Wu K, Wu Y. The emerging role of ferroptosis in female reproductive disorders. Biomed Pharmacother. 2023;166: 115415. https:\/\/doi.org\/10.1016\/j.biopha.2023.115415.","journal-title":"Biomed Pharmacother"},{"issue":"3","key":"7930_CR18","doi-asserted-by":"publisher","first-page":"1507","DOI":"10.1007\/s12035-023-03646-8","volume":"61","author":"NJ Dar","year":"2024","unstructured":"Dar NJ, John U, Bano N, Khan S, Bhat SA. Oxytosis\/ferroptosis in neurodegeneration: the underlying role of master regulator glutathione peroxidase 4 (GPX4). Mol Neurobiol. 2024;61(3):1507\u201326. https:\/\/doi.org\/10.1007\/s12035-023-03646-8.","journal-title":"Mol Neurobiol"},{"key":"7930_CR19","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2023.108237","volume":"180","author":"Y Zhang","year":"2023","unstructured":"Zhang Y, Yang Y, Chen W, et al. BaP\/BPDE suppressed endothelial cell angiogenesis to induce miscarriage by promoting MARCHF1\/GPX4-mediated ferroptosis. Environ Int. 2023;180: 108237. https:\/\/doi.org\/10.1016\/j.envint.2023.108237.","journal-title":"Environ Int"},{"key":"7930_CR20","doi-asserted-by":"publisher","first-page":"926780","DOI":"10.3389\/fneur.2022.926780","volume":"13","author":"F Li","year":"2022","unstructured":"Li F, Wang H, Chen H, et al. Mechanism of ferroptosis and its role in spinal cord injury. Front Neurol. 2022;13:926780. https:\/\/doi.org\/10.3389\/fneur.2022.926780. Published 2022 Jun 9.","journal-title":"Front Neurol"},{"issue":"7784","key":"7930_CR21","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1038\/s41586-019-1707-0","volume":"575","author":"S Doll","year":"2019","unstructured":"Doll S, Freitas FP, Shah R, et al. FSP1 is a glutathione-independent ferroptosis suppressor. Nature. 2019;575(7784):693\u20138. https:\/\/doi.org\/10.1038\/s41586-019-1707-0.","journal-title":"Nature"},{"key":"7930_CR22","doi-asserted-by":"publisher","first-page":"1020918","DOI":"10.3389\/fphar.2022.1020918","volume":"13","author":"Z Wei","year":"2022","unstructured":"Wei Z, Xie Y, Wei M, et al. New insights in ferroptosis: potential therapeutic targets for the treatment of ischemic stroke. Front Pharmacol. 2022;13:1020918. https:\/\/doi.org\/10.3389\/fphar.2022.1020918. Published 2022 Nov 8.","journal-title":"Front Pharmacol"},{"issue":"9","key":"7930_CR23","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1038\/s41419-023-06144-w","volume":"14","author":"J Li","year":"2023","unstructured":"Li J, Zheng S, Fan Y, Tan K. Emerging significance and therapeutic targets of ferroptosis: a potential avenue for human kidney diseases. Cell Death Dis. 2023;14(9):628. https:\/\/doi.org\/10.1038\/s41419-023-06144-w. Published 2023 Sep 22.","journal-title":"Cell Death Dis"},{"key":"7930_CR24","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.972753","volume":"13","author":"Y Zhang","year":"2022","unstructured":"Zhang Y, Huang X, Qi B, et al. Ferroptosis and musculoskeletal diseases: iron maiden cell death may be a promising therapeutic target. Front Immunol. 2022;13: 972753. https:\/\/doi.org\/10.3389\/fimmu.2022.972753.","journal-title":"Front Immunol"},{"issue":"7784","key":"7930_CR25","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1038\/s41586-019-1705-2","volume":"575","author":"K Bersuker","year":"2019","unstructured":"Bersuker K, Hendricks JM, Li Z, et al. The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis. Nature. 2019;575(7784):688\u201392. https:\/\/doi.org\/10.1038\/s41586-019-1705-2.","journal-title":"Nature"},{"issue":"2","key":"7930_CR26","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1016\/j.ncrna.2024.02.008","volume":"9","author":"H Shi","year":"2024","unstructured":"Shi H, Wang W, Li F, Guo A, Liu T. Model construction and application for predicting preeclampsia by sonoclot coagulation analyzer. Noncoding RNA Res. 2024;9(2):288\u201393. https:\/\/doi.org\/10.1016\/j.ncrna.2024.02.008. Published 2024 Feb 10.","journal-title":"Noncoding RNA Res"},{"key":"7930_CR27","doi-asserted-by":"publisher","first-page":"1385950","DOI":"10.3389\/fimmu.2024.1385950","volume":"15","author":"Y Shan","year":"2024","unstructured":"Shan Y, Hou B, Wang J, Chen A, Liu S. Exploring the role of exosomal microRNAs as potential biomarkers in preeclampsia. Front Immunol. 2024;15:1385950. https:\/\/doi.org\/10.3389\/fimmu.2024.1385950. Published 2024 Mar 19.","journal-title":"Front Immunol"},{"issue":"6","key":"7930_CR28","doi-asserted-by":"publisher","first-page":"492","DOI":"10.3390\/toxics11060492","volume":"11","author":"M Wu","year":"2023","unstructured":"Wu M, Yan F, Liu Q, et al. Effects of xenobiotic compounds on preeclampsia and potential mechanisms. Toxics. 2023;11(6):492. https:\/\/doi.org\/10.3390\/toxics11060492. Published 2023 May 31.","journal-title":"Toxics"},{"issue":"1","key":"7930_CR29","doi-asserted-by":"publisher","first-page":"778","DOI":"10.1186\/s12884-023-06074-7","volume":"23","author":"L Wei","year":"2023","unstructured":"Wei L, Liping Z, Suya K. Expression of insulin-like growth factor binding protein-3 in HELLP syndrome. BMC Pregnancy Childbirth. 2023;23(1):778. https:\/\/doi.org\/10.1186\/s12884-023-06074-7. Published 2023 Nov 10.","journal-title":"BMC Pregnancy Childbirth"},{"issue":"1","key":"7930_CR30","doi-asserted-by":"publisher","first-page":"2311888","DOI":"10.1080\/19490976.2024.2311888","volume":"16","author":"J Wang","year":"2024","unstructured":"Wang J, Gao Y, Ren S, et al. Gut microbiota-derived trimethylamine N-oxide: a novel target for the treatment of preeclampsia. Gut Microbes. 2024;16(1):2311888. https:\/\/doi.org\/10.1080\/19490976.2024.2311888.","journal-title":"Gut Microbes"},{"issue":"1","key":"7930_CR31","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1080\/10245332.2016.1220120","volume":"22","author":"CH Gutierrez-Aguirre","year":"2017","unstructured":"Gutierrez-Aguirre CH, Garc\u00eda-Lozano JA, Trevi\u00f1o-Montemayor OR, et al. Comparative analysis of iron status and other hematological parameters in preeclampsia. Hematology. 2017;22(1):36\u201340. https:\/\/doi.org\/10.1080\/10245332.2016.1220120.","journal-title":"Hematology"},{"issue":"2","key":"7930_CR32","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1093\/jn\/nxab368","volume":"152","author":"MJ Taeubert","year":"2022","unstructured":"Taeubert MJ, Wiertsema CJ, Vermeulen MJ, Quezada-Pinedo HG, Reiss IK, Muckenthaler MU, Gaillard R. Maternal iron status in early pregnancy and blood pressure throughout pregnancy, placental hemodynamics, and the risk of gestational hypertensive disorders. J Nutr. 2022;152(2):525\u201334. https:\/\/doi.org\/10.1093\/jn\/nxab368.","journal-title":"J Nutr"},{"key":"7930_CR33","doi-asserted-by":"publisher","first-page":"966400","DOI":"10.3389\/fphar.2022.966400","volume":"13","author":"ECA Veiga","year":"2022","unstructured":"Veiga ECA, Korkes HA, Salom\u00e3o KB, Cavalli RC. Association of LEPTIN and other inflammatory markers with preeclampsia: A systematic review. Front Pharmacol. 2022;13:966400. https:\/\/doi.org\/10.3389\/fphar.2022.966400. Published 2022 Aug 10.","journal-title":"Front Pharmacol"},{"issue":"5","key":"7930_CR34","doi-asserted-by":"publisher","DOI":"10.3390\/nu13051572","volume":"13","author":"AA Wawer","year":"2021","unstructured":"Wawer AA, Hodyl NA, Fairweather-Tait S, Froessler B. Are pregnant women who are living with overweight or obesity at greater risk of developing iron deficiency\/anaemia?? Nutrients. 2021;13(5): 1572. https:\/\/doi.org\/10.3390\/nu13051572.","journal-title":"Nutrients"},{"issue":"8","key":"7930_CR35","doi-asserted-by":"publisher","DOI":"10.3390\/life12081203","volume":"12","author":"B Koz\u0142owska","year":"2022","unstructured":"Koz\u0142owska B, Sochanowicz B, Kraj L, et al. Clinical and molecular aspects of iron metabolism in failing myocytes. Life. 2022;12(8): 1203. https:\/\/doi.org\/10.3390\/life12081203.","journal-title":"Life"},{"issue":"1","key":"7930_CR36","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2020.118890","volume":"1868","author":"Q Liu","year":"2021","unstructured":"Liu Q, Barker S, Knutson MD. Iron and manganese transport in mammalian systems. Biochimica et Biophysica Acta (BBA). 2021;1868(1): 118890. https:\/\/doi.org\/10.1016\/j.bbamcr.2020.118890.","journal-title":"Biochimica et Biophysica Acta (BBA)"},{"key":"7930_CR37","doi-asserted-by":"publisher","first-page":"1052540","DOI":"10.3389\/fmed.2022.1052540","volume":"9","author":"D Meng","year":"2023","unstructured":"Meng D, Zhu C, Jia R, Li Z, Wang W, Song S. The molecular mechanism of ferroptosis and its role in COPD. Front Med (Lausanne). 2023;9:1052540. https:\/\/doi.org\/10.3389\/fmed.2022.1052540. Published 2023 Jan 6.","journal-title":"Front Med (Lausanne)"},{"key":"7930_CR38","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2023.1151410","volume":"10","author":"Z Fang","year":"2023","unstructured":"Fang Z, Zheng S, Xie Y, Lin S, Zhang H, Yan J. Correlation between serum ferritin in early pregnancy and hypertensive disorders in pregnancy. Front Nutr. 2023;10: 1151410. https:\/\/doi.org\/10.3389\/fnut.2023.1151410.","journal-title":"Front Nutr"},{"issue":"10","key":"7930_CR39","doi-asserted-by":"publisher","first-page":"3411","DOI":"10.1016\/j.celrep.2020.02.049","volume":"30","author":"H Feng","year":"2020","unstructured":"Feng H, Schorpp K, Jin J, et al. Transferrin receptor is a specific ferroptosis marker. Cell Rep. 2020;30(10):3411\u2013e34237. https:\/\/doi.org\/10.1016\/j.celrep.2020.02.049.","journal-title":"Cell Rep"},{"key":"7930_CR40","doi-asserted-by":"publisher","first-page":"101402","DOI":"10.1016\/j.redox.2019.101402","volume":"29","author":"H Zhang","year":"2020","unstructured":"Zhang H, He Y, Wang JX, et al. miR-30-5p-mediated ferroptosis of trophoblasts is implicated in the pathogenesis of preeclampsia. Redox Biol. 2020;29:101402. https:\/\/doi.org\/10.1016\/j.redox.2019.101402.","journal-title":"Redox Biol"},{"issue":"12","key":"7930_CR41","doi-asserted-by":"publisher","DOI":"10.3390\/antiox8120594","volume":"8","author":"D Pellegrino","year":"2019","unstructured":"Pellegrino D, La Russa D, Marrone A. Oxidative imbalance and kidney damage: new study perspectives from animal models to hospitalized patients. Antioxidants. 2019;8(12): 594. https:\/\/doi.org\/10.3390\/antiox8120594.","journal-title":"Antioxidants"},{"issue":"3","key":"7930_CR42","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1016\/j.chembiol.2008.02.010","volume":"15","author":"WS Yang","year":"2008","unstructured":"Yang WS, Stockwell BR. Synthetic lethal screening identifies compounds activating iron-dependent, nonapoptotic cell death in oncogenic-RAS-harboring cancer cells. Chem Biol. 2008;15(3):234\u201345. https:\/\/doi.org\/10.1016\/j.chembiol.2008.02.010.","journal-title":"Chem Biol"},{"key":"7930_CR43","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2024.122555","volume":"343","author":"X Xu","year":"2024","unstructured":"Xu X, Zhu M, Zu Y, Wang G, Li X, Yan J. Nox2 inhibition reduces trophoblast ferroptosis in preeclampsia via the STAT3\/GPX4 pathway. Life Sci. 2024;343: 122555. https:\/\/doi.org\/10.1016\/j.lfs.2024.122555.","journal-title":"Life Sci"},{"issue":"5","key":"7930_CR44","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.1007\/s10815-022-02443-x","volume":"39","author":"SRA El-Khalik","year":"2022","unstructured":"El-Khalik SRA, Ibrahim RR, Ghafar MTA, Shatat D, El-Deeb OS. Novel insights into the SLC7A11-mediated ferroptosis signaling pathways in preeclampsia patients: identifying pannexin 1 and toll-like receptor 4 as innovative prospective diagnostic biomarkers. J Assist Reprod Genet. 2022;39(5):1115\u201324. https:\/\/doi.org\/10.1007\/s10815-022-02443-x.","journal-title":"J Assist Reprod Genet"},{"issue":"8","key":"7930_CR45","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1038\/s41419-023-06045-y","volume":"14","author":"Y Liu","year":"2023","unstructured":"Liu Y, Lu S, Wu LL, Yang L, Yang L, Wang J. The diversified role of mitochondria in ferroptosis in cancer. Cell Death Dis. 2023;14(8):519. https:\/\/doi.org\/10.1038\/s41419-023-06045-y. Published 2023 Aug 14.","journal-title":"Cell Death Dis"},{"issue":"1","key":"7930_CR46","doi-asserted-by":"publisher","DOI":"10.1038\/srep42303","volume":"7","author":"BC Marreiros","year":"2017","unstructured":"Marreiros BC, Sena FV, Sousa FM, et al. Structural and functional insights into the catalytic mechanism of the type II NADH:quinone oxidoreductase family. Sci Rep. 2017;7(1): 42303. https:\/\/doi.org\/10.1038\/srep42303.","journal-title":"Sci Rep"},{"issue":"3","key":"7930_CR47","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1038\/s41556-024-01364-4","volume":"26","author":"AJ Mathiowetz","year":"2024","unstructured":"Mathiowetz AJ, Olzmann JA. Lipid droplets and cellular lipid flux. Nat Cell Biol. 2024;26(3):331\u201345. https:\/\/doi.org\/10.1038\/s41556-024-01364-4.","journal-title":"Nat Cell Biol"},{"key":"7930_CR48","doi-asserted-by":"publisher","first-page":"1291099","DOI":"10.3389\/fphar.2023.1291099","volume":"14","author":"Y Lu","year":"2023","unstructured":"Lu Y, Zhao D, Liu M, et al. Gongying-jiedu-xiji recipe promotes the healing of venous ulcers by inhibiting ferroptosis via the CoQ-FSP1 axis. Front Pharmacol. 2023;14:1291099. https:\/\/doi.org\/10.3389\/fphar.2023.1291099. Published 2023 Dec 15.","journal-title":"Front Pharmacol"},{"key":"7930_CR49","doi-asserted-by":"publisher","unstructured":"Yang M, Tsui MG, Tsang JKW et al. Involvement of FSP1-CoQ10-NADH and GSH-GPx-4 pathways in retinal pigment epithelium ferroptosis [published correction appears in Cell Death Dis. 2024 Mar 8;15(3):197]. Cell Death Dis. 2022;13(5):468. Published 2022 May 18. https:\/\/doi.org\/10.1038\/s41419-022-04924-4","DOI":"10.1038\/s41419-022-04924-4"},{"key":"7930_CR50","doi-asserted-by":"publisher","unstructured":"Yin MK. The role of ferroptosis in preeclampsia and its mechanism.southern medical university. 2023.https:\/\/doi.org\/10.27003\/d.cnki.gojyu.2023.000104","DOI":"10.27003\/d.cnki.gojyu.2023.000104"},{"issue":"1\u20134","key":"7930_CR51","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1002\/biof.5520250117","volume":"25","author":"E Teran","year":"2005","unstructured":"Teran E, Vivero S, Racines-Orbe M, et al. Coenzyme Q10 is increased in placenta and cord blood during preeclampsia. Biofactors. 2005;25(1\u20134):153\u20138. https:\/\/doi.org\/10.1002\/biof.5520250117.","journal-title":"Biofactors"},{"issue":"4","key":"7930_CR52","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1080\/10641955.2019.1649420","volume":"38","author":"X Xu","year":"2019","unstructured":"Xu X, Pan JR, Zhang YZ. CoQ10 alleviate preeclampsia symptoms by enhancing the function of mitochondria in the placenta of pregnant rats with preeclampsia. Hypertens Pregnancy. 2019;38(4):217\u201322. https:\/\/doi.org\/10.1080\/10641955.2019.1649420.","journal-title":"Hypertens Pregnancy"},{"issue":"1","key":"7930_CR53","doi-asserted-by":"publisher","first-page":"F53","DOI":"10.1530\/REP-20-0153","volume":"161","author":"GJ Burton","year":"2021","unstructured":"Burton GJ, Cindrova-Davies T, Yung HW, Jauniaux E. HYPOXIA AND REPRODUCTIVE HEALTH: oxygen and development of the human placenta. Reproduction. 2021;161(1):F53\u201365. https:\/\/doi.org\/10.1530\/REP-20-0153.","journal-title":"Reproduction"},{"issue":"14","key":"7930_CR54","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15143731","volume":"15","author":"DF Pic\u00f3n","year":"2023","unstructured":"Pic\u00f3n DF, Skouta R. Unveiling the therapeutic potential of squalene synthase: deciphering its biochemical mechanism, disease implications, and intriguing ties to ferroptosis. Cancers (Basel). 2023;15(14): 3731. https:\/\/doi.org\/10.3390\/cancers15143731.","journal-title":"Cancers (Basel)"},{"issue":"2","key":"7930_CR55","doi-asserted-by":"publisher","first-page":"127","DOI":"10.22088\/IJMCM.BUMS.11.2.127","volume":"11","author":"F Khadir","year":"2022","unstructured":"Khadir F, Rahimi Z, Ghanbarpour A, Vaisi-Raygani A. Nrf2 rs6721961 and oxidative stress in preeclampsia: association with the risk of preeclampsia and Early-Onset preeclampsia. Int J Mol Cell Med. 2022;11(2):127\u201336. https:\/\/doi.org\/10.22088\/IJMCM.BUMS.11.2.127.","journal-title":"Int J Mol Cell Med"},{"issue":"12","key":"7930_CR56","first-page":"1217","volume":"72","author":"H Wiktor","year":"2001","unstructured":"Wiktor H, Kankofer M. Ocena nasilenia Nadtleniania lipid\u00f3w w \u0141ozyskach Kobiet z Ciazy Prawid\u0142owej i Powik\u0142anej Przez Preeklampsje [Assessment of lipid peroxidation intensification in normal and preeclamptic placentas]. Ginekol Pol. 2001;72(12):1217\u201321.","journal-title":"Ginekol Pol"},{"issue":"4","key":"7930_CR57","doi-asserted-by":"publisher","first-page":"1455","DOI":"10.1007\/s00018-020-03674-w","volume":"78","author":"CE Bowman","year":"2021","unstructured":"Bowman CE, Arany Z, Wolfgang MJ. Regulation of maternal-fetal metabolic communication. Cell Mol Life Sci. 2021;78(4):1455\u201386. https:\/\/doi.org\/10.1007\/s00018-020-03674-w.","journal-title":"Cell Mol Life Sci"},{"key":"7930_CR58","doi-asserted-by":"publisher","first-page":"802285","DOI":"10.3389\/fcell.2022.802285","volume":"10","author":"SW D\u2019Souza","year":"2022","unstructured":"D\u2019Souza SW, Glazier JD. Homocysteine metabolism in pregnancy and developmental impacts. Front Cell Dev Biol. 2022;10:802285. https:\/\/doi.org\/10.3389\/fcell.2022.802285. Published 2022 Jun 30.","journal-title":"Front Cell Dev Biol"}],"container-title":["BMC Pregnancy and Childbirth"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12884-025-07930-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12884-025-07930-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12884-025-07930-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T09:13:19Z","timestamp":1754471599000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcpregnancychildbirth.biomedcentral.com\/articles\/10.1186\/s12884-025-07930-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,6]]},"references-count":58,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["7930"],"URL":"https:\/\/doi.org\/10.1186\/s12884-025-07930-4","relation":{},"ISSN":["1471-2393"],"issn-type":[{"value":"1471-2393","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,6]]},"assertion":[{"value":"29 May 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 July 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 August 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the Ethics Committee of Yongchuan Hospital, Chongqing Medical University, China. Prior to the commencement of the study, informed consent was obtained from all patients.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"813"}}