{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T22:57:30Z","timestamp":1774479450203,"version":"3.50.1"},"reference-count":68,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2016,10,3]],"date-time":"2016-10-03T00:00:00Z","timestamp":1475452800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2012\/06955-0"],"award-info":[{"award-number":["2012\/06955-0"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2010\/00209-9; 2013\/16115-1; 2014\/13334-7"],"award-info":[{"award-number":["2010\/00209-9; 2013\/16115-1; 2014\/13334-7"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["302863\/2013-3"],"award-info":[{"award-number":["302863\/2013-3"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Cancer"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1186\/s12885-016-2811-2","type":"journal-article","created":{"date-parts":[[2016,10,3]],"date-time":"2016-10-03T07:06:50Z","timestamp":1475478410000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Leucine-rich diet alters the 1H-NMR based metabolomic profile without changing the Walker-256 tumour mass in rats"],"prefix":"10.1186","volume":"16","author":[{"given":"La\u00eds Rosa","family":"Viana","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael","family":"Canevarolo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna Caroline Perina","family":"Luiz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raquel Frias","family":"Soares","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camila","family":"Lubaczeuski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Carolina de Mattos","family":"Zeri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Cristina Cintra","family":"Gomes-Marcondes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,10,3]]},"reference":[{"issue":"2","key":"2811_CR1","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1097\/MOG.0b013e3283347e77","volume":"26","author":"MJ Tisdale","year":"2010","unstructured":"Tisdale MJ. Cancer cachexia. Curr Opin Gastroenterol. 2010;26(2):146\u201351.","journal-title":"Curr Opin Gastroenterol"},{"issue":"4","key":"2811_CR2","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1097\/MCO.0b013e328300ecc1","volume":"11","author":"BH Tan","year":"2008","unstructured":"Tan BH, Fearon KC. Cachexia: prevalence and impact in medicine. Curr Opin Clin Nutr Metab Care. 2008;11(4):400\u20137.","journal-title":"Curr Opin Clin Nutr Metab Care"},{"issue":"4","key":"2811_CR3","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1016\/j.cell.2010.07.011","volume":"142","author":"X Zhou","year":"2010","unstructured":"Zhou X, et al. Reversal of cancer cachexia and muscle wasting by ActRIIB antagonism leads to prolonged survival. Cell. 2010;142(4):531\u201343.","journal-title":"Cell"},{"issue":"3","key":"2811_CR4","doi-asserted-by":"publisher","first-page":"e92966","DOI":"10.1371\/journal.pone.0092966","volume":"9","author":"M Tsoli","year":"2014","unstructured":"Tsoli M, Schweiger M, Vanniasinghe AS, Painter A, Zechner R. Depletion of white adipose tissue in cancer cachexia syndrome is associated with inflammatory signaling and disrupted circadian regulation. PLoS One. 2014;9(3):e92966.","journal-title":"PLoS One"},{"issue":"2","key":"2811_CR5","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1152\/physrev.00016.2008","volume":"89","author":"MJ Tisdale","year":"2009","unstructured":"Tisdale MJ. Mechanisms of cancer cachexia. Physiol Rev. 2009;89(2):381\u2013410.","journal-title":"Physiol Rev"},{"key":"2811_CR6","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.semcdb.2015.12.022","volume":"54","author":"IJ Gallagher","year":"2016","unstructured":"Gallagher IJ, et al. Omics\/systems biology and cancer cachexia. Semin Cell Dev Biol. 2016;54:92\u2013103.","journal-title":"Semin Cell Dev Biol"},{"issue":"2","key":"2811_CR7","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1007\/s13539-012-0101-7","volume":"4","author":"H Der-Torossian","year":"2013","unstructured":"Der-Torossian H, et al. Metabolic derangements in the gastrocnemius and the effect of Compound A therapy in a murine model of cancer cachexia. J Cachexia Sarcopenia Muscle. 2013;4(2):145\u201355.","journal-title":"J Cachexia Sarcopenia Muscle"},{"issue":"4","key":"2811_CR8","doi-asserted-by":"publisher","first-page":"1953","DOI":"10.1021\/pr101198q","volume":"10","author":"G Shen","year":"2011","unstructured":"Shen G, Chen Y, Sun J, Zhang R, Zhang Y, He J, Tian Y, Song Y, Chen X, Abliz Z. Time-course changes in potential biomarkers detected using a metabonomic approach in Walker 256 tumor-bearing rats. J Proteome Res. 2011;10(4):1953\u201361.","journal-title":"J. Proteome Res"},{"issue":"8","key":"2811_CR9","doi-asserted-by":"publisher","first-page":"e003190","DOI":"10.1161\/JAHA.115.003190","volume":"5","author":"WG Hunter","year":"2016","unstructured":"Hunter WG, et al. Metabolomic profiling identifies novel circulating biomarkers of mitochondrial dysfunction differentially elevated in heart failure with preserved versus reduced ejection fraction: evidence for shared metabolic impairments in clinical heart failure. J Am Heart Assoc. 2016;5(8):e003190.","journal-title":"J Am Heart Assoc"},{"key":"2811_CR10","doi-asserted-by":"publisher","unstructured":"Ruiz-Rodado V, et al. 1H NMR-Linked Metabolomics Analysis of Liver from a Mouse Model of NP-C1 Disease. J Proteome Res. 2016. doi: 10.1021\/acs.jproteome.6b00238 .","DOI":"10.1021\/acs.jproteome.6b00238"},{"issue":"3","key":"2811_CR11","doi-asserted-by":"publisher","first-page":"266","DOI":"10.2174\/138620712799218563","volume":"15","author":"Q Bu","year":"2012","unstructured":"Bu Q, et al. Metabolomics: a revolution for novel cancer marker identification. Comb Chem High Throughput Screen. 2012;15(3):266\u201375.","journal-title":"Comb Chem High Throughput Screen"},{"issue":"2","key":"2811_CR12","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1158\/1078-0432.CCR-08-1059","volume":"15","author":"JL Spratlin","year":"2009","unstructured":"Spratlin JL, Serkova NJ, Eckhardt SG. Clinical applications of metabolomics in oncology: a review. Clin Cancer Res. 2009;15(2):431\u201340.","journal-title":"Clin Cancer Res"},{"key":"2811_CR13","doi-asserted-by":"crossref","unstructured":"Maschke J, et al. Nutritional care of cancer patients: a survey on patients' needs and medical care in reality. Int J Clin Oncol. 2016. doi: 10.1007\/s10147-016-1025-6","DOI":"10.1007\/s10147-016-1025-6"},{"issue":"5","key":"2811_CR14","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1095\/biolreprod.112.107276","volume":"88","author":"LR Viana","year":"2013","unstructured":"Viana LR, Gomes-Marcondes MC. Leucine-rich diet improves the serum amino acid profile and body composition of fetuses from tumor-bearing pregnant mice. Biol Reprod. 2013;88(5):121.","journal-title":"Biol Reprod"},{"issue":"2","key":"2811_CR15","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1007\/s00726-014-1866-0","volume":"47","author":"DA Columbus","year":"2015","unstructured":"Columbus DA, Fiorotto ML, Davis TA. Leucine is a major regulator of muscle protein synthesis in neonates. Amino Acids. 2015;47(2):259\u201370.","journal-title":"Amino Acids"},{"key":"2811_CR16","unstructured":"Moro T, et al. Amino Acid Sensing in Skeletal Muscle. Trends Endocrinol Metab. 2016. doi: 10.1016\/j ."},{"issue":"6 Suppl","key":"2811_CR17","doi-asserted-by":"crossref","first-page":"1553S","DOI":"10.1093\/jn\/135.6.1553S","volume":"135","author":"PJ Garlick","year":"2005","unstructured":"Garlick PJ. The role of leucine in the regulation of protein metabolism. J Nutr. 2005;135(6 Suppl):1553S\u20136S.","journal-title":"J Nutr"},{"issue":"4","key":"2811_CR18","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1007\/s13105-012-0164-0","volume":"68","author":"EM Salomao","year":"2012","unstructured":"Salomao EM, Gomes-Marcondes MC. Light aerobic physical exercise in combination with leucine and\/or glutamine-rich diet can improve the body composition and muscle protein metabolism in young tumor-bearing rats. J Physiol Biochem. 2012;68(4):493\u2013501.","journal-title":"J Physiol Biochem"},{"issue":"3","key":"2811_CR19","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1590\/S0100-879X2001000300006","volume":"34","author":"G Ventrucci","year":"2001","unstructured":"Ventrucci G, Mello MA, Gomes-Marcondes MC. Effect of a leucine-supplemented diet on body composition changes in pregnant rats bearing Walker 256 tumor. Braz J Med Biol Res. 2001;34(3):333\u20138.","journal-title":"Braz J Med Biol Res"},{"issue":"2","key":"2811_CR20","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.nut.2003.10.014","volume":"20","author":"G Ventrucci","year":"2004","unstructured":"Ventrucci G, et al. Effects of a leucine-rich diet on body composition during nutritional recovery in rats. Nutrition. 2004;20(2):213\u20137.","journal-title":"Nutrition"},{"key":"2811_CR21","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/1477-7827-12-2","volume":"12","author":"B Cruz","year":"2014","unstructured":"Cruz B, Gomes-Marcondes MC. Leucine-rich diet supplementation modulates foetal muscle protein metabolism impaired by Walker-256 tumour. Reprod Biol Endocrinol. 2014;12:2.","journal-title":"Reprod Biol Endocrinol"},{"issue":"10","key":"2811_CR22","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.1590\/S0100-879X1998001000017","volume":"31","author":"MC Gomes-Marcondes","year":"1998","unstructured":"Gomes-Marcondes MC, et al. Effect of Walker 256 tumor growth on intestinal absorption of leucine, methionine and glucose in newly weaned and mature rats. Braz J Med Biol Res. 1998;31(10):1345\u20138.","journal-title":"Braz J Med Biol Res"},{"issue":"1","key":"2811_CR23","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1016\/j.cyto.2013.05.018","volume":"64","author":"EM Goncalves","year":"2013","unstructured":"Goncalves EM, Salomao EM, Gomes-Marcondes MC. Leucine modulates the effect of Walker factor, a proteolysis-inducing factor-like protein from Walker tumours, on gene expression and cellular activity in C2C12 myotubes. Cytokine. 2013;64(1):343\u201350.","journal-title":"Cytokine"},{"issue":"8","key":"2811_CR24","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.1080\/01635581.2010.492082","volume":"62","author":"EM Salomao","year":"2010","unstructured":"Salomao EM, et al. Physical exercise and a leucine-rich diet modulate the muscle protein metabolism in Walker tumor-bearing rats. Nutr Cancer. 2010;62(8):1095\u2013104.","journal-title":"Nutr Cancer"},{"key":"2811_CR25","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1186\/1471-2407-7-42","volume":"7","author":"G Ventrucci","year":"2007","unstructured":"Ventrucci G, Mello MA, Gomes-Marcondes MC. Leucine-rich diet alters the eukaryotic translation initiation factors expression in skeletal muscle of tumour-bearing rats. BMC Cancer. 2007;7:42.","journal-title":"BMC Cancer"},{"issue":"10","key":"2811_CR26","doi-asserted-by":"publisher","first-page":"1628","DOI":"10.1038\/sj.bjc.6600236","volume":"86","author":"MC Gomes-Marcondes","year":"2002","unstructured":"Gomes-Marcondes MC, et al. Development of an in-vitro model system to investigate the mechanism of muscle protein catabolism induced by proteolysis-inducing factor. Br J Cancer. 2002;86(10):1628\u201333.","journal-title":"Br J Cancer"},{"issue":"1","key":"2811_CR27","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/S0304-3835(02)00006-X","volume":"180","author":"MC Gomes-Marcondes","year":"2002","unstructured":"Gomes-Marcondes MC, Tisdale MJ. Induction of protein catabolism and the ubiquitin-proteasome pathway by mild oxidative stress. Cancer Lett. 2002;180(1):69\u201374.","journal-title":"Cancer Lett"},{"issue":"11","key":"2811_CR28","doi-asserted-by":"publisher","first-page":"1589","DOI":"10.1590\/S0100-879X2003001100017","volume":"36","author":"MC Gomes-Marcondes","year":"2003","unstructured":"Gomes-Marcondes MC, et al. A leucine-supplemented diet improved protein content of skeletal muscle in young tumor-bearing rats. Braz J Med Biol Res. 2003;36(11):1589\u201394.","journal-title":"Braz J Med Biol Res"},{"issue":"1","key":"2811_CR29","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1007\/s00726-008-0222-7","volume":"38","author":"EM Goncalves","year":"2010","unstructured":"Goncalves EM, Gomes-Marcondes MC. Leucine affects the fibroblastic Vero cells stimulating the cell proliferation and modulating the proteolysis process. Amino Acids. 2010;38(1):145\u201353.","journal-title":"Amino Acids"},{"issue":"4","key":"2811_CR30","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1677\/erc.1.00828","volume":"11","author":"G Ventrucci","year":"2004","unstructured":"Ventrucci G, Mello MA, Gomes-Marcondes MC. Proteasome activity is altered in skeletal muscle tissue of tumour-bearing rats a leucine-rich diet. Endocr Relat Cancer. 2004;11(4):887\u201395.","journal-title":"Endocr Relat Cancer"},{"key":"2811_CR31","doi-asserted-by":"publisher","unstructured":"Toneto AT, et al. Nutritional leucine supplementation attenuates cardiac failure in tumour-bearing cachectic animals. J Cachexia Sarcopenia Muscle. 2016. In Press. doi: 10.1002\/jcsm.1210 .","DOI":"10.1002\/jcsm.1210"},{"issue":"6","key":"2811_CR32","doi-asserted-by":"publisher","first-page":"E601","DOI":"10.1152\/ajpendo.00089.2015","volume":"309","author":"DA Columbus","year":"2015","unstructured":"Columbus DA, et al. Impact of prolonged leucine supplementation on protein synthesis and lean growth in neonatal pigs. Am J Physiol Endocrinol Metab. 2015;309(6):E601\u201310.","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"2811_CR33","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1186\/s12885-016-2103-x","volume":"16","author":"BL Cruz","year":"2015","unstructured":"Cruz BL, et al. Dietary leucine supplementation minimises tumour-induced damage in placental tissues of pregnant, tumour-bearing rats. BMC Cancer. 2015;16:58.","journal-title":"BMC Cancer"},{"issue":"7-8","key":"2811_CR34","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1016\/S0899-9007(99)00095-7","volume":"15","author":"PW Emery","year":"1999","unstructured":"Emery PW. Cachexia in experimental models. Nutrition. 1999;15(7-8):600\u20133.","journal-title":"Nutrition"},{"issue":"11","key":"2811_CR35","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1093\/jn\/123.11.1939","volume":"123","author":"PG Reeves","year":"1993","unstructured":"Reeves PG, Nielsen FH, Fahey Jr GC. AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. J Nutr. 1993;123(11):1939\u201351.","journal-title":"J Nutr"},{"issue":"5","key":"2811_CR36","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1038\/sj.bjc.6602425","volume":"92","author":"C Vale","year":"2005","unstructured":"Vale C, et al. Trends in UK cancer trials: results from the UK Coordinating Committee for Cancer Research National Register of Cancer Trials. Br J Cancer. 2005;92(5):811\u20134.","journal-title":"Br J Cancer"},{"issue":"1","key":"2811_CR37","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1002\/nbm.740","volume":"5","author":"JE Belle Le","year":"2002","unstructured":"Le Belle JE, Harris NG, Williams SR, Bhakoo KK. A comparison of cell and tissue extraction techniques using high-resolution 1H-NMR spectroscopy. NMR Biomed. 2002;5(1):37\u201344.","journal-title":"NMR Biomed"},{"key":"2811_CR38","first-page":"221","volume-title":"Principles and Methods of toxicology","author":"SC Gad","year":"2009","unstructured":"Gad SC. Statistic for Toxicologists. In: Principles and Methods of toxicology. 4th ed. New York: Raven; 2009. p. 221\u201374.","edition":"4"},{"issue":"W1","key":"2811_CR39","doi-asserted-by":"publisher","first-page":"W251","DOI":"10.1093\/nar\/gkv380","volume":"43","author":"J Xia","year":"2015","unstructured":"Xia J, et al. MetaboAnalyst 3.0-making metabolomics more meaningful. Nucleic Acids Res. 2015;43(W1):W251\u20137.","journal-title":"Nucleic Acids Res"},{"key":"2811_CR40","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1146\/annurev.biochem.69.1.617","volume":"69","author":"M Ibba","year":"2000","unstructured":"Ibba M, Soll D. Aminoacyl-tRNA synthesis. Annu Rev Biochem. 2000;69:617\u201350.","journal-title":"Annu Rev Biochem"},{"issue":"3","key":"2811_CR41","doi-asserted-by":"crossref","first-page":"856S","DOI":"10.1093\/jn\/131.3.856S","volume":"131","author":"JC Anthony","year":"2001","unstructured":"Anthony JC, et al. Signaling pathways involved in translational control of protein synthesis in skeletal muscle by leucine. J Nutr. 2001;131(3):856S\u201360S.","journal-title":"J Nutr"},{"issue":"Database issue","key":"2811_CR42","doi-asserted-by":"publisher","first-page":"D603","DOI":"10.1093\/nar\/gkn810","volume":"37","author":"DS Wishart","year":"2009","unstructured":"Wishart DS, et al. HMDB: a knowledgebase for the human metabolome. Nucleic Acids Res. 2009;37(Database issue):D603\u201310.","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"2811_CR43","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1007\/s13539-013-0117-7","volume":"5","author":"M Sheffield-Moore","year":"2014","unstructured":"Sheffield-Moore M, et al. Isotopic decay of urinary or plasma 3-methylhistidine as a potential biomarker of pathologic skeletal muscle loss. J Cachexia Sarcopenia Muscle. 2014;5(1):19\u201325.","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"2811_CR44","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/1471-2407-2-7","volume":"2","author":"G Ventrucci","year":"2002","unstructured":"Ventrucci G, de Mello MA, Gomes-Marcondes MC. Effects of leucine supplemented diet on intestinal absorption in tumor bearing pregnant rats. BMC Cancer. 2002;2:7.","journal-title":"BMC Cancer"},{"issue":"2","key":"2811_CR45","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1095\/biolreprod.114.123307","volume":"92","author":"LR Viana","year":"2015","unstructured":"Viana LR, Gomes-Marcondes MC. A leucine-rich diet modulates the tumor-induced down-regulation of the MAPK\/ERK and PI3K\/Akt\/mTOR signaling pathways and maintains the expression of the ubiquitin-proteasome pathway in the placental tissue of NMRI mice. Biol Reprod. 2015;92(2):49.","journal-title":"Biol Reprod"},{"issue":"2","key":"2811_CR46","doi-asserted-by":"crossref","first-page":"544S","DOI":"10.1093\/jn\/136.2.544S","volume":"136","author":"E Blomstrand","year":"2006","unstructured":"Blomstrand E. A role for branched-chain amino acids in reducing central fatigue. J Nutr. 2006;136(2):544S\u20137S.","journal-title":"J Nutr"},{"key":"2811_CR47","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/2049-3002-2-18","volume":"2","author":"SK Shukla","year":"2014","unstructured":"Shukla SK, et al. Metabolic reprogramming induced by ketone bodies diminishes pancreatic cancer cachexia. Cancer Metab. 2014;2:18.","journal-title":"Cancer Metab"},{"issue":"6","key":"2811_CR48","doi-asserted-by":"publisher","first-page":"2450","DOI":"10.1046\/j.1471-4159.1995.65062450.x","volume":"65","author":"MG Bixel","year":"1995","unstructured":"Bixel MG, Hamprecht B. Generation of ketone bodies from leucine by cultured astroglial cells. J Neurochem. 1995;65(6):2450\u201361.","journal-title":"J Neurochem"},{"issue":"1","key":"2811_CR49","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/0003-9861(84)90596-4","volume":"233","author":"YY Yeh","year":"1984","unstructured":"Yeh YY. Ketone body synthesis from leucine by adipose tissue from different sites in the rat. Arch Biochem Biophys. 1984;233(1):10\u20138.","journal-title":"Arch Biochem Biophys"},{"issue":"5","key":"2811_CR50","doi-asserted-by":"publisher","first-page":"2181","DOI":"10.1074\/jbc.M115.676510","volume":"291","author":"X Zou","year":"2016","unstructured":"Zou X, et al. Acetoacetate Accelerates Muscle Regeneration and Ameliorates Muscular Dystrophy in Mice. J Biol Chem. 2016;291(5):2181\u201395.","journal-title":"J Biol Chem"},{"issue":"4","key":"2811_CR51","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1007\/s10545-014-9704-9","volume":"37","author":"T Fukao","year":"2014","unstructured":"Fukao T, et al. Ketone body metabolism and its defects. J Inherit Metab Dis. 2014;37(4):541\u201351.","journal-title":"J Inherit Metab Dis"},{"issue":"5","key":"2811_CR52","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1038\/icb.1979.54","volume":"57","author":"BA Magee","year":"1979","unstructured":"Magee BA, et al. The inhibition of malignant cell growth by ketone bodies. Aust J Exp Biol Med Sci. 1979;57(5):529\u201339.","journal-title":"Aust J Exp Biol Med Sci"},{"issue":"6","key":"2811_CR53","doi-asserted-by":"publisher","first-page":"e0127407","DOI":"10.1371\/journal.pone.0127407","volume":"10","author":"AM Poff","year":"2015","unstructured":"Poff AM, et al. Non-toxic metabolic management of metastatic cancer in vm mice: novel combination of ketogenic diet, ketone supplementation, and hyperbaric oxygen therapy. PLoS One. 2015;10(6):e0127407.","journal-title":"PLoS One"},{"issue":"6","key":"2811_CR54","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1016\/j.bbabio.2010.08.009","volume":"1807","author":"TN Seyfried","year":"2011","unstructured":"Seyfried TN, et al. Metabolic management of brain cancer. Biochim Biophys Acta. 2011;1807(6):577\u201394.","journal-title":"Biochim Biophys Acta"},{"issue":"5","key":"2811_CR55","doi-asserted-by":"publisher","first-page":"e0155050","DOI":"10.1371\/journal.pone.0155050","volume":"11","author":"RJ Klement","year":"2016","unstructured":"Klement RJ, et al. Anti-Tumor Effects of Ketogenic Diets in Mice: A Meta-Analysis. PLoS One. 2016;11(5):e0155050.","journal-title":"PLoS One"},{"issue":"6","key":"2811_CR56","doi-asserted-by":"publisher","first-page":"e65522","DOI":"10.1371\/journal.pone.0065522","volume":"8","author":"AM Poff","year":"2013","unstructured":"Poff AM, et al. The ketogenic diet and hyperbaric oxygen therapy prolong survival in mice with systemic metastatic cancer. PLoS One. 2013;8(6):e65522.","journal-title":"PLoS One"},{"issue":"6","key":"2811_CR57","doi-asserted-by":"publisher","first-page":"e0130357","DOI":"10.1371\/journal.pone.0130357","volume":"10","author":"EC Woolf","year":"2015","unstructured":"Woolf EC, et al. The ketogenic diet alters the hypoxic response and affects expression of proteins associated with angiogenesis, invasive potential and vascular permeability in a mouse glioma model. PLoS One. 2015;10(6):e0130357.","journal-title":"PLoS One"},{"issue":"1","key":"2811_CR58","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1038\/bjc.1985.153","volume":"52","author":"KC Fearon","year":"1985","unstructured":"Fearon KC, et al. Failure of systemic ketosis to control cachexia and the growth rate of the Walker 256 carcinosarcoma in rats. Br J Cancer. 1985;52(1):87\u201392.","journal-title":"Br J Cancer"},{"key":"2811_CR59","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1093\/neuonc\/now088","volume":"18","author":"HM Feyter De","year":"2016","unstructured":"De Feyter HM, et al. A ketogenic diet increases transport and oxidation of ketone bodies in RG2 and 9L gliomas without affecting tumor growth. Neuro Oncol. 2016;18:1079\u201387.","journal-title":"Neuro Oncol"},{"issue":"2","key":"2811_CR60","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1007\/s00109-015-1307-x","volume":"94","author":"I Marchiq","year":"2015","unstructured":"Marchiq I, Pouyssegur J. Hypoxia, cancer metabolism and the therapeutic benefit of targeting lactate\/H symporters. J Mol Med (Berl). 2015;94(2):155\u201371.","journal-title":"J Mol Med (Berl)"},{"issue":"22","key":"2811_CR61","doi-asserted-by":"publisher","first-page":"3368","DOI":"10.1182\/blood-2015-04-636332","volume":"125","author":"C Moreno","year":"2015","unstructured":"Moreno C. Chronic lymphocytic leukemia and the Warburg effect. Blood. 2015;125(22):3368\u20139.","journal-title":"Blood"},{"issue":"4","key":"2811_CR62","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1007\/s11306-014-0760-9","volume":"11","author":"B Vaitheesvaran","year":"2015","unstructured":"Vaitheesvaran B, et al. The Warburg effect: a balance of flux analysis. Metabolomics. 2015;11(4):787\u201396.","journal-title":"Metabolomics"},{"issue":"5","key":"2811_CR63","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1016\/j.cell.2008.08.021","volume":"134","author":"PP Hsu","year":"2008","unstructured":"Hsu PP, Sabatini DM. Cancer cell metabolism: Warburg and beyond. Cell. 2008;134(5):703\u20137.","journal-title":"Cell"},{"key":"2811_CR64","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1146\/annurev-cellbio-092910-154237","volume":"27","author":"SY Lunt","year":"2011","unstructured":"Lunt SY, Vander Heiden MG. Aerobic glycolysis: meeting the metabolic requirements of cell proliferation. Annu Rev Cell Dev Biol. 2011;27:441\u201364.","journal-title":"Annu Rev Cell Dev Biol"},{"issue":"4","key":"2811_CR65","first-page":"916","volume":"60","author":"S Walenta","year":"2000","unstructured":"Walenta S, et al. High lactate levels predict likelihood of metastases, tumor recurrence, and restricted patient survival in human cervical cancers. Cancer Res. 2000;60(4):916\u201321.","journal-title":"Cancer Res"},{"issue":"2","key":"2811_CR66","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.cmet.2012.06.011","volume":"16","author":"KC Fearon","year":"2012","unstructured":"Fearon KC, Glass DJ, Guttridge DC. Cancer cachexia: mediators, signaling, and metabolic pathways. Cell Metab. 2012;16(2):153\u201366.","journal-title":"Cell Metab"},{"issue":"7231","key":"2811_CR67","doi-asserted-by":"publisher","first-page":"910","DOI":"10.1038\/nature07762","volume":"457","author":"A Sreekumar","year":"2009","unstructured":"Sreekumar A, et al. Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression. Nature. 2009;457(7231):910\u20134.","journal-title":"Nature"},{"issue":"1","key":"2811_CR68","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/2049-3002-2-6","volume":"2","author":"KA Liu","year":"2014","unstructured":"Liu KA, et al. Leucine supplementation differentially enhances pancreatic cancer growth in lean and overweight mice. Cancer Metab. 2014;2(1):6.","journal-title":"Cancer Metab"}],"container-title":["BMC Cancer"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12885-016-2811-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12885-016-2811-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12885-016-2811-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,14]],"date-time":"2019-09-14T02:19:01Z","timestamp":1568427541000},"score":1,"resource":{"primary":{"URL":"http:\/\/bmccancer.biomedcentral.com\/articles\/10.1186\/s12885-016-2811-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,3]]},"references-count":68,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["2811"],"URL":"https:\/\/doi.org\/10.1186\/s12885-016-2811-2","relation":{},"ISSN":["1471-2407"],"issn-type":[{"value":"1471-2407","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,3]]},"article-number":"764"}}