{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T00:37:08Z","timestamp":1793752628518,"version":"4.6.1"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T00:00:00Z","timestamp":1756339200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T00:00:00Z","timestamp":1756339200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Pregnancy Childbirth"],"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Objective<\/jats:title>\n            <jats:p>Intrahepatic cholestasis of pregnancy (ICP) is associated with adverse perinatal outcomes. Accurate and timely diagnosis is essential to minimize maternal and fetal risks. The standard diagnostic method\u2014measurement of fasting serum bile acids (BA)\u2014poses challenges due to limited availability, high cost, and delayed results. This study aimed to evaluate the diagnostic and prognostic utility of the aspartate aminotransferase to platelet ratio index (APRI) and the De Ritis ratio in ICP.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>This retrospective case-control study included 238 pregnant women, categorized into three groups: mild ICP (<jats:italic>n<\/jats:italic>\u2009=\u200962), severe ICP (<jats:italic>n<\/jats:italic>\u2009=\u200957), and healthy controls (<jats:italic>n<\/jats:italic>\u2009=\u2009119). Demographic, biochemical, and perinatal outcomes were compared among the groups. APRI and De Ritis ratios were calculated and analyzed using receiver operating characteristic (ROC) curves and correlation analyses.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>APRI levels were significantly elevated in ICP patients and demonstrated strong diagnostic performance for identifying ICP (cut-off: 0.295; AUC\u2009=\u20090.842). The De Ritis ratio was significantly lower in both ICP groups compared with controls (cut-off: 1.097; AUC\u2009=\u20090.770). APRI also correlated with disease severity (cut-off: 0.615 for severe ICP; AUC\u2009=\u20090.868). Higher APRI values were associated with increased neonatal intensive care unit (NICU) admissions and lower gestational age and birth weight.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>APRI and De Ritis ratios are simple, inexpensive, and non-invasive markers that may aid in the diagnosis and severity assessment of ICP. They could serve as useful alternatives in clinical settings where BA testing is limited or unavailable.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/s12884-025-08056-3","type":"journal-article","created":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T06:39:23Z","timestamp":1756363163000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["The diagnostic and prognostic value of APRI and de Ritis ratio in intrahepatic cholestasis of pregnancy"],"prefix":"10.1186","volume":"25","author":[{"given":"Ebu Bekir S\u0131dd\u0131k","family":"Y\u0131lmaz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erkan","family":"Sa\u011flam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serenat","family":"Yalcin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa Ra\u015fit","family":"\u00d6zler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,8,28]]},"reference":[{"issue":"2","key":"8056_CR1","doi-asserted-by":"publisher","first-page":"100337","DOI":"10.1016\/j.xagr.2024.100337","volume":"4","author":"M Cemortan","year":"2024","unstructured":"Cemortan M, Iliadi-Tulbure C, Sagaidac I, Vulpe A, Bivol T, et al. 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Due to the retrospective design of the study and the use of anonymized patient data, the requirement for informed consent was waived by the Ethics Committee. The study was conducted in accordance with the ethical standards of the institutional and\/or national research committee, and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Clinical trial number"}}],"article-number":"892"}}