{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T17:27:52Z","timestamp":1750440472958},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2015,11,10]],"date-time":"2015-11-10T00:00:00Z","timestamp":1447113600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Cancer"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1186\/s12885-015-1908-3","type":"journal-article","created":{"date-parts":[[2015,11,10]],"date-time":"2015-11-10T08:31:02Z","timestamp":1447144262000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["From palliative to curative treatment - stage IV mucinous adenocarcinoma, successfully treated with metronomic capecitabine in combination with Bevacizumab and surgery- a case report"],"prefix":"10.1186","volume":"15","author":[{"given":"Karolina","family":"Vernmark","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Albertsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bergthor","family":"Bj\u00f6rnsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Gasslander","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Per","family":"Sandstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Feng","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annika","family":"Holmqvist","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2015,11,10]]},"reference":[{"issue":"6","key":"1908_CR1","first-page":"1057","volume":"14","author":"H Zhang","year":"1999","unstructured":"Zhang H, Evertsson S, Sun X. Clinicopathological and genetic characteristics of mucinous carcinomas in the colorectum. Int J Oncol. 1999;14(6):1057\u201361.","journal-title":"Int J Oncol"},{"issue":"5","key":"1908_CR2","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1136\/jclinpath-2011-200340","volume":"65","author":"J Verhulst","year":"2012","unstructured":"Verhulst J,\u00a0Ferdinande L, Demetter P, Ceelen W. Mucinous subtype as prognostic factor in colorectal cancer: a systematic review and meta-analysis. J Clin Pathol. 2012;65(5):381\u20138.","journal-title":"J Clin Pathol"},{"issue":"9","key":"1908_CR3","doi-asserted-by":"publisher","first-page":"2814","DOI":"10.1245\/s10434-012-2321-7","volume":"19","author":"JR Hyngstrom","year":"2012","unstructured":"Hyngstrom JR , Hu CY, Xing Y, You YN, Feig BW, Skibber JM et al. Clinicopathology and outcomes for mucinous and signet ring colorectal adenocarcinoma: analysis from the National Cancer Data Base. Ann Surg Oncol. 2012;19(9):2814\u201321.","journal-title":"Ann Surg Oncol"},{"issue":"9","key":"1908_CR4","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1002\/bjs.1800720915","volume":"72","author":"HC Umpleby","year":"1985","unstructured":"Umpleby HC, Ranson DL, Williamson RC. Peculiarities of mucinous colorectal carcinoma. Br J Surg. 1985;72(9):715\u20138.","journal-title":"Br J Surg"},{"issue":"2","key":"1908_CR5","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1002\/1096-9098(200010)75:2<103::AID-JSO6>3.0.CO;2-C","volume":"75","author":"T Nozoe","year":"2000","unstructured":"Nozoe T , Anai H, Nasu S, Sugimachi K. Clinicopathological characteristics of mucinous carcinoma of the colon and rectum. J Surg Oncol. 2000;75(2):103\u20137.","journal-title":"J Surg Oncol"},{"issue":"6","key":"1908_CR6","doi-asserted-by":"publisher","first-page":"908","DOI":"10.1309\/D4QM-379U-E8J2-9R1M","volume":"117","author":"F Akino","year":"2002","unstructured":"Akino F , Mitomi H, Nakamura T, Ohtani Y, Ichinoe M, Okayasu I. High apoptotic activity and low epithelial cell proliferation with underexpression of p21(WAF1\/CIP1) and p27Kip1 of mucinous carcinomas of the colorectum: comparison with well-differentiated type. Am J Clin Pathol. 2002;117(6):908\u201315.","journal-title":"Am J Clin Pathol"},{"issue":"10","key":"1908_CR7","first-page":"1022","volume":"115","author":"JH Connelly","year":"1991","unstructured":"Connelly JH, Robey-Cafferty SS, Cleary KR. Mucinous carcinomas of the colon and rectum. An analysis of 62 stage B and C lesions. Arch Pathol Lab Med. 1991;115(10):1022\u20135.","journal-title":"Arch Pathol Lab Med"},{"issue":"10","key":"1908_CR8","doi-asserted-by":"publisher","first-page":"1068","DOI":"10.1136\/jcp.41.10.1068","volume":"41","author":"TB Halvorsen","year":"1988","unstructured":"Halvorsen TB, Seim E. Influence of mucinous components on survival in colorectal adenocarcinomas: a multivariate analysis. J Clin Pathol. 1988;41(10):1068\u201372.","journal-title":"J Clin Pathol"},{"issue":"4","key":"1908_CR9","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1002\/(SICI)1096-9896(199708)182:4<380::AID-PATH871>3.0.CO;2-U","volume":"182","author":"L Messerini","year":"1997","unstructured":"Messerini L , Vitelli F, De Vitis LR, Mori S, Calzolari A, Palmirotta R et al. Microsatellite instability in sporadic mucinous colorectal carcinomas: relationship to clinico-pathological variables. J Pathol. 1997;182(4):380\u20134.","journal-title":"J Pathol"},{"issue":"6","key":"1908_CR10","doi-asserted-by":"publisher","first-page":"1062","DOI":"10.1016\/j.surg.2014.01.011","volume":"155","author":"RM Lupinacci","year":"2014","unstructured":"Lupinacci RM, Mello ES, Coelho FF, Kruger JA, Perini MV, Pinheiro RS et al. Prognostic implication of mucinous histology in resected colorectal cancer liver metastases. Surgery. 2014;155(6):1062\u20138.","journal-title":"Surgery"},{"issue":"8","key":"1908_CR11","doi-asserted-by":"publisher","first-page":"2232","DOI":"10.1245\/s10434-011-1612-8","volume":"18","author":"US Shin","year":"2011","unstructured":"Shin US, Yu CS, Kim JH, Kim TW, Lim SB, Yoon SN et al. Mucinous rectal cancer: effectiveness of preoperative chemoradiotherapy and prognosis. Ann Surg Oncol. 2011;18(8):2232\u20139.","journal-title":"Ann Surg Oncol"},{"issue":"12","key":"1908_CR12","doi-asserted-by":"publisher","first-page":"3588","DOI":"10.1002\/1097-0142(19931215)72:12<3588::AID-CNCR2820721207>3.0.CO;2-I","volume":"72","author":"M Younes","year":"1993","unstructured":"Younes M, Katikaneni PR, Lechago J. The value of the preoperative mucosal biopsy in the diagnosis of colorectal mucinous adenocarcinoma. Cancer. 1993;72(12):3588\u201392.","journal-title":"Cancer"},{"issue":"5","key":"1908_CR13","first-page":"665","volume":"89","author":"Y Niv","year":"1994","unstructured":"Niv Y. Mucin and colorectal cancer metastasis. Am J Gastroenterol. 1994;89(5):665\u20139.","journal-title":"Am J Gastroenterol"},{"issue":"3","key":"1908_CR14","doi-asserted-by":"publisher","first-page":"186","DOI":"10.4103\/0976-500X.136098","volume":"5","author":"R Maiti","year":"2014","unstructured":"Maiti R. Metronomic chemotherapy. J Pharmacol Pharmacother. 2014;5(3):186\u201392.","journal-title":"J Pharmacol Pharmacother"},{"issue":"16","key":"1908_CR15","doi-asserted-by":"publisher","first-page":"3387","DOI":"10.1016\/j.ejca.2013.06.038","volume":"49","author":"K Lien","year":"2013","unstructured":"Lien K, Georgsdottir S, Sivanathan L, Chan K, Emmenegger U. Low-dose metronomic chemotherapy: a systematic literature analysis. Eur J Cancer. 2013;49(16):3387\u201395.","journal-title":"Eur J Cancer"},{"issue":"1","key":"1908_CR16","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.ejca.2011.06.040","volume":"48","author":"P Fedele","year":"2012","unstructured":"Fedele P, Marino A, Orlando L, Schiavone P, Nacci A, Sponziello F et al. Efficacy and safety of low-dose metronomic chemotherapy with capecitabine in heavily pretreated patients with metastatic breast cancer. Eur J Cancer. 2012;48(1):24\u20139.","journal-title":"Eur J Cancer"},{"issue":"3","key":"1908_CR17","doi-asserted-by":"publisher","first-page":"870","DOI":"10.1007\/s12032-014-0870-2","volume":"31","author":"J Miger","year":"2014","unstructured":"Miger J, Holmqvist A, Sun XF, Albertsson M. Low-dose capecitabine (Xeloda) for treatment for gastrointestinal cancer. Med Oncol. 2014;31(3):870.","journal-title":"Med Oncol"},{"issue":"3","key":"1908_CR18","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1007\/s12032-015-0496-z","volume":"32","author":"A Romiti","year":"2015","unstructured":"Romiti A, Onesti CE, Roberto M, Barucca V, Tomao S, D'Antonio C et al. Continuous, low-dose capecitabine for patients with recurrent colorectal cancer. Med Oncol. 2015;32(3):54.","journal-title":"Med Oncol"},{"issue":"4","key":"1908_CR19","doi-asserted-by":"publisher","first-page":"58","DOI":"10.5493\/wjem.v4.i4.58","volume":"4","author":"A Digklia","year":"2014","unstructured":"Digklia A, Voutsadakis IA. Combinations of vascular endothelial growth factor pathway inhibitors with metronomic chemotherapy: Rational and current status. World J Exp Med. 2014;4(4):58\u201367.","journal-title":"World J Exp Med"},{"issue":"7","key":"1908_CR20","doi-asserted-by":"publisher","first-page":"1725","DOI":"10.1038\/bjc.2013.553","volume":"109","author":"RK Kelley","year":"2013","unstructured":"Kelley RK, Hwang J, Magbanua MJ, Watt L, Beumer JH, Christner SM et al. A phase 1 trial of imatinib, bevacizumab, and metronomic cyclophosphamide in advanced colorectal cancer. Br J Cancer. 2013;109(7):1725\u201334.","journal-title":"Br J Cancer"},{"issue":"6","key":"1908_CR21","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1556\/MaSeb.66.2013.6.5","volume":"66","author":"Z Baranyai","year":"2013","unstructured":"Baranyai Z, J\u00f3sa V, Krzystanek M, Eklund AC, Sz\u00e1sz AM, Sz\u00e1ll\u00e1si Z. Evaluation of thrombocytosis as predictive factor in colorectal cancer. Magy Seb. 2013;66(6):331\u20137.","journal-title":"Magy Seb"},{"issue":"8","key":"1908_CR22","doi-asserted-by":"publisher","first-page":"1757","DOI":"10.1038\/bjc.2013.118","volume":"108","author":"AI Phipps","year":"2013","unstructured":"Phipps AI, Buchanan DD, Makar KW, Win AK, Baron JA, Lindor NM et al. KRAS-mutation status in relation to colorectal cancer survival: the joint impact of correlated tumour markers. Br J Cancer. 2013;108(8):1757\u201364.","journal-title":"Br J Cancer"},{"issue":"6","key":"1908_CR23","doi-asserted-by":"publisher","first-page":"866","DOI":"10.1080\/02841860701203560","volume":"46","author":"H Carstens","year":"2007","unstructured":"Carstens H, Albertsson M. Successful treatment with low-dose capecitabine for disseminated esophageal adenocarcinoma. Acta Oncol. 2007;46(6):866\u20138.","journal-title":"Acta Oncol"}],"container-title":["BMC Cancer"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12885-015-1908-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12885-015-1908-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12885-015-1908-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2016,10,6]],"date-time":"2016-10-06T21:36:00Z","timestamp":1475789760000},"score":1,"resource":{"primary":{"URL":"http:\/\/bmccancer.biomedcentral.com\/articles\/10.1186\/s12885-015-1908-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11,10]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["1908"],"URL":"https:\/\/doi.org\/10.1186\/s12885-015-1908-3","relation":{},"ISSN":["1471-2407"],"issn-type":[{"value":"1471-2407","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11,10]]},"article-number":"884"}}