{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T17:01:54Z","timestamp":1788973314776,"version":"build-2803163510"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T00:00:00Z","timestamp":1771372800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T00:00:00Z","timestamp":1774483200000},"content-version":"vor","delay-in-days":36,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"the National Key Research and Development Program of China"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Pregnancy Childbirth"],"DOI":"10.1186\/s12884-026-08808-9","type":"journal-article","created":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T09:47:19Z","timestamp":1771408039000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Sleep disturbances and assisted reproduction outcomes in women undergoing IVF\/ICSI: a systematic review and meta-analysis"],"prefix":"10.1186","volume":"26","author":[{"given":"Yali","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nidong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingxin","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,18]]},"reference":[{"key":"8808_CR1","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1111\/j.2047-2927.2013.00110.x","volume":"1","author":"JF Louis","year":"2013","unstructured":"Louis JF, Thoma ME, S\u00f8rensen DN, McLain AC, King RB, Sundaram R, et al. The prevalence of couple infertility in the United States from a male perspective: evidence from a nationally representative sample. Andrology. 2013;1:741\u20138. https:\/\/doi.org\/10.1111\/j.2047-2927.2013.00110.x.","journal-title":"Andrology"},{"key":"8808_CR2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001356","volume":"9","author":"MN Mascarenhas","year":"2012","unstructured":"Mascarenhas MN, Flaxman SR, Boerma T, Vanderpoel S, Stevens GA. National, regional, and global trends in infertility prevalence since 1990: a systematic analysis of 277 health surveys. PLoS Med. 2012;9:e1001356. https:\/\/doi.org\/10.1371\/journal.pmed.1001356.","journal-title":"PLoS Med"},{"key":"8808_CR3","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1093\/humrep\/dev336","volume":"31","author":"DJ McLernon","year":"2016","unstructured":"McLernon DJ, Maheshwari A, Lee AJ, Bhattacharya S. Cumulative live birth rates after one or more complete cycles of IVF: a population-based study of linked cycle data from 178,898 women. Hum Reprod. 2016;31:572\u201381. https:\/\/doi.org\/10.1093\/humrep\/dev336.","journal-title":"Hum Reprod"},{"key":"8808_CR4","doi-asserted-by":"publisher","DOI":"10.1186\/s12958-022-00889-3","volume":"20","author":"G Beroukhim","year":"2022","unstructured":"Beroukhim G, Esencan E, Seifer DB. Impact of sleep patterns upon\u202ffemale\u202fneuroendocrinology and reproductive outcomes: a comprehensive review. Reprod Biol Endocrinol. 2022;20:16. https:\/\/doi.org\/10.1186\/s12958-022-00889-3.","journal-title":"Reprod Biol Endocrinol"},{"key":"8808_CR5","doi-asserted-by":"publisher","DOI":"10.1186\/s12905-024-03508-y","volume":"24","author":"J Li","year":"2024","unstructured":"Li J, Huang Y, Xu S, Wang Y. Sleep disturbances and female infertility: a systematic review. BMC Womens Health. 2024;24:643. https:\/\/doi.org\/10.1186\/s12905-024-03508-y.","journal-title":"BMC Womens Health"},{"key":"8808_CR6","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1178396","volume":"14","author":"Q-L Li","year":"2023","unstructured":"Li Q-L, Wang C, Cao K-X, Zhang L, Xu Y-S, Chang L, et al. Sleep characteristics before assisted reproductive technology treatment predict reproductive outcomes: a prospective cohort study of Chinese infertile women. Front Endocrinol. 2023;14:1178396. https:\/\/doi.org\/10.3389\/fendo.2023.1178396.","journal-title":"Front Endocrinol"},{"key":"8808_CR7","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1007\/s11325-019-01835-1","volume":"24","author":"H Kahal","year":"2020","unstructured":"Kahal H, Kyrou I, Uthman OA, Brown A, Johnson S, Wall PDH, et al. The prevalence of obstructive sleep apnoea in women with polycystic ovary syndrome: a systematic review and meta-analysis. Sleep Breath. 2020;24:339\u201350. https:\/\/doi.org\/10.1007\/s11325-019-01835-1.","journal-title":"Sleep Breath"},{"key":"8808_CR8","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1016\/j.sleep.2022.09.026","volume":"100","author":"JR Walter","year":"2022","unstructured":"Walter JR, Lee JY, Snoll B, Park JB, Kim DH, Xu S, et al. Pregnancy outcomes in infertility patients diagnosed with sleep disordered breathing with wireless wearable sensors. Sleep Med. 2022;100:511\u20137. https:\/\/doi.org\/10.1016\/j.sleep.2022.09.026.","journal-title":"Sleep Med"},{"key":"8808_CR9","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-22534-0","volume":"12","author":"M Reschini","year":"2022","unstructured":"Reschini M, Buoli M, Facchin F, Limena A, Dallagiovanna C, Bollati V, et al. Women\u2019s quality of sleep and in vitro fertilization success. Sci Rep. 2022;12:17477. https:\/\/doi.org\/10.1038\/s41598-022-22534-0.","journal-title":"Sci Rep"},{"key":"8808_CR10","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1016\/j.sleh.2021.10.011","volume":"8","author":"MT Philipsen","year":"2022","unstructured":"Philipsen MT, Knudsen UB, Zachariae R, Ingerslev HJ, Hvidt JEM, Frederiksen Y. Sleep, psychological distress, and clinical pregnancy outcome in women and their partners undergoing in vitro or intracytoplasmic sperm injection fertility treatment. Sleep Health. 2022;8:242\u20138. https:\/\/doi.org\/10.1016\/j.sleh.2021.10.011.","journal-title":"Sleep Health"},{"key":"8808_CR11","doi-asserted-by":"publisher","first-page":"1297","DOI":"10.1093\/humrep\/deac040","volume":"37","author":"Q-Y Yao","year":"2022","unstructured":"Yao Q-Y, Yuan X-Q, Liu C, Du Y-Y, Yao Y-C, Wu L-J, et al. Associations of sleep characteristics with outcomes of IVF\/ICSI treatment: a prospective cohort study. Hum Reprod. 2022;37:1297\u2013310. https:\/\/doi.org\/10.1093\/humrep\/deac040.","journal-title":"Hum Reprod"},{"key":"8808_CR12","doi-asserted-by":"publisher","unstructured":"Zhang J, Zhao L, Li Y, Dong H, Zhang H, Zhang Y, et al. Circadian clock regulates granulosa cell autophagy through NR1D1-mediated inhibition of ATG5. Am J Physiol Cell Physiol. United States; 2022;322:C231\u201345. https:\/\/doi.org\/10.1152\/ajpcell.00267.2021","DOI":"10.1152\/ajpcell.00267.2021"},{"key":"8808_CR13","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1177\/0748730414554222","volume":"30","author":"MT Sellix","year":"2015","unstructured":"Sellix MT. Circadian clock function in the mammalian ovary. J Biol Rhythms. 2015;30:7\u201319. https:\/\/doi.org\/10.1177\/0748730414554222.","journal-title":"J Biol Rhythms"},{"key":"8808_CR14","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1530\/REP-19-0615","volume":"160","author":"KT Rytk\u00f6nen","year":"2020","unstructured":"Rytk\u00f6nen KT, Heinosalo T, Mahmoudian M, Ma X, Perheentupa A, Elo LL, et al. Transcriptomic responses to hypoxia in endometrial and decidual stromal cells. Reproduction. 2020;160:39\u201351. https:\/\/doi.org\/10.1530\/REP-19-0615.","journal-title":"Reproduction"},{"key":"8808_CR15","doi-asserted-by":"publisher","first-page":"31","DOI":"10.5664\/jcsm.10780","volume":"20","author":"Q Zhang","year":"2024","unstructured":"Zhang Q, Wang Z, Ding J, Yan S, Hao Y, Chen H, et al. Effect of obstructive sleep apnea on in\u00a0vitro fertilization outcomes in women with polycystic ovary syndrome. J Clin Sleep Med. 2024;20:31\u20138. https:\/\/doi.org\/10.5664\/jcsm.10780.","journal-title":"J Clin Sleep Med"},{"key":"8808_CR16","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1111\/cen.13392","volume":"87","author":"H Kahal","year":"2017","unstructured":"Kahal H, Kyrou I, Tahrani AA, Randeva HS. Obstructive sleep apnoea and polycystic ovary syndrome: a comprehensive review of clinical interactions and underlying pathophysiology. Clin Endocrinol (Oxf). 2017;87:313\u20139. https:\/\/doi.org\/10.1111\/cen.13392.","journal-title":"Clin Endocrinol (Oxf)"},{"key":"8808_CR17","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.70293","volume":"15","author":"F Habibi","year":"2025","unstructured":"Habibi F, Nikbakht R, Jahanfar S, Ahmadi M, Eslami M, Azizi M, et al. Relationship between sleep disturbances and in vitro fertilization outcomes in infertile women: a systematic review and meta-analysis. Brain Behav. 2025;15:e70293. https:\/\/doi.org\/10.1002\/brb3.70293.","journal-title":"Brain Behav"},{"key":"8808_CR18","doi-asserted-by":"publisher","unstructured":"Cai S, Tan S, Gluckman PD, Godfrey KM, Saw S-M, Teoh OH, et al. Sleep Quality and Nocturnal Sleep Duration in Pregnancy and Risk of Gestational Diabetes Mellitus. Sleep. United States; 2017;40. https:\/\/doi.org\/10.1093\/sleep\/zsw058","DOI":"10.1093\/sleep\/zsw058"},{"key":"8808_CR19","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.sleep.2018.07.021","volume":"52","author":"Y-H Xu","year":"2018","unstructured":"Xu Y-H, Shi L, Bao Y-P, Chen S-J, Shi J, Zhang R-L, et al. Association between sleep duration during pregnancy and gestational diabetes mellitus: a meta-analysis. Sleep Med. 2018;52:67\u201374. https:\/\/doi.org\/10.1016\/j.sleep.2018.07.021.","journal-title":"Sleep Med"},{"key":"8808_CR20","doi-asserted-by":"publisher","DOI":"10.1111\/jsr.14191","volume":"33","author":"H Gao","year":"2024","unstructured":"Gao H, Miao C, Liu W, Sun Y, Li H, Wu Z, et al. Association of sleep duration and sleep quality with gestational diabetes mellitus in pregnant women after treatment with assisted reproductive technology: a birth cohort study. J Sleep Res. 2024;33:e14191. https:\/\/doi.org\/10.1111\/jsr.14191.","journal-title":"J Sleep Res"},{"key":"8808_CR21","doi-asserted-by":"publisher","first-page":"E463","DOI":"10.1210\/jc.2010-2098","volume":"96","author":"JJ Gooley","year":"2011","unstructured":"Gooley JJ, Chamberlain K, Smith KA, Khalsa SBS, Rajaratnam SMW, Van Reen E, et al. Exposure to room light before bedtime suppresses melatonin onset and shortens melatonin duration in humans. J Clin Endocrinol Metab United States. 2011;96:E463-472. https:\/\/doi.org\/10.1210\/jc.2010-2098.","journal-title":"J Clin Endocrinol Metab United States"},{"key":"8808_CR22","doi-asserted-by":"publisher","first-page":"H1991","DOI":"10.1152\/ajpheart.01132.2011","volume":"302","author":"JR Carter","year":"2012","unstructured":"Carter JR, Durocher JJ, Larson RA, DellaValla JP, Yang H. Sympathetic neural responses to 24-hour sleep deprivation in humans: sex differences. Am J Physiol Heart Circ Physiol. 2012;302:H1991-1997. https:\/\/doi.org\/10.1152\/ajpheart.01132.2011.","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"8808_CR23","first-page":"865","volume":"20","author":"R Leproult","year":"1997","unstructured":"Leproult R, Copinschi G, Buxton O, Van Cauter E. Sleep loss results in an elevation of cortisol levels the next evening. Sleep United States. 1997;20:865\u201370.","journal-title":"Sleep United States"},{"key":"8808_CR24","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.smrv.2017.06.011","volume":"39","author":"M Jike","year":"2018","unstructured":"Jike M, Itani O, Watanabe N, Buysse DJ, Kaneita Y. Long sleep duration and health outcomes: a systematic review, meta-analysis and meta-regression. Sleep Med Rev. 2018;39:25\u201336. https:\/\/doi.org\/10.1016\/j.smrv.2017.06.011.","journal-title":"Sleep Med Rev"},{"key":"8808_CR25","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1530\/REP-16-0641","volume":"153","author":"J Tong","year":"2017","unstructured":"Tong J, Sheng S, Sun Y, Li H, Li W-P, Zhang C, et al. Melatonin levels in follicular fluid as markers for IVF outcomes and predicting ovarian reserve. Reproduction. 2017;153:443\u201351. https:\/\/doi.org\/10.1530\/REP-16-0641.","journal-title":"Reproduction"},{"key":"8808_CR26","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1530\/REP-18-0211","volume":"156","author":"Q Yang","year":"2018","unstructured":"Yang Q, Dai S, Luo X, Zhu J, Li F, Liu J, et al. Melatonin attenuates postovulatory oocyte dysfunction by regulating SIRT1 expression. Reproduction. 2018;156:81\u201392. https:\/\/doi.org\/10.1530\/REP-18-0211.","journal-title":"Reproduction"},{"key":"8808_CR27","doi-asserted-by":"publisher","DOI":"10.1016\/j.gine.2025.101034","volume":"52","author":"MK Abd El-Haseeb","year":"2025","unstructured":"Abd El-Haseeb MK, Soliman Sallam OA, Abd El-Hamed MS. Investigating the impact of sleep disorders on intracytoplasmic sperm injection outcome: a prospective observational study. Cl\u00ednica e Investigaci\u00f3n en Ginecolog\u00eda y Obstetricia. 2025;52:101034. https:\/\/doi.org\/10.1016\/j.gine.2025.101034.","journal-title":"Cl\u00ednica e Investigaci\u00f3n en Ginecolog\u00eda y Obstetricia"},{"key":"8808_CR28","doi-asserted-by":"publisher","unstructured":"Wang H, Liang Y, Dong X, Fu M, Wang Y, Wang Y, Han H, Wang M, Zuo Y, Zhang S, Shen H, Han F, Gao F. Association between snoring and in vitro fertilization outcomes among infertile women. Sleep Med. 2025;128:74\u201381. https:\/\/doi.org\/10.1016\/j.sleep.2025.01.013. Epub2025 Jan 21. PMID: 39892082.","DOI":"10.1016\/j.sleep.2025.01.013"},{"key":"8808_CR29","doi-asserted-by":"publisher","unstructured":"Li N, Yang R, Zhao Y, Wang Y, Tang Q, Li J, Huang Y, Huang Y, Zhang L, Wang Y, Li R, Qiao J. Obstructive sleep apnea as a predictive indicator for in vitro fertilization and embryo transfer outcomes in patients with polycystic ovary syndrome: a prospective cohort study. Sleep Breath. 2025;29(4):237. https:\/\/doi.org\/10.1007\/s11325-025-03399-9. PMID: 40627095; PMCID: PMC12238160.","DOI":"10.1007\/s11325-025-03399-9"},{"key":"8808_CR30","doi-asserted-by":"publisher","unstructured":"Liu Z, Zheng Y, Wang B, Li J, Qin L, Li X, Liu X, Bian Y, Chen Z, Zhao H, Zhao S. The impact of sleep on in vitro fertilization embryo transfer outcomes: a prospective study. Fertil Steril. 2023;119(1):47\u201355. https:\/\/doi.org\/10.1016\/j.fertnstert.2022.10.015. Epub 2022 Nov 23. PMID:36435629.","DOI":"10.1016\/j.fertnstert.2022.10.015"},{"key":"8808_CR31","doi-asserted-by":"publisher","unstructured":"Yang M, Fangfang N, Qingxia M, Yan Z, Yangqian J, Hong L. Sleep quality is associated with the weight of newborns after in vitro fertilization (IVF)\/intra-cytoplasmic sperm injection (ICSI). Sleep Breath. 2022;26(4):2059\u201368. https:\/\/doi.org\/10.1007\/s11325-021-02498-7. Epub 2022 Jan 12. PMID: 35018557.","DOI":"10.1007\/s11325-021-02498-7"},{"key":"8808_CR32","doi-asserted-by":"publisher","unstructured":"Reschini M, Buoli M, Facchin F, Limena A, Dallagiovanna C, Bollati V, Somigliana E. Women's quality of sleep and in vitro fertilization success. Sci Rep. 2022;12(1):17477. https:\/\/doi.org\/10.1038\/s41598-022-22534-0. PMID: 36261696 ; PMCID: PMC9581906.","DOI":"10.1038\/s41598-022-22534-0"},{"key":"8808_CR33","doi-asserted-by":"publisher","unstructured":"Bariya S, Tao Y, Zhang R, Zhang M. Impact of sleep characteristics on IVF\/ICSI outcomes: A prospective cohort study. Sleep Med. 2025;126:122\u201335. https:\/\/doi.org\/10.1016\/j.sleep.2024.11.038. Epub 2024 Nov 29. PMID: 39672092.","DOI":"10.1016\/j.sleep.2024.11.038"},{"key":"8808_CR34","doi-asserted-by":"publisher","unstructured":"Philipsen MT, Knudsen UB, Zachariae R, Ingerslev HJ, Hvidt JEM, Frederiksen Y. Sleep, psychological distress, and clinical pregnancy outcome in women and their partners undergoing in vitro or intracytoplasmic sperm injection fertility treatment. Sleep Health. 2022;8(2):242\u20138. https:\/\/doi.org\/10.1016\/j.sleh.2021.10.011. Epub 2021 Dec 20. PMID: 34949542.","DOI":"10.1016\/j.sleh.2021.10.011"},{"key":"8808_CR35","doi-asserted-by":"publisher","unstructured":"Pimolsri C, Lyu X, Goldstein C, Fortin CN, Mumford SL, Smith YR, Lanham MS, O'Brien LM, Dunietz GL. Objective sleep duration and timing predicts completion of in vitro fertilization cycle. J Assist Reprod Genet. 2021;38(10):2687\u201396. https:\/\/doi.org\/10.1007\/s10815-021-02260-8. Epub2021 Aug 10. PMID: 34374922 ; PMCID: PMC8581147.","DOI":"10.1007\/s10815-021-02260-8"},{"key":"8808_CR36","doi-asserted-by":"publisher","unstructured":"Goldstein CA, Lanham MS, Smith YR, O'Brien LM. Sleep in women undergoing in vitro fertilization: a pilot study. Sleep Med. 2017;32:105\u201313. https:\/\/doi.org\/10.1016\/j.sleep.2016.12.007.\u00a0Epub 2016 Dec 21. PMID: 28366321 ; PMCID: PMC5380145.","DOI":"10.1016\/j.sleep.2016.12.007"}],"container-title":["BMC Pregnancy and Childbirth"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12884-026-08808-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12884-026-08808-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12884-026-08808-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T09:01:22Z","timestamp":1774515682000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12884-026-08808-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,18]]},"references-count":36,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["8808"],"URL":"https:\/\/doi.org\/10.1186\/s12884-026-08808-9","relation":{},"ISSN":["1471-2393"],"issn-type":[{"value":"1471-2393","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,18]]},"assertion":[{"value":"15 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 February 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 February 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable. This systematic review and meta-analysis synthesized data from previously published studies and did not involve the recruitment of human participants by the authors; therefore, institutional ethics approval and participant consent were not required. The review protocol was prospectively registered in PROSPERO (CRD420251118366).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable. This study includes no identifiable individual person\u2019s data.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"328"}}